hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05943
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| ENO1 | Alpha-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (C-myc promoter-binding protein) (Enolase 1) (MBP-1) (MPB-1) (Non-neural enolase) (NNE) (Phosphopyruvate hydratase) (Plasminogen-binding protein) | UniProt NCBI |
| LDHAL6B | L-lactate dehydrogenase A-like 6B (EC 1.1.1.27) | UniProt NCBI |
| ADSS2 | Adenylosuccinate synthetase isozyme 2 (AMPSase 2) (AdSS 2) (EC 6.3.4.4) (Adenylosuccinate synthetase, acidic isozyme) (Adenylosuccinate synthetase, liver isozyme) (L-type adenylosuccinate synthetase) (IMP--aspartate ligase 2) | UniProt NCBI |
| MTHFD1L | Monofunctional C1-tetrahydrofolate synthase, mitochondrial (EC 6.3.4.3) (Formyltetrahydrofolate synthetase) | UniProt NCBI |
| AHCY | Adenosylhomocysteinase (AdoHcyase) (EC 3.3.1.1) (S-adenosyl-L-homocysteine hydrolase) | UniProt NCBI |
| CALR | Calreticulin (CRP55) (Calregulin) (Endoplasmic reticulum resident protein 60) (ERp60) (HACBP) (grp60) | UniProt NCBI |
| RPE | Ribulose-phosphate 3-epimerase (EC 5.1.3.1) (Ribulose-5-phosphate-3-epimerase) | UniProt NCBI |
| DPP3 | Dipeptidyl peptidase 3 (EC 3.4.14.4) (Dipeptidyl aminopeptidase III) (Dipeptidyl arylamidase III) (Dipeptidyl peptidase III) (DPP III) (Enkephalinase B) | UniProt NCBI |
| ENO2 | Gamma-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (Enolase 2) (Neural enolase) (Neuron-specific enolase) (NSE) | UniProt NCBI |
| AKR1B15 | Aldo-keto reductase family 1 member B15 (EC 1.1.1.-) (EC 1.1.1.300) (EC 1.1.1.54) (Estradiol 17-beta-dehydrogenase AKR1B15) (Farnesol dehydrogenase) (EC 1.1.1.216) (Testosterone 17beta-dehydrogenase) (EC 1.1.1.64) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:01100 | 0.00015920856848 | 0.7 | LDHAL6B ENO2 RPE ADSS2 AHCY ENO1 MTHFD1L | Metabolic pathways |
| WP:WP534 | 0.000177606946834 | 0.3 | LDHAL6B ENO2 ENO1 | Glycolysis and Gluconeogenesis |
| KEGG:00010 | 0.000407414683827 | 0.3 | LDHAL6B ENO2 ENO1 | Glycolysis / Gluconeogenesis |
| REAC:R-HSA-1430728 | 0.000466695107701 | 0.8 | LDHAL6B AKR1B15 ENO2 RPE ADSS2 AHCY ENO1 MTHFD1L | Metabolism |
| KEGG:01230 | 0.000584726257012 | 0.3 | RPE ENO2 ENO1 | Biosynthesis of amino acids |
| KEGG:04066 | 0.00163740562511 | 0.3 | LDHAL6B ENO2 ENO1 | HIF-1 signaling pathway |
| KEGG:01200 | 0.00242295667073 | 0.3 | RPE ENO2 ENO1 | Carbon metabolism |
| WP:WP241 | 0.00948491249007 | 0.2 | MTHFD1L AHCY | One Carbon Metabolism |
| WP:WP2525 | 0.0109073591456 | 0.2 | MTHFD1L AHCY | Trans-sulfuration and one carbon metabolism |
| KEGG:00270 | 0.0198737758517 | 0.2 | AHCY LDHAL6B | Cysteine and methionine metabolism |
| REAC:R-HSA-70263 | 0.0365556262578 | 0.2 | ENO2 ENO1 | Gluconeogenesis |
| CORUM:5217 | 0.0499561984052 | 0.1 | CALR | Calreticulin homo-oligomer complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| AKR1B15 | ENO1 | 0.974 | 0.886 | Guru fraction treiber_WMM |
