hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_05993

Confidence: Medium

Genename	Protein Name	Links
BHLHE40	Class E basic helix-loop-helix protein 40 (bHLHe40) (Class B basic helix-loop-helix protein 2) (bHLHb2) (Differentially expressed in chondrocytes protein 1) (DEC1) (Enhancer-of-split and hairy-related protein 2) (SHARP-2) (Stimulated by retinoic acid gene 13 protein)	UniProt NCBI
FBXW11	F-box/WD repeat-containing protein 11 (F-box and WD repeats protein beta-TrCP2) (F-box/WD repeat-containing protein 1B) (Homologous to Slimb protein) (HOS)	UniProt NCBI
BTRC	F-box/WD repeat-containing protein 1A (E3RSIkappaB) (Epididymis tissue protein Li 2a) (F-box and WD repeats protein beta-TrCP) (pIkappaBalpha-E3 receptor subunit)	UniProt NCBI
EGFLAM	Pikachurin (Agrin-like protein) (EGF-like, fibronectin type-III and laminin G-like domain-containing protein)	UniProt NCBI
CDC34	Ubiquitin-conjugating enzyme E2 R1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme R1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme R1) (Ubiquitin-conjugating enzyme E2-32 kDa complementing) (Ubiquitin-conjugating enzyme E2-CDC34) (Ubiquitin-protein ligase R1)	UniProt NCBI
ADAMTS4	A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAM-TS 4) (ADAM-TS4) (ADAMTS-4) (EC 3.4.24.82) (ADMP-1) (Aggrecanase-1)	UniProt NCBI
ANGPTL7	Angiopoietin-related protein 7 (Angiopoietin-like factor) (Angiopoietin-like protein 7) (Cornea-derived transcript 6 protein)	UniProt NCBI
CDC25B	M-phase inducer phosphatase 2 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25B)	UniProt NCBI
USP37	Ubiquitin carboxyl-terminal hydrolase 37 (EC 3.4.19.12) (Deubiquitinating enzyme 37) (Ubiquitin thioesterase 37) (Ubiquitin-specific-processing protease 37)	UniProt NCBI
MLPH	Melanophilin (Exophilin-3) (Slp homolog lacking C2 domains a) (SlaC2-a) (Synaptotagmin-like protein 2a)	UniProt NCBI
TFAP4	Transcription factor AP-4 (Activating enhancer-binding protein 4) (Class C basic helix-loop-helix protein 41) (bHLHc41)	UniProt NCBI
HIVEP1	Zinc finger protein 40 (Cirhin interaction protein) (CIRIP) (Gate keeper of apoptosis-activating protein) (GAAP) (Human immunodeficiency virus type I enhancer-binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1)	UniProt NCBI
MYO10	Unconventional myosin-X (Unconventional myosin-10)	UniProt NCBI
TRPV6	Transient receptor potential cation channel subfamily V member 6 (TrpV6) (CaT-like) (CaT-L) (Calcium transport protein 1) (CaT1) (Epithelial calcium channel 2) (ECaC2)	UniProt NCBI
CDC25A	M-phase inducer phosphatase 1 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25A)	UniProt NCBI
RASSF3	Ras association domain-containing protein 3	UniProt NCBI
HIVEP2	Transcription factor HIVEP2 (Human immunodeficiency virus type I enhancer-binding protein 2) (HIV-EP2) (MHC-binding protein 2) (MBP-2)	UniProt NCBI
ZNF704	Zinc finger protein 704	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
KEGG:04710	0.000296010182672	0.166666666667	BHLHE40 BTRC FBXW11	Circadian rhythm
REAC:R-HSA-69275	0.0195019901146	0.222222222222	CDC25B FBXW11 BTRC CDC25A	G2/M Transition
REAC:R-HSA-453274	0.0203122287756	0.222222222222	CDC25B FBXW11 BTRC CDC25A	Mitotic G2-G2/M phases
KEGG:04120	0.0268517236697	0.166666666667	FBXW11 CDC34 BTRC	Ubiquitin mediated proteolysis
REAC:R-HSA-2871837	0.0281720773712	0.166666666667	FBXW11 CDC34 BTRC	FCERI mediated NF-kB activation
GO:0044772	0.0345679596564	0.388888888889	USP37 TFAP4 CDC25A CDC34 FBXW11 CDC25B BTRC	mitotic cell cycle phase transition
KEGG:04218	0.0369292734676	0.166666666667	CDC25A BTRC FBXW11	Cellular senescence
REAC:R-HSA-202424	0.0450646857835	0.166666666667	FBXW11 CDC34 BTRC	Downstream TCR signaling
REAC:R-HSA-5684264	0.0468258473561	0.111111111111	BTRC FBXW11	MAP3K8 (TPL2)-dependent MAPK1/3 activation
REAC:R-HSA-5607764	0.0497200130182	0.166666666667	FBXW11 CDC34 BTRC	CLEC7A (Dectin-1) signaling

