hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_06056
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CDKN1A | Cyclin-dependent kinase inhibitor 1 (CDK-interacting protein 1) (Melanoma differentiation-associated protein 6) (MDA-6) (p21) | UniProt NCBI |
| CDKN3 | Cyclin-dependent kinase inhibitor 3 (EC 3.1.3.16) (EC 3.1.3.48) (CDK2-associated dual-specificity phosphatase) (Cyclin-dependent kinase interactor 1) (Cyclin-dependent kinase-interacting protein 2) (Kinase-associated phosphatase) | UniProt NCBI |
| MAPK15 | Mitogen-activated protein kinase 15 (MAP kinase 15) (MAPK 15) (EC 2.7.11.24) (Extracellular signal-regulated kinase 7) (ERK-7) (Extracellular signal-regulated kinase 8) (ERK-8) | UniProt NCBI |
| CCND1 | G1/S-specific cyclin-D1 (B-cell lymphoma 1 protein) (BCL-1) (BCL-1 oncogene) (PRAD1 oncogene) | UniProt NCBI |
| CDKN1B | Cyclin-dependent kinase inhibitor 1B (Cyclin-dependent kinase inhibitor p27) (p27Kip1) | UniProt NCBI |
| CDKN1C | Cyclin-dependent kinase inhibitor 1C (Cyclin-dependent kinase inhibitor p57) (p57Kip2) | UniProt NCBI |
| ZNF2 | Zinc finger protein 2 (Zinc finger protein 2.2) (Zinc finger protein 661) | UniProt NCBI |
| RBL2 | Retinoblastoma-like protein 2 (130 kDa retinoblastoma-associated protein) (p130) (Retinoblastoma-related protein 2) (RBR-2) (pRb2) | UniProt NCBI |
| CDK2 | Cyclin-dependent kinase 2 (EC 2.7.11.22) (Cell division protein kinase 2) (p33 protein kinase) | UniProt NCBI |
| CDKN2C | Cyclin-dependent kinase 4 inhibitor C (Cyclin-dependent kinase 6 inhibitor) (p18-INK4c) (p18-INK6) | UniProt NCBI |
| CCND2 | G1/S-specific cyclin-D2 | UniProt NCBI |
| CCND3 | G1/S-specific cyclin-D3 | UniProt NCBI |
| CCNE2 | G1/S-specific cyclin-E2 | UniProt NCBI |
| RBL1 | Retinoblastoma-like protein 1 (107 kDa retinoblastoma-associated protein) (p107) (pRb1) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP179 | 1.01532220832e-19 | 0.785714285714 | CDKN1C CCND1 RBL2 CCNE2 CCND3 RBL1 CDKN2C CCND2 CDK2 CDKN1B CDKN1A | Cell Cycle |
| KEGG:04110 | 1.10167483996e-19 | 0.785714285714 | CDKN1C CCND1 RBL2 CCNE2 CCND3 RBL1 CDKN2C CCND2 CDK2 CDKN1B CDKN1A | Cell cycle |
| REAC:R-HSA-69236 | 2.26240703473e-18 | 0.642857142857 | RBL2 CCND1 CDKN1C CCND3 RBL1 CDKN2C CCND2 CDKN1B CDKN1A | G1 Phase |
| REAC:R-HSA-69231 | 2.26240703473e-18 | 0.642857142857 | RBL2 CCND1 CDKN1C CCND3 RBL1 CDKN2C CCND2 CDKN1B CDKN1A | Cyclin D associated events in G1 |
| REAC:R-HSA-453279 | 5.33471936081e-18 | 0.785714285714 | CDKN1C CCND1 RBL2 CCNE2 CCND3 RBL1 CDKN2C CCND2 CDK2 CDKN1B CDKN1A | Mitotic G1-G1/S phases |
