hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_06019

Confidence: Medium

Genename	Protein Name	Links
CDC40	Pre-mRNA-processing factor 17 (Cell division cycle 40 homolog) (EH-binding protein 3) (Ehb3) (PRP17 homolog) (hPRP17)	UniProt NCBI
NCBP2	Nuclear cap-binding protein subunit 2 (20 kDa nuclear cap-binding protein) (Cell proliferation-inducing gene 55 protein) (NCBP 20 kDa subunit) (CBP20) (NCBP-interacting protein 1) (NIP1)	UniProt NCBI
NCBP1	Nuclear cap-binding protein subunit 1 (80 kDa nuclear cap-binding protein) (CBP80) (NCBP 80 kDa subunit)	UniProt NCBI
PHAX	Phosphorylated adapter RNA export protein (RNA U small nuclear RNA export adapter protein)	UniProt NCBI
LENG1	Leukocyte receptor cluster member 1	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:1174	1.35146690511e-09	0.6	NCBP2 PHAX NCBP1	PHAX-CBC complex (cap binding complex)
CORUM:1176	1.35119464053e-08	0.6	NCBP2 PHAX NCBP1	CRM1-RAN-PHAX-CBC complex (cap binding complex)
CORUM:1172	6.70868171695e-06	0.4	NCBP2 NCBP1	CBC complex (cap binding complex)
CORUM:775	6.70868171695e-06	0.4	NCBP2 NCBP1	CBC complex (cap binding complex)
REAC:R-HSA-194441	5.30427262701e-05	0.6	NCBP2 PHAX NCBP1	Metabolism of non-coding RNA
REAC:R-HSA-191859	5.30427262701e-05	0.6	NCBP2 PHAX NCBP1	snRNP Assembly
REAC:R-HSA-72187	6.70990066737e-05	0.6	NCBP1 CDC40 NCBP2	mRNA 3'-end processing
CORUM:6129	0.000100576175246	0.4	NCBP2 NCBP1	CBP80/20- dependent translation complex
REAC:R-HSA-73856	0.000107327354708	0.6	NCBP1 CDC40 NCBP2	RNA Polymerase II Transcription Termination
REAC:R-HSA-159236	0.000135380656388	0.6	NCBP1 CDC40 NCBP2	Transport of Mature mRNA derived from an Intron-Containing Transcript
REAC:R-HSA-6807505	0.000175005907139	0.6	NCBP2 PHAX NCBP1	RNA polymerase II transcribes snRNA genes
REAC:R-HSA-72202	0.000197423805207	0.6	NCBP1 CDC40 NCBP2	Transport of Mature Transcript to Cytoplasm
WP:WP411	0.000211141596217	0.6	NCBP1 CDC40 NCBP2	mRNA Processing
KEGG:03040	0.000305495250573	0.6	NCBP1 CDC40 NCBP2	Spliceosome
KEGG:03013	0.000498609547209	0.6	NCBP2 PHAX NCBP1	RNA transport
CORUM:351	0.000596572408668	0.6	NCBP1 CDC40 NCBP2	Spliceosome
REAC:R-HSA-111367	0.000606744453221	0.4	NCBP2 NCBP1	SLBP independent Processing of Histone Pre-mRNAs
REAC:R-HSA-77588	0.000741476933235	0.4	NCBP2 NCBP1	SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
GO:0006405	0.00141941829177	0.8	NCBP1 CDC40 PHAX NCBP2	RNA export from nucleus
REAC:R-HSA-77595	0.00230284247734	0.4	NCBP2 NCBP1	Processing of Intronless Pre-mRNAs
REAC:R-HSA-8851708	0.00230284247734	0.4	NCBP2 NCBP1	Signaling by FGFR2 IIIa TM
GO:0050657	0.00245191852964	0.8	NCBP1 CDC40 PHAX NCBP2	nucleic acid transport
GO:0050658	0.00245191852964	0.8	NCBP1 CDC40 PHAX NCBP2	RNA transport
REAC:R-HSA-72163	0.00246885319177	0.6	NCBP1 CDC40 NCBP2	mRNA Splicing - Major Pathway
REAC:R-HSA-8953854	0.00262978456954	0.8	NCBP1 CDC40 PHAX NCBP2	Metabolism of RNA
GO:0051236	0.00265571901763	0.8	NCBP1 CDC40 PHAX NCBP2	establishment of RNA localization
REAC:R-HSA-72172	0.00281668881241	0.6	NCBP1 CDC40 NCBP2	mRNA Splicing
REAC:R-HSA-167242	0.00340529843133	0.4	NCBP2 NCBP1	Abortive elongation of HIV-1 transcript in the absence of Tat
