hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05961
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| BAZ1A | Bromodomain adjacent to zinc finger domain protein 1A (ATP-dependent chromatin-remodeling protein) (ATP-utilizing chromatin assembly and remodeling factor 1) (hACF1) (CHRAC subunit ACF1) (Williams syndrome transcription factor-related chromatin-remodeling factor 180) (WCRF180) (hWALp1) | UniProt NCBI |
| POLE2 | DNA polymerase epsilon subunit 2 (EC 2.7.7.7) (DNA polymerase II subunit 2) (DNA polymerase epsilon subunit B) | UniProt NCBI |
| POLE | DNA polymerase epsilon catalytic subunit A (EC 2.7.7.7) (DNA polymerase II subunit A) | UniProt NCBI |
| POLE3 | DNA polymerase epsilon subunit 3 (EC 2.7.7.7) (Arsenic-transactivated protein) (AsTP) (Chromatin accessibility complex 17 kDa protein) (CHRAC-17) (HuCHRAC17) (DNA polymerase II subunit 3) (DNA polymerase epsilon subunit p17) | UniProt NCBI |
| CHRAC1 | Chromatin accessibility complex protein 1 (CHRAC-1) (Chromatin accessibility complex 15 kDa protein) (CHRAC-15) (HuCHRAC15) (DNA polymerase epsilon subunit p15) | UniProt NCBI |
| POLE4 | DNA polymerase epsilon subunit 4 (EC 2.7.7.7) (DNA polymerase II subunit 4) (DNA polymerase epsilon subunit p12) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0008622 | 4.91515675326e-14 | 0.833333333333 | POLE2 CHRAC1 POLE3 POLE4 POLE | epsilon DNA polymerase complex |
| REAC:R-HSA-68952 | 8.39486242387e-11 | 0.666666666667 | POLE2 POLE3 POLE4 POLE | DNA replication initiation |
| REAC:R-HSA-174430 | 8.39486242387e-11 | 0.666666666667 | POLE2 POLE3 POLE4 POLE | Telomere C-strand synthesis initiation |
| GO:0042575 | 2.14561866932e-10 | 0.833333333333 | POLE2 CHRAC1 POLE3 POLE4 POLE | DNA polymerase complex |
| CORUM:1108 | 6.18993641784e-10 | 0.666666666667 | POLE2 POLE3 POLE4 POLE | DNA synthesome complex (15 subunits) |
| CORUM:1111 | 1.07903889482e-09 | 0.666666666667 | POLE2 POLE3 POLE4 POLE | DNA synthesome complex (17 subunits) |
| CORUM:1099 | 1.07903889482e-09 | 0.666666666667 | POLE2 POLE3 POLE4 POLE | DNA synthesome complex (17 subunits) |
| GO:0003887 | 1.29312581721e-09 | 0.833333333333 | POLE2 CHRAC1 POLE3 POLE4 POLE | DNA-directed DNA polymerase activity |
| GO:0034061 | 4.82439758657e-09 | 0.833333333333 | POLE2 CHRAC1 POLE3 POLE4 POLE | DNA polymerase activity |
| REAC:R-HSA-5651801 | 7.16758219917e-09 | 0.666666666667 | POLE2 POLE3 POLE4 POLE | PCNA-Dependent Long Patch Base Excision Repair |
| CORUM:234 | 9.01288868683e-09 | 0.5 | CHRAC1 BAZ1A POLE3 | HuCHRAC complex |
| KEGG:03410 | 1.21475962261e-08 | 0.666666666667 | POLE2 POLE3 POLE4 POLE | Base excision repair |
| REAC:R-HSA-174417 | 1.27214964402e-08 | 0.666666666667 | POLE2 POLE3 POLE4 POLE | Telomere C-strand (Lagging Strand) Synthesis |
| REAC:R-HSA-110373 | 1.51430095798e-08 | 0.666666666667 | POLE2 POLE3 POLE4 POLE | Resolution of AP sites via the multiple-nucleotide patch replacement pathway |
| REAC:R-HSA-5696397 | 1.51430095798e-08 | 0.666666666667 | POLE2 POLE3 POLE4 POLE | Gap-filling DNA repair synthesis and ligation in GG-NER |
| KEGG:03030 | 1.98900494732e-08 | 0.666666666667 | POLE2 POLE3 POLE4 POLE | DNA replication |
| REAC:R-HSA-180786 | 3.27882210208e-08 | 0.666666666667 | POLE2 POLE3 POLE4 POLE | Extension of Telomeres |
| REAC:R-HSA-110314 | 3.27882210208e-08 | 0.666666666667 | POLE2 POLE3 POLE4 POLE | Recognition of DNA damage by PCNA-containing replication complex |