| WP:WP45 | 3.39697804315e-17 | 0.642857142857 | CDKN1C CCND1 CCNE2 CCND3 CDK2 CDKN2C CCND2 CDKN1B CDKN1A | G1 to S cell cycle control |
| GO:0000082 | 3.60918453817e-14 | 0.785714285714 | RBL2 CCND1 CCNE2 CCND3 RBL1 CDKN3 CDKN2C CCND2 CDK2 CDKN1B CDKN1A | G1/S transition of mitotic cell cycle |
| GO:0044843 | 6.92443071671e-14 | 0.785714285714 | RBL2 CCND1 CCNE2 CCND3 RBL1 CDKN3 CDKN2C CCND2 CDK2 CDKN1B CDKN1A | cell cycle G1/S phase transition |
| GO:0000079 | 7.3789218106e-14 | 0.642857142857 | CDKN1C CCND1 CCNE2 CCND3 CDKN2C CDKN3 CCND2 CDKN1B CDKN1A | regulation of cyclin-dependent protein serine/threonine kinase activity |
| GO:1904029 | 1.0940841215e-13 | 0.642857142857 | CDKN1C CCND1 CCNE2 CCND3 CDKN2C CDKN3 CCND2 CDKN1B CDKN1A | regulation of cyclin-dependent protein kinase activity |
| KEGG:05203 | 6.76301274729e-13 | 0.642857142857 | RBL2 CCND1 CCNE2 CCND3 RBL1 CCND2 CDK2 CDKN1B CDKN1A | Viral carcinogenesis |
| WP:WP707 | 6.53097881352e-12 | 0.5 | CCND1 CCNE2 CCND3 CDKN1A CCND2 CDKN1B CDK2 | DNA Damage Response |
| REAC:R-HSA-69278 | 6.5382503421e-12 | 0.785714285714 | CDKN1C CCND1 RBL2 CCNE2 CCND3 RBL1 CDKN2C CCND2 CDK2 CDKN1B CDKN1A | Cell Cycle, Mitotic |
| WP:WP1530 | 8.99154539119e-12 | 0.5 | CCND1 CCNE2 CCND3 CDKN1A CCND2 CDKN1B CDK2 | miRNA Regulation of DNA Damage Response |
| GO:2000045 | 9.44465985096e-12 | 0.642857142857 | RBL2 CCND1 CCND3 RBL1 CDKN2C CCND2 CDK2 CDKN1B CDKN1A | regulation of G1/S transition of mitotic cell cycle |
| KEGG:04218 | 1.00891615447e-11 | 0.571428571429 | RBL2 CCND1 CCNE2 RBL1 CCND3 CDK2 CCND2 CDKN1A | Cellular senescence |
| GO:1902806 | 2.14264953425e-11 | 0.642857142857 | RBL2 CCND1 CCND3 RBL1 CDKN2C CCND2 CDK2 CDKN1B CDKN1A | regulation of cell cycle G1/S phase transition |
| REAC:R-HSA-1640170 | 4.74737106084e-11 | 0.785714285714 | CDKN1C CCND1 RBL2 CCNE2 CCND3 RBL1 CDKN2C CCND2 CDK2 CDKN1B CDKN1A | Cell Cycle |
| GO:0016538 | 5.41703114655e-11 | 0.5 | CCND1 CCNE2 CCND3 CDKN2C CCND2 CDKN1B CDKN1A | cyclin-dependent protein serine/threonine kinase regulator activity |
| KEGG:05165 | 6.72156528128e-11 | 0.642857142857 | RBL2 CCND1 CCNE2 CCND3 RBL1 CCND2 CDK2 CDKN1B CDKN1A | Human papillomavirus infection |
| GO:0051338 | 2.4777964213e-10 | 0.857142857143 | CDKN1C CCND1 RBL2 CCNE2 CCND3 CDKN2C RBL1 CDKN3 MAPK15 CCND2 CDKN1B CDKN1A | regulation of transferase activity |
| GO:0044772 | 4.49636519502e-10 | 0.785714285714 | RBL2 CCND1 CCNE2 CCND3 RBL1 CDKN3 CDKN2C CCND2 CDK2 CDKN1B CDKN1A | mitotic cell cycle phase transition |
