hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05962
Confidence: Extremely High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PPP2R1A | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (Medium tumor antigen-associated 61 kDa protein) (PP2A subunit A isoform PR65-alpha) (PP2A subunit A isoform R1-alpha) | UniProt NCBI |
| PPP2CA | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PP2A-alpha) (EC 3.1.3.16) (Replication protein C) (RP-C) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1543 | 1.67592346237e-06 | 1.0 | PPP2R1A PPP2CA | PPP2CA-PPP2R1A complex |
| CORUM:6182 | 5.02777038712e-06 | 1.0 | PPP2R1A PPP2CA | PP2A A/C-striatin complex |
| CORUM:6183 | 5.02777038712e-06 | 1.0 | PPP2R1A PPP2CA | PP2A A/C-SG2NA complex |
| CORUM:1544 | 5.02777038712e-06 | 1.0 | PPP2R1A PPP2CA | PPP2CA-PPP2R1A-PPP2R3A complex |
| CORUM:7005 | 1.00555407742e-05 | 1.0 | PPP2R1A PPP2CA | PP2A-NR3A complex |
| CORUM:5876 | 1.67592346237e-05 | 1.0 | PPP2R1A PPP2CA | PPP2R1A-PPP2R1B-PPP2CA-PPME1-EIF4A1 complex |
| REAC:R-HSA-163767 | 3.51943927099e-05 | 1.0 | PPP2R1A PPP2CA | PP2A-mediated dephosphorylation of key metabolic factors |
| REAC:R-HSA-2465910 | 7.54165558069e-05 | 1.0 | PPP2R1A PPP2CA | MASTL Facilitates Mitotic Progression |
| REAC:R-HSA-2995383 | 7.54165558069e-05 | 1.0 | PPP2R1A PPP2CA | Initiation of Nuclear Envelope Reformation |
| REAC:R-HSA-2995410 | 7.54165558069e-05 | 1.0 | PPP2R1A PPP2CA | Nuclear Envelope Reassembly |
| REAC:R-HSA-9634600 | 0.000110610948517 | 1.0 | PPP2R1A PPP2CA | Regulation of glycolysis by fructose 2,6-bisphosphate metabolism |
| REAC:R-HSA-113501 | 0.000130722030065 | 1.0 | PPP2R1A PPP2CA | Inhibition of replication initiation of damaged DNA by RB1/E2F1 |
| REAC:R-HSA-202670 | 0.000130722030065 | 1.0 | PPP2R1A PPP2CA | ERKs are inactivated |
| REAC:R-HSA-5467337 | 0.000152509035076 | 1.0 | PPP2R1A PPP2CA | APC truncation mutants have impaired AXIN binding |
| REAC:R-HSA-4839735 | 0.000152509035076 | 1.0 | PPP2R1A PPP2CA | AXIN mutants destabilize the destruction complex, activating WNT signaling |
| REAC:R-HSA-5467340 | 0.000152509035076 | 1.0 | PPP2R1A PPP2CA | AXIN missense mutants destabilize the destruction complex |
| REAC:R-HSA-5467348 | 0.000152509035076 | 1.0 | PPP2R1A PPP2CA | Truncations of AMER1 destabilize the destruction complex |
| REAC:R-HSA-4839748 | 0.000152509035076 | 1.0 | PPP2R1A PPP2CA | AMER1 mutants destabilize the destruction complex |
| REAC:R-HSA-4839744 | 0.000152509035076 | 1.0 | PPP2R1A PPP2CA | truncated APC mutants destabilize the destruction complex |
| REAC:R-HSA-1295596 | 0.000152509035076 | 1.0 | PPP2R1A PPP2CA | Spry regulation of FGF signaling |
| REAC:R-HSA-5358747 | 0.000175971963549 | 1.0 | PPP2R1A PPP2CA | S33 mutants of beta-catenin aren't phosphorylated |
| REAC:R-HSA-5358752 | 0.000175971963549 | 1.0 | PPP2R1A PPP2CA | T41 mutants of beta-catenin aren't phosphorylated |
