hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_05984

Confidence: Medium High

Genename	Protein Name	Links
NAXE	NAD(P)H-hydrate epimerase (EC 5.1.99.6) (Apolipoprotein A-I-binding protein) (AI-BP) (NAD(P)HX epimerase) (YjeF N-terminal domain-containing protein 1) (YjeF_N1)	UniProt NCBI
UBQLN4	Ubiquilin-4 (Ataxin-1 interacting ubiquitin-like protein) (A1Up) (Ataxin-1 ubiquitin-like-interacting protein A1U) (Connexin43-interacting protein of 75 kDa) (CIP75)	UniProt NCBI
MTHFD1	C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) [Cleaved into: C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed] [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate synthetase (EC 6.3.4.3)]	UniProt NCBI
FARS2	Phenylalanine--tRNA ligase, mitochondrial (EC 6.1.1.20) (Phenylalanyl-tRNA synthetase) (PheRS)	UniProt NCBI
UBQLN1	Ubiquilin-1 (Protein linking IAP with cytoskeleton 1) (PLIC-1) (hPLIC-1)	UniProt NCBI
COQ3	Ubiquinone biosynthesis O-methyltransferase, mitochondrial (3-demethylubiquinol 3-O-methyltransferase) (EC 2.1.1.64) (Polyprenyldihydroxybenzoate methyltransferase) (EC 2.1.1.114)	UniProt NCBI
TRAP1	Heat shock protein 75 kDa, mitochondrial (HSP 75) (TNFR-associated protein 1) (Tumor necrosis factor type 1 receptor-associated protein) (TRAP-1)	UniProt NCBI
ACSF3	Acyl-CoA synthetase family member 3, mitochondrial (EC 6.2.1.-)	UniProt NCBI
ACOX1	Peroxisomal acyl-coenzyme A oxidase 1 (AOX) (EC 1.3.3.6) (Palmitoyl-CoA oxidase) (Straight-chain acyl-CoA oxidase) (SCOX) [Cleaved into: Peroxisomal acyl-CoA oxidase 1, A chain; Peroxisomal acyl-CoA oxidase 1, B chain; Peroxisomal acyl-CoA oxidase 1, C chain]	UniProt NCBI
TXNDC17	Thioredoxin domain-containing protein 17 (14 kDa thioredoxin-related protein) (TRP14) (Protein 42-9-9) (Thioredoxin-like protein 5)	UniProt NCBI
FKBP2	Peptidyl-prolyl cis-trans isomerase FKBP2 (PPIase FKBP2) (EC 5.2.1.8) (13 kDa FK506-binding protein) (13 kDa FKBP) (FKBP-13) (FK506-binding protein 2) (FKBP-2) (Immunophilin FKBP13) (Rotamase)	UniProt NCBI
IDH1	Isocitrate dehydrogenase [NADP] cytoplasmic (IDH) (EC 1.1.1.42) (Cytosolic NADP-isocitrate dehydrogenase) (IDP) (NADP(+)-specific ICDH) (Oxalosuccinate decarboxylase)	UniProt NCBI
MTHFD1L	Monofunctional C1-tetrahydrofolate synthase, mitochondrial (EC 6.3.4.3) (Formyltetrahydrofolate synthetase)	UniProt NCBI
NPEPL1	Probable aminopeptidase NPEPL1 (EC 3.4.11.-) (Aminopeptidase-like 1)	UniProt NCBI
LGALS1	Galectin-1 (Gal-1) (14 kDa laminin-binding protein) (HLBP14) (14 kDa lectin) (Beta-galactoside-binding lectin L-14-I) (Galaptin) (HBL) (HPL) (Lactose-binding lectin 1) (Lectin galactoside-binding soluble 1) (Putative MAPK-activating protein PM12) (S-Lac lectin 1)	UniProt NCBI
DHFR	Dihydrofolate reductase (EC 1.5.1.3)	UniProt NCBI
IDH2	Isocitrate dehydrogenase [NADP], mitochondrial (IDH) (EC 1.1.1.42) (ICD-M) (IDP) (NADP(+)-specific ICDH) (Oxalosuccinate decarboxylase)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-196854	6.56230022222e-06	0.352941176471	MTHFD1L MTHFD1 NAXE DHFR IDH1 COQ3	Metabolism of vitamins and cofactors
