hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_05922

Confidence: Very High

Genename	Protein Name	Links
MCM2	DNA replication licensing factor MCM2 (EC 3.6.4.12) (Minichromosome maintenance protein 2 homolog) (Nuclear protein BM28)	UniProt NCBI
MCM7	DNA replication licensing factor MCM7 (EC 3.6.4.12) (CDC47 homolog) (P1.1-MCM3)	UniProt NCBI
MCM5	DNA replication licensing factor MCM5 (EC 3.6.4.12) (CDC46 homolog) (P1-CDC46)	UniProt NCBI
MCM4	DNA replication licensing factor MCM4 (EC 3.6.4.12) (CDC21 homolog) (P1-CDC21)	UniProt NCBI
MCMBP	Mini-chromosome maintenance complex-binding protein (MCM-BP) (MCM-binding protein)	UniProt NCBI
MCM6	DNA replication licensing factor MCM6 (EC 3.6.4.12) (p105MCM)	UniProt NCBI
MCM3	DNA replication licensing factor MCM3 (EC 3.6.4.12) (DNA polymerase alpha holoenzyme-associated protein P1) (P1-MCM3) (RLF subunit beta) (p102)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:387	2.45834046217e-20	0.857142857143	MCM5 MCM2 MCM4 MCM3 MCM6 MCM7	MCM complex
GO:0042555	1.22930232891e-18	1.0	MCMBP MCM5 MCM2 MCM4 MCM3 MCM6 MCM7	MCM complex
REAC:R-HSA-176974	7.13872444958e-17	0.857142857143	MCM5 MCM2 MCM4 MCM3 MCM6 MCM7	Unwinding of DNA
GO:0036388	1.61749489514e-16	0.857142857143	MCM5 MCM2 MCM4 MCM3 MCM6 MCM7	pre-replicative complex assembly
GO:0006267	1.61749489514e-16	0.857142857143	MCM5 MCM2 MCM4 MCM3 MCM6 MCM7	pre-replicative complex assembly involved in nuclear cell cycle DNA replication
GO:1902299	1.61749489514e-16	0.857142857143	MCM5 MCM2 MCM4 MCM3 MCM6 MCM7	pre-replicative complex assembly involved in cell cycle DNA replication
GO:0000727	1.06730077033e-14	0.857142857143	MCM5 MCM2 MCM4 MCM3 MCM6 MCM7	double-strand break repair via break-induced replication
KEGG:03030	4.70991784532e-14	0.857142857143	MCM5 MCM2 MCM4 MCM3 MCM6 MCM7	DNA replication
REAC:R-HSA-69190	6.99307747711e-14	0.857142857143	MCM5 MCM2 MCM4 MCM3 MCM6 MCM7	DNA strand elongation
REAC:R-HSA-68962	8.54660187695e-14	0.857142857143	MCM5 MCM2 MCM4 MCM3 MCM6 MCM7	Activation of the pre-replicative complex
WP:WP466	1.2869199642e-13	0.857142857143	MCM5 MCM2 MCM4 MCM3 MCM6 MCM7	DNA Replication
REAC:R-HSA-176187	1.79351701411e-13	0.857142857143	MCM5 MCM2 MCM4 MCM3 MCM6 MCM7	Activation of ATR in response to replication stress
CORUM:2792	9.08345369489e-13	0.571428571429	MCM2 MCM6 MCM4 MCM7	MCM2-MCM4-MCM6-MCM7 complex
WP:WP45	1.66485079619e-12	0.857142857143	MCM5 MCM2 MCM4 MCM3 MCM6 MCM7	G1 to S cell cycle control
GO:0003688	3.10707502205e-12	0.857142857143	MCM5 MCM2 MCM4 MCM3 MCM6 MCM7	DNA replication origin binding
