hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06034
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| NADK2 | NAD kinase 2, mitochondrial (EC 2.7.1.23) (Mitochondrial NAD kinase) (NAD kinase domain-containing protein 1, mitochondrial) | UniProt NCBI |
| STRADB | STE20-related kinase adapter protein beta (STRAD beta) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein) (CALS-21) (ILP-interacting protein) (Pseudokinase ALS2CR2) | UniProt NCBI |
| STRADA | STE20-related kinase adapter protein alpha (STRAD alpha) (STE20-related adapter protein) (Serologically defined breast cancer antigen NY-BR-96) | UniProt NCBI |
| STK11 | Serine/threonine-protein kinase STK11 (EC 2.7.11.1) (Liver kinase B1) (LKB1) (hLKB1) (Renal carcinoma antigen NY-REN-19) | UniProt NCBI |
| CAB39 | Calcium-binding protein 39 (MO25alpha) (Protein Mo25) | UniProt NCBI |
| MVD | Diphosphomevalonate decarboxylase (EC 4.1.1.33) (Mevalonate (diphospho)decarboxylase) (MDDase) (Mevalonate pyrophosphate decarboxylase) | UniProt NCBI |
| CAB39L | Calcium-binding protein 39-like (Antigen MLAA-34) (MO25beta) (Mo25-like protein) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-380972 | 5.64001821847e-11 | 0.714285714286 | STRADB STRADA CAB39 CAB39L STK11 | Energy dependent regulation of mTOR by LKB1-AMPK |
| REAC:R-HSA-165159 | 3.30003828923e-10 | 0.714285714286 | STRADB STRADA CAB39 CAB39L STK11 | mTOR signalling |
| CORUM:6053 | 3.38154272427e-09 | 0.428571428571 | STRADA STK11 CAB39 | LKB1-STRAD-MO25 complex |
| KEGG:04152 | 2.39024614212e-08 | 0.714285714286 | STRADB STRADA CAB39 CAB39L STK11 | AMPK signaling pathway |
| KEGG:04150 | 8.53938355673e-08 | 0.714285714286 | STRADB STRADA CAB39 CAB39L STK11 | mTOR signaling pathway |
| WP:WP1403 | 5.7157777521e-07 | 0.571428571429 | STRADA STRADB STK11 CAB39 | AMP-activated Protein Kinase (AMPK) Signaling |
| WP:WP3595 | 0.000150938581911 | 0.285714285714 | STRADB STK11 | mir-124 predicted interactions with cell cycle and differentiation |
| WP:WP3932 | 0.000152413265395 | 0.571428571429 | STRADA CAB39 CAB39L STK11 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| GO:0007050 | 0.000321055197854 | 0.714285714286 | STRADB STRADA CAB39 CAB39L STK11 | cell cycle arrest |
| GO:0016773 | 0.00127532367729 | 0.857142857143 | STRADA CAB39L STK11 STRADB CAB39 NADK2 | phosphotransferase activity, alcohol group as acceptor |
| GO:0016301 | 0.00211480680865 | 0.857142857143 | STRADA CAB39L STK11 STRADB CAB39 NADK2 | kinase activity |
| GO:0016772 | 0.00651861911974 | 0.857142857143 | STRADA CAB39L STK11 STRADB CAB39 NADK2 | transferase activity, transferring phosphorus-containing groups |
| GO:0004674 | 0.00891451540705 | 0.714285714286 | STRADB STRADA CAB39 CAB39L STK11 | protein serine/threonine kinase activity |
| GO:0045786 | 0.0387059497805 | 0.714285714286 | STRADB STRADA CAB39 CAB39L STK11 | negative regulation of cell cycle |
| GO:0004672 | 0.0406938796461 | 0.714285714286 | STRADB STRADA CAB39 CAB39L STK11 | protein kinase activity |
| WP:WP4189 | 0.0499886427319 | 0.142857142857 | MVD | Mevalonate arm of cholesterol biosynthesis pathway with inhibitors |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CAB39L | CAB39 | 0.992 | 0.912 | bioplex (CAB39L) bioplex_WMM |
| STRADA | STK11 | 0.976 | 0.889 | bioplex (STK11) bioplex_WMM |
| CAB39 | STRADB | 0.907 | 0.83 | bioplex (STRADB) bioplex_WMM |
| CAB39L | STRADA | 0.893 | 0.819 | bioplex (CAB39L) bioplex_WMM |
| STK11 | STRADB | 0.602 | 0.671 | bioplex (STK11,STRADB) bioplex_WMM |
| STK11 | CAB39 | 0.09 | 0.354 | bioplex (STK11) bioplex_WMM |
| CAB39 | MVD | 0.037 | 0.265 | fraction |
| NADK2 | MVD | 0.03 | 0.235 | fraction |
| CAB39L | STK11 | 0.029 | 0.231 | bioplex (CAB39L) bioplex_WMM |
| CAB39L | MVD | 0.023 | 0.208 | fraction |
| STRADA | CAB39 | 0.012 | 0.15 | bioplex_WMM WMM_only |
| STRADA | STRADB | 0.008 | 0.038 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_06034 has an average edge precision of 0.467 which is ranked 2734 out of all 6965 complexes.
Related Complexes