hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05974
Confidence: Extremely High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| NUP107 | Nuclear pore complex protein Nup107 (107 kDa nucleoporin) (Nucleoporin Nup107) | UniProt NCBI |
| NUP133 | Nuclear pore complex protein Nup133 (133 kDa nucleoporin) (Nucleoporin Nup133) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1347 | 1.00555407742e-05 | 1.0 | NUP133 NUP107 | NPC subcomplex (NUP98, NUP107, NUP133, NUP160) |
| CORUM:87 | 6.03332446455e-05 | 1.0 | NUP133 NUP107 | Nup 107-160 subcomplex |
| HP:0100720 | 0.000260475748797 | 1.0 | NUP133 NUP107 | Hypoplasia of the ear cartilage |
| HP:0000092 | 0.000400731921226 | 1.0 | NUP133 NUP107 | Tubular atrophy |
| HP:0002410 | 0.000454162844056 | 1.0 | NUP133 NUP107 | Aqueductal stenosis |
| REAC:R-HSA-168333 | 0.000633499068778 | 1.0 | NUP133 NUP107 | NEP/NS2 Interacts with the Cellular Export Machinery |
| REAC:R-HSA-170822 | 0.000633499068778 | 1.0 | NUP133 NUP107 | Regulation of Glucokinase by Glucokinase Regulatory Protein |
| REAC:R-HSA-168271 | 0.000633499068778 | 1.0 | NUP133 NUP107 | Transport of Ribonucleoproteins into the Host Nucleus |
| REAC:R-HSA-5619107 | 0.000633499068778 | 1.0 | NUP133 NUP107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) |
| REAC:R-HSA-168274 | 0.000633499068778 | 1.0 | NUP133 NUP107 | Export of Viral Ribonucleoproteins from Nucleus |
| REAC:R-HSA-159227 | 0.000729026706133 | 1.0 | NUP133 NUP107 | Transport of the SLBP independent Mature mRNA |
| REAC:R-HSA-180910 | 0.000729026706133 | 1.0 | NUP133 NUP107 | Vpr-mediated nuclear import of PICs |
| REAC:R-HSA-180746 | 0.000729026706133 | 1.0 | NUP133 NUP107 | Nuclear import of Rev protein |
| REAC:R-HSA-4085377 | 0.000779304410004 | 1.0 | NUP133 NUP107 | SUMOylation of SUMOylation proteins |
| REAC:R-HSA-165054 | 0.000779304410004 | 1.0 | NUP133 NUP107 | Rev-mediated nuclear export of HIV RNA |
| REAC:R-HSA-159230 | 0.000779304410004 | 1.0 | NUP133 NUP107 | Transport of the SLBP Dependant Mature mRNA |
| REAC:R-HSA-3301854 | 0.000831258037338 | 1.0 | NUP133 NUP107 | Nuclear Pore Complex (NPC) Disassembly |
| REAC:R-HSA-177243 | 0.000884887588134 | 1.0 | NUP133 NUP107 | Interactions of Rev with host cellular proteins |
| REAC:R-HSA-176033 | 0.000884887588134 | 1.0 | NUP133 NUP107 | Interactions of Vpr with host cellular proteins |
| REAC:R-HSA-3232142 | 0.000940193062392 | 1.0 | NUP133 NUP107 | SUMOylation of ubiquitinylation proteins |
| HP:0002036 | 0.00100182980306 | 1.0 | NUP133 NUP107 | Hiatus hernia |
| REAC:R-HSA-159231 | 0.00111616502594 | 1.0 | NUP133 NUP107 | Transport of Mature mRNA Derived from an Intronless Transcript |
| REAC:R-HSA-168276 | 0.00111616502594 | 1.0 | NUP133 NUP107 | NS1 Mediated Effects on Host Pathways |
| REAC:R-HSA-168253 | 0.00117817419405 | 1.0 | NUP133 NUP107 | Host Interactions with Influenza Factors |
| REAC:R-HSA-159234 | 0.00117817419405 | 1.0 | NUP133 NUP107 | Transport of Mature mRNAs Derived from Intronless Transcripts |
| REAC:R-HSA-168325 | 0.00130722030065 | 1.0 | NUP133 NUP107 | Viral Messenger RNA Synthesis |
| REAC:R-HSA-4570464 | 0.0014429701011 | 1.0 | NUP133 NUP107 | SUMOylation of RNA binding proteins |
| REAC:R-HSA-4615885 | 0.0014429701011 | 1.0 | NUP133 NUP107 | SUMOylation of DNA replication proteins |
| HP:0000097 | 0.00145265321444 | 1.0 | NUP133 NUP107 | Focal segmental glomerulosclerosis |