REAC:R-HSA-1839126	0.0040368179849	0.4	NCBP2 NCBP1	FGFR2 mutant receptor activation
GO:0051168	0.00406013264988	0.8	NCBP1 CDC40 PHAX NCBP2	nuclear export
GO:0015931	0.00435640040345	0.8	NCBP1 CDC40 PHAX NCBP2	nucleobase-containing compound transport
REAC:R-HSA-6803529	0.00437263170532	0.4	NCBP2 NCBP1	FGFR2 alternative splicing
GO:0005846	0.00450823411379	0.4	NCBP2 NCBP1	nuclear cap binding complex
GO:0006408	0.00450823411379	0.4	NCBP2 PHAX	snRNA export from nucleus
REAC:R-HSA-75067	0.00508433997358	0.4	NCBP2 NCBP1	Processing of Capped Intronless Pre-mRNA
REAC:R-HSA-72086	0.00546022370076	0.4	NCBP2 NCBP1	mRNA Capping
REAC:R-HSA-72203	0.00567167369058	0.6	NCBP1 CDC40 NCBP2	Processing of Capped Intron-Containing Pre-mRNA
GO:0006403	0.00583116822137	0.8	NCBP1 CDC40 PHAX NCBP2	RNA localization
REAC:R-HSA-159227	0.00584945327803	0.4	NCBP2 NCBP1	Transport of the SLBP independent Mature mRNA
REAC:R-HSA-159230	0.00625202329777	0.4	NCBP2 NCBP1	Transport of the SLBP Dependant Mature mRNA
REAC:R-HSA-167158	0.00709716303977	0.4	NCBP2 NCBP1	Formation of the HIV-1 Early Elongation Complex
REAC:R-HSA-113418	0.00709716303977	0.4	NCBP2 NCBP1	Formation of the Early Elongation Complex
REAC:R-HSA-5655253	0.0075397219523	0.4	NCBP2 NCBP1	Signaling by FGFR2 in disease
REAC:R-HSA-159231	0.00894729002053	0.4	NCBP2 NCBP1	Transport of Mature mRNA Derived from an Intronless Transcript
REAC:R-HSA-159234	0.00944309181669	0.4	NCBP2 NCBP1	Transport of Mature mRNAs Derived from Intronless Transcripts
REAC:R-HSA-167200	0.0126969553517	0.4	NCBP2 NCBP1	Formation of HIV-1 elongation complex containing HIV-1 Tat
REAC:R-HSA-167246	0.0126969553517	0.4	NCBP2 NCBP1	Tat-mediated elongation of the HIV-1 transcript
REAC:R-HSA-167169	0.0126969553517	0.4	NCBP2 NCBP1	HIV Transcription Elongation
GO:0051030	0.0135228859698	0.4	NCBP2 PHAX	snRNA transport
REAC:R-HSA-167152	0.0138877528683	0.4	NCBP2 NCBP1	Formation of HIV elongation complex in the absence of HIV Tat
KEGG:03015	0.0162467151192	0.4	NCBP2 NCBP1	mRNA surveillance pathway
REAC:R-HSA-72165	0.017778070678	0.4	NCBP2 NCBP1	mRNA Splicing - Minor Pathway
REAC:R-HSA-1226099	0.0184727645209	0.4	NCBP2 NCBP1	Signaling by FGFR in disease
REAC:R-HSA-5654738	0.0221443716613	0.4	NCBP2 NCBP1	Signaling by FGFR2
REAC:R-HSA-75955	0.0229182830201	0.4	NCBP2 NCBP1	RNA Polymerase II Transcription Elongation
REAC:R-HSA-112382	0.0229182830201	0.4	NCBP2 NCBP1	Formation of RNA Pol II elongation complex
REAC:R-HSA-73857	0.0251017869848	0.8	NCBP1 CDC40 PHAX NCBP2	RNA Polymerase II Transcription
GO:0006913	0.0252719643298	0.8	NCBP1 CDC40 PHAX NCBP2	nucleocytoplasmic transport
GO:0051169	0.0264249728386	0.8	NCBP1 CDC40 PHAX NCBP2	nuclear transport
REAC:R-HSA-190236	0.0295837500362	0.4	NCBP2 NCBP1	Signaling by FGFR
REAC:R-HSA-167172	0.0332320424718	0.4	NCBP2 NCBP1	Transcription of the HIV genome
REAC:R-HSA-74160	0.038571388232	0.8	NCBP1 CDC40 PHAX NCBP2	Gene expression (Transcription)
REAC:R-HSA-674695	0.0443461879505	0.4	NCBP2 NCBP1	RNA Polymerase II Pre-transcription Events
GO:0042795	0.0493791608738	0.6	NCBP2 PHAX NCBP1	snRNA transcription by RNA polymerase II
CORUM:1190	0.0499494897235	0.2	NCBP1	NCBP-NIP1 complex

