hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_06022

Confidence: Medium

Genename	Protein Name	Links
AMER1	APC membrane recruitment protein 1 (Amer1) (Protein FAM123B) (Wilms tumor gene on the X chromosome protein)	UniProt NCBI
CDH1	Cadherin-1 (CAM 120/80) (Epithelial cadherin) (E-cadherin) (Uvomorulin) (CD antigen CD324) [Cleaved into: E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3]	UniProt NCBI
CDH2	Cadherin-2 (CDw325) (Neural cadherin) (N-cadherin) (CD antigen CD325)	UniProt NCBI
AXIN1	Axin-1 (Axis inhibition protein 1) (hAxin)	UniProt NCBI
APC	Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5)	UniProt NCBI
CDH3	Cadherin-3 (Placental cadherin) (P-cadherin)	UniProt NCBI
CTNNA3	Catenin alpha-3 (Alpha T-catenin) (Cadherin-associated protein)	UniProt NCBI
CDH12	Cadherin-12 (Brain cadherin) (BR-cadherin) (Neural type cadherin 2) (N-cadherin 2)	UniProt NCBI
CDH4	Cadherin-4 (Retinal cadherin) (R-CAD) (R-cadherin)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0016342	2.06331179847e-11	0.666666666667	APC CDH4 CDH3 CDH1 CDH2 CDH12	catenin complex
REAC:R-HSA-418990	3.30352397046e-10	0.555555555556	CDH2 CDH1 CDH12 CDH3 CDH4	Adherens junctions interactions
GO:0005913	3.81307899109e-10	0.777777777778	CTNNA3 CDH12 CDH4 CDH2 CDH1 CDH3 APC	cell-cell adherens junction
REAC:R-HSA-421270	4.42710587603e-09	0.555555555556	CDH2 CDH1 CDH12 CDH3 CDH4	Cell-cell junction organization
GO:0008013	2.05828779234e-08	0.666666666667	CTNNA3 APC AMER1 CDH1 CDH2 AXIN1	beta-catenin binding
WP:WP4540	4.48427962261e-08	0.555555555556	CDH2 CDH1 CDH12 CDH3 CDH4	Pathways Regulating Hippo Signaling
REAC:R-HSA-446728	5.27548438946e-08	0.555555555556	CDH2 CDH1 CDH12 CDH3 CDH4	Cell junction organization
WP:WP4541	1.00743310898e-07	0.555555555556	CDH2 CDH1 CDH12 CDH3 CDH4	Hippo-Merlin Signaling Dysregulation
GO:0007043	1.82138454758e-07	0.666666666667	APC CDH4 CDH3 CDH1 CDH2 CDH12	cell-cell junction assembly
GO:0016339	2.43442094601e-07	0.555555555556	CDH2 CDH1 CDH12 CDH3 CDH4	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
GO:0044331	3.32834717277e-07	0.555555555556	CDH2 CDH1 CDH12 CDH3 CDH4	cell-cell adhesion mediated by cadherin
REAC:R-HSA-1500931	3.52161923781e-07	0.555555555556	CDH2 CDH1 CDH12 CDH3 CDH4	Cell-Cell communication
GO:0045216	5.83332926163e-07	0.666666666667	APC CDH4 CDH3 CDH1 CDH2 CDH12	cell-cell junction organization
GO:0005911	1.09484694777e-06	0.777777777778	CTNNA3 CDH12 CDH4 CDH2 CDH1 CDH3 APC	cell-cell junction
GO:0019897	1.21321601902e-06	0.666666666667	APC CDH4 CDH3 CDH1 CDH2 CDH12	extrinsic component of plasma membrane
KEGG:05213	1.22519009449e-06	0.444444444444	CDH1 APC AXIN1 CTNNA3	Endometrial cancer
WP:WP4155	2.02177194243e-06	0.444444444444	CDH1 APC AXIN1 CTNNA3	Endometrial cancer
GO:0007156	4.2717666465e-06	0.555555555556	CDH2 CDH1 CDH12 CDH3 CDH4	homophilic cell adhesion via plasma membrane adhesion molecules
REAC:R-HSA-4839744	1.10264957252e-05	0.333333333333	APC AXIN1 AMER1	truncated APC mutants destabilize the destruction complex
REAC:R-HSA-4839735	1.10264957252e-05	0.333333333333	APC AXIN1 AMER1	AXIN mutants destabilize the destruction complex, activating WNT signaling
REAC:R-HSA-5467337	1.10264957252e-05	0.333333333333	APC AXIN1 AMER1	APC truncation mutants have impaired AXIN binding
REAC:R-HSA-5467348	1.10264957252e-05	0.333333333333	APC AXIN1 AMER1	Truncations of AMER1 destabilize the destruction complex
