hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_06014
Confidence: Medium  
ProteinsGenename | Protein Name | Links |
---|---|---|
FGFR1 | Fibroblast growth factor receptor 1 (FGFR-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (BFGFR) (bFGF-R-1) (Fms-like tyrosine kinase 2) (FLT-2) (N-sam) (Proto-oncogene c-Fgr) (CD antigen CD331) | UniProt   NCBI |
RPS6KA3 | Ribosomal protein S6 kinase alpha-3 (S6K-alpha-3) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (p90RSK3) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPK-activated protein kinase 1b) (MAPKAP kinase 1b) (MAPKAPK-1b) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) | UniProt   NCBI |
ZBTB7B | Zinc finger and BTB domain-containing protein 7B (Krueppel-related zinc finger protein cKrox) (hcKrox) (T-helper-inducing POZ/Krueppel-like factor) (Zinc finger and BTB domain-containing protein 15) (Zinc finger protein 67 homolog) (Zfp-67) (Zinc finger protein 857B) (Zinc finger protein Th-POK) | UniProt   NCBI |
FGFR2 | Fibroblast growth factor receptor 2 (FGFR-2) (EC 2.7.10.1) (K-sam) (KGFR) (Keratinocyte growth factor receptor) (CD antigen CD332) | UniProt   NCBI |
MORN2 | MORN repeat-containing protein 2 (MORN motif protein in testis) | UniProt   NCBI |
STMN3 | Stathmin-3 (SCG10-like protein) | UniProt   NCBI |
FGFR3 | Fibroblast growth factor receptor 3 (FGFR-3) (EC 2.7.10.1) (CD antigen CD333) | UniProt   NCBI |
DNAJC30 | DnaJ homolog subfamily C member 30, mitochondrial (Williams-Beuren syndrome chromosomal region 18 protein) | UniProt   NCBI |
SNX22 | Sorting nexin-22 | UniProt   NCBI |
C8orf74 | Uncharacterized protein C8orf74 | UniProt   NCBI |
Enrichments
Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
---|---|---|---|---|
  HP:0003795 | 1.57833996515e-06 | 0.3 | FGFR2 FGFR1 FGFR3 | Short middle phalanx of toe |
  HP:0002676 | 5.52029503233e-06 | 0.3 | FGFR2 FGFR1 FGFR3 | Cloverleaf skull |
  HP:0010183 | 1.32393664744e-05 | 0.3 | FGFR2 FGFR1 FGFR3 | Abnormality of the middle phalanges of the toes |
  HP:0000678 | 6.28539528181e-05 | 0.4 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Dental crowding |
  HP:0100538 | 9.81363041183e-05 | 0.4 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Abnormality of the supraorbital ridges |
  GO:0005007 | 0.000108905457596 | 0.3 | FGFR2 FGFR1 FGFR3 | fibroblast growth factor-activated receptor activity |
  HP:0004440 | 0.000128203350686 | 0.3 | FGFR2 FGFR1 FGFR3 | Coronal craniosynostosis |
  HP:0100498 | 0.000153547520595 | 0.4 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Deviation of toes |
  HP:0001500 | 0.000160895336238 | 0.4 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Broad finger |
  HP:0000327 | 0.000271047346494 | 0.4 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Hypoplasia of the maxilla |
