hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05968
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| IDH1 | Isocitrate dehydrogenase [NADP] cytoplasmic (IDH) (EC 1.1.1.42) (Cytosolic NADP-isocitrate dehydrogenase) (IDP) (NADP(+)-specific ICDH) (Oxalosuccinate decarboxylase) | UniProt NCBI |
| MTHFD1L | Monofunctional C1-tetrahydrofolate synthase, mitochondrial (EC 6.3.4.3) (Formyltetrahydrofolate synthetase) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-196854 | 0.024074640537 | 1.0 | IDH1 MTHFD1L | Metabolism of vitamins and cofactors |
| REAC:R-HSA-2978092 | 0.0249595281251 | 0.5 | IDH1 | Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate |
| REAC:R-HSA-389542 | 0.0249595281251 | 0.5 | IDH1 | NADPH regeneration |
| CORUM:404 | 0.0249595281251 | 0.5 | IDH1 | Isocitrate dehydrogenase [NADP], cytoplasmic |
| KEGG:01210 | 0.0369186440558 | 0.5 | IDH1 | 2-Oxocarboxylic acid metabolism |
| KEGG:00670 | 0.0390890159223 | 0.5 | MTHFD1L | One carbon pool by folate |
| WP:WP3585 | 0.0499262710315 | 0.5 | IDH1 | Cytosine methylation |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| IDH1 | MTHFD1L | 0.955 | 0.862 | bioplex_WMM youn_WMM fraction |
Images
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Complex HuMAP2_05968 has an average edge precision of 0.862 which is ranked 710 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| IDH1 | HuMAP2_00182 HuMAP2_00843 HuMAP2_04319 HuMAP2_05071 HuMAP2_05968 HuMAP2_05984 |
| MTHFD1L | HuMAP2_00843 HuMAP2_05943 HuMAP2_05968 HuMAP2_05984 HuMAP2_06767 |