REAC:R-HSA-4839748	1.10264957252e-05	0.333333333333	APC AXIN1 AMER1	AMER1 mutants destabilize the destruction complex
REAC:R-HSA-5467340	1.10264957252e-05	0.333333333333	APC AXIN1 AMER1	AXIN missense mutants destabilize the destruction complex
KEGG:04514	1.25145595549e-05	0.444444444444	CDH2 CDH1 CDH3 CDH4	Cell adhesion molecules (CAMs)
REAC:R-HSA-5339716	1.37789529156e-05	0.333333333333	APC AXIN1 AMER1	Misspliced GSK3beta mutants stabilize beta-catenin
REAC:R-HSA-5358747	1.37789529156e-05	0.333333333333	APC AXIN1 AMER1	S33 mutants of beta-catenin aren't phosphorylated
REAC:R-HSA-5358749	1.37789529156e-05	0.333333333333	APC AXIN1 AMER1	S37 mutants of beta-catenin aren't phosphorylated
REAC:R-HSA-4839743	1.37789529156e-05	0.333333333333	APC AXIN1 AMER1	phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
REAC:R-HSA-5358751	1.37789529156e-05	0.333333333333	APC AXIN1 AMER1	S45 mutants of beta-catenin aren't phosphorylated
REAC:R-HSA-5358752	1.37789529156e-05	0.333333333333	APC AXIN1 AMER1	T41 mutants of beta-catenin aren't phosphorylated
GO:0034329	1.42479377807e-05	0.666666666667	APC CDH4 CDH3 CDH1 CDH2 CDH12	cell junction assembly
REAC:R-HSA-196299	2.05802714271e-05	0.333333333333	APC AXIN1 AMER1	Beta-catenin phosphorylation cascade
KEGG:05226	3.56228964414e-05	0.444444444444	CDH1 APC AXIN1 CTNNA3	Gastric cancer
GO:0034330	3.82130916155e-05	0.666666666667	APC CDH4 CDH3 CDH1 CDH2 CDH12	cell junction organization
CORUM:3004	4.02261743042e-05	0.222222222222	AXIN1 APC	APC-AXIN1-CTNNB1 complex
GO:0019898	4.03666840352e-05	0.666666666667	APC CDH4 CDH3 CDH1 CDH2 CDH12	extrinsic component of membrane
GO:0005912	4.11374402531e-05	0.777777777778	CTNNA3 CDH12 CDH4 CDH2 CDH1 CDH3 APC	adherens junction
GO:0070161	4.8595981113e-05	0.777777777778	CTNNA3 CDH12 CDH4 CDH2 CDH1 CDH3 APC	anchoring junction
KEGG:04390	4.9212345545e-05	0.444444444444	CDH1 APC AXIN1 CTNNA3	Hippo signaling pathway
GO:1904885	7.62415024416e-05	0.333333333333	APC AXIN1 AMER1	beta-catenin destruction complex assembly
CORUM:6353	8.0427137187e-05	0.222222222222	AXIN1 APC	beta-Catenin destruction complex
CORUM:3166	8.0427137187e-05	0.222222222222	AXIN1 APC	AXIN1-APC-CTNNB1-GSK3B complex
GO:0034332	0.00011242670706	0.555555555556	CDH2 CDH1 CDH12 CDH3 CDH4	adherens junction organization
REAC:R-HSA-4791275	0.00012239415243	0.333333333333	APC AXIN1 AMER1	Signaling by WNT in cancer
REAC:R-HSA-4641262	0.00012239415243	0.333333333333	APC AXIN1 AMER1	Disassembly of the destruction complex and recruitment of AXIN to the membrane
GO:0098742	0.000298608290977	0.555555555556	CDH2 CDH1 CDH12 CDH3 CDH4	cell-cell adhesion via plasma-membrane adhesion molecules
GO:0045296	0.000359723071507	0.666666666667	CTNNA3 CDH12 CDH4 CDH3 CDH1 CDH2	cadherin binding
WP:WP2064	0.000628245131475	0.333333333333	CDH1 AXIN1 CDH2	Neural Crest Differentiation
GO:0030054	0.000715760481065	0.777777777778	CTNNA3 CDH12 CDH4 CDH2 CDH1 CDH3 APC	cell junction
GO:0045295	0.00125570522129	0.333333333333	CDH1 APC CDH2	gamma-catenin binding
GO:0098797	0.00137640098394	0.666666666667	APC CDH4 CDH3 CDH1 CDH2 CDH12	plasma membrane protein complex
WP:WP3859	0.00203255436892	0.222222222222	CDH1 CDH2	TGF-B Signaling in Thyroid Cells for Epithelial-Mesenchymal Transition
GO:0050839	0.00257185346749	0.666666666667	CTNNA3 CDH12 CDH4 CDH3 CDH1 CDH2	cell adhesion molecule binding
