hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06036
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PRUNE2 | Protein prune homolog 2 (BNIP2 motif-containing molecule at the C-terminal region 1) | UniProt NCBI |
| SRC | Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src) | UniProt NCBI |
| ACBD7 | Acyl-CoA-binding domain-containing protein 7 | UniProt NCBI |
| FYN | Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene Syn) (Proto-oncogene c-Fyn) (Src-like kinase) (SLK) (p59-Fyn) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4357 | 0.000387405527127 | 0.5 | SRC FYN | NRF2-ARE regulation |
| WP:WP2332 | 0.00124082421052 | 0.5 | SRC FYN | Interleukin-11 Signaling Pathway |
| WP:WP2203 | 0.00137286558226 | 0.5 | SRC FYN | Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway |
| WP:WP286 | 0.00144137960059 | 0.5 | SRC FYN | IL-3 Signaling Pathway |
| WP:WP304 | 0.00257484178538 | 0.5 | SRC FYN | Kit receptor signaling pathway |
| WP:WP2037 | 0.00450871467598 | 0.5 | SRC FYN | Prolactin Signaling Pathway |
| WP:WP2034 | 0.00450871467598 | 0.5 | SRC FYN | Leptin signaling pathway |
| WP:WP4298 | 0.0046318251922 | 0.5 | SRC FYN | Viral Acute Myocarditis |
| KEGG:04520 | 0.00467243468204 | 0.5 | SRC FYN | Adherens junction |
| WP:WP185 | 0.0071289861505 | 0.5 | SRC FYN | Integrin-mediated Cell Adhesion |
| REAC:R-HSA-1227986 | 0.00862684444961 | 0.5 | SRC FYN | Signaling by ERBB2 |
| REAC:R-HSA-2219530 | 0.00991669978918 | 0.5 | SRC FYN | Constitutive Signaling by Aberrant PI3K in Cancer |
| WP:WP4549 | 0.0109018647515 | 0.5 | SRC FYN | Fragile X Syndrome |
| KEGG:04611 | 0.0121132892553 | 0.5 | SRC FYN | Platelet activation |
| WP:WP2380 | 0.0152387809455 | 0.5 | SRC FYN | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| REAC:R-HSA-6811558 | 0.0234490216385 | 0.5 | SRC FYN | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
| REAC:R-HSA-2219528 | 0.0248339118539 | 0.5 | SRC FYN | PI3K/AKT Signaling in Cancer |
| KEGG:04360 | 0.0267154932054 | 0.5 | SRC FYN | Axon guidance |
| GO:1903997 | 0.0270421395626 | 0.5 | SRC FYN | positive regulation of non-membrane spanning protein tyrosine kinase activity |
| REAC:R-HSA-199418 | 0.0284687652941 | 0.5 | SRC FYN | Negative regulation of the PI3K/AKT network |
| WP:WP306 | 0.0290430519819 | 0.5 | SRC FYN | Focal Adhesion |
| KEGG:04510 | 0.0350038155474 | 0.5 | SRC FYN | Focal adhesion |
| WP:WP3888 | 0.0393304030404 | 0.5 | SRC FYN | VEGFA-VEGFR2 Signaling Pathway |
| GO:1903995 | 0.0405595771497 | 0.5 | SRC FYN | regulation of non-membrane spanning protein tyrosine kinase activity |
| WP:WP3943 | 0.0416857670091 | 0.25 | SRC | Robo4 and VEGF Signaling Pathways Crosstalk |
| CORUM:2073 | 0.0499140284799 | 0.25 | SRC | TNFRSF11A-TRAF6-SRC complex |
| CORUM:2351 | 0.0499140284799 | 0.25 | FYN | ITGB6-FYN-FN1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| SRC | FYN | 0.397 | 0.557 | bioplex (FYN) bioplex_WMM |
| FYN | PRUNE2 | 0.023 | 0.211 | bioplex (PRUNE2) bioplex_WMM |
| SRC | ACBD7 | 0.022 | 0.205 | bioplex (ACBD7) bioplex_WMM |
| SRC | PRUNE2 | 0.021 | 0.185 | bioplex (PRUNE2) bioplex_WMM |
| FYN | ACBD7 | 0.008 | 0.067 | bioplex (ACBD7) bioplex_WMM |
Images
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Complex HuMAP2_06036 has an average edge precision of 0.245 which is ranked 5459 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| PRUNE2 | HuMAP2_02828 HuMAP2_06036 |
| SRC | HuMAP2_00821 HuMAP2_02828 HuMAP2_06036 |
| ACBD7 | HuMAP2_02828 HuMAP2_06036 |
| FYN | HuMAP2_00821 HuMAP2_02828 HuMAP2_04012 HuMAP2_06036 |