  HP:0008368 | 0.000277754863218 | 0.3 | FGFR2 FGFR1 FGFR3 | Tarsal synostosis |
  HP:0005347 | 0.000294015268291 | 0.2 | FGFR2 FGFR1 | Cartilaginous trachea |
  HP:0008122 | 0.000294015268291 | 0.2 | FGFR2 FGFR1 | Calcaneonavicular fusion |
  HP:0009140 | 0.000407339699917 | 0.3 | FGFR2 FGFR1 FGFR3 | Synostosis involving bones of the feet |
  HP:0009138 | 0.000407339699917 | 0.3 | FGFR2 FGFR1 FGFR3 | Synostosis involving bones of the lower limbs |
  HP:0000326 | 0.000429555576402 | 0.4 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Abnormality of the maxilla |
  HP:0000506 | 0.000461513324227 | 0.4 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Telecanthus |
  KEGG:05230 | 0.000490786933665 | 0.3 | FGFR2 FGFR1 FGFR3 | Central carbon metabolism in cancer |
  WP:WP4155 | 0.000503966439829 | 0.3 | FGFR2 FGFR1 FGFR3 | Endometrial cancer |
  WP:WP382 | 0.000556234612026 | 0.4 | FGFR2 FGFR3 RPS6KA3 FGFR1 | MAPK Signaling Pathway |
  HP:0000262 | 0.000571863230327 | 0.3 | FGFR2 FGFR1 FGFR3 | Turricephaly |
  KEGG:04010 | 0.000793496536397 | 0.4 | FGFR2 FGFR3 RPS6KA3 FGFR1 | MAPK signaling pathway |
  HP:0100583 | 0.000881729914172 | 0.2 | FGFR2 FGFR3 | Corneal perforation |
  HP:0009462 | 0.000881729914172 | 0.2 | FGFR2 FGFR3 | Radial deviation of the 3rd finger |
  HP:0009637 | 0.000881729914172 | 0.2 | FGFR2 FGFR3 | Absent proximal phalanx of thumb |
  HP:0009740 | 0.000881729914172 | 0.2 | FGFR2 FGFR3 | Aplasia of the parotid gland |
  HP:0009741 | 0.000881729914172 | 0.2 | FGFR2 FGFR3 | Nephrosclerosis |
  HP:0007892 | 0.000881729914172 | 0.2 | FGFR2 FGFR3 | Hypoplasia of the lacrimal punctum |
  HP:0007656 | 0.000881729914172 | 0.2 | FGFR2 FGFR3 | Lacrimal gland aplasia |
  HP:0005707 | 0.000881729914172 | 0.2 | FGFR2 FGFR3 | Bilateral triphalangeal thumbs |
  HP:0009899 | 0.000881729914172 | 0.2 | FGFR2 FGFR3 | Prominent crus of helix |
  HP:0032107 | 0.000881729914172 | 0.2 | FGFR2 FGFR3 | Limbal stem cell deficiency |
  HP:0008454 | 0.000881729914172 | 0.2 | RPS6KA3 FGFR3 | Lumbar kyphosis |
  WP:WP2064 | 0.000932152967241 | 0.3 | FGFR2 FGFR1 FGFR3 | Neural Crest Differentiation |
  HP:0005819 | 0.00102214764966 | 0.3 | FGFR2 FGFR1 FGFR3 | Short middle phalanx of finger |
  REAC:R-HSA-1226099 | 0.00104952641894 | 0.3 | FGFR2 FGFR1 FGFR3 | Signaling by FGFR in disease |
  HP:0010055 | 0.00131607508928 | 0.3 | FGFR2 FGFR1 FGFR3 | Broad hallux |
  WP:WP4540 | 0.00140000217968 | 0.3 | FGFR2 FGFR1 FGFR3 | Pathways Regulating Hippo Signaling |
  HP:0010051 | 0.00154026138941 | 0.3 | FGFR2 FGFR1 FGFR3 | Deviation of the hallux |
  HP:0100266 | 0.0016612744098 | 0.3 | FGFR2 FGFR1 FGFR3 | Synostosis of carpals/tarsals |
  HP:0009843 | 0.0016612744098 | 0.3 | FGFR2 FGFR1 FGFR3 | Aplasia/Hypoplasia of the middle phalanges of the hand |
  HP:0009317 | 0.00176282826969 | 0.2 | FGFR2 FGFR3 | Deviation of the 3rd finger |