REAC:R-HSA-195253	0.00262805592471	0.333333333333	APC AXIN1 AMER1	Degradation of beta-catenin by the destruction complex
WP:WP3664	0.00263099189183	0.222222222222	AXIN1 APC	Regulation of Wnt/B-catenin Signaling by Small Molecule Compounds
GO:0007155	0.00370838881787	0.777777777778	CTNNA3 CDH12 CDH4 CDH2 CDH1 CDH3 APC	cell adhesion
GO:0022610	0.00388870361722	0.777777777778	CTNNA3 CDH12 CDH4 CDH2 CDH1 CDH3 APC	biological adhesion
KEGG:05200	0.0053385061568	0.444444444444	CDH1 APC AXIN1 CTNNA3	Pathways in cancer
GO:0098609	0.00541933383372	0.666666666667	CTNNA3 CDH12 CDH4 CDH3 CDH1 CDH2	cell-cell adhesion
WP:000000	0.00566194757866	1.0	CTNNA3 CDH12 CDH4 AMER1 CDH2 CDH1 CDH3 AXIN1 APC	WIKIPATHWAYS
WP:WP2870	0.00578912212965	0.222222222222	AXIN1 APC	Extracellular vesicle-mediated signaling in recipient cells
HP:0006572	0.00629966976086	0.222222222222	AXIN1 APC	Subacute progressive viral hepatitis
HP:0200040	0.00809703709436	0.222222222222	CDH1 APC	Epidermoid cyst
GO:1904886	0.00865220447533	0.333333333333	APC AXIN1 AMER1	beta-catenin destruction complex disassembly
GO:0005509	0.0124957886572	0.555555555556	CDH2 CDH1 CDH12 CDH3 CDH4	calcium ion binding
HP:0031105	0.0151837461583	0.333333333333	CDH1 AXIN1 APC	Abnormal uterus morphology
HP:0006562	0.0175215982818	0.222222222222	AXIN1 APC	Viral hepatitis
REAC:R-HSA-525793	0.0192586333795	0.222222222222	CDH4 CDH2	Myogenesis
GO:0042803	0.0193514179379	0.666666666667	AXIN1 CDH4 CDH3 CDH1 CDH2 CDH12	protein homodimerization activity
GO:0016328	0.0196973219908	0.333333333333	CDH1 AXIN1 APC	lateral plasma membrane
HP:0025245	0.0204354580639	0.222222222222	CDH1 APC	Cutaneous cyst
WP:WP363	0.0225232351461	0.222222222222	AXIN1 APC	Wnt Signaling Pathway
KEGG:05217	0.0251525923213	0.222222222222	AXIN1 APC	Basal cell carcinoma
HP:0001413	0.0305121976344	0.222222222222	AXIN1 APC	Micronodular cirrhosis
WP:WP3680	0.0372407964212	0.222222222222	AXIN1 APC	Association Between Physico-Chemical Features and Toxicity Associated Pathways
KEGG:04520	0.0381609675213	0.222222222222	CDH1 CTNNA3	Adherens junction
KEGG:05412	0.041537807514	0.222222222222	CTNNA3 CDH2	Arrhythmogenic right ventricular cardiomyopathy (ARVC)
REAC:R-HSA-111465	0.0425936191784	0.222222222222	CDH1 APC	Apoptotic cleavage of cellular proteins
KEGG:05100	0.0426944930847	0.222222222222	CDH1 CTNNA3	Bacterial invasion of epithelial cells
HP:0000670	0.0435861607848	0.333333333333	CDH1 APC CDH3	Carious teeth
GO:0008092	0.0444700914144	0.666666666667	APC CDH4 CDH3 CDH1 CDH2 CDH12	cytoskeletal protein binding
WP:WP2118	0.0446506170878	0.222222222222	CTNNA3 CDH2	Arrhythmogenic Right Ventricular Cardiomyopathy
WP:WP4216	0.0472664972196	0.222222222222	AXIN1 APC	Chromosomal and microsatellite instability in colorectal cancer
HP:0001428	0.0474589469464	0.333333333333	CDH1 AXIN1 APC	Somatic mutation
CORUM:2968	0.0499262710315	0.111111111111	AXIN1	Axin-SMAD3 complex
CORUM:1909	0.0499262710315	0.111111111111	APC	APC-DLG4 complex
CORUM:933	0.0499262710315	0.111111111111	APC	SCRIB-APC complex
CORUM:5281	0.0499262710315	0.111111111111	CDH1	Cell-cell junction complex (CDH1-CTNNB1)
CORUM:5319	0.0499262710315	0.111111111111	CDH1	CDH1-CKS1B complex
CORUM:5320	0.0499262710315	0.111111111111	CDH1	CDH1-SKP2 complex
CORUM:6269	0.0499262710315	0.111111111111	CDH2	DLL1-CTNNB1-CDH2 complex
CORUM:3168	0.0499262710315	0.111111111111	AXIN1	DAXX-AXIN complex
CORUM:1844	0.0499262710315	0.111111111111	APC	APC-IQGAP1 complex

