hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05931
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| IRF9 | Interferon regulatory factor 9 (IRF-9) (IFN-alpha-responsive transcription factor subunit) (ISGF3 p48 subunit) (Interferon-stimulated gene factor 3 gamma) (ISGF-3 gamma) (Transcriptional regulator ISGF3 subunit gamma) | UniProt NCBI |
| RPS26P11 | NCBI | |
| ZNF692 | Zinc finger protein 692 | UniProt NCBI |
| STAT1 | Signal transducer and activator of transcription 1-alpha/beta (Transcription factor ISGF-3 components p91/p84) | UniProt NCBI |
| STAT2 | Signal transducer and activator of transcription 2 (p113) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:60 | 6.75231048499e-10 | 0.75 | STAT1 IRF9 STAT2 | Interferon-stimulated gene factor 3 transcription complex ISGF3 |
| WP:WP2113 | 1.26324459387e-08 | 0.75 | STAT1 IRF9 STAT2 | Type III interferon signaling |
| WP:WP4197 | 2.57005041727e-07 | 0.75 | STAT1 IRF9 STAT2 | The human immune response to tuberculosis |
| WP:WP619 | 5.8597456504e-07 | 0.75 | STAT1 IRF9 STAT2 | Type II interferon signaling (IFNG) |
| WP:WP585 | 5.58230464391e-06 | 0.75 | STAT1 IRF9 STAT2 | Interferon type I signaling pathways |
| KEGG:04625 | 2.94026709165e-05 | 0.75 | STAT1 IRF9 STAT2 | C-type lectin receptor signaling pathway |
| KEGG:04380 | 4.73495151826e-05 | 0.75 | STAT1 IRF9 STAT2 | Osteoclast differentiation |
| WP:WP4495 | 7.55497829866e-05 | 0.5 | STAT1 STAT2 | IL-10 Anti-inflammatory Signaling Pathway |
| KEGG:04630 | 7.70325801518e-05 | 0.75 | STAT1 IRF9 STAT2 | JAK-STAT signaling pathway |
| KEGG:05162 | 9.12832394729e-05 | 0.75 | STAT1 IRF9 STAT2 | Measles |
| KEGG:05160 | 0.000109599393216 | 0.75 | STAT1 IRF9 STAT2 | Hepatitis C |
| KEGG:05164 | 0.000141415901292 | 0.75 | STAT1 IRF9 STAT2 | Influenza A |
| KEGG:04217 | 0.000153246296181 | 0.75 | STAT1 IRF9 STAT2 | Necroptosis |
| KEGG:04621 | 0.000172197671977 | 0.75 | STAT1 IRF9 STAT2 | NOD-like receptor signaling pathway |
| KEGG:05167 | 0.000196203606831 | 0.75 | STAT1 IRF9 STAT2 | Kaposi sarcoma-associated herpesvirus infection |
| KEGG:05169 | 0.000267914054047 | 0.75 | STAT1 IRF9 STAT2 | Epstein-Barr virus infection |
| REAC:R-HSA-913531 | 0.00115530951203 | 0.75 | STAT1 IRF9 STAT2 | Interferon Signaling |
| KEGG:05165 | 0.00132804938561 | 0.75 | STAT1 IRF9 STAT2 | Human papillomavirus infection |
| REAC:R-HSA-8854691 | 0.00153629461685 | 0.5 | STAT1 STAT2 | Interleukin-20 family signaling |
| KEGG:05168 | 0.00237639508828 | 0.75 | STAT1 IRF9 STAT2 | Herpes simplex virus 1 infection |
| WP:WP4341 | 0.00326331699224 | 0.5 | STAT1 STAT2 | Non-genomic actions of 1,25 dihydroxyvitamin D3 |
| WP:WP236 | 0.00997499186767 | 0.5 | STAT1 STAT2 | Adipogenesis |
| GO:0000978 | 0.010859578747 | 1.0 | STAT1 STAT2 IRF9 ZNF692 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| WP:WP3929 | 0.012672821387 | 0.5 | STAT1 STAT2 | Chemokine signaling pathway |
| GO:0000987 | 0.0128783441389 | 1.0 | STAT1 STAT2 IRF9 ZNF692 | proximal promoter sequence-specific DNA binding |
| REAC:R-HSA-909733 | 0.0165385846138 | 0.5 | STAT2 IRF9 | Interferon alpha/beta signaling |
| KEGG:04062 | 0.016608760826 | 0.5 | STAT1 STAT2 | Chemokine signaling pathway |
| WP:WP4666 | 0.0173163427152 | 0.5 | STAT1 STAT2 | Hepatitis B infection |
| KEGG:05161 | 0.0235873467107 | 0.5 | STAT1 STAT2 | Hepatitis B |
| GO:0071357 | 0.0275320606423 | 0.75 | STAT1 IRF9 STAT2 | cellular response to type I interferon |
| GO:0060337 | 0.0275320606423 | 0.75 | STAT1 IRF9 STAT2 | type I interferon signaling pathway |
| GO:0034340 | 0.0320435644688 | 0.75 | STAT1 IRF9 STAT2 | response to type I interferon |
| CORUM:5573 | 0.0499140284799 | 0.25 | STAT1 | Stat1-alpha-dimer-CBP DNA-protein complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| IRF9 | STAT2 | 0.213 | 0.464 | bioplex (IRF9,STAT2) bioplex_WMM |
| STAT2 | ZNF692 | 0.133 | 0.405 | bioplex (STAT2) bioplex_WMM |
| ZNF692 | RPS26P11 | 0.062 | 0.34 | bioplex (ZNF692) bioplex_WMM |
| STAT1 | STAT2 | 0.056 | 0.316 | bioplex (STAT1,STAT2) bioplex_WMM youn_WMM gupta_WMM |
| IRF9 | STAT1 | 0.008 | 0.084 | bioplex_WMM WMM_only |
| STAT1 | ZNF692 | 0.008 | 0.084 | bioplex_WMM WMM_only |
| IRF9 | ZNF692 | 0.008 | 0.085 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_05931 has an average edge precision of 0.254 which is ranked 5313 out of all 6965 complexes.
Related Complexes