hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06049
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| YME1L1 | ATP-dependent zinc metalloprotease YME1L1 (EC 3.4.24.-) (ATP-dependent metalloprotease FtsH1) (Meg-4) (Presenilin-associated metalloprotease) (PAMP) (YME1-like protein 1) | UniProt NCBI |
| CFAP410 | Cilia- and flagella-associated protein 410 (C21orf-HUMF09G8.5) (Leucine-rich repeat-containing protein 76) (YF5/A2) | UniProt NCBI |
| NEK1 | Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (Never in mitosis A-related kinase 1) (NimA-related protein kinase 1) (Renal carcinoma antigen NY-REN-55) | UniProt NCBI |
| TTC25 | Tetratricopeptide repeat protein 25 (TPR repeat protein 25) | UniProt NCBI |
| ARMC4 | Armadillo repeat-containing protein 4 | UniProt NCBI |
| TEKT4 | Tektin-4 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0031815 | 0.000214084736825 | 0.666666666667 | TTC25 NEK1 ARMC4 CFAP410 | Abnormal oral physiology |
| HP:0012206 | 0.000247562723131 | 0.5 | TTC25 ARMC4 CFAP410 | Abnormal sperm motility |
| HP:0012207 | 0.000247562723131 | 0.5 | TTC25 ARMC4 CFAP410 | Reduced sperm motility |
| HP:0002094 | 0.0016225899291 | 0.666666666667 | TTC25 NEK1 ARMC4 CFAP410 | Dyspnea |
| HP:0002087 | 0.00179196473391 | 0.666666666667 | TTC25 NEK1 ARMC4 CFAP410 | Abnormality of the upper respiratory tract |
| HP:0002789 | 0.00275483584429 | 0.5 | TTC25 ARMC4 NEK1 | Tachypnea |
| HP:0000025 | 0.00903835350739 | 0.5 | TTC25 ARMC4 CFAP410 | Functional abnormality of male internal genitalia |
| HP:0002090 | 0.00923202229008 | 0.5 | TTC25 ARMC4 CFAP410 | Pneumonia |
| HP:0012874 | 0.014740486186 | 0.5 | TTC25 ARMC4 CFAP410 | Abnormal male reproductive system physiology |
| HP:0000750 | 0.0184323571644 | 0.666666666667 | TTC25 ARMC4 YME1L1 NEK1 | Delayed speech and language development |
| HP:0000765 | 0.0289490814787 | 0.666666666667 | TTC25 NEK1 ARMC4 CFAP410 | Abnormality of the thorax |
| HP:0002088 | 0.0431284498901 | 0.666666666667 | TTC25 NEK1 ARMC4 CFAP410 | Abnormal lung morphology |
| HP:0030195 | 0.044443111782 | 0.333333333333 | CFAP410 NEK1 | Fatigable weakness of swallowing muscles |
| HP:0025425 | 0.0470489782673 | 0.333333333333 | CFAP410 NEK1 | Laryngospasm |
| HP:0025142 | 0.0492588760355 | 0.666666666667 | TTC25 NEK1 ARMC4 CFAP410 | Constitutional symptom |
| HP:0031603 | 0.0497285764978 | 0.333333333333 | TTC25 ARMC4 | Impaired nasal mucociliary clearance |
| HP:0031602 | 0.0497285764978 | 0.333333333333 | TTC25 ARMC4 | Abnormal mucociliary clearance |
| HP:0012261 | 0.0497285764978 | 0.333333333333 | TTC25 ARMC4 | Abnormal respiratory motile cilium physiology |
| HP:0012263 | 0.0497285764978 | 0.333333333333 | TTC25 ARMC4 | Immotile cilia |
| HP:0012262 | 0.0497285764978 | 0.333333333333 | TTC25 ARMC4 | Abnormal ciliary motility |
| HP:0031456 | 0.0497285764978 | 0.333333333333 | TTC25 ARMC4 | Ectopic pregnancy |
| HP:0040262 | 0.0497285764978 | 0.333333333333 | TTC25 ARMC4 | Glue ear |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| NEK1 | CFAP410 | 0.998 | 0.943 | hein_WMM bioplex_WMM boldt (CFAP410,NEK1) hein (NEK1) gupta_WMM boldt_WMM |
| TTC25 | ARMC4 | 0.124 | 0.397 | bioplex (TTC25) bioplex_WMM |
| NEK1 | TTC25 | 0.102 | 0.366 | bioplex (TTC25) bioplex_WMM |
| NEK1 | TEKT4 | 0.096 | 0.359 | bioplex (TEKT4) bioplex_WMM |
| TTC25 | CFAP410 | 0.068 | 0.348 | bioplex (TTC25) bioplex_WMM |
| TTC25 | YME1L1 | 0.026 | 0.218 | bioplex (TTC25) bioplex_WMM |
| CFAP410 | TEKT4 | 0.009 | 0.101 | bioplex (TEKT4) bioplex_WMM |
| NEK1 | ARMC4 | 0.008 | 0.066 | bioplex_WMM WMM_only |
| CFAP410 | ARMC4 | 0.008 | 0.044 | bioplex_WMM WMM_only |
| ARMC4 | YME1L1 | 0.007 | 0.013 | bioplex_WMM WMM_only |
| NEK1 | YME1L1 | 0.007 | 0.004 | bioplex_WMM WMM_only |
| CFAP410 | YME1L1 | 0.007 | 0.003 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_06049 has an average edge precision of 0.239 which is ranked 5550 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| YME1L1 | HuMAP2_01908 HuMAP2_06049 |
| CFAP410 | HuMAP2_00805 HuMAP2_01908 HuMAP2_02878 HuMAP2_06049 |
| NEK1 | HuMAP2_00805 HuMAP2_01908 HuMAP2_02878 HuMAP2_06049 HuMAP2_06217 |
| TTC25 | HuMAP2_00805 HuMAP2_01908 HuMAP2_06049 |
| ARMC4 | HuMAP2_00805 HuMAP2_01908 HuMAP2_06049 |
| TEKT4 | HuMAP2_02639 HuMAP2_06049 HuMAP2_06178 HuMAP2_06217 HuMAP2_06686 |