hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06032
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| GNAS | Neuroendocrine secretory protein 55 (NESP55) [Cleaved into: LHAL tetrapeptide; GPIPIRRH peptide] | UniProt NCBI |
| OCIAD1 | OCIA domain-containing protein 1 (Ovarian cancer immunoreactive antigen domain containing 1) (Ovarian carcinoma immunoreactive antigen) | UniProt NCBI |
| TRO | Trophinin (MAGE-D3 antigen) | UniProt NCBI |
| GNA12 | Guanine nucleotide-binding protein subunit alpha-12 (G alpha-12) (G-protein subunit alpha-12) | UniProt NCBI |
| GNAL | Guanine nucleotide-binding protein G(olf) subunit alpha (Adenylate cyclase-stimulating G alpha protein, olfactory type) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP35 | 7.07040269841e-05 | 0.6 | GNAS GNAL GNA12 | G Protein Signaling Pathways |
| GO:0031683 | 0.000507918241599 | 0.6 | GNAS GNAL GNA12 | G-protein beta/gamma-subunit complex binding |
| HP:0012049 | 0.00208920255027 | 0.4 | GNAS GNAL | Laryngeal dystonia |
| GO:0005834 | 0.00235581550516 | 0.6 | GNAS GNAL GNA12 | heterotrimeric G-protein complex |
| GO:1905360 | 0.00235581550516 | 0.6 | GNAS GNAL GNA12 | GTPase complex |
| KEGG:04730 | 0.00587609842855 | 0.4 | GNAS GNA12 | Long-term depression |
| WP:WP2032 | 0.00688743357746 | 0.4 | GNAS GNA12 | Human Thyroid Stimulating Hormone (TSH) signaling pathway |
| WP:WP4540 | 0.0123508080289 | 0.4 | GNAS GNAL | Pathways Regulating Hippo Signaling |
| KEGG:05146 | 0.0151578406027 | 0.4 | GNAS GNAL | Amoebiasis |
| KEGG:05142 | 0.0162467151192 | 0.4 | GNAS GNAL | Chagas disease (American trypanosomiasis) |
| KEGG:04928 | 0.0197369504817 | 0.4 | GNAS GNA12 | Parathyroid hormone synthesis, secretion and action |
| KEGG:04270 | 0.0205580217111 | 0.4 | GNAS GNA12 | Vascular smooth muscle contraction |
| KEGG:04728 | 0.030676003082 | 0.4 | GNAS GNAL | Dopaminergic synapse |
| KEGG:04072 | 0.0332521613209 | 0.4 | GNAS GNA12 | Phospholipase D signaling pathway |
| CORUM:3110 | 0.0499494897235 | 0.2 | GNA12 | ITGAV-P2RY2-GNA12 complex |
| CORUM:7097 | 0.0499494897235 | 0.2 | GNAS | GNAS-L-GNB1-GNG1 complex |
| CORUM:7143 | 0.0499494897235 | 0.2 | GNAS | GNAS-L-GNB2-GNG1 complex |
| CORUM:7144 | 0.0499494897235 | 0.2 | GNAS | GNAS-L-GNB3-GNG1 complex |
| CORUM:7145 | 0.0499494897235 | 0.2 | GNAS | GNAS-L-GNB4-GNG1 complex |
| CORUM:7146 | 0.0499494897235 | 0.2 | GNAS | GNAS-L-GNB1-GNG1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| GNAS | GNAL | 1.0 | 0.949 | bioplex (GNAS) bioplex_WMM gupta_WMM boldt_WMM |
| GNAS | OCIAD1 | 0.602 | 0.67 | bioplex (GNAS) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| GNAS | GNA12 | 0.296 | 0.496 | bioplex (GNAS) bioplex_WMM |
| GNAS | TRO | 0.129 | 0.399 | bioplex (GNAS) bioplex_WMM youn_WMM |
| GNAL | GNA12 | 0.009 | 0.1 | bioplex_WMM WMM_only |
| GNAL | TRO | 0.008 | 0.019 | bioplex_WMM WMM_only |
| GNA12 | TRO | 0.007 | 0.013 | bioplex_WMM WMM_only |
| GNAL | OCIAD1 | 0.007 | 0.008 | bioplex_WMM WMM_only |
| OCIAD1 | GNA12 | 0.007 | 0.008 | bioplex_WMM WMM_only |
| OCIAD1 | TRO | 0.006 | 0.004 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_06032 has an average edge precision of 0.267 which is ranked 5101 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| GNAS | HuMAP2_00029 HuMAP2_00231 HuMAP2_03216 HuMAP2_04786 HuMAP2_06032 |
| OCIAD1 | HuMAP2_00029 HuMAP2_03216 HuMAP2_06032 |
| TRO | HuMAP2_03216 HuMAP2_06032 |
| GNA12 | HuMAP2_03216 HuMAP2_06032 HuMAP2_06727 |
| GNAL | HuMAP2_00029 HuMAP2_00231 HuMAP2_03216 HuMAP2_04786 HuMAP2_06032 |