  HP:0009629 | 0.00176282826969 | 0.2 | FGFR2 FGFR3 | Aplasia/Hypoplasia of the proximal phalanx of the thumb |
  HP:0007732 | 0.00176282826969 | 0.2 | FGFR2 FGFR3 | Lacrimal gland hypoplasia |
  HP:0000198 | 0.00176282826969 | 0.2 | FGFR2 FGFR3 | Absence of Stensen duct |
  HP:0007900 | 0.00176282826969 | 0.2 | FGFR2 FGFR3 | Hypoplastic lacrimal duct |
  HP:0008080 | 0.00176282826969 | 0.2 | FGFR2 FGFR1 | Hallux varus |
  HP:0011318 | 0.00176282826969 | 0.2 | FGFR2 FGFR1 | Bicoronal synostosis |
  HP:0008743 | 0.00176282826969 | 0.2 | FGFR2 FGFR3 | Coronal hypospadias |
  HP:0005037 | 0.00176282826969 | 0.2 | FGFR2 FGFR3 | Proximal radio-ulnar synostosis |
  HP:0000606 | 0.0018562130093 | 0.4 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Abnormality of the periorbital region |
  HP:0009833 | 0.00192188714397 | 0.3 | FGFR2 FGFR1 FGFR3 | Abnormal middle phalanx morphology of the hand |
  WP:WP3931 | 0.00200111496645 | 0.3 | FGFR2 FGFR1 FGFR3 | ESC Pluripotency Pathways |
  HP:0009803 | 0.00220150412662 | 0.4 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Short phalanx of finger |
  WP:WP4541 | 0.00225584986278 | 0.3 | FGFR2 FGFR1 FGFR3 | Hippo-Merlin Signaling Dysregulation |
  HP:0000614 | 0.00236150736559 | 0.3 | FGFR2 FGFR1 FGFR3 | Abnormal nasolacrimal system morphology |
  HP:0001837 | 0.00252162873364 | 0.3 | FGFR2 FGFR1 FGFR3 | Broad toe |
  HP:0006482 | 0.00253361522712 | 0.4 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Abnormality of dental morphology |
  HP:0006292 | 0.00259238771153 | 0.4 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Abnormality of dental eruption |
  HP:0100257 | 0.00268878775834 | 0.3 | FGFR2 FGFR1 FGFR3 | Ectrodactyly |
  HP:0000629 | 0.00286313232317 | 0.3 | FGFR2 RPS6KA3 FGFR3 | Periorbital fullness |
  HP:0008038 | 0.0029369948895 | 0.2 | FGFR2 FGFR3 | Aplastic/hypoplastic lacrimal glands |
  HP:0011479 | 0.0029369948895 | 0.2 | FGFR2 FGFR3 | Abnormal lacrimal punctum morphology |
  HP:0001092 | 0.0029369948895 | 0.2 | FGFR2 FGFR3 | Absent lacrimal punctum |
  KEGG:04550 | 0.00303956607979 | 0.3 | FGFR2 FGFR1 FGFR3 | Signaling pathways regulating pluripotency of stem cells |
  HP:0002308 | 0.00323396853444 | 0.3 | FGFR2 FGFR1 FGFR3 | Arnold-Chiari malformation |
  HP:0000676 | 0.00323396853444 | 0.3 | FGFR2 FGFR1 FGFR3 | Abnormality of the incisor |
  HP:0009767 | 0.00360112362912 | 0.4 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Aplasia/Hypoplasia of the phalanges of the hand |
  HP:0000270 | 0.00429711659447 | 0.3 | FGFR2 RPS6KA3 FGFR3 | Delayed cranial suture closure |
  HP:0009895 | 0.00440391455079 | 0.2 | FGFR2 FGFR3 | Abnormality of the crus of the helix |
  HP:0010239 | 0.00440391455079 | 0.2 | FGFR2 FGFR3 | Aplasia of the middle phalanx of the hand |
