hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_06044

Confidence: Medium High

Genename	Protein Name	Links
VTI1B	Vesicle transport through interaction with t-SNAREs homolog 1B (Vesicle transport v-SNARE protein Vti1-like 1) (Vti1-rp1)	UniProt NCBI
PTTG1IP	Pituitary tumor-transforming gene 1 protein-interacting protein (Pituitary tumor-transforming gene protein-binding factor) (PBF) (PTTG-binding factor)	UniProt NCBI
NAPG	Gamma-soluble NSF attachment protein (SNAP-gamma) (N-ethylmaleimide-sensitive factor attachment protein gamma)	UniProt NCBI
SNAP23	Synaptosomal-associated protein 23 (SNAP-23) (Vesicle-membrane fusion protein SNAP-23)	UniProt NCBI
STX16	Syntaxin-16 (Syn16)	UniProt NCBI
STX8	Syntaxin-8	UniProt NCBI
STX7	Syntaxin-7	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
KEGG:04130	3.62035496321e-11	0.714285714286	SNAP23 VTI1B STX7 STX8 STX16	SNARE interactions in vesicular transport
GO:0031201	2.15953733604e-10	0.857142857143	STX16 NAPG STX8 SNAP23 STX7 VTI1B	SNARE complex
GO:0000149	1.3364284564e-08	0.857142857143	STX16 NAPG STX8 SNAP23 STX7 VTI1B	SNARE binding
GO:0005484	2.44468179357e-08	0.714285714286	SNAP23 VTI1B STX7 STX8 STX16	SNAP receptor activity
GO:0061025	6.12451997474e-08	0.857142857143	STX16 NAPG STX8 SNAP23 STX7 VTI1B	membrane fusion
GO:0019905	5.41068134386e-07	0.714285714286	STX16 SNAP23 STX7 STX8 NAPG	syntaxin binding
GO:0006906	2.38895426042e-06	0.714285714286	SNAP23 VTI1B STX7 STX8 STX16	vesicle fusion
GO:0090174	3.60213544234e-06	0.714285714286	SNAP23 VTI1B STX7 STX8 STX16	organelle membrane fusion
GO:0048284	1.15614394234e-05	0.714285714286	SNAP23 VTI1B STX7 STX8 STX16	organelle fusion
CORUM:877	0.000100648251269	0.285714285714	STX16 VTI1B	SNARE complex (VAMP4, STX6, STX16, VTI1a, VTI1b)
GO:0048278	0.000138393555724	0.571428571429	STX16 VTI1B STX7 STX8	vesicle docking
GO:0019869	0.000380900357231	0.428571428571	STX8 STX7 VTI1B	chloride channel inhibitor activity
GO:0017081	0.000907263777246	0.428571428571	STX8 STX7 VTI1B	chloride channel regulator activity
GO:0061024	0.00166727147917	0.857142857143	STX16 NAPG STX8 SNAP23 STX7 VTI1B	membrane organization
GO:0016050	0.0018532045628	0.714285714286	SNAP23 VTI1B STX7 STX8 STX16	vesicle organization
GO:0046907	0.00363859974134	1.0	STX16 NAPG STX8 PTTG1IP SNAP23 STX7 VTI1B	intracellular transport
GO:0071705	0.00632623715462	1.0	STX16 NAPG STX8 PTTG1IP SNAP23 STX7 VTI1B	nitrogen compound transport
GO:0008200	0.0115540711621	0.428571428571	STX8 STX7 VTI1B	ion channel inhibitor activity
GO:0098796	0.0126459869113	0.857142857143	STX16 NAPG STX8 SNAP23 STX7 VTI1B	membrane protein complex
GO:0016248	0.0128352677703	0.428571428571	STX8 STX7 VTI1B	channel inhibitor activity
GO:0140056	0.0147440727408	0.571428571429	STX16 VTI1B STX7 STX8	organelle localization by membrane tethering
GO:0051649	0.015479871164	1.0	STX16 NAPG STX8 PTTG1IP SNAP23 STX7 VTI1B	establishment of localization in cell
GO:0006886	0.0180209467821	0.857142857143	NAPG STX16 STX8 PTTG1IP STX7 VTI1B	intracellular protein transport
GO:0071702	0.0180623174395	1.0	STX16 NAPG STX8 PTTG1IP SNAP23 STX7 VTI1B	organic substance transport
GO:0022406	0.0187784910979	0.571428571429	STX16 VTI1B STX7 STX8	membrane docking
REAC:R-HSA-6811438	0.0296729390946	0.285714285714	NAPG STX16	Intra-Golgi traffic
REAC:R-HSA-6811440	0.0338846637816	0.285714285714	NAPG STX16	Retrograde transport at the Trans-Golgi-Network
GO:0051640	0.0371718917346	0.714285714286	SNAP23 VTI1B STX7 STX8 STX16	organelle localization
CORUM:801	0.0499886427319	0.142857142857	SNAP23	SNARE complex (STX2, SNAP23)
CORUM:805	0.0499886427319	0.142857142857	SNAP23	SNARE complex (STX4, SNAP23)
CORUM:820	0.0499886427319	0.142857142857	SNAP23	SNARE complex (STX6, SNAP23)
CORUM:730	0.0499886427319	0.142857142857	SNAP23	SNARE complex (STX4, SNAP23, VAMP1)
CORUM:915	0.0499886427319	0.142857142857	SNAP23	SNARE complex (SNAP23, STX1A)