Edges

Protein 1	Protein 2	Score	Precision	Evidence
FBXW11	BTRC	0.987	0.902	hein_WMM bioplex (BTRC,FBXW11) bioplex_WMM youn_WMM gupta_WMM
HIVEP1	BTRC	0.966	0.876	bioplex (BTRC) bioplex_WMM
HIVEP2	BTRC	0.873	0.805	bioplex (BTRC) bioplex_WMM
BTRC	MLPH	0.744	0.74	bioplex (BTRC) bioplex_WMM
CDC25B	BTRC	0.517	0.631	hein_WMM bioplex (BTRC,CDC25B) bioplex_WMM hein (CDC25B)
BTRC	CDC34	0.312	0.505	bioplex (BTRC) bioplex_WMM
BTRC	EGFLAM	0.303	0.497	bioplex (BTRC) bioplex_WMM
RASSF3	BTRC	0.301	0.496	bioplex (BTRC) bioplex_WMM
USP37	BTRC	0.275	0.487	bioplex (BTRC) bioplex_WMM
BTRC	BHLHE40	0.209	0.456	bioplex (BTRC) bioplex_WMM
BTRC	CDC25A	0.134	0.406	bioplex (BTRC,CDC25A) bioplex_WMM
CDC25B	FBXW11	0.091	0.354	hein_WMM bioplex (CDC25B) bioplex_WMM hein (CDC25B)
TFAP4	FBXW11	0.078	0.352	hein_WMM bioplex (TFAP4) bioplex_WMM hein (FBXW11)
MYO10	BTRC	0.034	0.262	bioplex (BTRC) bioplex_WMM
TFAP4	ADAMTS4	0.033	0.254	bioplex (TFAP4) bioplex_WMM
FBXW11	HIVEP2	0.03	0.239	bioplex (FBXW11) bioplex_WMM
BTRC	TRPV6	0.03	0.23	bioplex (BTRC) bioplex_WMM
TFAP4	BTRC	0.027	0.231	bioplex (BTRC,TFAP4) bioplex_WMM
TFAP4	ANGPTL7	0.026	0.221	bioplex (TFAP4) bioplex_WMM
FBXW11	HIVEP1	0.026	0.22	bioplex (FBXW11) bioplex_WMM youn_WMM
BTRC	ZNF704	0.022	0.205	bioplex (ZNF704) bioplex_WMM
FBXW11	ZNF704	0.017	0.171	bioplex (ZNF704) bioplex_WMM
FBXW11	USP37	0.016	0.162	bioplex (FBXW11) bioplex_WMM
FBXW11	CDC25A	0.013	0.143	bioplex (CDC25A) bioplex_WMM
HIVEP1	HIVEP2	0.011	0.141	bioplex_WMM WMM_only
USP37	HIVEP1	0.01	0.128	bioplex_WMM WMM_only
USP37	HIVEP2	0.01	0.128	bioplex_WMM WMM_only
MLPH	BHLHE40	0.009	0.095	bioplex_WMM WMM_only
BHLHE40	TRPV6	0.009	0.095	bioplex_WMM WMM_only
MLPH	TRPV6	0.009	0.095	bioplex_WMM WMM_only
CDC34	BHLHE40	0.008	0.091	bioplex_WMM WMM_only
RASSF3	MLPH	0.008	0.091	bioplex_WMM WMM_only
CDC25A	BHLHE40	0.008	0.091	bioplex_WMM WMM_only
CDC25B	MLPH	0.008	0.091	bioplex_WMM WMM_only
CDC25B	BHLHE40	0.008	0.091	bioplex_WMM WMM_only
RASSF3	TRPV6	0.008	0.091	bioplex_WMM WMM_only
HIVEP2	MLPH	0.008	0.091	bioplex_WMM WMM_only
HIVEP1	TRPV6	0.008	0.091	bioplex_WMM WMM_only
CDC25B	TRPV6	0.008	0.091	bioplex_WMM WMM_only
CDC25A	TRPV6	0.008	0.091	bioplex_WMM WMM_only
MLPH	EGFLAM	0.008	0.091	bioplex_WMM WMM_only
HIVEP1	BHLHE40	0.008	0.091	bioplex_WMM WMM_only
MYO10	BHLHE40	0.008	0.091	bioplex_WMM WMM_only
MLPH	CDC25A	0.008	0.091	bioplex_WMM WMM_only
HIVEP2	TRPV6	0.008	0.091	bioplex_WMM WMM_only
MLPH	CDC34	0.008	0.091	bioplex_WMM WMM_only
RASSF3	BHLHE40	0.008	0.091	bioplex_WMM WMM_only
EGFLAM	TRPV6	0.008	0.091	bioplex_WMM WMM_only
HIVEP1	MLPH	0.008	0.091	bioplex_WMM WMM_only
EGFLAM	BHLHE40	0.008	0.091	bioplex_WMM WMM_only
CDC34	TRPV6	0.008	0.091	bioplex_WMM WMM_only
MYO10	TRPV6	0.008	0.091	bioplex_WMM WMM_only
MYO10	MLPH	0.008	0.091	bioplex_WMM WMM_only
HIVEP2	BHLHE40	0.008	0.091	bioplex_WMM WMM_only