| REAC:R-HSA-6791312 | 6.05685849371e-10 | 0.428571428571 | RBL2 CCNE2 RBL1 CDKN1A CDKN1B CDK2 | TP53 Regulates Transcription of Cell Cycle Genes |
| KEGG:04115 | 7.69006080057e-10 | 0.428571428571 | CCND1 CCNE2 CCND3 CDKN1A CCND2 CDK2 | p53 signaling pathway |
| GO:0044770 | 9.10485465628e-10 | 0.785714285714 | RBL2 CCND1 CCNE2 CCND3 RBL1 CDKN3 CDKN2C CCND2 CDK2 CDKN1B CDKN1A | cell cycle phase transition |
| REAC:R-HSA-69206 | 2.7150568817e-09 | 0.5 | RBL2 CCND1 CCNE2 RBL1 CDKN1A CDKN1B CDK2 | G1/S Transition |
| WP:WP4172 | 3.38606458447e-09 | 0.571428571429 | RBL2 CCND1 CCNE2 CCND3 CDK2 CCND2 CDKN1B CDKN1A | PI3K-Akt Signaling Pathway |
| GO:0000278 | 3.51021769102e-09 | 0.857142857143 | CDKN1C CCND1 RBL2 CCNE2 CCND3 RBL1 CDKN3 CDKN2C CCND2 CDK2 CDKN1B CDKN1A | mitotic cell cycle |
| KEGG:04151 | 3.54763249348e-09 | 0.571428571429 | RBL2 CCND1 CCNE2 CCND3 CDK2 CCND2 CDKN1B CDKN1A | PI3K-Akt signaling pathway |
| GO:0043549 | 4.48615737638e-09 | 0.785714285714 | CDKN1C CCND1 RBL2 CCNE2 CCND3 RBL1 CDKN3 CDKN2C CCND2 CDKN1B CDKN1A | regulation of kinase activity |
| WP:WP2261 | 4.84346459678e-09 | 0.428571428571 | CCND1 CDKN2C CDKN1A CCND2 CDKN1B CDK2 | Signaling Pathways in Glioblastoma |
| GO:0019887 | 5.62946665045e-09 | 0.571428571429 | CDKN1C CCND1 CCNE2 CCND3 CDKN2C CCND2 CDKN1B CDKN1A | protein kinase regulator activity |
| KEGG:05169 | 6.39114528884e-09 | 0.5 | CCND1 CCNE2 CCND3 CDKN1A CCND2 CDKN1B CDK2 | Epstein-Barr virus infection |
| WP:WP2446 | 6.96880791705e-09 | 0.428571428571 | CCND1 CCNE2 CCND3 CDKN1A CDKN1B CDK2 | Retinoblastoma Gene in Cancer |
| GO:0051726 | 8.98510852045e-09 | 0.857142857143 | CDKN1C CCND1 RBL2 CCNE2 CCND3 RBL1 CDKN3 CDKN2C CCND2 CDK2 CDKN1B CDKN1A | regulation of cell cycle |
| KEGG:05166 | 1.07345247003e-08 | 0.5 | CCND1 CCNE2 CCND3 CDKN1A CDKN2C CCND2 CDK2 | Human T-cell leukemia virus 1 infection |
| WP:WP4658 | 1.19494937467e-08 | 0.428571428571 | CDKN1C CCND1 CCNE2 CDKN1A CDKN1B CDK2 | Small cell lung cancer |
| GO:0000307 | 1.58775085875e-08 | 0.428571428571 | CCND1 CCNE2 CCND3 CDKN1A CCND2 CDK2 | cyclin-dependent protein kinase holoenzyme complex |
| REAC:R-HSA-69202 | 1.70135913755e-08 | 0.428571428571 | RBL2 CCND1 CCNE2 CDKN1A CDKN1B CDK2 | Cyclin E associated events during G1/S transition |
| GO:0019207 | 1.90921595138e-08 | 0.571428571429 | CDKN1C CCND1 CCNE2 CCND3 CDKN2C CCND2 CDKN1B CDKN1A | kinase regulator activity |
| REAC:R-HSA-69656 | 1.97317857302e-08 | 0.428571428571 | RBL2 CCND1 CCNE2 CDKN1A CDKN1B CDK2 | Cyclin A:Cdk2-associated events at S phase entry |
| WP:WP710 | 2.07759908277e-08 | 0.428571428571 | RBL2 CCND1 CCND3 CCND2 CDKN1B CDKN1A | DNA Damage Response (only ATM dependent) |