GO:0043648	7.24894924164e-06	0.352941176471	MTHFD1L IDH1 DHFR MTHFD1 ACSF3 IDH2	dicarboxylic acid metabolic process
KEGG:00670	5.54649675944e-05	0.176470588235	MTHFD1L MTHFD1 DHFR	One carbon pool by folate
GO:0009108	0.00011304742374	0.352941176471	MTHFD1L COQ3 NAXE DHFR MTHFD1 ACSF3	coenzyme biosynthetic process
GO:0051186	0.000113210355912	0.470588235294	MTHFD1L COQ3 NAXE IDH1 MTHFD1 ACSF3 DHFR IDH2	cofactor metabolic process
REAC:R-HSA-196757	0.000161990797449	0.176470588235	MTHFD1L MTHFD1 DHFR	Metabolism of folate and pterines
REAC:R-HSA-8978934	0.000241754813558	0.176470588235	COQ3 IDH1 DHFR	Metabolism of cofactors
GO:0046654	0.000246852342475	0.176470588235	MTHFD1L MTHFD1 DHFR	tetrahydrofolate biosynthetic process
WP:WP241	0.000305342611667	0.176470588235	MTHFD1L MTHFD1 DHFR	One Carbon Metabolism
WP:WP2525	0.000377882496523	0.176470588235	MTHFD1L MTHFD1 DHFR	Trans-sulfuration and one carbon metabolism
GO:0009396	0.00123252169378	0.176470588235	MTHFD1L MTHFD1 DHFR	folic acid-containing compound biosynthetic process
GO:0051188	0.00153632202599	0.352941176471	MTHFD1L COQ3 NAXE DHFR MTHFD1 ACSF3	cofactor biosynthetic process
REAC:R-HSA-196849	0.00180952698945	0.235294117647	NAXE DHFR MTHFD1 MTHFD1L	Metabolism of water-soluble vitamins and cofactors
KEGG:01100	0.00198734727599	0.470588235294	MTHFD1L ACSF3 MTHFD1 IDH1 COQ3 DHFR ACOX1 IDH2	Metabolic pathways
GO:0006732	0.00280314952478	0.352941176471	MTHFD1L COQ3 NAXE DHFR MTHFD1 ACSF3	coenzyme metabolic process
WP:WP3585	0.00337462093652	0.117647058824	IDH2 IDH1	Cytosine methylation
KEGG:04146	0.00440886796951	0.176470588235	IDH2 ACOX1 IDH1	Peroxisome
WP:WP4259	0.00514875086926	0.117647058824	MTHFD1 DHFR	Disorders of Folate Metabolism and Transport
GO:0005739	0.00519089167211	0.588235294118	FARS2 COQ3 NAXE MTHFD1 IDH1 TRAP1 ACSF3 DHFR IDH2 MTHFD1L	mitochondrion
GO:0042559	0.00737429365883	0.176470588235	MTHFD1L MTHFD1 DHFR	pteridine-containing compound biosynthetic process
GO:0005759	0.00857693550321	0.411764705882	FARS2 COQ3 MTHFD1L NAXE TRAP1 ACSF3 IDH2	mitochondrial matrix
KEGG:01210	0.00918226262983	0.117647058824	IDH2 IDH1	2-Oxocarboxylic acid metabolism
GO:0046653	0.0135004782501	0.176470588235	MTHFD1L MTHFD1 DHFR	tetrahydrofolate metabolic process
KEGG:01200	0.0152742106837	0.176470588235	IDH2 ACOX1 IDH1	Carbon metabolism
HP:0006765	0.0166765837362	0.117647058824	IDH2 IDH1	Chondrosarcoma
REAC:R-HSA-1430728	0.0214578363867	0.529411764706	MTHFD1L COQ3 NAXE MTHFD1 IDH1 TRAP1 ACSF3 DHFR IDH2	Metabolism
KEGG:00020	0.0271918365817	0.117647058824	IDH2 IDH1	Citrate cycle (TCA cycle)
HP:0005701	0.0310878361697	0.117647058824	IDH2 IDH1	Multiple enchondromatosis
HP:0100764	0.0399432405396	0.117647058824	IDH2 IDH1	Lymphangioma
GO:0046655	0.041581827932	0.176470588235	MTHFD1L MTHFD1 DHFR	folic acid metabolic process
GO:0044281	0.0440457501726	0.588235294118	FARS2 COQ3 NAXE MTHFD1 IDH1 ACSF3 DHFR ACOX1 IDH2 MTHFD1L	small molecule metabolic process
CORUM:404	0.049626053094	0.0588235294118	IDH1	Isocitrate dehydrogenase [NADP], cytoplasmic
CORUM:6948	0.049626053094	0.0588235294118	IDH2	Isocitrate dehydrogenase [NADP], mitochondrial