| REAC:R-HSA-4839743 | 0.000175971963549 | 1.0 | PPP2R1A PPP2CA | phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex |
| REAC:R-HSA-5358751 | 0.000175971963549 | 1.0 | PPP2R1A PPP2CA | S45 mutants of beta-catenin aren't phosphorylated |
| REAC:R-HSA-5339716 | 0.000175971963549 | 1.0 | PPP2R1A PPP2CA | Misspliced GSK3beta mutants stabilize beta-catenin |
| REAC:R-HSA-5358749 | 0.000175971963549 | 1.0 | PPP2R1A PPP2CA | S37 mutants of beta-catenin aren't phosphorylated |
| KEGG:04730 | 0.000201046815819 | 1.0 | PPP2R1A PPP2CA | Long-term depression |
| REAC:R-HSA-196299 | 0.000227925590883 | 1.0 | PPP2R1A PPP2CA | Beta-catenin phosphorylation cascade |
| REAC:R-HSA-389513 | 0.000227925590883 | 1.0 | PPP2R1A PPP2CA | CTLA4 inhibitory signaling |
| REAC:R-HSA-432142 | 0.000227925590883 | 1.0 | PPP2R1A PPP2CA | Platelet sensitization by LDL |
| WP:WP500 | 0.000261924676198 | 1.0 | PPP2R1A PPP2CA | Glycogen Synthesis and Degradation |
| REAC:R-HSA-5654732 | 0.000286582912066 | 1.0 | PPP2R1A PPP2CA | Negative regulation of FGFR3 signaling |
| REAC:R-HSA-5654733 | 0.000387138319809 | 1.0 | PPP2R1A PPP2CA | Negative regulation of FGFR4 signaling |
| REAC:R-HSA-5654726 | 0.000387138319809 | 1.0 | PPP2R1A PPP2CA | Negative regulation of FGFR1 signaling |
| REAC:R-HSA-113510 | 0.000387138319809 | 1.0 | PPP2R1A PPP2CA | E2F mediated regulation of DNA replication |
| REAC:R-HSA-198753 | 0.000387138319809 | 1.0 | PPP2R1A PPP2CA | ERK/MAPK targets |
| REAC:R-HSA-5654727 | 0.000424008635981 | 1.0 | PPP2R1A PPP2CA | Negative regulation of FGFR2 signaling |
| REAC:R-HSA-180024 | 0.000424008635981 | 1.0 | PPP2R1A PPP2CA | DARPP-32 events |
| KEGG:04350 | 0.000438130325039 | 1.0 | PPP2R1A PPP2CA | TGF-beta signaling pathway |
| REAC:R-HSA-198725 | 0.000502777038712 | 1.0 | PPP2R1A PPP2CA | Nuclear Events (kinase and transcription factor activation) |
| REAC:R-HSA-69273 | 0.000502777038712 | 1.0 | PPP2R1A PPP2CA | Cyclin A/B1/B2 associated events during G2/M transition |
| KEGG:05142 | 0.000558495798951 | 1.0 | PPP2R1A PPP2CA | Chagas disease (American trypanosomiasis) |
| KEGG:03015 | 0.000558495798951 | 1.0 | PPP2R1A PPP2CA | mRNA surveillance pathway |
| REAC:R-HSA-5654741 | 0.000633499068778 | 1.0 | PPP2R1A PPP2CA | Signaling by FGFR3 |
| REAC:R-HSA-5673000 | 0.000680424925724 | 1.0 | PPP2R1A PPP2CA | RAF activation |
| REAC:R-HSA-5654743 | 0.000729026706133 | 1.0 | PPP2R1A PPP2CA | Signaling by FGFR4 |
| REAC:R-HSA-4791275 | 0.000729026706133 | 1.0 | PPP2R1A PPP2CA | Signaling by WNT in cancer |
| REAC:R-HSA-4641262 | 0.000729026706133 | 1.0 | PPP2R1A PPP2CA | Disassembly of the destruction complex and recruitment of AXIN to the membrane |
| REAC:R-HSA-450282 | 0.000779304410004 | 1.0 | PPP2R1A PPP2CA | MAPK targets/ Nuclear events mediated by MAP kinases |