  HP:0011482 | 0.00440391455079 | 0.2 | FGFR2 FGFR3 | Abnormal lacrimal gland morphology |
  HP:0009618 | 0.00440391455079 | 0.2 | FGFR2 FGFR3 | Abnormality of the proximal phalanx of the thumb |
  HP:0001227 | 0.00440391455079 | 0.2 | FGFR2 FGFR3 | Abnormality of the thenar eminence |
  HP:0000620 | 0.00440391455079 | 0.2 | FGFR2 FGFR3 | Dacryocystitis |
  HP:0001245 | 0.00440391455079 | 0.2 | FGFR2 FGFR3 | Small thenar eminence |
  WP:WP51 | 0.00487042942288 | 0.3 | FGFR2 FGFR1 FGFR3 | Regulation of Actin Cytoskeleton |
  HP:0011304 | 0.00503416384107 | 0.3 | FGFR2 FGFR1 FGFR3 | Broad thumb |
  HP:0010535 | 0.00503416384107 | 0.3 | FGFR2 RPS6KA3 FGFR3 | Sleep apnea |
  HP:0011800 | 0.00536645250856 | 0.4 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Midface retrusion |
  HP:0000940 | 0.00600288766054 | 0.4 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Abnormal diaphysis morphology |
  HP:0009381 | 0.00611416030239 | 0.4 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Short finger |
  HP:0006110 | 0.00616327225309 | 0.2 | FGFR2 FGFR1 | Shortening of all middle phalanges of the fingers |
  HP:0009659 | 0.00616327225309 | 0.2 | FGFR2 FGFR3 | Partial absence of thumb |
  HP:0000244 | 0.00616327225309 | 0.2 | FGFR2 FGFR1 | Brachyturricephaly |
  HP:0004150 | 0.00616327225309 | 0.2 | FGFR2 FGFR3 | Abnormal 3rd finger morphology |
  HP:0003070 | 0.00616327225309 | 0.2 | FGFR2 FGFR1 | Elbow ankylosis |
  HP:0009804 | 0.00622695403843 | 0.4 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Reduced number of teeth |
  HP:0000692 | 0.00693641167649 | 0.4 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Misalignment of teeth |
  HP:0004691 | 0.00739736827554 | 0.3 | FGFR2 RPS6KA3 FGFR1 | 2-3 toe syndactyly |
  HP:0011329 | 0.0075719372093 | 0.4 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Abnormality of cranial sutures |
  WP:WP4223 | 0.0078484775429 | 0.3 | FGFR2 FGFR1 FGFR3 | Ras Signaling |
  HP:3000022 | 0.00821475321822 | 0.2 | FGFR2 FGFR3 | Abnormality of cartilage of external ear |
  HP:0000197 | 0.00821475321822 | 0.2 | FGFR2 FGFR3 | Abnormal parotid gland morphology |
  KEGG:04015 | 0.00836838302524 | 0.3 | FGFR2 FGFR1 FGFR3 | Rap1 signaling pathway |
  HP:0009768 | 0.00844385682417 | 0.3 | FGFR2 FGFR1 FGFR3 | Broad phalanges of the hand |
  HP:0001831 | 0.00881326532308 | 0.3 | FGFR2 FGFR1 FGFR3 | Short toe |
  GO:0017134 | 0.00884603119732 | 0.3 | FGFR2 FGFR1 FGFR3 | fibroblast growth factor binding |
  HP:0006483 | 0.00912084810626 | 0.4 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Abnormal number of teeth |
  HP:0000973 | 0.00998522965779 | 0.3 | FGFR2 RPS6KA3 FGFR3 | Cutis laxa |
  KEGG:04014 | 0.0100396314587 | 0.3 | FGFR2 FGFR1 FGFR3 | Ras signaling pathway |
  HP:0001850 | 0.0103976059523 | 0.3 | FGFR2 FGFR1 FGFR3 | Abnormality of the tarsal bones |
