hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_05950
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CDK5R1 | Cyclin-dependent kinase 5 activator 1 (CDK5 activator 1) (Cyclin-dependent kinase 5 regulatory subunit 1) (TPKII regulatory subunit) [Cleaved into: Cyclin-dependent kinase 5 activator 1, p35 (p35); Cyclin-dependent kinase 5 activator 1, p25 (p25) (Tau protein kinase II 23 kDa subunit) (p23)] | UniProt NCBI |
| CDK20 | Cyclin-dependent kinase 20 (EC 2.7.11.22) (CDK-activating kinase p42) (CAK-kinase p42) (Cell cycle-related kinase) (Cell division protein kinase 20) (Cyclin-dependent protein kinase H) (Cyclin-kinase-activating kinase p42) | UniProt NCBI |
| CDK5 | Cyclin-dependent-like kinase 5 (EC 2.7.11.1) (Cell division protein kinase 5) (Serine/threonine-protein kinase PSSALRE) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) | UniProt NCBI |
| CCNI2 | Cyclin-I2 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-9032845 | 0.000100528399861 | 0.5 | CDK5 CDK5R1 | Activated NTRK2 signals through CDK5 |
| REAC:R-HSA-399956 | 0.00120515287053 | 0.5 | CDK5 CDK5R1 | CRMPs in Sema3A signaling |
| WP:WP3878 | 0.0015833920549 | 0.5 | CDK5 CDK5R1 | ATM Signaling Network in Development and Disease |
| REAC:R-HSA-9006115 | 0.0019074750117 | 0.5 | CDK5 CDK5R1 | Signaling by NTRK2 (TRKB) |
| KEGG:05030 | 0.00206562690353 | 0.5 | CDK5 CDK5R1 | Cocaine addiction |
| REAC:R-HSA-8862803 | 0.00210807296175 | 0.5 | CDK5 CDK5R1 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models |
| REAC:R-HSA-8863678 | 0.00210807296175 | 0.5 | CDK5 CDK5R1 | Neurodegenerative Diseases |
| WP:WP2059 | 0.00527207105384 | 0.5 | CDK5 CDK5R1 | Alzheimers Disease |
| WP:WP2380 | 0.0152387809455 | 0.5 | CDK5 CDK5R1 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| REAC:R-HSA-373755 | 0.017117349746 | 0.5 | CDK5 CDK5R1 | Semaphorin interactions |
| KEGG:05010 | 0.0232850911193 | 0.5 | CDK5 CDK5R1 | Alzheimer disease |
| REAC:R-HSA-6804756 | 0.0408500448467 | 0.5 | CDK5 CDK5R1 | Regulation of TP53 Activity through Phosphorylation |
| REAC:R-HSA-166520 | 0.0408500448467 | 0.5 | CDK5 CDK5R1 | Signaling by NTRKs |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CDK20 | CDK5 | 0.994 | 0.921 | bioplex (CDK5) bioplex_WMM |
| CDK5R1 | CDK5 | 0.661 | 0.698 | bioplex (CDK5R1) bioplex_WMM |
| CDK5 | CCNI2 | 0.183 | 0.438 | bioplex (CCNI2) bioplex_WMM |
Images
Click to enlarge
Complex HuMAP2_05950 has an average edge precision of 0.686 which is ranked 1435 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| CDK5R1 | HuMAP2_05673 HuMAP2_05950 HuMAP2_06571 |
| CDK20 | HuMAP2_04781 HuMAP2_05950 HuMAP2_06068 HuMAP2_06571 |
| CDK5 | HuMAP2_05673 HuMAP2_05950 HuMAP2_06068 HuMAP2_06571 |
| CCNI2 | HuMAP2_05673 HuMAP2_05950 |