REAC:R-HSA-68867	8.42897445322e-12	0.857142857143	MCM5 MCM2 MCM4 MCM3 MCM6 MCM7	Assembly of the pre-replicative complex
REAC:R-HSA-68949	1.10273472623e-11	0.857142857143	MCM5 MCM2 MCM4 MCM3 MCM6 MCM7	Orc1 removal from chromatin
REAC:R-HSA-69002	3.36474050891e-11	0.857142857143	MCM5 MCM2 MCM4 MCM3 MCM6 MCM7	DNA Replication Pre-Initiation
REAC:R-HSA-69052	4.46966038931e-11	0.857142857143	MCM5 MCM2 MCM4 MCM3 MCM6 MCM7	Switching of origins to a post-replicative state
WP:WP179	7.2482059599e-11	0.857142857143	MCM5 MCM2 MCM4 MCM3 MCM6 MCM7	Cell Cycle
KEGG:04110	8.78984306893e-11	0.857142857143	MCM5 MCM2 MCM4 MCM3 MCM6 MCM7	Cell cycle
GO:0006261	1.38694507595e-10	1.0	MCMBP MCM5 MCM2 MCM4 MCM3 MCM6 MCM7	DNA-dependent DNA replication
REAC:R-HSA-69239	2.53025172523e-10	0.857142857143	MCM5 MCM2 MCM4 MCM3 MCM6 MCM7	Synthesis of DNA
REAC:R-HSA-69306	3.78014029917e-10	0.857142857143	MCM5 MCM2 MCM4 MCM3 MCM6 MCM7	DNA Replication
REAC:R-HSA-69206	4.57595719183e-10	0.857142857143	MCM5 MCM2 MCM4 MCM3 MCM6 MCM7	G1/S Transition
GO:0033260	4.69206908828e-10	0.857142857143	MCM5 MCM2 MCM4 MCM3 MCM6 MCM7	nuclear DNA replication
GO:0044786	7.48133794918e-10	0.857142857143	MCM5 MCM2 MCM4 MCM3 MCM6 MCM7	cell cycle DNA replication
REAC:R-HSA-453279	9.68838483071e-10	0.857142857143	MCM5 MCM2 MCM4 MCM3 MCM6 MCM7	Mitotic G1-G1/S phases
REAC:R-HSA-69242	1.56262436644e-09	0.857142857143	MCM5 MCM2 MCM4 MCM3 MCM6 MCM7	S Phase
REAC:R-HSA-69481	2.10657452907e-09	0.857142857143	MCM5 MCM2 MCM4 MCM3 MCM6 MCM7	G2/M Checkpoints
WP:WP4352	2.85197423499e-09	0.857142857143	MCM5 MCM2 MCM4 MCM3 MCM6 MCM7	Ciliary landscape
CORUM:1452	3.38154272427e-09	0.428571428571	MCM2 MCM6 MCM7	MCM2-MCM6-MCM7 complex
CORUM:2791	3.38154272427e-09	0.428571428571	MCM6 MCM4 MCM7	MCM4-MCM6-MCM7 complex
GO:0006260	4.68419884849e-09	1.0	MCMBP MCM5 MCM2 MCM4 MCM3 MCM6 MCM7	DNA replication
GO:0003697	1.99807823439e-08	0.857142857143	MCM5 MCM2 MCM4 MCM3 MCM6 MCM7	single-stranded DNA binding
GO:0006270	2.44468179357e-08	0.714285714286	MCM3 MCM7 MCM4 MCM5 MCM2	DNA replication initiation
REAC:R-HSA-69620	5.59924446252e-08	0.857142857143	MCM5 MCM2 MCM4 MCM3 MCM6 MCM7	Cell Cycle Checkpoints
GO:0000784	7.56545265843e-08	0.857142857143	MCM5 MCM2 MCM4 MCM3 MCM6 MCM7	nuclear chromosome, telomeric region
GO:0000725	9.2783024887e-08	0.857142857143	MCM5 MCM2 MCM4 MCM3 MCM6 MCM7	recombinational repair
GO:0000724	9.2783024887e-08	0.857142857143	MCM5 MCM2 MCM4 MCM3 MCM6 MCM7	double-strand break repair via homologous recombination
MIRNA:hsa-miR-34a-5p	1.25598934995e-07	1.0	MCMBP MCM5 MCM2 MCM4 MCM3 MCM6 MCM7	hsa-miR-34a-5p