| KEGG:04068 | 2.67290503629e-08 | 0.428571428571 | RBL2 CCND1 CDKN1A CCND2 CDKN1B CDK2 | FoxO signaling pathway |
| GO:2000134 | 3.01172599794e-08 | 0.5 | RBL2 CCND1 RBL1 CDKN1A CDKN2C CDKN1B CDK2 | negative regulation of G1/S transition of mitotic cell cycle |
| GO:1902807 | 3.2706466608e-08 | 0.5 | RBL2 CCND1 RBL1 CDKN1A CDKN2C CDKN1B CDK2 | negative regulation of cell cycle G1/S phase transition |
| GO:1903047 | 4.54941643689e-08 | 0.785714285714 | RBL2 CCND1 CCNE2 CCND3 RBL1 CDKN3 CDKN2C CCND2 CDK2 CDKN1B CDKN1A | mitotic cell cycle process |
| WP:WP1545 | 4.78854580828e-08 | 0.285714285714 | CDKN1B CCND1 CDKN1A CCND3 | miRNAs involved in DNA damage response |
| KEGG:05162 | 5.40062750507e-08 | 0.428571428571 | CCND1 CCNE2 CCND3 CCND2 CDKN1B CDK2 | Measles |
| HP:0006744 | 7.98700049338e-08 | 0.285714285714 | CDKN1B CDKN1A CDKN2C CDKN1C | Adrenocortical carcinoma |
| KEGG:04934 | 9.69853823894e-08 | 0.428571428571 | CCND1 CCNE2 CDKN2C CDKN1A CDKN1B CDK2 | Cushing syndrome |
| GO:0071900 | 9.92847101889e-08 | 0.642857142857 | CDKN1C CCND1 CCNE2 CCND3 CDKN2C CDKN3 CCND2 CDKN1B CDKN1A | regulation of protein serine/threonine kinase activity |
| GO:0007346 | 1.01035080007e-07 | 0.714285714286 | RBL2 CCND1 CDKN1C CCND3 RBL1 CDKN2C CCND2 CDK2 CDKN1B CDKN1A | regulation of mitotic cell cycle |
| REAC:R-HSA-6804116 | 1.23417975065e-07 | 0.285714285714 | CDK2 CDKN1B CDKN1A CCNE2 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest |
| CORUM:311 | 1.40594241297e-07 | 0.214285714286 | CCND1 CDKN1A CDK2 | Cell cycle kinase complex CDK2 |
| GO:1901990 | 1.69176486997e-07 | 0.642857142857 | RBL2 CCND1 CCND3 RBL1 CDKN2C CCND2 CDK2 CDKN1B CDKN1A | regulation of mitotic cell cycle phase transition |
| HP:0003072 | 1.8858156397e-07 | 0.357142857143 | CDKN1B CCND1 CDKN1A CDKN2C CDKN1C | Hypercalcemia |
| GO:0016310 | 2.24557079864e-07 | 0.928571428571 | CDKN1C CCND1 RBL2 CCNE2 CCND3 CDKN2C RBL1 CDKN3 MAPK15 CCND2 CDK2 CDKN1B CDKN1A | phosphorylation |
| GO:1901987 | 3.15656462846e-07 | 0.642857142857 | RBL2 CCND1 CCND3 RBL1 CDKN2C CCND2 CDK2 CDKN1B CDKN1A | regulation of cell cycle phase transition |
| CORUM:313 | 3.51290867842e-07 | 0.214285714286 | CCND1 CDKN1A CCND3 | Cell cycle kinase complex CDK5 |
| REAC:R-HSA-187577 | 4.05581772367e-07 | 0.357142857143 | CDK2 CDKN1B CCND1 CDKN1A CCNE2 | SCF(Skp2)-mediated degradation of p27/p21 |
| REAC:R-HSA-212436 | 4.90086887267e-07 | 0.714285714286 | RBL2 ZNF2 CCNE2 CCND3 RBL1 CCND2 CDK2 CDKN1B CDKN1A CCND1 | Generic Transcription Pathway |