  KEGG:04810 | 0.0105303258854 | 0.3 | FGFR2 FGFR1 FGFR3 | Regulation of actin cytoskeleton |
  HP:0001233 | 0.0105580428902 | 0.2 | FGFR2 FGFR3 | 2-3 finger syndactyly |
  HP:0001783 | 0.0105580428902 | 0.2 | FGFR2 FGFR1 | Broad metatarsal |
  HP:0006501 | 0.010821080098 | 0.3 | FGFR2 FGFR1 FGFR3 | Aplasia/Hypoplasia of the radius |
  HP:0003312 | 0.0108926099659 | 0.4 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Abnormal form of the vertebral bodies |
  HP:0006265 | 0.0110654027539 | 0.4 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Aplasia/Hypoplasia of fingers |
  HP:0000601 | 0.0112557940356 | 0.3 | FGFR2 FGFR1 FGFR3 | Hypotelorism |
  HP:0007360 | 0.0125216870835 | 0.4 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Aplasia/Hypoplasia of the cerebellum |
  HP:0001156 | 0.0127131941594 | 0.4 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Brachydactyly |
  HP:0000689 | 0.013109879185 | 0.3 | FGFR2 RPS6KA3 FGFR3 | Dental malocclusion |
  HP:0002781 | 0.0131928269349 | 0.2 | FGFR2 FGFR3 | Upper airway obstruction |
  HP:0003041 | 0.0131928269349 | 0.2 | FGFR2 FGFR1 | Humeroradial synostosis |
  HP:0003938 | 0.0131928269349 | 0.2 | FGFR2 FGFR1 | Synostosis involving the elbow |
  HP:0100871 | 0.0147494223508 | 0.4 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Abnormality of the palm |
  HP:0004279 | 0.0151551018147 | 0.3 | FGFR2 FGFR1 FGFR3 | Short palm |
  HP:0009802 | 0.0161187912402 | 0.2 | FGFR2 FGFR3 | Aplasia of the phalanges of the hand |
  HP:0410007 | 0.0161187912402 | 0.2 | FGFR2 FGFR3 | Abnormality of cartilage morphology |
  HP:0009823 | 0.0161187912402 | 0.2 | FGFR2 FGFR3 | Aplasia involving bones of the upper limbs |
  HP:0000236 | 0.0162521992163 | 0.3 | FGFR2 RPS6KA3 FGFR3 | Abnormality of the anterior fontanelle |
  HP:0006503 | 0.0174004457576 | 0.3 | FGFR2 FGFR1 FGFR3 | Aplasia/hypoplasia involving forearm bones |
  HP:0005922 | 0.0174997075091 | 0.4 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Abnormal hand morphology |
  HP:0011218 | 0.0174997075091 | 0.4 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Abnormal shape of the frontal region |
  HP:0002007 | 0.0174997075091 | 0.4 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Frontal bossing |
  HP:0009601 | 0.0179940984144 | 0.3 | FGFR2 FGFR1 FGFR3 | Aplasia/Hypoplasia of the thumb |
  HP:0003745 | 0.0186009560916 | 0.3 | FGFR3 RPS6KA3 FGFR1 | Sporadic |
  HP:0100238 | 0.0186009560916 | 0.3 | FGFR2 FGFR1 FGFR3 | Synostosis involving bones of the upper limbs |
  HP:0009944 | 0.0193356219159 | 0.2 | FGFR2 FGFR3 | Partial duplication of thumb phalanx |
  HP:0000680 | 0.0193356219159 | 0.2 | FGFR2 FGFR3 | Delayed eruption of primary teeth |
  HP:0000522 | 0.0193356219159 | 0.2 | FGFR2 FGFR3 | Alacrima |
  HP:0011386 | 0.0193356219159 | 0.2 | FGFR2 FGFR3 | Narrow internal auditory canal |