GO:0000781	2.05916453656e-07	0.857142857143	MCM5 MCM2 MCM4 MCM3 MCM6 MCM7	chromosome, telomeric region
GO:1902969	2.81450928027e-07	0.571428571429	MCM6 MCM4 MCM3 MCM2	mitotic DNA replication
GO:0003678	7.16123219857e-07	0.714285714286	MCM2 MCM6 MCM4 MCM5 MCM7	DNA helicase activity
GO:0006268	8.53321565671e-07	0.571428571429	MCM2 MCM6 MCM4 MCM7	DNA unwinding involved in DNA replication
GO:0043138	8.53321565671e-07	0.571428571429	MCM2 MCM6 MCM5 MCM7	3'-5' DNA helicase activity
CORUM:5611	9.65174231113e-07	0.428571428571	MCM6 MCM4 MCM2	Emerin complex 24
GO:0065004	1.33598389589e-06	0.857142857143	MCM5 MCM2 MCM4 MCM3 MCM6 MCM7	protein-DNA complex assembly
REAC:R-HSA-69278	1.91008072332e-06	0.857142857143	MCM5 MCM2 MCM4 MCM3 MCM6 MCM7	Cell Cycle, Mitotic
GO:0000082	1.94088919272e-06	0.857142857143	MCM5 MCM2 MCM4 MCM3 MCM6 MCM7	G1/S transition of mitotic cell cycle
WP:WP2446	1.99495642073e-06	0.571428571429	MCM6 MCM4 MCM3 MCM7	Retinoblastoma Gene in Cancer
GO:0017116	2.02789502131e-06	0.571428571429	MCM2 MCM6 MCM5 MCM7	single-stranded DNA helicase activity
GO:0006310	2.18720984474e-06	0.857142857143	MCM5 MCM2 MCM4 MCM3 MCM6 MCM7	DNA recombination
GO:0044843	2.75840102142e-06	0.857142857143	MCM5 MCM2 MCM4 MCM3 MCM6 MCM7	cell cycle G1/S phase transition
GO:0006302	4.27721086393e-06	0.857142857143	MCM5 MCM2 MCM4 MCM3 MCM6 MCM7	double-strand break repair
GO:0071824	5.13215507167e-06	0.857142857143	MCM5 MCM2 MCM4 MCM3 MCM6 MCM7	protein-DNA complex subunit organization
REAC:R-HSA-1640170	5.63049101506e-06	0.857142857143	MCM5 MCM2 MCM4 MCM3 MCM6 MCM7	Cell Cycle
GO:0004386	7.48884975909e-06	0.714285714286	MCM2 MCM6 MCM4 MCM5 MCM7	helicase activity
GO:0008094	8.37777986794e-06	0.714285714286	MCM2 MCM6 MCM4 MCM5 MCM7	DNA-dependent ATPase activity
GO:0098687	1.23783079708e-05	0.857142857143	MCM5 MCM2 MCM4 MCM3 MCM6 MCM7	chromosomal region
GO:1902292	1.27120391093e-05	0.428571428571	MCM2 MCM3 MCM4	cell cycle DNA replication initiation
GO:1902315	1.27120391093e-05	0.428571428571	MCM2 MCM3 MCM4	nuclear cell cycle DNA replication initiation
GO:1902975	1.27120391093e-05	0.428571428571	MCM2 MCM3 MCM4	mitotic DNA replication initiation
MIRNA:hsa-miR-1-3p	6.11426246005e-05	0.857142857143	MCM5 MCM2 MCM4 MCM3 MCM6 MCM7	hsa-miR-1-3p
GO:0044454	0.000178438272233	1.0	MCMBP MCM5 MCM2 MCM4 MCM3 MCM6 MCM7	nuclear chromosome part
GO:0000228	0.000215060913588	1.0	MCMBP MCM5 MCM2 MCM4 MCM3 MCM6 MCM7	nuclear chromosome
GO:0140097	0.000217910906533	0.714285714286	MCM2 MCM6 MCM4 MCM5 MCM7	catalytic activity, acting on DNA
