hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05935
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| EIF4A1 | Eukaryotic initiation factor 4A-I (eIF-4A-I) (eIF4A-I) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-1) | UniProt NCBI |
| EIF4G2 | Eukaryotic translation initiation factor 4 gamma 2 (eIF-4-gamma 2) (eIF-4G 2) (eIF4G 2) (Death-associated protein 5) (DAP-5) (p97) | UniProt NCBI |
| THEMIS2 | Protein THEMIS2 (Induced by contact to basement membrane 1 protein) (Protein ICB-1) (Thymocyte-expressed molecule involved in selection protein 2) | UniProt NCBI |
| LASP1 | LIM and SH3 domain protein 1 (LASP-1) (Metastatic lymph node gene 50 protein) (MLN 50) | UniProt NCBI |
| EIF4E3 | Eukaryotic translation initiation factor 4E type 3 (eIF-4E type 3) (eIF-4E3) (eIF4E type 3) (eIF4E-3) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-1169408 | 0.00012942105654 | 0.6 | EIF4A1 EIF4E3 EIF4G2 | ISG15 antiviral mechanism |
| GO:0016281 | 0.000149729915117 | 0.6 | EIF4A1 EIF4E3 EIF4G2 | eukaryotic translation initiation factor 4F complex |
| REAC:R-HSA-1169410 | 0.000175005907139 | 0.6 | EIF4A1 EIF4E3 EIF4G2 | Antiviral mechanism by IFN-stimulated genes |
| REAC:R-HSA-913531 | 0.00230616063943 | 0.6 | EIF4A1 EIF4E3 EIF4G2 | Interferon Signaling |
| GO:0003743 | 0.00964423896068 | 0.6 | EIF4A1 EIF4E3 EIF4G2 | translation initiation factor activity |
| KEGG:03013 | 0.0489206453689 | 0.4 | EIF4A1 EIF4G2 | RNA transport |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| EIF4A1 | EIF4G2 | 0.718 | 0.73 | hein_WMM youn (EIF4A1) bioplex (EIF4A1) bioplex_WMM boldt youn_WMM fraction boldt_WMM treiber_WMM |
| EIF4A1 | EIF4E3 | 0.253 | 0.479 | bioplex (EIF4A1,EIF4E3) bioplex_WMM |
| EIF4A1 | LASP1 | 0.153 | 0.412 | bioplex_WMM youn_WMM fraction treiber_WMM |
| EIF4E3 | THEMIS2 | 0.082 | 0.35 | bioplex (EIF4E3) bioplex_WMM |
| EIF4G2 | EIF4E3 | 0.008 | 0.065 | bioplex_WMM WMM_only |
| EIF4G2 | LASP1 | 0.007 | 0.003 | youn_WMM WMM_only |
Images
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Complex HuMAP2_05935 has an average edge precision of 0.34 which is ranked 4128 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| EIF4A1 | HuMAP2_00055 HuMAP2_03421 HuMAP2_04458 HuMAP2_05935 |
| EIF4G2 | HuMAP2_00055 HuMAP2_03421 HuMAP2_05935 |
| THEMIS2 | HuMAP2_02986 HuMAP2_05935 |
| LASP1 | HuMAP2_05935 |
| EIF4E3 | HuMAP2_02986 HuMAP2_05935 |