| REAC:R-HSA-5656169 | 3.76416846139e-08 | 0.666666666667 | POLE2 POLE3 POLE4 POLE | Termination of translesion DNA synthesis |
| KEGG:03420 | 4.57986525811e-08 | 0.666666666667 | POLE2 POLE3 POLE4 POLE | Nucleotide excision repair |
| REAC:R-HSA-68962 | 4.89421979513e-08 | 0.666666666667 | POLE2 POLE3 POLE4 POLE | Activation of the pre-replicative complex |
| REAC:R-HSA-73933 | 6.26114845342e-08 | 0.666666666667 | POLE2 POLE3 POLE4 POLE | Resolution of Abasic Sites (AP sites) |
| REAC:R-HSA-110313 | 8.82386282266e-08 | 0.666666666667 | POLE2 POLE3 POLE4 POLE | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template |
| REAC:R-HSA-5696400 | 1.21019310036e-07 | 0.666666666667 | POLE2 POLE3 POLE4 POLE | Dual Incision in GG-NER |
| REAC:R-HSA-73893 | 2.13011432628e-07 | 0.666666666667 | POLE2 POLE3 POLE4 POLE | DNA Damage Bypass |
| WP:WP4022 | 4.50738420864e-07 | 0.666666666667 | POLE2 POLE3 POLE4 POLE | Pyrimidine metabolism |
| REAC:R-HSA-6782210 | 7.57405773874e-07 | 0.666666666667 | POLE2 POLE3 POLE4 POLE | Gap-filling DNA repair synthesis and ligation in TC-NER |
| REAC:R-HSA-5685942 | 8.06984733932e-07 | 0.666666666667 | POLE2 POLE3 POLE4 POLE | HDR through Homologous Recombination (HRR) |
| REAC:R-HSA-6782135 | 8.06984733932e-07 | 0.666666666667 | POLE2 POLE3 POLE4 POLE | Dual incision in TC-NER |
| REAC:R-HSA-6781827 | 1.69781798539e-06 | 0.666666666667 | POLE2 POLE3 POLE4 POLE | Transcription-Coupled Nucleotide Excision Repair (TC-NER) |
| REAC:R-HSA-157579 | 1.97964398673e-06 | 0.666666666667 | POLE2 POLE3 POLE4 POLE | Telomere Maintenance |
| REAC:R-HSA-5696399 | 2.29512356464e-06 | 0.666666666667 | POLE2 POLE3 POLE4 POLE | Global Genome Nucleotide Excision Repair (GG-NER) |
| REAC:R-HSA-69002 | 2.40820312913e-06 | 0.666666666667 | POLE2 POLE3 POLE4 POLE | DNA Replication Pre-Initiation |
| REAC:R-HSA-73884 | 2.64682448332e-06 | 0.666666666667 | POLE2 POLE3 POLE4 POLE | Base Excision Repair |
| GO:0016779 | 6.26212265329e-06 | 0.833333333333 | POLE2 CHRAC1 POLE3 POLE4 POLE | nucleotidyltransferase activity |
| REAC:R-HSA-73886 | 6.35809703042e-06 | 0.666666666667 | POLE2 POLE3 POLE4 POLE | Chromosome Maintenance |
| GO:0032201 | 6.40626927361e-06 | 0.666666666667 | POLE2 POLE3 POLE4 POLE | telomere maintenance via semi-conservative replication |
| REAC:R-HSA-5696398 | 6.84789868567e-06 | 0.666666666667 | POLE2 POLE3 POLE4 POLE | Nucleotide Excision Repair |
| REAC:R-HSA-69239 | 9.09450019206e-06 | 0.666666666667 | POLE2 POLE3 POLE4 POLE | Synthesis of DNA |
| GO:0006270 | 1.00004074113e-05 | 0.666666666667 | POLE2 POLE3 POLE4 POLE | DNA replication initiation |
| REAC:R-HSA-69306 | 1.18518696073e-05 | 0.666666666667 | POLE2 POLE3 POLE4 POLE | DNA Replication |
| GO:0006261 | 1.24105644798e-05 | 0.833333333333 | POLE2 POLE3 POLE BAZ1A POLE4 | DNA-dependent DNA replication |
| REAC:R-HSA-5693567 | 1.3444306072e-05 | 0.666666666667 | POLE2 POLE3 POLE4 POLE | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) |
| REAC:R-HSA-69206 | 1.3444306072e-05 | 0.666666666667 | POLE2 POLE3 POLE4 POLE | G1/S Transition |
| REAC:R-HSA-5693538 | 1.61264536488e-05 | 0.666666666667 | POLE2 POLE3 POLE4 POLE | Homology Directed Repair |
| REAC:R-HSA-453279 | 2.20593865609e-05 | 0.666666666667 | POLE2 POLE3 POLE4 POLE | Mitotic G1-G1/S phases |
| REAC:R-HSA-69242 | 3.02487101892e-05 | 0.666666666667 | POLE2 POLE3 POLE4 POLE | S Phase |
| REAC:R-HSA-5693532 | 3.42582751834e-05 | 0.666666666667 | POLE2 POLE3 POLE4 POLE | DNA Double-Strand Break Repair |