GO:0032508	0.000229373391109	0.571428571429	MCM2 MCM6 MCM4 MCM7	DNA duplex unwinding
GO:0006281	0.000268383673618	0.857142857143	MCM5 MCM2 MCM4 MCM3 MCM6 MCM7	DNA repair
TF:M00739_1	0.000269264884738	1.0	MCMBP MCM5 MCM2 MCM4 MCM3 MCM6 MCM7	Factor: E2F-4:DP-2; motif: TTTCSCGC; match class: 1
GO:0044772	0.000321955679491	0.857142857143	MCM5 MCM2 MCM4 MCM3 MCM6 MCM7	mitotic cell cycle phase transition
GO:0032392	0.00047187431931	0.571428571429	MCM2 MCM6 MCM4 MCM7	DNA geometric change
GO:0044770	0.000472769829579	0.857142857143	MCM5 MCM2 MCM4 MCM3 MCM6 MCM7	cell cycle phase transition
GO:0042623	0.000558514532351	0.714285714286	MCM2 MCM6 MCM4 MCM5 MCM7	ATPase activity, coupled
GO:0022402	0.000570238264329	1.0	MCMBP MCM5 MCM2 MCM4 MCM3 MCM6 MCM7	cell cycle process
GO:0044427	0.00123884712147	1.0	MCMBP MCM5 MCM2 MCM4 MCM3 MCM6 MCM7	chromosomal part
GO:1990837	0.00130144068187	0.857142857143	MCM5 MCM2 MCM4 MCM3 MCM6 MCM7	sequence-specific double-stranded DNA binding
GO:0005694	0.0015963674554	1.0	MCMBP MCM5 MCM2 MCM4 MCM3 MCM6 MCM7	chromosome
GO:0007049	0.00190142502119	1.0	MCMBP MCM5 MCM2 MCM4 MCM3 MCM6 MCM7	cell cycle
GO:0006271	0.00215539204286	0.428571428571	MCM7 MCM3 MCM4	DNA strand elongation involved in DNA replication
MIRNA:hsa-miR-193b-3p	0.00266468756331	0.714285714286	MCM3 MCM6 MCM4 MCM5 MCM7	hsa-miR-193b-3p
GO:0003690	0.002705999719	0.857142857143	MCM5 MCM2 MCM4 MCM3 MCM6 MCM7	double-stranded DNA binding
GO:0006259	0.00389469755603	0.857142857143	MCM5 MCM2 MCM4 MCM3 MCM6 MCM7	DNA metabolic process
GO:0006974	0.00392756126787	0.857142857143	MCM5 MCM2 MCM4 MCM3 MCM6 MCM7	cellular response to DNA damage stimulus
GO:1903047	0.00399398022056	0.857142857143	MCM5 MCM2 MCM4 MCM3 MCM6 MCM7	mitotic cell cycle process
GO:0016887	0.00409284107934	0.714285714286	MCM2 MCM6 MCM4 MCM5 MCM7	ATPase activity
GO:0043565	0.00627141713812	0.857142857143	MCM5 MCM2 MCM4 MCM3 MCM6 MCM7	sequence-specific DNA binding
GO:0022616	0.00640641290662	0.428571428571	MCM7 MCM3 MCM4	DNA strand elongation
GO:0000278	0.00995795310122	0.857142857143	MCM5 MCM2 MCM4 MCM3 MCM6 MCM7	mitotic cell cycle
GO:0034622	0.0111566389539	0.857142857143	MCM5 MCM2 MCM4 MCM3 MCM6 MCM7	cellular protein-containing complex assembly
GO:1990518	0.0283955176165	0.285714285714	MCM6 MCM7	single-stranded 3'-5' DNA helicase activity
TF:M00431_1	0.0284539665555	1.0	MCMBP MCM5 MCM2 MCM4 MCM3 MCM6 MCM7	Factor: E2F-1; motif: TTTSGCGS; match class: 1
CORUM:0000000	0.0437772681198	0.857142857143	MCM5 MCM2 MCM4 MCM3 MCM6 MCM7	CORUM root
CORUM:6261	0.0499886427319	0.142857142857	MCM2	Histone-2-Histone-4-ASF1-MCM2 complex

