hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_05936
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| AP3S1 | AP-3 complex subunit sigma-1 (AP-3 complex subunit sigma-3A) (Adaptor-related protein complex 3 subunit sigma-1) (Clathrin-associated/assembly/adaptor protein, small 3) (Sigma-3A-adaptin) (Sigma3A-adaptin) (Sigma-adaptin 3a) | UniProt NCBI |
| AP3D1 | AP-3 complex subunit delta-1 (AP-3 complex subunit delta) (Adaptor-related protein complex 3 subunit delta-1) (Delta-adaptin) | UniProt NCBI |
| AP3B1 | AP-3 complex subunit beta-1 (Adaptor protein complex AP-3 subunit beta-1) (Adaptor-related protein complex 3 subunit beta-1) (Beta-3A-adaptin) (Clathrin assembly protein complex 3 beta-1 large chain) | UniProt NCBI |
| AP3M1 | AP-3 complex subunit mu-1 (AP-3 adaptor complex mu3A subunit) (Adaptor-related protein complex 3 subunit mu-1) (Mu-adaptin 3A) (Mu3A-adaptin) | UniProt NCBI |
| AP3M2 | AP-3 complex subunit mu-2 (Adaptor-related protein complex 3 subunit mu-2) (Clathrin assembly protein assembly protein complex 3 mu-2 medium chain) (Clathrin coat assembly protein AP47 homolog 2) (Clathrin coat-associated protein AP47 homolog 2) (Golgi adaptor AP-1 47 kDa protein homolog 2) (HA1 47 kDa subunit homolog 2) (Mu3B-adaptin) (P47B) | UniProt NCBI |
| AP3B2 | AP-3 complex subunit beta-2 (Adaptor protein complex AP-3 subunit beta-2) (Adaptor-related protein complex 3 subunit beta-2) (Beta-3B-adaptin) (Clathrin assembly protein complex 3 beta-2 large chain) (Neuron-specific vesicle coat protein beta-NAP) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:59 | 2.86704718913e-20 | 1.0 | AP3S1 AP3M1 AP3D1 AP3M2 AP3B2 AP3B1 | AP3 adaptor complex |
| CORUM:652 | 2.04993874023e-17 | 1.0 | AP3S1 AP3M1 AP3D1 AP3M2 AP3B2 AP3B1 | AP3-BLOC1 complex |
| GO:0048490 | 4.08556518089e-14 | 1.0 | AP3S1 AP3M1 AP3D1 AP3M2 AP3B2 AP3B1 | anterograde synaptic vesicle transport |
| GO:0099517 | 4.08556518089e-14 | 1.0 | AP3S1 AP3M1 AP3D1 AP3M2 AP3B2 AP3B1 | synaptic vesicle transport along microtubule |
| GO:0099514 | 4.08556518089e-14 | 1.0 | AP3S1 AP3M1 AP3D1 AP3M2 AP3B2 AP3B1 | synaptic vesicle cytoskeletal transport |
| GO:0048489 | 4.43979715097e-12 | 1.0 | AP3S1 AP3M1 AP3D1 AP3M2 AP3B2 AP3B1 | synaptic vesicle transport |
| GO:0008089 | 9.11356025303e-12 | 1.0 | AP3S1 AP3M1 AP3D1 AP3M2 AP3B2 AP3B1 | anterograde axonal transport |
| GO:0047496 | 9.11356025303e-12 | 1.0 | AP3S1 AP3M1 AP3D1 AP3M2 AP3B2 AP3B1 | vesicle transport along microtubule |
| KEGG:04142 | 1.00721592662e-11 | 1.0 | AP3S1 AP3M1 AP3D1 AP3M2 AP3B2 AP3B1 | Lysosome |
| GO:0097479 | 1.26712602449e-11 | 1.0 | AP3S1 AP3M1 AP3D1 AP3M2 AP3B2 AP3B1 | synaptic vesicle localization |
| GO:0099518 | 2.68884724727e-11 | 1.0 | AP3S1 AP3M1 AP3D1 AP3M2 AP3B2 AP3B1 | vesicle cytoskeletal trafficking |
| GO:0098930 | 3.09217433437e-11 | 1.0 | AP3S1 AP3M1 AP3D1 AP3M2 AP3B2 AP3B1 | axonal transport |
| GO:0008088 | 5.94528302381e-11 | 1.0 | AP3S1 AP3M1 AP3D1 AP3M2 AP3B2 AP3B1 | axo-dendritic transport |
| GO:0072384 | 2.4750538733e-10 | 1.0 | AP3S1 AP3M1 AP3D1 AP3M2 AP3B2 AP3B1 | organelle transport along microtubule |
| GO:0010970 | 1.8777812173e-08 | 1.0 | AP3S1 AP3M1 AP3D1 AP3M2 AP3B2 AP3B1 | transport along microtubule |
| GO:0099111 | 3.67864745509e-08 | 1.0 | AP3S1 AP3M1 AP3D1 AP3M2 AP3B2 AP3B1 | microtubule-based transport |