Edges

Protein 1	Protein 2	Score	Precision	Evidence
IDH2	FKBP2	0.999	0.949	bioplex_WMM fraction
MTHFD1L	IDH2	0.991	0.911	bioplex_WMM youn_WMM fraction treiber_WMM
MTHFD1	IDH2	0.991	0.91	bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM
IDH1	MTHFD1L	0.955	0.862	bioplex_WMM youn_WMM fraction
TXNDC17	IDH2	0.937	0.85	bioplex_WMM fraction
MTHFD1L	FKBP2	0.857	0.794	bioplex_WMM fraction
IDH1	IDH2	0.733	0.738	bioplex_WMM youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM
IDH1	TXNDC17	0.682	0.71	bioplex_WMM fraction
MTHFD1	FKBP2	0.634	0.684	bioplex_WMM gupta_WMM fraction boldt_WMM
IDH1	NAXE	0.538	0.642	bioplex_WMM fraction
ACSF3	IDH2	0.5	0.621	bioplex_WMM youn_WMM fraction
IDH1	UBQLN4	0.439	0.584	bioplex_WMM fraction
LGALS1	FKBP2	0.337	0.526	fraction
TXNDC17	MTHFD1L	0.309	0.502	bioplex_WMM fraction
NPEPL1	IDH2	0.302	0.497	fraction
IDH1	FKBP2	0.297	0.497	bioplex_WMM Guru fraction
NPEPL1	MTHFD1L	0.267	0.483	fraction
LGALS1	MTHFD1L	0.214	0.464	fraction
NAXE	MTHFD1L	0.176	0.435	bioplex_WMM fraction
ACOX1	IDH2	0.174	0.434	bioplex_WMM fraction
UBQLN1	IDH2	0.171	0.429	bioplex_WMM fraction
TRAP1	ACSF3	0.162	0.42	bioplex (ACSF3) bioplex_WMM fraction
UBQLN4	MTHFD1L	0.147	0.409	bioplex_WMM fraction
TRAP1	MTHFD1L	0.136	0.406	bioplex_WMM fraction treiber_WMM
NPEPL1	NAXE	0.134	0.405	fraction
TXNDC17	FARS2	0.132	0.405	fraction
LGALS1	ACOX1	0.129	0.399	bioplex_WMM fraction
UBQLN4	ACSF3	0.126	0.4	fraction
UBQLN1	FARS2	0.107	0.373	bioplex_WMM fraction
ACOX1	MTHFD1L	0.107	0.373	bioplex_WMM fraction
FARS2	IDH2	0.102	0.365	fraction
UBQLN1	UBQLN4	0.101	0.364	bioplex_WMM fraction
LGALS1	IDH2	0.1	0.361	bioplex_WMM fraction treiber_WMM
MTHFD1	COQ3	0.099	0.358	fraction
UBQLN1	ACSF3	0.097	0.358	fraction
ACOX1	TXNDC17	0.094	0.356	bioplex_WMM fraction
TRAP1	MTHFD1	0.088	0.354	bioplex_WMM boldt fraction boldt_WMM treiber_WMM
FARS2	FKBP2	0.088	0.352	fraction
UBQLN4	IDH2	0.083	0.35	bioplex_WMM fraction
LGALS1	COQ3	0.071	0.353	fraction
FARS2	MTHFD1L	0.068	0.347	bioplex_WMM fraction
NPEPL1	MTHFD1	0.064	0.349	fraction
UBQLN1	MTHFD1L	0.062	0.341	bioplex_WMM fraction
IDH1	LGALS1	0.061	0.335	bioplex_WMM fraction
MTHFD1L	COQ3	0.06	0.336	fraction
ACOX1	MTHFD1	0.056	0.313	bioplex_WMM fraction
DHFR	UBQLN4	0.052	0.301	bioplex_WMM fraction
NAXE	UBQLN4	0.05	0.298	bioplex_WMM fraction
IDH1	UBQLN1	0.049	0.294	bioplex_WMM fraction
ACSF3	TXNDC17	0.047	0.293	fraction
TRAP1	IDH2	0.045	0.279	bioplex_WMM boldt fraction boldt_WMM treiber_WMM
UBQLN1	DHFR	0.043	0.269	bioplex_WMM fraction
ACOX1	FARS2	0.043	0.269	bioplex_WMM fraction
LGALS1	TXNDC17	0.041	0.271	bioplex_WMM fraction
