hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05928
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| WDR77 | Methylosome protein 50 (MEP-50) (Androgen receptor cofactor p44) (WD repeat-containing protein 77) (p44/Mep50) | UniProt NCBI |
| PRMT5 | Protein arginine N-methyltransferase 5 (EC 2.1.1.320) (72 kDa ICln-binding protein) (Histone-arginine N-methyltransferase PRMT5) (Jak-binding protein 1) (Shk1 kinase-binding protein 1 homolog) (SKB1 homolog) (SKB1Hs) [Cleaved into: Protein arginine N-methyltransferase 5, N-terminally processed] | UniProt NCBI |
| CLNS1A | Methylosome subunit pICln (Chloride channel, nucleotide sensitive 1A) (Chloride conductance regulatory protein ICln) (I(Cln)) (Chloride ion current inducer protein) (ClCI) (Reticulocyte pICln) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:2838 | 2.25356268047e-10 | 1.0 | WDR77 CLNS1A PRMT5 | MEP50-PRMT5-ICLN complex |
| CORUM:837 | 2.25356268047e-10 | 1.0 | WDR77 CLNS1A PRMT5 | MEP50-PRMT5-ICLN complex |
| CORUM:836 | 3.35600554376e-06 | 0.666666666667 | CLNS1A PRMT5 | 20S methyltransferase core complex |
| REAC:R-HSA-194441 | 8.81209945571e-06 | 1.0 | WDR77 CLNS1A PRMT5 | Metabolism of non-coding RNA |
| REAC:R-HSA-191859 | 8.81209945571e-06 | 1.0 | WDR77 CLNS1A PRMT5 | snRNP Assembly |
| CORUM:825 | 1.00675659188e-05 | 0.666666666667 | CLNS1A PRMT5 | JBP1-pICln complex |
| GO:0034709 | 1.99800867251e-05 | 1.0 | WDR77 CLNS1A PRMT5 | methylosome |
| CORUM:819 | 2.01342304124e-05 | 0.666666666667 | CLNS1A PRMT5 | 20S methylosome-SmD complex |
| CORUM:6858 | 3.35555483123e-05 | 0.666666666667 | WDR77 PRMT5 | CHTOP-methylosome complex |
| CORUM:832 | 5.03310689057e-05 | 0.666666666667 | CLNS1A PRMT5 | Anti-Sm protein complex |
| CORUM:834 | 5.03310689057e-05 | 0.666666666667 | CLNS1A PRMT5 | 20S methylosome and RG-containing Sm protein complex |
| CORUM:810 | 7.04603414803e-05 | 0.666666666667 | WDR77 PRMT5 | FCP1-associated protein complex |
| CORUM:811 | 7.04603414803e-05 | 0.666666666667 | WDR77 PRMT5 | FCP1-associated protein complex |
| GO:0000387 | 0.000766145507331 | 1.0 | WDR77 CLNS1A PRMT5 | spliceosomal snRNP assembly |
| KEGG:03013 | 0.00517225695918 | 0.666666666667 | CLNS1A PRMT5 | RNA transport |
| GO:0034708 | 0.0180261250619 | 1.0 | WDR77 CLNS1A PRMT5 | methyltransferase complex |
| REAC:R-HSA-3214858 | 0.0200378707185 | 0.666666666667 | WDR77 PRMT5 | RMTs methylate histone arginines |
| REAC:R-HSA-8953854 | 0.0206735000409 | 1.0 | WDR77 CLNS1A PRMT5 | Metabolism of RNA |
| CORUM:1748 | 0.0249904952816 | 0.333333333333 | PRMT5 | PRMT5 complex |
| CORUM:2764 | 0.0249904952816 | 0.333333333333 | PRMT5 | PRMT5 complex |
| CORUM:6853 | 0.0499776345577 | 0.333333333333 | PRMT5 | COPRS-PRMT5 complex |
| CORUM:7410 | 0.0499776345577 | 0.333333333333 | PRMT5 | CAPG-PRMT5 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| WDR77 | PRMT5 | 1.0 | 0.949 | hein_WMM bioplex (WDR77) bioplex_WMM boldt youn_WMM hein (PRMT5) Malo gupta_WMM fraction boldt_WMM |
| CLNS1A | PRMT5 | 0.865 | 0.801 | hein_WMM bioplex_WMM boldt youn_WMM hein (PRMT5) gupta_WMM boldt_WMM |
| CLNS1A | WDR77 | 0.027 | 0.223 | hein_WMM bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
Images
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Complex HuMAP2_05928 has an average edge precision of 0.658 which is ranked 1606 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| WDR77 | HuMAP2_02069 HuMAP2_04365 HuMAP2_04507 HuMAP2_05928 HuMAP2_06950 |
| PRMT5 | HuMAP2_02069 HuMAP2_04365 HuMAP2_04507 HuMAP2_05928 HuMAP2_06099 HuMAP2_06950 |
| CLNS1A | HuMAP2_00104 HuMAP2_02578 HuMAP2_04365 HuMAP2_05928 HuMAP2_06950 |