| GO:0030705 | 5.11701228139e-08 | 1.0 | AP3S1 AP3M1 AP3D1 AP3M2 AP3B2 AP3B1 | cytoskeleton-dependent intracellular transport |
| GO:0051650 | 6.47984375402e-08 | 1.0 | AP3S1 AP3M1 AP3D1 AP3M2 AP3B2 AP3B1 | establishment of vesicle localization |
| GO:0051648 | 8.75595904946e-08 | 1.0 | AP3S1 AP3M1 AP3D1 AP3M2 AP3B2 AP3B1 | vesicle localization |
| GO:0007018 | 6.69828055445e-07 | 1.0 | AP3S1 AP3M1 AP3D1 AP3M2 AP3B2 AP3B1 | microtubule-based movement |
| GO:0051656 | 4.10837007153e-06 | 1.0 | AP3S1 AP3M1 AP3D1 AP3M2 AP3B2 AP3B1 | establishment of organelle localization |
| CORUM:2308 | 8.39001385941e-06 | 0.333333333333 | AP3S1 AP3D1 | AP3D1-AP3S1 complex |
| GO:0051640 | 6.07883504192e-05 | 1.0 | AP3S1 AP3M1 AP3D1 AP3M2 AP3B2 AP3B1 | organelle localization |
| GO:0007017 | 0.000269369436793 | 1.0 | AP3S1 AP3M1 AP3D1 AP3M2 AP3B2 AP3B1 | microtubule-based process |
| GO:0030119 | 0.00661098268806 | 0.5 | AP3S1 AP3D1 AP3M2 | AP-type membrane coat adaptor complex |
| CORUM:0000000 | 0.0090785708022 | 1.0 | AP3S1 AP3M1 AP3D1 AP3M2 AP3B2 AP3B1 | CORUM root |
| HP:0001107 | 0.0142301190129 | 0.333333333333 | AP3D1 AP3B1 | Ocular albinism |
| REAC:R-HSA-432722 | 0.0314333263146 | 0.333333333333 | AP3S1 AP3B1 | Golgi Associated Vesicle Biogenesis |
| GO:0006928 | 0.0328558479428 | 1.0 | AP3S1 AP3M1 AP3D1 AP3M2 AP3B2 AP3B1 | movement of cell or subcellular component |
| GO:0046907 | 0.038148924612 | 1.0 | AP3S1 AP3M1 AP3D1 AP3M2 AP3B2 AP3B1 | intracellular transport |
| CORUM:2307 | 0.0499726005494 | 0.166666666667 | AP3D1 | AP3D1-AP3S2 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| AP3D1 | AP3B1 | 1.0 | 0.949 | bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM |
| AP3S1 | AP3D1 | 0.994 | 0.919 | bioplex (AP3S1) bioplex_WMM youn_WMM gupta_WMM fraction |
| AP3S1 | AP3B1 | 0.988 | 0.901 | bioplex (AP3S1) bioplex_WMM youn_WMM gupta_WMM fraction |
| AP3D1 | AP3M1 | 0.988 | 0.901 | bioplex (AP3M1) bioplex_WMM youn_WMM gupta_WMM fraction |
| AP3S1 | AP3M1 | 0.988 | 0.901 | bioplex (AP3M1,AP3S1) bioplex_WMM youn_WMM gupta_WMM fraction |
| AP3M1 | AP3B1 | 0.988 | 0.901 | bioplex (AP3M1) bioplex_WMM boldt youn_WMM Malo gupta_WMM fraction boldt_WMM |
| AP3S1 | AP3B2 | 0.967 | 0.877 | bioplex (AP3S1) bioplex_WMM youn_WMM |
| AP3M1 | AP3B2 | 0.922 | 0.843 | bioplex (AP3M1) bioplex_WMM youn_WMM |
| AP3S1 | AP3M2 | 0.792 | 0.758 | bioplex (AP3M2,AP3S1) bioplex_WMM youn_WMM fraction |
| AP3B1 | AP3M2 | 0.253 | 0.477 | bioplex (AP3M2) bioplex_WMM youn_WMM fraction |
| AP3M1 | AP3M2 | 0.1 | 0.361 | bioplex (AP3M1) bioplex_WMM youn_WMM |
| AP3D1 | AP3M2 | 0.098 | 0.357 | bioplex (AP3M2) bioplex_WMM youn_WMM fraction |
| AP3M2 | AP3B2 | 0.012 | 0.149 | bioplex_WMM WMM_only |
| AP3B1 | AP3B2 | 0.011 | 0.141 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| AP3D1 | AP3B2 | 0.009 | 0.103 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
Images
Click to enlarge
Complex HuMAP2_05936 has an average edge precision of 0.636 which is ranked 1740 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| AP3S1 | HuMAP2_00924 HuMAP2_02783 HuMAP2_05936 HuMAP2_06447 |
| AP3D1 | HuMAP2_00924 HuMAP2_05936 HuMAP2_06447 |
| AP3B1 | HuMAP2_00924 HuMAP2_05936 HuMAP2_06447 |
| AP3M1 | HuMAP2_00924 HuMAP2_02783 HuMAP2_05936 HuMAP2_06447 |
| AP3M2 | HuMAP2_00924 HuMAP2_05936 HuMAP2_06447 |
| AP3B2 | HuMAP2_00924 HuMAP2_01887 HuMAP2_02783 HuMAP2_05936 HuMAP2_06447 |