| KEGG:04114 | 0.000827384972793 | 1.0 | PPP2R1A PPP2CA | Oocyte meiosis |
| KEGG:04071 | 0.000858752944782 | 1.0 | PPP2R1A PPP2CA | Sphingolipid signaling pathway |
| KEGG:04152 | 0.000906899134346 | 1.0 | PPP2R1A PPP2CA | AMPK signaling pathway |
| REAC:R-HSA-6804757 | 0.000997174460113 | 1.0 | PPP2R1A PPP2CA | Regulation of TP53 Degradation |
| REAC:R-HSA-6806003 | 0.0010558317813 | 1.0 | PPP2R1A PPP2CA | Regulation of TP53 Expression and Degradation |
| REAC:R-HSA-5654736 | 0.0010558317813 | 1.0 | PPP2R1A PPP2CA | Signaling by FGFR1 |
| KEGG:04728 | 0.00105921617042 | 1.0 | PPP2R1A PPP2CA | Dopaminergic synapse |
| REAC:R-HSA-5675221 | 0.00111616502594 | 1.0 | PPP2R1A PPP2CA | Negative regulation of MAPK pathway |
| KEGG:04261 | 0.00120453012438 | 1.0 | PPP2R1A PPP2CA | Adrenergic signaling in cardiomyocytes |
| KEGG:05160 | 0.00133933945516 | 1.0 | PPP2R1A PPP2CA | Hepatitis C |
| REAC:R-HSA-69236 | 0.0014429701011 | 1.0 | PPP2R1A PPP2CA | G1 Phase |
| REAC:R-HSA-69231 | 0.0014429701011 | 1.0 | PPP2R1A PPP2CA | Cyclin D associated events in G1 |
| KEGG:04390 | 0.00146058031434 | 1.0 | PPP2R1A PPP2CA | Hippo signaling pathway |
| KEGG:04530 | 0.00152317036077 | 1.0 | PPP2R1A PPP2CA | Tight junction |
| WP:WP399 | 0.00173473868048 | 1.0 | PPP2R1A PPP2CA | Wnt Signaling Pathway and Pluripotency |
| REAC:R-HSA-388841 | 0.00239824647466 | 1.0 | PPP2R1A PPP2CA | Costimulation by the CD28 family |
| REAC:R-HSA-5654738 | 0.00277030148331 | 1.0 | PPP2R1A PPP2CA | Signaling by FGFR2 |
| REAC:R-HSA-450294 | 0.00327307852202 | 1.0 | PPP2R1A PPP2CA | MAP kinase activation |
| REAC:R-HSA-70171 | 0.00359485582679 | 1.0 | PPP2R1A PPP2CA | Glycolysis |
| REAC:R-HSA-190236 | 0.00370546677531 | 1.0 | PPP2R1A PPP2CA | Signaling by FGFR |
| REAC:R-HSA-448424 | 0.00393171644273 | 1.0 | PPP2R1A PPP2CA | Interleukin-17 signaling |
| REAC:R-HSA-6811558 | 0.00393171644273 | 1.0 | PPP2R1A PPP2CA | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
| REAC:R-HSA-187037 | 0.00440432685912 | 1.0 | PPP2R1A PPP2CA | Signaling by NTRK1 (TRKA) |
| REAC:R-HSA-199418 | 0.00477638186777 | 1.0 | PPP2R1A PPP2CA | Negative regulation of the PI3K/AKT network |
| REAC:R-HSA-418346 | 0.00490375205091 | 1.0 | PPP2R1A PPP2CA | Platelet homeostasis |
| REAC:R-HSA-168142 | 0.00556574181855 | 1.0 | PPP2R1A PPP2CA | Toll Like Receptor 10 (TLR10) Cascade |
| REAC:R-HSA-195253 | 0.00556574181855 | 1.0 | PPP2R1A PPP2CA | Degradation of beta-catenin by the destruction complex |
| REAC:R-HSA-70326 | 0.00556574181855 | 1.0 | PPP2R1A PPP2CA | Glucose metabolism |
| REAC:R-HSA-975871 | 0.00556574181855 | 1.0 | PPP2R1A PPP2CA | MyD88 cascade initiated on plasma membrane |
| REAC:R-HSA-168176 | 0.00556574181855 | 1.0 | PPP2R1A PPP2CA | Toll Like Receptor 5 (TLR5) Cascade |
| HP:0001357 | 0.00571376931014 | 1.0 | PPP2R1A PPP2CA | Plagiocephaly |