NAXE	TRAP1	0.041	0.267	bioplex_WMM fraction
UBQLN4	ACOX1	0.04	0.267	bioplex_WMM fraction
TRAP1	COQ3	0.038	0.266	fraction
UBQLN1	NAXE	0.037	0.267	bioplex_WMM fraction
UBQLN1	ACOX1	0.035	0.264	bioplex_WMM fraction
TXNDC17	FKBP2	0.033	0.247	bioplex_WMM fraction
NPEPL1	COQ3	0.032	0.242	fraction
TRAP1	FKBP2	0.032	0.242	bioplex_WMM fraction boldt_WMM
IDH1	MTHFD1	0.031	0.239	bioplex_WMM youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM
LGALS1	MTHFD1	0.03	0.232	bioplex_WMM fraction
LGALS1	FARS2	0.027	0.224	fraction
NAXE	ACOX1	0.025	0.218	bioplex_WMM fraction
TRAP1	ACOX1	0.02	0.186	bioplex_WMM fraction
NAXE	ACSF3	0.02	0.184	fraction
NAXE	MTHFD1	0.017	0.168	bioplex_WMM fraction
ACSF3	ACOX1	0.013	0.155	fraction
ACSF3	FKBP2	0.013	0.147	fraction
UBQLN1	FKBP2	0.011	0.144	bioplex_WMM fraction
DHFR	MTHFD1L	0.01	0.135	bioplex_WMM youn_WMM fraction
TRAP1	UBQLN4	0.01	0.102	bioplex_WMM fraction
NAXE	TXNDC17	0.008	0.04	bioplex_WMM fraction
IDH1	ACOX1	0.007	0.001	bioplex_WMM WMM_only
MTHFD1	FARS2	0.007	0.002	bioplex_WMM WMM_only
TRAP1	FARS2	0.007	0.002	bioplex_WMM WMM_only
ACSF3	MTHFD1	0.007	0.001	bioplex_WMM youn_WMM WMM_only
DHFR	ACSF3	0.007	0.003	youn_WMM WMM_only
DHFR	ACOX1	0.007	0.003	bioplex_WMM WMM_only
TRAP1	TXNDC17	0.006	0.007	bioplex_WMM fraction
DHFR	IDH2	0.006	0.005	bioplex_WMM youn_WMM gupta_WMM WMM_only
TXNDC17	COQ3	0.006	0.003	bioplex (COQ3)
UBQLN1	TRAP1	0.006	0.011	bioplex_WMM fraction
TXNDC17	MTHFD1	0.006	0.01	bioplex_WMM fraction
DHFR	TRAP1	0.005	0.013	bioplex_WMM fraction
ACSF3	MTHFD1L	0.005	0.013	bioplex (ACSF3) bioplex_WMM youn_WMM
UBQLN4	MTHFD1	0.005	0.009	bioplex_WMM fraction
DHFR	TXNDC17	0.005	0.012	bioplex_WMM fraction
LGALS1	UBQLN4	0.004	0.01	bioplex_WMM fraction
IDH1	TRAP1	0.003	0.013	bioplex_WMM Guru fraction boldt_WMM treiber_WMM
ACOX1	FKBP2	0.003	0.013	fraction
NAXE	IDH2	0.003	0.012	bioplex_WMM fraction
NAXE	FKBP2	0.0	0.017	bioplex_WMM fraction
MTHFD1	MTHFD1L	0.0	0.012	bioplex_WMM youn_WMM fraction treiber_WMM
UBQLN4	FKBP2	0.0	0.007	bioplex_WMM fraction
NPEPL1	UBQLN1	0.0	0.01	fraction
UBQLN4	TXNDC17	0.0	0.004	bioplex_WMM fraction
LGALS1	TRAP1	0.0	0.009	bioplex_WMM fraction treiber_WMM
DHFR	FKBP2	0.0	0.009	bioplex_WMM gupta_WMM fraction
DHFR	MTHFD1	0.0	0.001	bioplex_WMM youn_WMM gupta_WMM fraction
UBQLN1	LGALS1	0.0	0.003	bioplex_WMM fraction
NPEPL1	DHFR	0.0	0.003	fraction
DHFR	NAXE	0.0	0.001	bioplex_WMM fraction
LGALS1	NAXE	0.0	0.003	bioplex_WMM fraction treiber_WMM
IDH1	DHFR	0.0	0.001	bioplex_WMM youn_WMM gupta_WMM fraction
UBQLN1	MTHFD1	0.0	0.002	bioplex_WMM fraction
UBQLN1	TXNDC17	0.0	0.001	bioplex_WMM fraction

