hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05918
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| ALDH18A1 | Delta-1-pyrroline-5-carboxylate synthase (P5CS) (Aldehyde dehydrogenase family 18 member A1) [Includes: Glutamate 5-kinase (GK) (EC 2.7.2.11) (Gamma-glutamyl kinase); Gamma-glutamyl phosphate reductase (GPR) (EC 1.2.1.41) (Glutamate-5-semialdehyde dehydrogenase) (Glutamyl-gamma-semialdehyde dehydrogenase)] | UniProt NCBI |
| LONP1 | Lon protease homolog, mitochondrial (EC 3.4.21.53) (LONHs) (Lon protease-like protein) (LONP) (Mitochondrial ATP-dependent protease Lon) (Serine protease 15) | UniProt NCBI |
| PPAT | Amidophosphoribosyltransferase (ATase) (EC 2.4.2.14) (Glutamine phosphoribosylpyrophosphate amidotransferase) (GPAT) | UniProt NCBI |
| PC | Pyruvate carboxylase, mitochondrial (EC 6.4.1.1) (Pyruvic carboxylase) (PCB) | UniProt NCBI |
| PCCA | Propionyl-CoA carboxylase alpha chain, mitochondrial (PCCase subunit alpha) (EC 6.4.1.3) (Propanoyl-CoA:carbon dioxide ligase subunit alpha) | UniProt NCBI |
| IARS2 | Isoleucine--tRNA ligase, mitochondrial (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) (IleRS) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-3371599 | 0.000465187760645 | 0.333333333333 | PC PCCA | Defective HLCS causes multiple carboxylase deficiency |
| REAC:R-HSA-3323169 | 0.000620139265586 | 0.333333333333 | PC PCCA | Defects in biotin (Btn) metabolism |
| HP:0001374 | 0.000914762075078 | 0.5 | ALDH18A1 LONP1 IARS2 | Congenital hip dislocation |
| REAC:R-HSA-196780 | 0.0012174763081 | 0.333333333333 | PC PCCA | Biotin transport and metabolism |
| HP:0000519 | 0.00129428949367 | 0.5 | ALDH18A1 LONP1 IARS2 | Developmental cataract |
| HP:0025356 | 0.00189957809204 | 0.5 | ALDH18A1 PCCA PC | Psychomotor retardation |
| REAC:R-HSA-3296482 | 0.00464022545552 | 0.333333333333 | PC PCCA | Defects in vitamin and cofactor metabolism |
| HP:0011849 | 0.0089304858519 | 0.666666666667 | ALDH18A1 IARS2 LONP1 PCCA | Abnormal bone ossification |
| HP:0003330 | 0.0139359737399 | 0.666666666667 | ALDH18A1 IARS2 LONP1 PCCA | Abnormal bone structure |
| KEGG:01230 | 0.0153684049392 | 0.333333333333 | ALDH18A1 PC | Biosynthesis of amino acids |
| HP:0002827 | 0.0197311756416 | 0.5 | ALDH18A1 LONP1 IARS2 | Hip dislocation |
| WP:WP3925 | 0.021066272601 | 0.333333333333 | ALDH18A1 PC | Amino Acid metabolism |
| HP:0007700 | 0.0289200021372 | 0.5 | ALDH18A1 LONP1 IARS2 | Ocular anterior segment dysgenesis |
| HP:0030311 | 0.032813556514 | 0.5 | ALDH18A1 LONP1 IARS2 | Lower extremity joint dislocation |
| KEGG:01100 | 0.0331288091988 | 0.666666666667 | ALDH18A1 PCCA PPAT PC | Metabolic pathways |
| KEGG:01200 | 0.039527830217 | 0.333333333333 | PC PCCA | Carbon metabolism |
| HP:0012758 | 0.0404781039435 | 0.833333333333 | ALDH18A1 IARS2 PCCA LONP1 PC | Neurodevelopmental delay |
| GO:0009374 | 0.0405595771497 | 0.333333333333 | PC PCCA | biotin binding |
| HP:0001384 | 0.0405599116431 | 0.5 | ALDH18A1 LONP1 IARS2 | Abnormality of the hip joint |
| HP:0005262 | 0.0442958584683 | 0.5 | ALDH18A1 LONP1 IARS2 | Abnormality of the synovia |
| CORUM:7057 | 0.0499726005494 | 0.166666666667 | PCCA | Propionyl-CoA carboxylase |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| ALDH18A1 | PCCA | 0.978 | 0.894 | bioplex (PCCA) bioplex_WMM boldt gupta_WMM fraction boldt_WMM treiber_WMM |
| ALDH18A1 | LONP1 | 0.493 | 0.62 | bioplex_WMM boldt gupta_WMM fraction boldt_WMM treiber_WMM |
| PC | PCCA | 0.163 | 0.42 | bioplex_WMM boldt fraction boldt_WMM treiber_WMM |
| PC | ALDH18A1 | 0.125 | 0.399 | bioplex_WMM boldt fraction boldt_WMM treiber_WMM |
| IARS2 | PCCA | 0.059 | 0.331 | bioplex_WMM boldt fraction boldt_WMM |
| IARS2 | PPAT | 0.043 | 0.27 | bioplex (IARS2) bioplex_WMM youn_WMM fraction |
| IARS2 | ALDH18A1 | 0.034 | 0.259 | bioplex (IARS2) bioplex_WMM boldt gupta_WMM fraction boldt_WMM treiber_WMM |
| PPAT | LONP1 | 0.007 | 0.004 | bioplex_WMM youn_WMM WMM_only |
| PPAT | PC | 0.007 | 0.002 | bioplex_WMM WMM_only |
| PPAT | ALDH18A1 | 0.0 | 0.014 | bioplex_WMM fraction |
| IARS2 | LONP1 | 0.0 | 0.017 | bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM |
| PPAT | PCCA | 0.0 | 0.006 | bioplex_WMM fraction |
| IARS2 | PC | 0.0 | 0.009 | bioplex_WMM boldt fraction boldt_WMM treiber_WMM |
| LONP1 | PCCA | 0.0 | 0.006 | bioplex_WMM boldt fraction boldt_WMM |
| PC | LONP1 | 0.0 | 0.001 | hein_WMM bioplex_WMM boldt fraction boldt_WMM treiber_WMM |
Images
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Complex HuMAP2_05918 has an average edge precision of 0.217 which is ranked 5914 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| ALDH18A1 | HuMAP2_01499 HuMAP2_04069 HuMAP2_05918 |
| LONP1 | HuMAP2_01499 HuMAP2_01826 HuMAP2_05918 |
| PPAT | HuMAP2_01042 HuMAP2_01476 HuMAP2_02684 HuMAP2_03901 HuMAP2_05568 HuMAP2_05918 |
| PC | HuMAP2_01499 HuMAP2_05918 |
| PCCA | HuMAP2_02308 HuMAP2_04069 HuMAP2_05729 HuMAP2_05918 |
| IARS2 | HuMAP2_01042 HuMAP2_02684 HuMAP2_03901 HuMAP2_05918 |