  HP:0000453 | 0.0198548415518 | 0.3 | FGFR2 FGFR1 FGFR3 | Choanal atresia |
  HP:0006009 | 0.0198548415518 | 0.3 | FGFR2 FGFR1 FGFR3 | Broad phalanx |
  HP:0002360 | 0.0203374120668 | 0.4 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Sleep disturbance |
  HP:0001792 | 0.0205021463394 | 0.3 | FGFR2 RPS6KA3 FGFR1 | Small nail |
  HP:0000889 | 0.0211632101569 | 0.3 | FGFR2 FGFR1 FGFR3 | Abnormality of the clavicle |
  HP:0001991 | 0.0218381709897 | 0.3 | FGFR2 FGFR1 FGFR3 | Aplasia/Hypoplasia of toe |
  HP:0001159 | 0.0220211110756 | 0.4 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Syndactyly |
  HP:0001773 | 0.0225271666167 | 0.3 | FGFR2 FGFR1 FGFR3 | Short foot |
  HP:0009999 | 0.0228430052933 | 0.2 | FGFR2 FGFR3 | Partial duplication of the phalanx of hand |
  HP:0000495 | 0.0228430052933 | 0.2 | FGFR2 FGFR3 | Recurrent corneal erosions |
  HP:0000235 | 0.0229004548125 | 0.4 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Abnormality of the fontanelles or cranial sutures |
  HP:0000415 | 0.0232303346105 | 0.3 | FGFR2 FGFR1 FGFR3 | Abnormality of the choanae |
  HP:0005622 | 0.0246797369582 | 0.3 | FGFR2 FGFR1 FGFR3 | Broad long bones |
  HP:0010161 | 0.0246797369582 | 0.3 | FGFR2 FGFR1 FGFR3 | Abnormality of the phalanges of the toes |
  HP:0003764 | 0.0246797369582 | 0.3 | FGFR2 FGFR1 FGFR3 | Nevus |
  HP:0000452 | 0.0266406279253 | 0.2 | FGFR2 FGFR1 | Choanal stenosis |
  HP:0009825 | 0.0266406279253 | 0.2 | FGFR2 FGFR3 | Aplasia involving bones of the extremities |
  HP:0010286 | 0.0266406279253 | 0.2 | FGFR2 FGFR3 | Abnormal salivary gland morphology |
  HP:0000256 | 0.028034485482 | 0.4 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Macrocephaly |
  HP:0040194 | 0.028034485482 | 0.4 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Increased head circumference |
  HP:0100761 | 0.0307281765862 | 0.2 | FGFR2 FGFR1 | Visceral angiomatosis |
  HP:0002780 | 0.0307281765862 | 0.2 | FGFR2 FGFR1 | Bronchomalacia |
  HP:0011384 | 0.0307281765862 | 0.2 | FGFR2 FGFR3 | Abnormality of the internal auditory canal |
  HP:0000410 | 0.0307281765862 | 0.2 | FGFR2 FGFR3 | Mixed hearing impairment |
  HP:3000030 | 0.0307281765862 | 0.2 | FGFR2 FGFR1 | Abnormality of bony orbit of skull |
  HP:0000586 | 0.0307281765862 | 0.2 | FGFR2 FGFR1 | Shallow orbits |
  HP:0001844 | 0.0310716135242 | 0.3 | FGFR2 FGFR1 FGFR3 | Abnormality of the hallux |
  HP:0040070 | 0.031269787984 | 0.4 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Abnormal upper limb bone morphology |
  WP:WP474 | 0.0317302164968 | 0.2 | FGFR1 FGFR3 | Endochondral Ossification |
  HP:0008067 | 0.031939698511 | 0.3 | FGFR2 RPS6KA3 FGFR3 | Abnormally lax or hyperextensible skin |
  HP:0003468 | 0.0327925369413 | 0.4 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Abnormal vertebral morphology |