Images

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Complex HuMAP2_05984 has an average edge precision of 0.27 which is ranked 5022 out of all 6965 complexes.

Related Complexes

Genename	Complexes
NAXE	HuMAP2_00843 HuMAP2_02671 HuMAP2_05071 HuMAP2_05984 HuMAP2_06785
UBQLN4	HuMAP2_00843 HuMAP2_05594 HuMAP2_05984
MTHFD1	HuMAP2_00843 HuMAP2_02118 HuMAP2_02671 HuMAP2_03723 HuMAP2_04603 HuMAP2_04763 HuMAP2_05984 HuMAP2_06767
FARS2	HuMAP2_00843 HuMAP2_05984
UBQLN1	HuMAP2_00203 HuMAP2_05594 HuMAP2_05984 HuMAP2_06180 HuMAP2_06957
COQ3	HuMAP2_02118 HuMAP2_05395 HuMAP2_05984
TRAP1	HuMAP2_00843 HuMAP2_01944 HuMAP2_02765 HuMAP2_03554 HuMAP2_03790 HuMAP2_05642 HuMAP2_05984
ACSF3	HuMAP2_00843 HuMAP2_01944 HuMAP2_04319 HuMAP2_05594 HuMAP2_05984
ACOX1	HuMAP2_00843 HuMAP2_05984 HuMAP2_06911
TXNDC17	HuMAP2_00843 HuMAP2_02703 HuMAP2_03127 HuMAP2_03244 HuMAP2_04319 HuMAP2_04573 HuMAP2_05984
FKBP2	HuMAP2_01636 HuMAP2_03277 HuMAP2_05984 HuMAP2_06767 HuMAP2_06776
IDH1	HuMAP2_00182 HuMAP2_00843 HuMAP2_04319 HuMAP2_05071 HuMAP2_05968 HuMAP2_05984
MTHFD1L	HuMAP2_00843 HuMAP2_05943 HuMAP2_05968 HuMAP2_05984 HuMAP2_06767
NPEPL1	HuMAP2_00048 HuMAP2_00843 HuMAP2_02671 HuMAP2_03021 HuMAP2_05984 HuMAP2_06579
LGALS1	HuMAP2_00367 HuMAP2_04447 HuMAP2_04851 HuMAP2_05369 HuMAP2_05984
DHFR	HuMAP2_00203 HuMAP2_02674 HuMAP2_04839 HuMAP2_05594 HuMAP2_05984
IDH2	HuMAP2_00843 HuMAP2_03723 HuMAP2_04319 HuMAP2_04573 HuMAP2_05984 HuMAP2_06767

hu.MAP 2.0: Complex View

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Complex: HuMAP2_05984