| REAC:R-HSA-975138 | 0.00584226918984 | 1.0 | PPP2R1A PPP2CA | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| REAC:R-HSA-168181 | 0.00598304676068 | 1.0 | PPP2R1A PPP2CA | Toll Like Receptor 7/8 (TLR7/8) Cascade |
| REAC:R-HSA-975155 | 0.00598304676068 | 1.0 | PPP2R1A PPP2CA | MyD88 dependent cascade initiated on endosome |
| REAC:R-HSA-111885 | 0.00612550025498 | 1.0 | PPP2R1A PPP2CA | Opioid Signalling |
| KEGG:04151 | 0.00654350485448 | 1.0 | PPP2R1A PPP2CA | PI3K-Akt signaling pathway |
| REAC:R-HSA-168188 | 0.00656291627866 | 1.0 | PPP2R1A PPP2CA | Toll Like Receptor TLR6:TLR2 Cascade |
| REAC:R-HSA-166058 | 0.00656291627866 | 1.0 | PPP2R1A PPP2CA | MyD88:MAL(TIRAP) cascade initiated on plasma membrane |
| REAC:R-HSA-168138 | 0.00656291627866 | 1.0 | PPP2R1A PPP2CA | Toll Like Receptor 9 (TLR9) Cascade |
| REAC:R-HSA-168164 | 0.00671207346681 | 1.0 | PPP2R1A PPP2CA | Toll Like Receptor 3 (TLR3) Cascade |
| REAC:R-HSA-166520 | 0.00686290657842 | 1.0 | PPP2R1A PPP2CA | Signaling by NTRKs |
| REAC:R-HSA-168179 | 0.0070154156135 | 1.0 | PPP2R1A PPP2CA | Toll Like Receptor TLR1:TLR2 Cascade |
| REAC:R-HSA-141444 | 0.0070154156135 | 1.0 | PPP2R1A PPP2CA | Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal |
| REAC:R-HSA-141424 | 0.0070154156135 | 1.0 | PPP2R1A PPP2CA | Amplification of signal from the kinetochores |
| REAC:R-HSA-181438 | 0.0070154156135 | 1.0 | PPP2R1A PPP2CA | Toll Like Receptor 2 (TLR2) Cascade |
| KEGG:05165 | 0.00707836525128 | 1.0 | PPP2R1A PPP2CA | Human papillomavirus infection |
| REAC:R-HSA-166166 | 0.00716960057204 | 1.0 | PPP2R1A PPP2CA | MyD88-independent TLR4 cascade |
| REAC:R-HSA-937061 | 0.00716960057204 | 1.0 | PPP2R1A PPP2CA | TRIF(TICAM1)-mediated TLR4 signaling |
| REAC:R-HSA-163685 | 0.00780309964082 | 1.0 | PPP2R1A PPP2CA | Integration of energy metabolism |
| REAC:R-HSA-69618 | 0.00950416195513 | 1.0 | PPP2R1A PPP2CA | Mitotic Spindle Checkpoint |
| REAC:R-HSA-975957 | 0.0106052436699 | 1.0 | PPP2R1A PPP2CA | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
| REAC:R-HSA-927802 | 0.0106052436699 | 1.0 | PPP2R1A PPP2CA | Nonsense-Mediated Decay (NMD) |
| REAC:R-HSA-166016 | 0.0115688996608 | 1.0 | PPP2R1A PPP2CA | Toll Like Receptor 4 (TLR4) Cascade |
| REAC:R-HSA-2500257 | 0.0119660935214 | 1.0 | PPP2R1A PPP2CA | Resolution of Sister Chromatid Cohesion |
| WP:WP3932 | 0.0121610546673 | 1.0 | PPP2R1A PPP2CA | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| REAC:R-HSA-69206 | 0.014052618232 | 1.0 | PPP2R1A PPP2CA | G1/S Transition |
| REAC:R-HSA-68875 | 0.0144900342557 | 1.0 | PPP2R1A PPP2CA | Mitotic Prophase |
| REAC:R-HSA-5663220 | 0.0147112561527 | 1.0 | PPP2R1A PPP2CA | RHO GTPases Activate Formins |
| WP:WP4172 | 0.015291110435 | 1.0 | PPP2R1A PPP2CA | PI3K-Akt Signaling Pathway |
| GO:0042532 | 0.0162296428096 | 1.0 | PPP2R1A PPP2CA | negative regulation of tyrosine phosphorylation of STAT protein |