Edges

Protein 1	Protein 2	Score	Precision	Evidence
NCBP2	PHAX	0.093	0.355	hein_WMM youn (NCBP2) bioplex_WMM youn_WMM hein (NCBP2)
NCBP2	NCBP1	0.048	0.293	hein_WMM youn (NCBP2) bioplex_WMM Guru youn_WMM hein (NCBP1,NCBP2) fraction
NCBP1	PHAX	0.026	0.22	hein_WMM bioplex_WMM youn_WMM hein (NCBP1,PHAX) gupta_WMM
CDC40	NCBP1	0.026	0.218	bioplex_WMM Guru youn_WMM fraction treiber_WMM
NCBP2	LENG1	0.023	0.208	hein_WMM hein (NCBP2)
CDC40	NCBP2	0.008	0.086	bioplex_WMM WMM_only
LENG1	PHAX	0.007	0.003	hein_WMM youn_WMM WMM_only
CDC40	LENG1	0.007	0.001	youn_WMM WMM_only
NCBP1	LENG1	0.007	0.004	hein_WMM youn_WMM WMM_only
CDC40	PHAX	0.0	0.0	bioplex_WMM youn_WMM fraction

Images

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Complex HuMAP2_06019 has an average edge precision of 0.139 which is ranked 6784 out of all 6965 complexes.

Related Complexes

Genename	Complexes
CDC40	HuMAP2_00326 HuMAP2_01472 HuMAP2_03672 HuMAP2_04055 HuMAP2_05530 HuMAP2_06019 HuMAP2_06944
NCBP2	HuMAP2_00359 HuMAP2_00427 HuMAP2_01066 HuMAP2_06019 HuMAP2_06262 HuMAP2_06277 HuMAP2_06561
NCBP1	HuMAP2_00427 HuMAP2_01066 HuMAP2_06019 HuMAP2_06277
PHAX	HuMAP2_00427 HuMAP2_06019 HuMAP2_06277
LENG1	HuMAP2_00427 HuMAP2_06019 HuMAP2_06277

hu.MAP 2.0: Complex View

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Complex: HuMAP2_06019