| GO:0007049 | 7.18957085065e-07 | 0.857142857143 | CDKN1C CCND1 RBL2 CCNE2 CCND3 RBL1 CDKN3 CDKN2C CCND2 CDK2 CDKN1B CDKN1A | cell cycle |
| KEGG:05215 | 7.33801614474e-07 | 0.357142857143 | CDK2 CDKN1B CCND1 CDKN1A CCNE2 | Prostate cancer |
| KEGG:05222 | 8.202588393e-07 | 0.357142857143 | CDK2 CDKN1B CCND1 CDKN1A CCNE2 | Small cell lung cancer |
| REAC:R-HSA-69242 | 9.56385932055e-07 | 0.428571428571 | RBL2 CCND1 CCNE2 CDKN1A CDKN1B CDK2 | S Phase |
| GO:0050790 | 1.09600573618e-06 | 0.857142857143 | CDKN1C CCND1 RBL2 CCNE2 CCND3 CDKN2C RBL1 CDKN3 MAPK15 CCND2 CDKN1B CDKN1A | regulation of catalytic activity |
| HP:0100641 | 1.158825564e-06 | 0.285714285714 | CDKN1B CDKN1A CDKN2C CDKN1C | Neoplasm of the adrenal cortex |
| GO:0045930 | 1.35446376274e-06 | 0.571428571429 | RBL2 CCND1 CDKN1C RBL1 CDKN1A CDKN2C CDKN1B CDK2 | negative regulation of mitotic cell cycle |
| REAC:R-HSA-73857 | 1.41848981915e-06 | 0.714285714286 | RBL2 ZNF2 CCNE2 CCND3 RBL1 CCND2 CDK2 CDKN1B CDKN1A CCND1 | RNA Polymerase II Transcription |
| REAC:R-HSA-8849470 | 1.67621023234e-06 | 0.214285714286 | CDKN1B CDK2 CCND1 | PTK6 Regulates Cell Cycle |
| GO:1902554 | 1.77975301715e-06 | 0.428571428571 | CCND1 CCNE2 CCND3 CDKN1A CCND2 CDK2 | serine/threonine protein kinase complex |
| REAC:R-HSA-1538133 | 2.14874887803e-06 | 0.285714285714 | CDK2 CCNE2 RBL1 RBL2 | G0 and Early G1 |
| GO:0045786 | 3.83392897311e-06 | 0.642857142857 | RBL2 CCND1 CDKN1C RBL1 CDKN1A CDKN3 CDKN2C CDKN1B CDK2 | negative regulation of cell cycle |
| REAC:R-HSA-74160 | 4.09731258236e-06 | 0.714285714286 | RBL2 ZNF2 CCNE2 CCND3 RBL1 CCND2 CDK2 CDKN1B CDKN1A CCND1 | Gene expression (Transcription) |
| KEGG:05200 | 4.16931023474e-06 | 0.5 | CCND1 CCNE2 CCND3 CDKN1A CCND2 CDKN1B CDK2 | Pathways in cancer |
| GO:0042325 | 4.20758443682e-06 | 0.785714285714 | CDKN1C CCND1 RBL2 CCNE2 CCND3 RBL1 CDKN3 CDKN2C CCND2 CDKN1B CDKN1A | regulation of phosphorylation |
| GO:0022402 | 4.78890070707e-06 | 0.785714285714 | RBL2 CCND1 CCNE2 CCND3 RBL1 CDKN3 CDKN2C CCND2 CDK2 CDKN1B CDKN1A | cell cycle process |
| KEGG:05226 | 4.86688885457e-06 | 0.357142857143 | CDK2 CDKN1B CCND1 CDKN1A CCNE2 | Gastric cancer |
| HP:0030688 | 5.15958462144e-06 | 0.214285714286 | CDKN1B CDKN1A CDKN2C | Increased glucagon level |
| HP:0011761 | 5.15958462144e-06 | 0.214285714286 | CDKN1B CDKN1A CDKN2C | Pituitary null cell adenoma |
| HP:0030404 | 5.15958462144e-06 | 0.214285714286 | CDKN1B CDKN1A CDKN2C | Glucagonoma |
| HP:0008291 | 5.15958462144e-06 | 0.214285714286 | CDKN1B CDKN1A CDKN2C | Pituitary corticotropic cell adenoma |