Edges

Protein 1	Protein 2	Score	Precision	Evidence
MCM7	MCM3	1.0	0.949	hein_WMM bioplex (MCM3,MCM7) bioplex_WMM Guru boldt hein (MCM3) Malo gupta_WMM fraction boldt_WMM treiber_WMM
MCM6	MCM2	1.0	0.949	hein_WMM bioplex_WMM Guru boldt hein (MCM2,MCM6) Malo fraction boldt_WMM treiber_WMM
MCM5	MCM3	1.0	0.949	hein_WMM bioplex (MCM3) bioplex_WMM Guru youn_WMM hein (MCM3) Malo gupta_WMM fraction boldt_WMM treiber_WMM
MCM6	MCM4	1.0	0.949	hein_WMM bioplex_WMM Guru boldt hein (MCM6) Malo gupta_WMM fraction boldt_WMM treiber_WMM
MCM2	MCM4	1.0	0.949	hein_WMM bioplex_WMM Guru boldt hein (MCM2) Malo fraction boldt_WMM treiber_WMM
MCM2	MCM3	1.0	0.949	hein_WMM bioplex (MCM3) bioplex_WMM Guru boldt hein (MCM2,MCM3) Malo fraction boldt_WMM treiber_WMM
MCM3	MCM4	1.0	0.949	hein_WMM bioplex (MCM3) bioplex_WMM Guru boldt hein (MCM3) Malo gupta_WMM fraction boldt_WMM treiber_WMM
MCM7	MCM2	1.0	0.949	hein_WMM bioplex (MCM7) bioplex_WMM Guru boldt hein (MCM2) Malo fraction boldt_WMM treiber_WMM
MCM5	MCM2	1.0	0.949	hein_WMM bioplex_WMM Guru hein (MCM2) Malo fraction boldt_WMM treiber_WMM
MCM7	MCM4	1.0	0.949	hein_WMM bioplex (MCM7) bioplex_WMM Guru boldt Malo gupta_WMM fraction boldt_WMM treiber_WMM
MCM6	MCM3	1.0	0.949	hein_WMM bioplex (MCM3) bioplex_WMM Guru boldt youn_WMM hein (MCM3,MCM6) Malo gupta_WMM fraction boldt_WMM treiber_WMM
MCM6	MCM7	1.0	0.949	hein_WMM bioplex (MCM7) bioplex_WMM Guru boldt hein (MCM6) Malo gupta_WMM fraction boldt_WMM treiber_WMM
MCM3	MCMBP	1.0	0.949	hein_WMM bioplex (MCM3) bioplex_WMM Guru youn_WMM hein (MCM3) Malo gupta_WMM fraction treiber_WMM
MCM5	MCMBP	0.999	0.949	hein_WMM bioplex_WMM Guru youn_WMM Malo gupta_WMM fraction treiber_WMM
MCM6	MCMBP	0.999	0.949	hein_WMM bioplex_WMM Guru youn_WMM hein (MCM6) Malo gupta_WMM fraction treiber_WMM
MCM5	MCM6	0.998	0.94	hein_WMM bioplex_WMM Guru youn_WMM Malo gupta_WMM fraction boldt_WMM treiber_WMM
MCM5	MCM4	0.997	0.934	hein_WMM bioplex_WMM Guru Malo gupta_WMM fraction boldt_WMM treiber_WMM
MCM5	MCM7	0.997	0.933	hein_WMM bioplex (MCM7) bioplex_WMM Guru Malo gupta_WMM fraction boldt_WMM treiber_WMM
MCM7	MCMBP	0.712	0.728	hein_WMM bioplex (MCM7) bioplex_WMM Guru Malo gupta_WMM fraction treiber_WMM
MCM2	MCMBP	0.009	0.097	hein_WMM bioplex_WMM WMM_only treiber_WMM
MCM4	MCMBP	0.009	0.093	hein_WMM bioplex_WMM gupta_WMM WMM_only treiber_WMM

Images

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Complex HuMAP2_05922 has an average edge precision of 0.855 which is ranked 745 out of all 6965 complexes.

Related Complexes

Genename	Complexes
MCM2	HuMAP2_00191 HuMAP2_00901 HuMAP2_02127 HuMAP2_03737 HuMAP2_05922
MCM7	HuMAP2_00191 HuMAP2_00486 HuMAP2_02127 HuMAP2_02643 HuMAP2_03207 HuMAP2_03737 HuMAP2_04095 HuMAP2_05922
MCM5	HuMAP2_00191 HuMAP2_02127 HuMAP2_03207 HuMAP2_03737 HuMAP2_05922
MCM4	HuMAP2_00191 HuMAP2_00486 HuMAP2_00901 HuMAP2_02127 HuMAP2_03737 HuMAP2_05922
MCMBP	HuMAP2_00191 HuMAP2_02127 HuMAP2_02938 HuMAP2_03737 HuMAP2_04825 HuMAP2_05922
MCM6	HuMAP2_00191 HuMAP2_00901 HuMAP2_02127 HuMAP2_03737 HuMAP2_05922
MCM3	HuMAP2_00191 HuMAP2_00246 HuMAP2_02127 HuMAP2_03207 HuMAP2_03737 HuMAP2_05922

hu.MAP 2.0: Complex View

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Complex: HuMAP2_05922