hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06039
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| MAP1S | Microtubule-associated protein 1S (MAP-1S) (BPY2-interacting protein 1) (Microtubule-associated protein 8) (Variable charge Y chromosome 2-interacting protein 1) (VCY2-interacting protein 1) (VCY2IP-1) [Cleaved into: MAP1S heavy chain; MAP1S light chain] | UniProt NCBI |
| STK4 | Serine/threonine-protein kinase 4 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 1) (MST-1) (STE20-like kinase MST1) (Serine/threonine-protein kinase Krs-2) [Cleaved into: Serine/threonine-protein kinase 4 37kDa subunit (MST1/N); Serine/threonine-protein kinase 4 18kDa subunit (MST1/C)] | UniProt NCBI |
| STK3 | Serine/threonine-protein kinase 3 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 2) (MST-2) (STE20-like kinase MST2) (Serine/threonine-protein kinase Krs-1) [Cleaved into: Serine/threonine-protein kinase 3 36kDa subunit (MST2/N); Serine/threonine-protein kinase 3 20kDa subunit (MST2/C)] | UniProt NCBI |
| RASSF1 | Ras association domain-containing protein 1 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6716 | 1.50819606993e-05 | 0.5 | STK4 STK3 | DLG5-MST1-MST2 complex |
| WP:WP4537 | 0.000318702346676 | 0.5 | RASSF1 STK3 | Hippo-Yap signaling pathway |
| KEGG:04392 | 0.000649790903665 | 0.5 | RASSF1 STK3 | Hippo signaling pathway - multiple species |
| REAC:R-HSA-2028269 | 0.00171688133139 | 0.5 | STK4 STK3 | Signaling by Hippo |
| WP:WP3959 | 0.00248310593375 | 0.5 | RASSF1 STK3 | DNA IR-Double Strand Breaks (DSBs) and cellular response via ATM |
| KEGG:05223 | 0.00401698930658 | 0.5 | STK4 RASSF1 | Non-small cell lung cancer |
| WP:WP4255 | 0.00403274972955 | 0.5 | STK4 RASSF1 | Non-small cell lung cancer |
| WP:WP4223 | 0.0197782099748 | 0.5 | STK4 RASSF1 | Ras Signaling |
| KEGG:04390 | 0.0198080875546 | 0.5 | RASSF1 STK3 | Hippo signaling pathway |
| KEGG:04014 | 0.0331864260111 | 0.5 | STK4 RASSF1 | Ras signaling pathway |
| WP:WP382 | 0.0393304030404 | 0.5 | STK4 STK3 | MAPK Signaling Pathway |
| CORUM:6403 | 0.0499140284799 | 0.25 | STK4 | MST1-SAV1 complex |
| CORUM:6404 | 0.0499140284799 | 0.25 | STK3 | MST2-SAV1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| RASSF1 | STK4 | 1.0 | 0.949 | hein_WMM bioplex (RASSF1) bioplex_WMM hein (RASSF1) |
| STK4 | STK3 | 1.0 | 0.949 | hein_WMM bioplex_WMM boldt youn_WMM Malo gupta_WMM fraction boldt_WMM |
| RASSF1 | STK3 | 0.999 | 0.949 | hein_WMM bioplex (RASSF1) bioplex_WMM hein (RASSF1) |
| MAP1S | RASSF1 | 0.995 | 0.923 | hein_WMM bioplex (RASSF1) bioplex_WMM hein (RASSF1) |
| MAP1S | STK4 | 0.009 | 0.104 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| MAP1S | STK3 | 0.008 | 0.088 | hein_WMM bioplex_WMM youn_WMM WMM_only |
Images
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Complex HuMAP2_06039 has an average edge precision of 0.66 which is ranked 1593 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| MAP1S | HuMAP2_02203 HuMAP2_05929 HuMAP2_06039 |
| STK4 | HuMAP2_02757 HuMAP2_03087 HuMAP2_05897 HuMAP2_05914 HuMAP2_06039 HuMAP2_06856 |
| STK3 | HuMAP2_02757 HuMAP2_03087 HuMAP2_05897 HuMAP2_05914 HuMAP2_06039 HuMAP2_06856 |
| RASSF1 | HuMAP2_02203 HuMAP2_02757 HuMAP2_05914 HuMAP2_05929 HuMAP2_06039 |