hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05938
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| TTC21B | Tetratricopeptide repeat protein 21B (TPR repeat protein 21B) (Intraflagellar transport 139 homolog) | UniProt NCBI |
| IFT43 | Intraflagellar transport protein 43 homolog | UniProt NCBI |
| TYK2 | Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4536 | 0.00501588895599 | 0.666666666667 | IFT43 TTC21B | Genes related to primary cilium development (based on CRISPR) |
| HP:0000090 | 0.00556051868131 | 0.666666666667 | IFT43 TTC21B | Nephronophthisis |
| HP:0100957 | 0.00834660940556 | 0.666666666667 | IFT43 TTC21B | Abnormal renal medulla morphology |
| REAC:R-HSA-5620924 | 0.00851790571699 | 0.666666666667 | IFT43 TTC21B | Intraflagellar transport |
| HP:0000773 | 0.0121532611158 | 0.666666666667 | IFT43 TTC21B | Short ribs |
| HP:0003774 | 0.0183346678183 | 0.666666666667 | IFT43 TTC21B | Stage 5 chronic kidney disease |
| HP:0012622 | 0.0278358341925 | 0.666666666667 | IFT43 TTC21B | Chronic kidney disease |
| GO:0030991 | 0.0283955176165 | 0.666666666667 | IFT43 TTC21B | intraciliary transport particle A |
| HP:0006712 | 0.0314403819239 | 0.666666666667 | IFT43 TTC21B | Aplasia/Hypoplasia of the ribs |
| HP:0002088 | 0.0377003342294 | 1.0 | IFT43 TTC21B TYK2 | Abnormal lung morphology |
| HP:0002983 | 0.0384790851177 | 0.666666666667 | IFT43 TTC21B | Micromelia |
| HP:0000774 | 0.0401392937999 | 0.666666666667 | IFT43 TTC21B | Narrow chest |
| CORUM:5178 | 0.0499776345577 | 0.333333333333 | TYK2 | JAK2-PAFR-TYK2 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| TTC21B | IFT43 | 0.995 | 0.924 | bioplex (IFT43) bioplex_WMM boldt (IFT43) boldt_WMM |
| IFT43 | TYK2 | 0.073 | 0.354 | bioplex (IFT43) bioplex_WMM boldt (IFT43) boldt_WMM |
| TTC21B | TYK2 | 0.007 | 0.003 | bioplex_WMM boldt boldt_WMM |
Images
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Complex HuMAP2_05938 has an average edge precision of 0.427 which is ranked 3052 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| TTC21B | HuMAP2_00920 HuMAP2_01229 HuMAP2_05938 |
| IFT43 | HuMAP2_01229 HuMAP2_03603 HuMAP2_05938 |
| TYK2 | HuMAP2_05938 HuMAP2_06447 HuMAP2_06850 |