| HP:0030687 | 5.15958462144e-06 | 0.214285714286 | CDKN1B CDKN1A CDKN2C | Abnormal glucagon level |
| HP:0100522 | 5.15958462144e-06 | 0.214285714286 | CDKN1B CDKN1A CDKN2C | Thymoma |
| HP:0012197 | 5.15958462144e-06 | 0.214285714286 | CDKN1B CDKN1A CDKN2C | Insulinoma |
| GO:1902911 | 5.1728815624e-06 | 0.428571428571 | CCND1 CCNE2 CCND3 CDKN1A CCND2 CDK2 | protein kinase complex |
| WP:WP2877 | 5.66510472481e-06 | 0.357142857143 | CDKN1B CCND1 CDKN1A CDKN2C CDK2 | Vitamin D Receptor Pathway |
| HP:0100634 | 6.61411764018e-06 | 0.285714285714 | CDKN1B CDKN1A CDKN2C CCND1 | Neuroendocrine neoplasm |
| GO:0045859 | 6.71557244282e-06 | 0.642857142857 | CDKN1C CCND1 CCNE2 CCND3 CDKN2C CDKN3 CCND2 CDKN1B CDKN1A | regulation of protein kinase activity |
| GO:0007050 | 7.54711075525e-06 | 0.5 | RBL2 CCND1 CDKN2C CDKN1A CDKN3 CDKN1B CDK2 | cell cycle arrest |
| HP:0100631 | 8.94148250005e-06 | 0.285714285714 | CDKN1B CDKN1A CDKN2C CDKN1C | Neoplasm of the adrenal gland |
| HP:0008208 | 1.0313451964e-05 | 0.214285714286 | CDKN1B CDKN1A CDKN2C | Parathyroid hyperplasia |
| HP:0008261 | 1.0313451964e-05 | 0.214285714286 | CDKN1B CDKN1A CDKN2C | Pancreatic islet cell adenoma |
| HP:0030405 | 1.0313451964e-05 | 0.214285714286 | CDKN1B CDKN1A CDKN2C | Pancreatic endocrine tumor |
| WP:WP53 | 1.04574649918e-05 | 0.214285714286 | RBL2 RBL1 CDK2 | ID signaling pathway |
| GO:1901991 | 1.04670361784e-05 | 0.5 | RBL2 CCND1 RBL1 CDKN1A CDKN2C CDKN1B CDK2 | negative regulation of mitotic cell cycle phase transition |
| HP:0004363 | 1.14106826842e-05 | 0.357142857143 | CDKN1B CCND1 CDKN1A CDKN2C CDKN1C | Abnormal circulating calcium concentration |
| KEGG:05206 | 1.20303442524e-05 | 0.357142857143 | CDKN1B CCND1 CCNE2 CDKN1A CCND2 | MicroRNAs in cancer |
| GO:0019220 | 1.27829584076e-05 | 0.785714285714 | CDKN1C CCND1 RBL2 CCNE2 CCND3 RBL1 CDKN3 CDKN2C CCND2 CDKN1B CDKN1A | regulation of phosphate metabolic process |
| GO:0051174 | 1.28986506558e-05 | 0.785714285714 | CDKN1C CCND1 RBL2 CCNE2 CCND3 RBL1 CDKN3 CDKN2C CCND2 CDKN1B CDKN1A | regulation of phosphorus metabolic process |
| HP:0100568 | 1.34480524567e-05 | 0.357142857143 | CDKN1B CCND1 CDKN1A CDKN2C CDKN1C | Neoplasm of the endocrine system |
| GO:1901988 | 1.63567210044e-05 | 0.5 | RBL2 CCND1 RBL1 CDKN1A CDKN2C CDKN1B CDK2 | negative regulation of cell cycle phase transition |
| GO:0090068 | 1.69082075297e-05 | 0.5 | RBL2 CCND1 CCND3 CDKN1A CCND2 CDKN1B CDK2 | positive regulation of cell cycle process |
| HP:0007449 | 1.80385410749e-05 | 0.214285714286 | CDKN1B CDKN1A CDKN2C | Confetti-like hypopigmented macules |