TFAP4	MLPH	0.008	0.087	bioplex_WMM WMM_only
USP37	BHLHE40	0.008	0.087	bioplex_WMM WMM_only
USP37	MLPH	0.008	0.087	bioplex_WMM WMM_only
TFAP4	BHLHE40	0.008	0.087	bioplex_WMM WMM_only
USP37	TRPV6	0.008	0.087	bioplex_WMM WMM_only
TFAP4	TRPV6	0.008	0.087	bioplex_WMM WMM_only
CDC25B	EGFLAM	0.008	0.085	bioplex_WMM WMM_only
CDC25B	HIVEP1	0.008	0.085	bioplex_WMM WMM_only
CDC25B	MYO10	0.008	0.085	bioplex_WMM WMM_only
RASSF3	CDC34	0.008	0.085	bioplex_WMM WMM_only
CDC25B	HIVEP2	0.008	0.085	bioplex_WMM WMM_only
HIVEP1	CDC25A	0.008	0.085	bioplex_WMM WMM_only
CDC34	CDC25A	0.008	0.085	bioplex_WMM WMM_only
HIVEP1	MYO10	0.008	0.085	bioplex_WMM WMM_only
HIVEP2	CDC25A	0.008	0.085	bioplex_WMM WMM_only
RASSF3	CDC25B	0.008	0.085	bioplex_WMM WMM_only
RASSF3	HIVEP2	0.008	0.085	bioplex_WMM WMM_only
RASSF3	MYO10	0.008	0.085	bioplex_WMM WMM_only
HIVEP2	MYO10	0.008	0.085	bioplex_WMM WMM_only
MYO10	CDC34	0.008	0.085	bioplex_WMM WMM_only
MYO10	CDC25A	0.008	0.085	bioplex_WMM WMM_only
CDC25B	CDC34	0.008	0.085	bioplex_WMM WMM_only
RASSF3	CDC25A	0.008	0.085	bioplex_WMM WMM_only
CDC25A	EGFLAM	0.008	0.085	bioplex_WMM WMM_only
CDC34	EGFLAM	0.008	0.085	bioplex_WMM WMM_only
HIVEP2	CDC34	0.008	0.085	bioplex_WMM WMM_only
RASSF3	HIVEP1	0.008	0.085	bioplex_WMM WMM_only
HIVEP1	CDC34	0.008	0.085	bioplex_WMM WMM_only
MYO10	EGFLAM	0.008	0.085	bioplex_WMM WMM_only
HIVEP2	EGFLAM	0.008	0.085	bioplex_WMM WMM_only
HIVEP1	EGFLAM	0.008	0.085	bioplex_WMM WMM_only
RASSF3	EGFLAM	0.008	0.085	bioplex_WMM WMM_only
CDC25B	CDC25A	0.008	0.066	bioplex_WMM boldt boldt_WMM
TFAP4	HIVEP1	0.008	0.067	hein_WMM bioplex_WMM WMM_only
USP37	CDC25A	0.008	0.067	bioplex_WMM WMM_only
USP37	CDC34	0.008	0.067	bioplex_WMM WMM_only
TFAP4	HIVEP2	0.008	0.067	bioplex_WMM WMM_only
CDC25B	USP37	0.008	0.067	bioplex_WMM WMM_only
TFAP4	CDC25B	0.008	0.067	bioplex_WMM WMM_only
RASSF3	TFAP4	0.008	0.067	bioplex_WMM WMM_only
TFAP4	MYO10	0.008	0.067	bioplex_WMM WMM_only
TFAP4	CDC25A	0.008	0.067	bioplex_WMM WMM_only
TFAP4	CDC34	0.008	0.067	bioplex_WMM WMM_only
USP37	EGFLAM	0.008	0.067	bioplex_WMM WMM_only
RASSF3	USP37	0.008	0.067	bioplex_WMM WMM_only
USP37	MYO10	0.008	0.067	bioplex_WMM WMM_only
ADAMTS4	ANGPTL7	0.008	0.067	bioplex_WMM WMM_only
TFAP4	EGFLAM	0.008	0.067	bioplex_WMM WMM_only
TFAP4	USP37	0.008	0.06	bioplex_WMM WMM_only
FBXW11	BHLHE40	0.007	0.004	bioplex_WMM WMM_only
FBXW11	MLPH	0.007	0.004	bioplex_WMM WMM_only
FBXW11	TRPV6	0.007	0.004	bioplex_WMM WMM_only
BTRC	ANGPTL7	0.007	0.006	bioplex_WMM WMM_only
RASSF3	FBXW11	0.007	0.006	bioplex_WMM WMM_only
FBXW11	CDC34	0.007	0.006	bioplex_WMM WMM_only
FBXW11	ANGPTL7	0.007	0.006	bioplex_WMM WMM_only
FBXW11	EGFLAM	0.007	0.006	bioplex_WMM WMM_only
FBXW11	MYO10	0.007	0.006	bioplex_WMM WMM_only
BTRC	ADAMTS4	0.007	0.003	bioplex_WMM WMM_only
FBXW11	ADAMTS4	0.007	0.004	bioplex_WMM WMM_only