Edges

Protein 1	Protein 2	Score	Precision	Evidence
CTNNA3	CDH4	0.998	0.939	bioplex (CTNNA3) bioplex_WMM
CTNNA3	CDH3	0.882	0.817	bioplex (CTNNA3) bioplex_WMM
CTNNA3	CDH12	0.722	0.732	bioplex (CTNNA3) bioplex_WMM
CTNNA3	CDH1	0.435	0.579	bioplex (CTNNA3) bioplex_WMM
CTNNA3	APC	0.145	0.408	bioplex (CTNNA3) bioplex_WMM
AMER1	APC	0.144	0.406	hein_WMM bioplex_WMM youn_WMM hein (APC)
CTNNA3	CDH2	0.083	0.349	bioplex (CTNNA3) bioplex_WMM
AXIN1	AMER1	0.031	0.24	hein_WMM hein (AXIN1)
AXIN1	APC	0.029	0.233	hein_WMM hein (APC,AXIN1) gupta_WMM
CDH12	CDH4	0.009	0.095	bioplex_WMM WMM_only
CDH2	CDH1	0.008	0.094	bioplex_WMM WMM_only
CDH4	CDH3	0.008	0.091	bioplex_WMM WMM_only
CDH12	CDH3	0.008	0.091	bioplex_WMM WMM_only
CDH4	CDH1	0.008	0.085	bioplex_WMM WMM_only
CDH12	CDH1	0.008	0.085	bioplex_WMM WMM_only
CDH3	CDH1	0.008	0.06	bioplex_WMM WMM_only
CDH4	APC	0.008	0.042	bioplex_WMM WMM_only
CDH12	APC	0.008	0.042	bioplex_WMM WMM_only
CDH12	AMER1	0.008	0.033	bioplex_WMM WMM_only
CDH4	AMER1	0.008	0.033	bioplex_WMM WMM_only
CDH3	APC	0.008	0.014	bioplex_WMM WMM_only
CDH3	AMER1	0.008	0.01	bioplex_WMM WMM_only
CDH1	APC	0.007	0.006	bioplex_WMM WMM_only
CDH1	AMER1	0.007	0.016	bioplex_WMM WMM_only
CDH12	CDH2	0.007	0.016	bioplex_WMM WMM_only
CDH4	CDH2	0.007	0.016	bioplex_WMM WMM_only
CDH3	CDH2	0.007	0.008	bioplex_WMM WMM_only
CDH2	APC	0.007	0.006	bioplex_WMM WMM_only
CDH2	AMER1	0.006	0.006	bioplex_WMM WMM_only
CTNNA3	AMER1	0.004	0.011	bioplex (CTNNA3) bioplex_WMM

Images

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Complex HuMAP2_06022 has an average edge precision of 0.185 which is ranked 6369 out of all 6965 complexes.

Related Complexes

Genename	Complexes
AMER1	HuMAP2_02274 HuMAP2_04643 HuMAP2_05355 HuMAP2_06022
CDH1	HuMAP2_01324 HuMAP2_01868 HuMAP2_02274 HuMAP2_02710 HuMAP2_04643 HuMAP2_04810 HuMAP2_05168 HuMAP2_06022
CDH2	HuMAP2_00477 HuMAP2_00625 HuMAP2_04278 HuMAP2_04643 HuMAP2_06022
AXIN1	HuMAP2_00965 HuMAP2_02771 HuMAP2_04332 HuMAP2_04384 HuMAP2_04643 HuMAP2_05355 HuMAP2_06022 HuMAP2_06340
APC	HuMAP2_02274 HuMAP2_04643 HuMAP2_05355 HuMAP2_06022
CDH3	HuMAP2_00477 HuMAP2_00625 HuMAP2_02259 HuMAP2_05748 HuMAP2_05798 HuMAP2_06022
CTNNA3	HuMAP2_00477 HuMAP2_00625 HuMAP2_02259 HuMAP2_02274 HuMAP2_04278 HuMAP2_04643 HuMAP2_05168 HuMAP2_06022
CDH12	HuMAP2_00477 HuMAP2_00625 HuMAP2_02259 HuMAP2_04278 HuMAP2_04643 HuMAP2_06022
CDH4	HuMAP2_00477 HuMAP2_00625 HuMAP2_02259 HuMAP2_04278 HuMAP2_04643 HuMAP2_06022

hu.MAP 2.0: Complex View

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Complex: HuMAP2_06022