Edges

Protein 1	Protein 2	Score	Precision	Evidence
STX8	STX7	0.84	0.784	hein_WMM bioplex (STX7) bioplex_WMM youn_WMM gupta_WMM
STX7	PTTG1IP	0.5	0.621	hein_WMM bioplex (STX7) bioplex_WMM
STX8	VTI1B	0.429	0.577	hein_WMM bioplex (VTI1B) bioplex_WMM
NAPG	STX7	0.092	0.355	bioplex (NAPG,STX7) bioplex_WMM
STX16	STX7	0.087	0.352	bioplex (STX7) bioplex_WMM youn_WMM gupta_WMM
VTI1B	STX7	0.084	0.349	hein_WMM bioplex (STX7,VTI1B) bioplex_WMM
STX7	SNAP23	0.071	0.353	bioplex (STX7) bioplex_WMM youn_WMM gupta_WMM
NAPG	VTI1B	0.064	0.35	bioplex (NAPG,VTI1B) bioplex_WMM
NAPG	STX8	0.053	0.301	bioplex (NAPG) bioplex_WMM
STX16	PTTG1IP	0.009	0.108	bioplex_WMM WMM_only
STX8	PTTG1IP	0.009	0.105	hein_WMM bioplex_WMM WMM_only
STX16	STX8	0.009	0.097	bioplex_WMM gupta_WMM WMM_only
STX16	VTI1B	0.008	0.087	bioplex_WMM WMM_only
STX16	NAPG	0.008	0.089	bioplex_WMM WMM_only
VTI1B	PTTG1IP	0.008	0.091	hein_WMM bioplex_WMM WMM_only
NAPG	PTTG1IP	0.008	0.082	bioplex_WMM WMM_only
PTTG1IP	SNAP23	0.008	0.015	bioplex_WMM WMM_only
STX16	SNAP23	0.007	0.005	bioplex_WMM youn_WMM gupta_WMM WMM_only
STX8	SNAP23	0.006	0.004	bioplex_WMM gupta_WMM WMM_only
NAPG	SNAP23	0.005	0.009	bioplex (NAPG) bioplex_WMM
VTI1B	SNAP23	0.004	0.011	bioplex (VTI1B) bioplex_WMM

Images

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Complex HuMAP2_06044 has an average edge precision of 0.226 which is ranked 5762 out of all 6965 complexes.

Related Complexes

Genename	Complexes
VTI1B	HuMAP2_00576 HuMAP2_00644 HuMAP2_05921 HuMAP2_06044
PTTG1IP	HuMAP2_00644 HuMAP2_03346 HuMAP2_05921 HuMAP2_06044
NAPG	HuMAP2_00576 HuMAP2_00644 HuMAP2_05921 HuMAP2_06044
SNAP23	HuMAP2_00644 HuMAP2_03346 HuMAP2_04346 HuMAP2_06044
STX16	HuMAP2_00269 HuMAP2_01117 HuMAP2_01151 HuMAP2_01744 HuMAP2_01973 HuMAP2_02966 HuMAP2_03180 HuMAP2_03346 HuMAP2_03550 HuMAP2_05186 HuMAP2_06044 HuMAP2_06557 HuMAP2_06565
STX8	HuMAP2_00576 HuMAP2_00644 HuMAP2_00837 HuMAP2_05921 HuMAP2_06044
STX7	HuMAP2_00576 HuMAP2_00644 HuMAP2_00837 HuMAP2_03346 HuMAP2_05921 HuMAP2_06044

hu.MAP 2.0: Complex View

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Complex: HuMAP2_06044