| REAC:R-HSA-2980766 | 0.00165916422775 | 1.0 | NUP133 NUP107 | Nuclear Envelope Breakdown |
| KEGG:03013 | 0.00169649664321 | 1.0 | NUP133 NUP107 | RNA transport |
| HP:0005108 | 0.00176322045339 | 1.0 | NUP133 NUP107 | Abnormality of the intervertebral disk |
| REAC:R-HSA-194441 | 0.00205300624141 | 1.0 | NUP133 NUP107 | Metabolism of non-coding RNA |
| REAC:R-HSA-191859 | 0.00205300624141 | 1.0 | NUP133 NUP107 | snRNP Assembly |
| REAC:R-HSA-6784531 | 0.00239824647466 | 1.0 | NUP133 NUP107 | tRNA processing in the nucleus |
| REAC:R-HSA-3371453 | 0.00348592080174 | 1.0 | NUP133 NUP107 | Regulation of HSF1-mediated heat shock response |
| REAC:R-HSA-4551638 | 0.00348592080174 | 1.0 | NUP133 NUP107 | SUMOylation of chromatin organization proteins |
| REAC:R-HSA-70171 | 0.00359485582679 | 1.0 | NUP133 NUP107 | Glycolysis |
| REAC:R-HSA-1169408 | 0.00370546677531 | 1.0 | NUP133 NUP107 | ISG15 antiviral mechanism |
| REAC:R-HSA-159236 | 0.00381775364729 | 1.0 | NUP133 NUP107 | Transport of Mature mRNA derived from an Intron-Containing Transcript |
| HP:0003073 | 0.00409080502918 | 1.0 | NUP133 NUP107 | Hypoalbuminemia |
| REAC:R-HSA-3108214 | 0.004164669804 | 1.0 | NUP133 NUP107 | SUMOylation of DNA damage response and repair proteins |
| HP:0000096 | 0.00425777666302 | 1.0 | NUP133 NUP107 | Glomerulosclerosis |
| HP:0012116 | 0.00425777666302 | 1.0 | NUP133 NUP107 | Abnormal albumin level |
| REAC:R-HSA-1169410 | 0.00452666927187 | 1.0 | NUP133 NUP107 | Antiviral mechanism by IFN-stimulated genes |
| REAC:R-HSA-72202 | 0.00490375205091 | 1.0 | NUP133 NUP107 | Transport of Mature Transcript to Cytoplasm |
| REAC:R-HSA-5619102 | 0.0052959181411 | 1.0 | NUP133 NUP107 | SLC transporter disorders |
| REAC:R-HSA-70326 | 0.00556574181855 | 1.0 | NUP133 NUP107 | Glucose metabolism |
| REAC:R-HSA-3371556 | 0.00598304676068 | 1.0 | NUP133 NUP107 | Cellular response to heat stress |
| HP:0003774 | 0.00694601996791 | 1.0 | NUP133 NUP107 | Stage 5 chronic kidney disease |
| REAC:R-HSA-141444 | 0.0070154156135 | 1.0 | NUP133 NUP107 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal |
| REAC:R-HSA-141424 | 0.0070154156135 | 1.0 | NUP133 NUP107 | Amplification of signal from the kinetochores |
| HP:0001181 | 0.00716308309191 | 1.0 | NUP133 NUP107 | Adducted thumb |
| HP:0000091 | 0.00829849020205 | 1.0 | NUP133 NUP107 | Abnormal renal tubule morphology |
| REAC:R-HSA-72306 | 0.00863268175469 | 1.0 | NUP133 NUP107 | tRNA processing |
| REAC:R-HSA-5578749 | 0.00863268175469 | 1.0 | NUP133 NUP107 | Transcriptional regulation by small RNAs |
| REAC:R-HSA-69618 | 0.00950416195513 | 1.0 | NUP133 NUP107 | Mitotic Spindle Checkpoint |
| HP:0000341 | 0.00977118001255 | 1.0 | NUP133 NUP107 | Narrow forehead |
| HP:0000601 | 0.00977118001255 | 1.0 | NUP133 NUP107 | Hypotelorism |
| HP:0012622 | 0.0105526072589 | 1.0 | NUP133 NUP107 | Chronic kidney disease |
| REAC:R-HSA-2500257 | 0.0119660935214 | 1.0 | NUP133 NUP107 | Resolution of Sister Chromatid Cohesion |
| REAC:R-HSA-162909 | 0.0123699910758 | 1.0 | NUP133 NUP107 | Host Interactions of HIV factors |
| HP:0000112 | 0.0124928176442 | 1.0 | NUP133 NUP107 | Nephropathy |
| REAC:R-HSA-168273 | 0.014052618232 | 1.0 | NUP133 NUP107 | Influenza Viral RNA Transcription and Replication |
| REAC:R-HSA-68875 | 0.0144900342557 | 1.0 | NUP133 NUP107 | Mitotic Prophase |
| REAC:R-HSA-211000 | 0.0144900342557 | 1.0 | NUP133 NUP107 | Gene Silencing by RNA |