Images

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Complex HuMAP2_05993 has an average edge precision of 0.146 which is ranked 6732 out of all 6965 complexes.

Related Complexes

Genename	Complexes
BHLHE40	HuMAP2_05993
FBXW11	HuMAP2_01350 HuMAP2_03573 HuMAP2_04700 HuMAP2_05993
BTRC	HuMAP2_04363 HuMAP2_04700 HuMAP2_05993
EGFLAM	HuMAP2_05993
CDC34	HuMAP2_05993
ADAMTS4	HuMAP2_05522 HuMAP2_05993 HuMAP2_06745
ANGPTL7	HuMAP2_05522 HuMAP2_05993
CDC25B	HuMAP2_01350 HuMAP2_03573 HuMAP2_04363 HuMAP2_05993
USP37	HuMAP2_02668 HuMAP2_04374 HuMAP2_05993
MLPH	HuMAP2_04363 HuMAP2_04700 HuMAP2_05993
TFAP4	HuMAP2_01350 HuMAP2_04420 HuMAP2_05522 HuMAP2_05993
HIVEP1	HuMAP2_03573 HuMAP2_04363 HuMAP2_04700 HuMAP2_05993
MYO10	HuMAP2_03611 HuMAP2_05006 HuMAP2_05238 HuMAP2_05993
TRPV6	HuMAP2_05993
CDC25A	HuMAP2_05993
RASSF3	HuMAP2_00028 HuMAP2_00129 HuMAP2_05993
HIVEP2	HuMAP2_03573 HuMAP2_04363 HuMAP2_04700 HuMAP2_05993
ZNF704	HuMAP2_05993

hu.MAP 2.0: Complex View

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Complex: HuMAP2_05993