  WP:WP3932 | 0.0343790872 | 0.3 | FGFR2 FGFR1 FGFR3 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
  HP:0100712 | 0.0351053382716 | 0.2 | RPS6KA3 FGFR3 | Abnormality of the lumbar spine |
  HP:0100702 | 0.0351053382716 | 0.2 | FGFR2 FGFR1 | Arachnoid cyst |
  HP:0010059 | 0.0351053382716 | 0.2 | FGFR2 FGFR1 | Broad hallux phalanx |
  HP:0100700 | 0.0351053382716 | 0.2 | FGFR2 FGFR1 | Abnormal arachnoid mater morphology |
  HP:0000633 | 0.0351053382716 | 0.2 | FGFR2 FGFR3 | Decreased lacrimation |
  HP:0000954 | 0.0384664357231 | 0.3 | FGFR2 RPS6KA3 FGFR3 | Single transverse palmar crease |
  HP:0000104 | 0.0394647443381 | 0.3 | FGFR2 FGFR1 FGFR3 | Renal agenesis |
  HP:0002410 | 0.0397718001983 | 0.2 | FGFR2 FGFR1 | Aqueductal stenosis |
  HP:0007461 | 0.0397718001983 | 0.2 | FGFR2 FGFR1 | Hemangiomatosis |
  HP:0000494 | 0.0407818407083 | 0.4 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Downslanted palpebral fissures |
  HP:0030084 | 0.041698812194 | 0.4 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Clinodactyly |
  KEGG:04151 | 0.0420237476017 | 0.3 | FGFR2 FGFR1 FGFR3 | PI3K-Akt signaling pathway |
  HP:0000303 | 0.0436281181449 | 0.3 | FGFR2 RPS6KA3 FGFR1 | Mandibular prognathia |
  HP:0001363 | 0.0436281181449 | 0.3 | FGFR2 FGFR1 FGFR3 | Craniosynostosis |
  HP:0011065 | 0.0447272498042 | 0.2 | FGFR2 FGFR3 | Conical incisor |
  HP:0031013 | 0.0447272498042 | 0.2 | FGFR2 FGFR1 | Ankylosis |
  HP:0005280 | 0.0450278518397 | 0.4 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Depressed nasal bridge |
  HP:0005927 | 0.0455188812335 | 0.4 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Aplasia/hypoplasia involving bones of the hand |
  HP:0100755 | 0.0458137496085 | 0.3 | FGFR2 RPS6KA3 FGFR3 | Abnormality of salivation |
  HP:0005916 | 0.0458137496085 | 0.3 | FGFR3 RPS6KA3 FGFR1 | Abnormal metacarpal morphology |
  WP:WP4172 | 0.0479719964262 | 0.3 | FGFR2 FGFR1 FGFR3 | PI3K-Akt Signaling Pathway |
  CORUM:6834 | 0.0499561984052 | 0.1 | FGFR1 | FGF21-FGFR1c-KLB complex |
  CORUM:6836 | 0.0499561984052 | 0.1 | FGFR1 | FGFR1c-KLB complex |
  CORUM:912 | 0.0499561984052 | 0.1 | FGFR1 | FGFR1-KAL11 complex |
  CORUM:6828 | 0.0499561984052 | 0.1 | FGFR1 | FGF21-FGFR1c-KLB complex |
  HP:0000579 | 0.0499713747483 | 0.2 | FGFR2 FGFR3 | Nasolacrimal duct obstruction |
Edges
Protein 1 | Protein 2 | Score | Precision | Evidence |
---|---|---|---|---|
 FGFR2 |  FGFR3 | 0.995 | 0.924           | bioplex (FGFR2)     bioplex_WMM     |
 FGFR2 |  FGFR1 | 0.707 | 0.729           | bioplex (FGFR2)     bioplex_WMM     |
 FGFR2 |  C8orf74 | 0.535 | 0.64           | bioplex (C8orf74)     bioplex_WMM     |
 MORN2 |  C8orf74 | 0.303 | 0.498           | bioplex (C8orf74)     bioplex_WMM     |