| REAC:R-HSA-168898 | 0.0163067352889 | 1.0 | PPP2R1A PPP2CA | Toll-like Receptor Cascades |
| REAC:R-HSA-453279 | 0.0179843346747 | 1.0 | PPP2R1A PPP2CA | Mitotic G1-G1/S phases |
| GO:0007084 | 0.020287053512 | 1.0 | PPP2R1A PPP2CA | mitotic nuclear envelope reassembly |
| REAC:R-HSA-5633007 | 0.0205233587202 | 1.0 | PPP2R1A PPP2CA | Regulation of TP53 Activity |
| HP:0012448 | 0.024648352588 | 1.0 | PPP2R1A PPP2CA | Delayed myelination |
| REAC:R-HSA-2467813 | 0.0279091534189 | 1.0 | PPP2R1A PPP2CA | Separation of Sister Chromatids |
| HP:0002194 | 0.0293135400377 | 1.0 | PPP2R1A PPP2CA | Delayed gross motor development |
| REAC:R-HSA-69275 | 0.0300912057669 | 1.0 | PPP2R1A PPP2CA | G2/M Transition |
| REAC:R-HSA-68882 | 0.0304096312248 | 1.0 | PPP2R1A PPP2CA | Mitotic Anaphase |
| REAC:R-HSA-68877 | 0.0304096312248 | 1.0 | PPP2R1A PPP2CA | Mitotic Prometaphase |
| REAC:R-HSA-2555396 | 0.0307297326061 | 1.0 | PPP2R1A PPP2CA | Mitotic Metaphase and Anaphase |
| REAC:R-HSA-453274 | 0.0307297326061 | 1.0 | PPP2R1A PPP2CA | Mitotic G2-G2/M phases |
| REAC:R-HSA-5673001 | 0.0313749631391 | 1.0 | PPP2R1A PPP2CA | RAF/MAP kinase cascade |
| REAC:R-HSA-5684996 | 0.0330173681322 | 1.0 | PPP2R1A PPP2CA | MAPK1/MAPK3 signaling |
| REAC:R-HSA-9607240 | 0.0371300843089 | 1.0 | PPP2R1A PPP2CA | FLT3 Signaling |
| GO:1904893 | 0.0410249304355 | 1.0 | PPP2R1A PPP2CA | negative regulation of receptor signaling pathway via STAT |
| GO:0046426 | 0.0410249304355 | 1.0 | PPP2R1A PPP2CA | negative regulation of receptor signaling pathway via JAK-STAT |
| REAC:R-HSA-201681 | 0.0411120784555 | 1.0 | PPP2R1A PPP2CA | TCF dependent signaling in response to WNT |
| REAC:R-HSA-1257604 | 0.0422332712518 | 1.0 | PPP2R1A PPP2CA | PIP3 activates AKT signaling |
| REAC:R-HSA-449836 | 0.0429891127334 | 1.0 | PPP2R1A PPP2CA | Other interleukin signaling |
| REAC:R-HSA-5683057 | 0.0464733576116 | 1.0 | PPP2R1A PPP2CA | MAPK family signaling cascades |
| CORUM:6159 | 0.0499173803268 | 0.5 | PPP2CA | LPP-PPP2CA-PPP2R3A complex |
| CORUM:1132 | 0.0499173803268 | 0.5 | PPP2R1A | RFC2-RIalpha complex |
| CORUM:1131 | 0.0499173803268 | 0.5 | PPP2R1A | RFC2-RIalpha complex |
| CORUM:6111 | 0.0499173803268 | 0.5 | PPP2CA | protein phosphatase 2A C-subunit-synapsin complex |
| CORUM:6180 | 0.0499173803268 | 0.5 | PPP2R1A | PPP2R1A-PPP2R3B complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PPP2R1A | PPP2CA | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru boldt (PPP2R1A) hein (PPP2CA,PPP2R1A) gupta_WMM fraction boldt_WMM |
Images
Click to enlarge
Complex HuMAP2_05962 has an average edge precision of 0.949 which is ranked 5 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| PPP2R1A | HuMAP2_02007 HuMAP2_02325 HuMAP2_04458 HuMAP2_05962 |
| PPP2CA | HuMAP2_02007 HuMAP2_03694 HuMAP2_04458 HuMAP2_05962 |