| GO:0140097 | 6.28582159941e-05 | 0.833333333333 | POLE2 CHRAC1 POLE3 POLE4 POLE | catalytic activity, acting on DNA |
| GO:0033260 | 9.85570254489e-05 | 0.666666666667 | POLE2 POLE3 POLE4 POLE | nuclear DNA replication |
| GO:0044786 | 0.000133653758006 | 0.666666666667 | POLE2 POLE3 POLE4 POLE | cell cycle DNA replication |
| GO:0006260 | 0.000150202934951 | 0.833333333333 | POLE2 POLE3 POLE BAZ1A POLE4 | DNA replication |
| GO:0061695 | 0.000213275731053 | 0.833333333333 | POLE2 CHRAC1 POLE3 POLE4 POLE | transferase complex, transferring phosphorus-containing groups |
| REAC:R-HSA-73894 | 0.000503324377427 | 0.666666666667 | POLE2 POLE3 POLE4 POLE | DNA Repair |
| CORUM:6665 | 0.000761852030483 | 0.333333333333 | POLE4 POLE3 | ATAC complex, YEATS2-linked |
| GO:0044454 | 0.00288133296855 | 1.0 | CHRAC1 POLE4 POLE2 POLE3 POLE BAZ1A | nuclear chromosome part |
| GO:0051276 | 0.00288133296855 | 1.0 | CHRAC1 POLE4 POLE2 POLE3 POLE BAZ1A | chromosome organization |
| REAC:R-HSA-69278 | 0.00331294271573 | 0.666666666667 | POLE2 POLE3 POLE4 POLE | Cell Cycle, Mitotic |
| GO:0000228 | 0.0033810209942 | 1.0 | CHRAC1 POLE4 POLE2 POLE3 POLE BAZ1A | nuclear chromosome |
| WP:WP466 | 0.00477752328717 | 0.333333333333 | POLE2 POLE | DNA Replication |
| REAC:R-HSA-1640170 | 0.00675311119139 | 0.666666666667 | POLE2 POLE3 POLE4 POLE | Cell Cycle |
| GO:0008623 | 0.00676235117068 | 0.333333333333 | CHRAC1 BAZ1A | CHRAC |
| GO:0000723 | 0.00729807142385 | 0.666666666667 | POLE2 POLE3 POLE4 POLE | telomere maintenance |
| CORUM:0000000 | 0.0090785708022 | 1.0 | CHRAC1 POLE4 POLE2 POLE3 POLE BAZ1A | CORUM root |
| GO:0032200 | 0.0101950303288 | 0.666666666667 | POLE2 POLE3 POLE4 POLE | telomere organization |
| WP:WP45 | 0.0107960863784 | 0.333333333333 | POLE2 POLE | G1 to S cell cycle control |
| GO:1902494 | 0.013185208462 | 1.0 | CHRAC1 POLE4 POLE2 POLE3 POLE BAZ1A | catalytic complex |
| GO:0044427 | 0.0151552637177 | 1.0 | CHRAC1 POLE4 POLE2 POLE3 POLE BAZ1A | chromosomal part |
| GO:0005694 | 0.0188325821521 | 1.0 | CHRAC1 POLE4 POLE2 POLE3 POLE BAZ1A | chromosome |
| WP:WP2446 | 0.0205911896387 | 0.333333333333 | POLE2 POLE | Retinoblastoma Gene in Cancer |
| GO:0000082 | 0.0236425639653 | 0.666666666667 | POLE2 POLE3 POLE4 POLE | G1/S transition of mitotic cell cycle |
| GO:0044843 | 0.0298264479231 | 0.666666666667 | POLE2 POLE3 POLE4 POLE | cell cycle G1/S phase transition |
| CORUM:94 | 0.0499726005494 | 0.166666666667 | BAZ1A | SNF2H-BAZ1A complex |
| CORUM:925 | 0.0499726005494 | 0.166666666667 | BAZ1A | SNF2H-BAZ1A complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| POLE3 | CHRAC1 | 0.988 | 0.901 | bioplex_WMM Guru fraction |
| POLE3 | POLE4 | 0.951 | 0.858 | bioplex_WMM Guru Malo fraction |
| POLE | POLE4 | 0.311 | 0.504 | bioplex_WMM Malo fraction |
| POLE3 | POLE | 0.27 | 0.483 | bioplex_WMM Malo fraction |
| POLE | POLE2 | 0.216 | 0.464 | bioplex (POLE,POLE2) bioplex_WMM Malo fraction |
| BAZ1A | CHRAC1 | 0.064 | 0.349 | bioplex_WMM fraction |
| POLE2 | POLE4 | 0.045 | 0.285 | bioplex (POLE2) bioplex_WMM |
| POLE3 | BAZ1A | 0.027 | 0.227 | bioplex_WMM Guru fraction |
| POLE3 | POLE2 | 0.015 | 0.14 | bioplex (POLE2) bioplex_WMM |
| POLE | BAZ1A | 0.007 | 0.002 | youn_WMM WMM_only |
Images
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Complex HuMAP2_05961 has an average edge precision of 0.421 which is ranked 3099 out of all 6965 complexes.
Related Complexes