 RPS6KA3 |  FGFR2 | 0.046 | 0.293           | bioplex (FGFR2)     bioplex_WMM     |
 FGFR2 |  DNAJC30 | 0.043 | 0.269           | bioplex (FGFR2)     bioplex_WMM     |
 FGFR2 |  STMN3 | 0.032 | 0.246           | bioplex (FGFR2)     bioplex_WMM     |
 SNX22 |  FGFR2 | 0.028 | 0.23           | bioplex (FGFR2)     bioplex_WMM     |
 ZBTB7B |  FGFR2 | 0.026 | 0.219           | bioplex (FGFR2)     bioplex_WMM     |
 FGFR3 |  STMN3 | 0.008 | 0.095           | bioplex_WMM     WMM_only     |
 ZBTB7B |  STMN3 | 0.008 | 0.091           | bioplex_WMM     WMM_only     |
 SNX22 |  STMN3 | 0.008 | 0.087           | bioplex_WMM     WMM_only     |
 ZBTB7B |  FGFR3 | 0.008 | 0.085           | bioplex_WMM     WMM_only     |
 FGFR1 |  FGFR3 | 0.008 | 0.068           | bioplex_WMM     WMM_only     |
 SNX22 |  FGFR3 | 0.008 | 0.065           | bioplex_WMM     WMM_only     |
 SNX22 |  ZBTB7B | 0.008 | 0.067           | bioplex_WMM     WMM_only     |
 STMN3 |  DNAJC30 | 0.008 | 0.06           | bioplex_WMM     WMM_only     |
 RPS6KA3 |  STMN3 | 0.008 | 0.041           | bioplex_WMM     WMM_only     |
 MORN2 |  FGFR2 | 0.008 | 0.041           | bioplex_WMM     WMM_only     |
 FGFR3 |  DNAJC30 | 0.008 | 0.022           | bioplex_WMM     WMM_only     |
 ZBTB7B |  DNAJC30 | 0.008 | 0.025           | bioplex_WMM     WMM_only     |
 RPS6KA3 |  FGFR3 | 0.008 | 0.013           | bioplex_WMM     WMM_only     |
 ZBTB7B |  RPS6KA3 | 0.008 | 0.025           | bioplex_WMM     WMM_only     |
 SNX22 |  DNAJC30 | 0.008 | 0.015           | bioplex_WMM     WMM_only     |
 FGFR1 |  STMN3 | 0.007 | 0.006           | bioplex_WMM     WMM_only     |
 SNX22 |  RPS6KA3 | 0.007 | 0.008           | bioplex_WMM     WMM_only     |
 ZBTB7B |  FGFR1 | 0.007 | 0.005           | bioplex_WMM     WMM_only     |
 SNX22 |  FGFR1 | 0.007 | 0.004           | bioplex_WMM     WMM_only     |
 RPS6KA3 |  DNAJC30 | 0.007 | 0.003           | bioplex_WMM     WMM_only     |
 FGFR1 |  DNAJC30 | 0.007 | 0.003           | bioplex_WMM     WMM_only     |
 RPS6KA3 |  FGFR1 | 0.007 | 0.004           | bioplex_WMM     WMM_only     |
Images
Click to enlarge

Complex HuMAP2_06014 has an average edge precision of 0.157 which is ranked 6651 out of all 6965 complexes.
Related Complexes
Genename | Complexes |
---|---|
FGFR1 | HuMAP2_02095 HuMAP2_06014 HuMAP2_06274 HuMAP2_06605 |
RPS6KA3 | HuMAP2_00566 HuMAP2_05297 HuMAP2_05462 HuMAP2_06014 HuMAP2_06605 |
ZBTB7B | HuMAP2_00242 HuMAP2_03451 HuMAP2_05640 HuMAP2_06014 |
FGFR2 | HuMAP2_02095 HuMAP2_06014 HuMAP2_06274 HuMAP2_06605 |
MORN2 | HuMAP2_00597 HuMAP2_06014 HuMAP2_06930 |
STMN3 | HuMAP2_06014 |
FGFR3 | HuMAP2_02095 HuMAP2_02142 HuMAP2_06014 HuMAP2_06274 HuMAP2_06605 |
DNAJC30 | HuMAP2_06014 HuMAP2_06605 |
SNX22 | HuMAP2_00180 HuMAP2_00264 HuMAP2_04649 HuMAP2_04800 HuMAP2_05827 HuMAP2_06014 |
C8orf74 | HuMAP2_02095 HuMAP2_06014 HuMAP2_06930 |