hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05934
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| NUDT5 | ADP-sugar pyrophosphatase (EC 3.6.1.13) (8-oxo-dGDP phosphatase) (EC 3.6.1.58) (Nuclear ATP-synthesis protein NUDIX5) (EC 2.7.7.96) (Nucleoside diphosphate-linked moiety X motif 5) (Nudix motif 5) (hNUDT5) (YSA1H) | UniProt NCBI |
| PYCR2 | Pyrroline-5-carboxylate reductase 2 (P5C reductase 2) (P5CR 2) (EC 1.5.1.2) | UniProt NCBI |
| PYCR1 | Pyrroline-5-carboxylate reductase 1, mitochondrial (P5C reductase 1) (P5CR 1) (EC 1.5.1.2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8964539 | 0.000441698392473 | 0.666666666667 | PYCR1 PYCR2 | Glutamate and glutamine metabolism |
| KEGG:00330 | 0.000504120803948 | 0.666666666667 | PYCR1 PYCR2 | Arginine and proline metabolism |
| WP:WP4290 | 0.000824391260345 | 0.666666666667 | PYCR1 PYCR2 | Metabolic reprogramming in colon cancer |
| KEGG:01230 | 0.00110943942397 | 0.666666666667 | PYCR1 PYCR2 | Biosynthesis of amino acids |
| GO:0004735 | 0.00811409485621 | 0.666666666667 | PYCR1 PYCR2 | pyrroline-5-carboxylate reductase activity |
| GO:0055129 | 0.00811409485621 | 0.666666666667 | PYCR1 PYCR2 | L-proline biosynthetic process |
| KEGG:01100 | 0.0105851300972 | 1.0 | PYCR1 NUDT5 PYCR2 | Metabolic pathways |
| GO:0006561 | 0.0135228859698 | 0.666666666667 | PYCR1 PYCR2 | proline biosynthetic process |
| HP:0000325 | 0.0393048254184 | 0.666666666667 | PYCR1 PYCR2 | Triangular face |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PYCR2 | PYCR1 | 1.0 | 0.949 | hein_WMM bioplex (PYCR1,PYCR2) bioplex_WMM boldt youn_WMM Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| NUDT5 | PYCR2 | 0.992 | 0.912 | bioplex (PYCR2) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| NUDT5 | PYCR1 | 0.971 | 0.882 | bioplex (PYCR1) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM |
Images
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Complex HuMAP2_05934 has an average edge precision of 0.914 which is ranked 495 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| NUDT5 | HuMAP2_00177 HuMAP2_00369 HuMAP2_00616 HuMAP2_05934 |
| PYCR2 | HuMAP2_00177 HuMAP2_00369 HuMAP2_00616 HuMAP2_03284 HuMAP2_05934 HuMAP2_06951 |
| PYCR1 | HuMAP2_00177 HuMAP2_00369 HuMAP2_00616 HuMAP2_05934 HuMAP2_06951 |