| AKR1B15 | ENO2 | 0.968 | 0.88 | Guru fraction |
| CALR | ENO1 | 0.967 | 0.877 | bioplex_WMM Guru boldt fraction boldt_WMM treiber_WMM |
| ADSS2 | ENO2 | 0.959 | 0.865 | Guru fraction |
| ENO1 | ENO2 | 0.942 | 0.855 | bioplex (ENO2) bioplex_WMM treiber_WMM |
| CALR | ENO2 | 0.931 | 0.846 | bioplex (ENO2) bioplex_WMM Guru fraction treiber_WMM |
| AHCY | DPP3 | 0.915 | 0.839 | bioplex (DPP3) bioplex_WMM Guru fraction treiber_WMM |
| DPP3 | ENO1 | 0.831 | 0.778 | bioplex (DPP3) bioplex_WMM fraction treiber_WMM |
| DPP3 | ENO2 | 0.827 | 0.774 | bioplex_WMM fraction |
| RPE | ENO2 | 0.791 | 0.758 | fraction |
| AKR1B15 | LDHAL6B | 0.757 | 0.747 | fraction |
| ADSS2 | ENO1 | 0.745 | 0.74 | bioplex (ADSS2) bioplex_WMM Guru boldt fraction boldt_WMM treiber_WMM |
| MTHFD1L | ENO2 | 0.721 | 0.732 | fraction |
| ADSS2 | RPE | 0.712 | 0.727 | fraction |
| LDHAL6B | ENO2 | 0.698 | 0.719 | fraction |
| AHCY | ENO2 | 0.681 | 0.708 | bioplex (ENO2) bioplex_WMM Guru gupta_WMM fraction treiber_WMM |
| ENO1 | LDHAL6B | 0.662 | 0.698 | bioplex (LDHAL6B) fraction treiber_WMM |
| AKR1B15 | AHCY | 0.596 | 0.666 | Guru fraction treiber_WMM |
| ADSS2 | DPP3 | 0.58 | 0.662 | bioplex_WMM fraction |
| AHCY | RPE | 0.553 | 0.646 | bioplex (RPE) fraction |
| DPP3 | MTHFD1L | 0.551 | 0.644 | bioplex_WMM fraction treiber_WMM |
| ADSS2 | LDHAL6B | 0.359 | 0.541 | fraction |
| ENO1 | RPE | 0.35 | 0.536 | bioplex (RPE) fraction |
| MTHFD1L | ENO1 | 0.323 | 0.512 | bioplex_WMM fraction |
| AHCY | ENO1 | 0.182 | 0.438 | bioplex (AHCY) bioplex_WMM Guru boldt fraction boldt_WMM treiber_WMM |
| AKR1B15 | ADSS2 | 0.085 | 0.348 | Guru fraction |
| AHCY | LDHAL6B | 0.08 | 0.35 | bioplex (LDHAL6B) fraction treiber_WMM |
| DPP3 | RPE | 0.062 | 0.34 | fraction |
| MTHFD1L | RPE | 0.042 | 0.27 | fraction |
| ADSS2 | AHCY | 0.029 | 0.23 | bioplex (ADSS2) bioplex_WMM fraction treiber_WMM |
| ADSS2 | MTHFD1L | 0.029 | 0.23 | bioplex_WMM fraction |
| AHCY | MTHFD1L | 0.008 | 0.066 | bioplex_WMM youn_WMM fraction |
| CALR | ADSS2 | 0.007 | 0.003 | bioplex (ADSS2) bioplex_WMM treiber_WMM |
| CALR | MTHFD1L | 0.007 | 0.002 | bioplex_WMM WMM_only treiber_WMM |
| AKR1B15 | CALR | 0.007 | 0.0 | WMM_only treiber_WMM |
| CALR | DPP3 | 0.007 | 0.005 | bioplex (DPP3) bioplex_WMM treiber_WMM |
| CALR | LDHAL6B | 0.007 | 0.005 | bioplex (LDHAL6B) treiber_WMM |
| CALR | RPE | 0.006 | 0.006 | bioplex (RPE) |
| MTHFD1L | LDHAL6B | 0.004 | 0.005 | bioplex (LDHAL6B) bioplex_WMM |
| CALR | AHCY | 0.0 | 0.001 | bioplex (AHCY) bioplex_WMM boldt gupta_WMM fraction boldt_WMM treiber_WMM |
Images
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Complex HuMAP2_05943 has an average edge precision of 0.498 which is ranked 2504 out of all 6965 complexes.
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