| REAC:R-HSA-5663220 | 0.0147112561527 | 1.0 | NUP133 NUP107 | RHO GTPases Activate Formins |
| REAC:R-HSA-162599 | 0.0147112561527 | 1.0 | NUP133 NUP107 | Late Phase of HIV Life Cycle |
| REAC:R-HSA-168255 | 0.0158425044898 | 1.0 | NUP133 NUP107 | Influenza Life Cycle |
| REAC:R-HSA-162587 | 0.0177396498492 | 1.0 | NUP133 NUP107 | HIV Life Cycle |
| REAC:R-HSA-168254 | 0.0182306954237 | 1.0 | NUP133 NUP107 | Influenza Infection |
| HP:0001622 | 0.019295242007 | 1.0 | NUP133 NUP107 | Premature birth |
| HP:0000100 | 0.019295242007 | 1.0 | NUP133 NUP107 | Nephrotic syndrome |
| REAC:R-HSA-5619115 | 0.0202619146601 | 1.0 | NUP133 NUP107 | Disorders of transmembrane transporters |
| GO:0031080 | 0.020287053512 | 1.0 | NUP133 NUP107 | nuclear pore outer ring |
| HP:0001302 | 0.0203872364924 | 1.0 | NUP133 NUP107 | Pachygyria |
| REAC:R-HSA-3108232 | 0.0229517718172 | 1.0 | NUP133 NUP107 | SUMO E3 ligases SUMOylate target proteins |
| REAC:R-HSA-2990846 | 0.0246461304377 | 1.0 | NUP133 NUP107 | SUMOylation |
| REAC:R-HSA-913531 | 0.0252243240322 | 1.0 | NUP133 NUP107 | Interferon Signaling |
| HP:0031263 | 0.0258806032458 | 1.0 | NUP133 NUP107 | Abnormal renal corpuscle morphology |
| HP:0000095 | 0.0258806032458 | 1.0 | NUP133 NUP107 | Abnormality of renal glomerulus morphology |
| HP:0001339 | 0.0275703561803 | 1.0 | NUP133 NUP107 | Lissencephaly |
| REAC:R-HSA-2467813 | 0.0279091534189 | 1.0 | NUP133 NUP107 | Separation of Sister Chromatids |
| REAC:R-HSA-68882 | 0.0304096312248 | 1.0 | NUP133 NUP107 | Mitotic Anaphase |
| REAC:R-HSA-68877 | 0.0304096312248 | 1.0 | NUP133 NUP107 | Mitotic Prometaphase |
| HP:0000093 | 0.0306559919738 | 1.0 | NUP133 NUP107 | Proteinuria |
| REAC:R-HSA-2555396 | 0.0307297326061 | 1.0 | NUP133 NUP107 | Mitotic Metaphase and Anaphase |
| HP:0020129 | 0.0343827988412 | 1.0 | NUP133 NUP107 | Abnormal urine protein level |
| GO:0006999 | 0.0351642260875 | 1.0 | NUP133 NUP107 | nuclear pore organization |
| HP:0011035 | 0.0358354520556 | 1.0 | NUP133 NUP107 | Abnormal renal cortex morphology |
| HP:0100490 | 0.0408946925611 | 1.0 | NUP133 NUP107 | Camptodactyly of finger |
| REAC:R-HSA-162906 | 0.0414841334642 | 1.0 | NUP133 NUP107 | HIV Infection |
| HP:0001220 | 0.0419466138543 | 1.0 | NUP133 NUP107 | Interphalangeal joint contracture of finger |
| HP:0000400 | 0.0440905296328 | 1.0 | NUP133 NUP107 | Macrotia |
| HP:0006261 | 0.0457335305099 | 1.0 | NUP133 NUP107 | Abnormal phalangeal joint morphology of the hand |
| REAC:R-HSA-72203 | 0.046079515598 | 1.0 | NUP133 NUP107 | Processing of Capped Intron-Containing Pre-mRNA |
| HP:0012575 | 0.047406586281 | 1.0 | NUP133 NUP107 | Abnormal nephron morphology |
| HP:0004374 | 0.0485386539584 | 1.0 | NUP133 NUP107 | Hemiplegia/hemiparesis |
| HP:0012785 | 0.0491096969462 | 1.0 | NUP133 NUP107 | Flexion contracture of finger |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| NUP107 | NUP133 | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru boldt youn_WMM hein (NUP107) Malo gupta_WMM fraction boldt_WMM treiber_WMM |
Images
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Complex HuMAP2_05974 has an average edge precision of 0.949 which is ranked 5 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| NUP107 | HuMAP2_00541 HuMAP2_01007 HuMAP2_03792 HuMAP2_05315 HuMAP2_05974 |
| NUP133 | HuMAP2_00541 HuMAP2_05560 HuMAP2_05974 |