hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05958
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| HSD17B10 | 3-hydroxyacyl-CoA dehydrogenase type-2 (EC 1.1.1.35) (17-beta-hydroxysteroid dehydrogenase 10) (17-beta-HSD 10) (EC 1.1.1.51) (2-methyl-3-hydroxybutyryl-CoA dehydrogenase) (MHBD) (3-hydroxy-2-methylbutyryl-CoA dehydrogenase) (EC 1.1.1.178) (3-hydroxyacyl-CoA dehydrogenase type II) (Endoplasmic reticulum-associated amyloid beta-peptide-binding protein) (Mitochondrial ribonuclease P protein 2) (Mitochondrial RNase P protein 2) (Short chain dehydrogenase/reductase family 5C member 1) (Short-chain type dehydrogenase/reductase XH98G2) (Type II HADH) | UniProt NCBI |
| LDHA | L-lactate dehydrogenase A chain (LDH-A) (EC 1.1.1.27) (Cell proliferation-inducing gene 19 protein) (LDH muscle subunit) (LDH-M) (Renal carcinoma antigen NY-REN-59) | UniProt NCBI |
| AKR1B10 | Aldo-keto reductase family 1 member B10 (EC 1.1.1.300) (EC 1.1.1.54) (ARL-1) (Aldose reductase-like) (Aldose reductase-related protein) (ARP) (hARP) (Small intestine reductase) (SI reductase) | UniProt NCBI |
| HNRNPA1L2 | Heterogeneous nuclear ribonucleoprotein A1-like 2 (hnRNP A1-like 2) (hnRNP core protein A1-like 2) | UniProt NCBI |
| LDHB | L-lactate dehydrogenase B chain (LDH-B) (EC 1.1.1.27) (LDH heart subunit) (LDH-H) (Renal carcinoma antigen NY-REN-46) | UniProt NCBI |
| AKR1B15 | Aldo-keto reductase family 1 member B15 (EC 1.1.1.-) (EC 1.1.1.300) (EC 1.1.1.54) (Estradiol 17-beta-dehydrogenase AKR1B15) (Farnesol dehydrogenase) (EC 1.1.1.216) (Testosterone 17beta-dehydrogenase) (EC 1.1.1.64) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0016616 | 3.872315266e-06 | 0.833333333333 | LDHA LDHB AKR1B10 AKR1B15 HSD17B10 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| GO:0016614 | 5.44729960606e-06 | 0.833333333333 | LDHA LDHB AKR1B10 AKR1B15 HSD17B10 | oxidoreductase activity, acting on CH-OH group of donors |
| KEGG:00640 | 0.00349258474935 | 0.333333333333 | LDHA LDHB | Propanoate metabolism |
| KEGG:00620 | 0.00460906737116 | 0.333333333333 | LDHA LDHB | Pyruvate metabolism |
| WP:WP534 | 0.00524729006009 | 0.333333333333 | LDHA LDHB | Glycolysis and Gluconeogenesis |
| KEGG:00270 | 0.00642969194212 | 0.333333333333 | LDHA LDHB | Cysteine and methionine metabolism |
| REAC:R-HSA-70268 | 0.00895825109095 | 0.333333333333 | LDHA LDHB | Pyruvate metabolism |
| KEGG:00010 | 0.0120956152943 | 0.333333333333 | LDHA LDHB | Glycolysis / Gluconeogenesis |
| KEGG:05230 | 0.013683677248 | 0.333333333333 | LDHA LDHB | Central carbon metabolism in cancer |
| WP:WP4018 | 0.0174151198914 | 0.333333333333 | LDHA LDHB | Pathways in clear cell renal cell carcinoma |
| GO:0016491 | 0.0222446676534 | 0.833333333333 | LDHA LDHB AKR1B10 AKR1B15 HSD17B10 | oxidoreductase activity |
| REAC:R-HSA-1430728 | 0.0278608311428 | 0.833333333333 | LDHA LDHB AKR1B10 AKR1B15 HSD17B10 | Metabolism |
| KEGG:04922 | 0.0280749165362 | 0.333333333333 | LDHA LDHB | Glucagon signaling pathway |
| REAC:R-HSA-71406 | 0.029137346631 | 0.333333333333 | LDHA LDHB | Pyruvate metabolism and Citric Acid (TCA) cycle |
| KEGG:04066 | 0.0304541793376 | 0.333333333333 | LDHA LDHB | HIF-1 signaling pathway |
| KEGG:01100 | 0.0331288091988 | 0.666666666667 | LDHA LDHB AKR1B10 HSD17B10 | Metabolic pathways |
| CORUM:7429 | 0.0499726005494 | 0.166666666667 | HSD17B10 | HSD17B10-TRMT10C complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| AKR1B10 | AKR1B15 | 0.998 | 0.939 | bioplex (AKR1B10) bioplex_WMM |
| LDHB | AKR1B15 | 0.709 | 0.728 | fraction |
| LDHA | AKR1B15 | 0.709 | 0.729 | fraction treiber_WMM |
| LDHB | HNRNPA1L2 | 0.429 | 0.577 | youn_WMM gupta_WMM fraction |
| LDHA | HNRNPA1L2 | 0.347 | 0.536 | youn_WMM gupta_WMM fraction |
| AKR1B15 | HSD17B10 | 0.297 | 0.497 | Guru fraction treiber_WMM |
| LDHA | AKR1B10 | 0.246 | 0.469 | bioplex (AKR1B10) fraction treiber_WMM |
| AKR1B10 | LDHB | 0.241 | 0.468 | bioplex (AKR1B10) fraction treiber_WMM |
| LDHA | LDHB | 0.203 | 0.455 | hein_WMM bioplex (LDHA,LDHB) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM |
| HNRNPA1L2 | AKR1B15 | 0.016 | 0.161 | fraction |
| HNRNPA1L2 | HSD17B10 | 0.0 | 0.001 | youn_WMM gupta_WMM fraction |
| LDHB | HSD17B10 | 0.0 | 0.0 | bioplex (HSD17B10) bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| LDHA | HSD17B10 | 0.0 | 0.001 | bioplex (HSD17B10) bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
Images
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Complex HuMAP2_05958 has an average edge precision of 0.428 which is ranked 3044 out of all 6965 complexes.
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