| HP:0011760 | 1.80385410749e-05 | 0.214285714286 | CDKN1B CDKN1A CDKN2C | Pituitary growth hormone cell adenoma |
| HP:0006767 | 1.80385410749e-05 | 0.214285714286 | CDKN1B CDKN1A CDKN2C | Pituitary prolactin cell adenoma |
| HP:0100521 | 1.80385410749e-05 | 0.214285714286 | CDKN1B CDKN1A CDKN2C | Neoplasm of the thymus |
| HP:0010927 | 1.83892061423e-05 | 0.357142857143 | CDKN1B CCND1 CDKN1A CDKN2C CDKN1C | Abnormal blood inorganic cation concentration |
| GO:0006796 | 1.92428451641e-05 | 0.928571428571 | CDKN1C CCND1 RBL2 CCNE2 CCND3 CDKN2C RBL1 CDKN3 MAPK15 CCND2 CDK2 CDKN1B CDKN1A | phosphate-containing compound metabolic process |
| GO:0006793 | 2.19577984993e-05 | 0.928571428571 | CDKN1C CCND1 RBL2 CCNE2 CCND3 CDKN2C RBL1 CDKN3 MAPK15 CCND2 CDK2 CDKN1B CDKN1A | phosphorus metabolic process |
| WP:WP2032 | 2.31207308788e-05 | 0.285714285714 | CDK2 CDKN1B CCND3 RBL2 | Human Thyroid Stimulating Hormone (TSH) signaling pathway |
| GO:0010564 | 2.3690338795e-05 | 0.642857142857 | RBL2 CCND1 CCND3 RBL1 CDKN2C CCND2 CDK2 CDKN1B CDKN1A | regulation of cell cycle process |
| HP:0008256 | 2.88456745376e-05 | 0.214285714286 | CDKN1B CDKN1A CDKN2C | Adrenocortical adenoma |
| HP:0012029 | 2.88456745376e-05 | 0.214285714286 | CDKN1B CDKN1A CDKN2C | Abnormal urine hormone level |
| HP:0012030 | 2.88456745376e-05 | 0.214285714286 | CDKN1B CDKN1A CDKN2C | Increased urinary cortisol level |
| HP:0002044 | 2.88456745376e-05 | 0.214285714286 | CDKN1B CDKN1A CDKN2C | Zollinger-Ellison syndrome |
| GO:0065009 | 3.38101474517e-05 | 0.857142857143 | CDKN1C CCND1 RBL2 CCNE2 CCND3 CDKN2C RBL1 CDKN3 MAPK15 CCND2 CDKN1B CDKN1A | regulation of molecular function |
| HP:0100007 | 3.78795495629e-05 | 0.285714285714 | CDKN1B CDKN1A CDKN2C CCND1 | Neoplasm of the peripheral nervous system |
| HP:0100570 | 4.32445379223e-05 | 0.214285714286 | CDKN1B CDKN1A CDKN2C | Carcinoid tumor |
| GO:0006468 | 4.82112360936e-05 | 0.785714285714 | CDKN1C CCND1 CCNE2 CCND3 CDKN2C CDK2 CDKN3 MAPK15 CCND2 CDKN1B CDKN1A | protein phosphorylation |
| HP:0001031 | 6.17436813154e-05 | 0.214285714286 | CDKN1B CDKN1A CDKN2C | Subcutaneous lipoma |
| HP:0008283 | 6.17436813154e-05 | 0.214285714286 | CDKN1B CDKN1A CDKN2C | Fasting hyperinsulinemia |
| KEGG:01522 | 6.33107856213e-05 | 0.285714285714 | CDKN1B CDKN1A CDKN2C CCND1 | Endocrine resistance |
| GO:0045787 | 8.4800985906e-05 | 0.5 | RBL2 CCND1 CCND3 CDKN1A CCND2 CDKN1B CDK2 | positive regulation of cell cycle |
| HP:0020073 | 8.48505208484e-05 | 0.214285714286 | CDKN1B CDKN1A CDKN2C | Hypopigmented macule |
| REAC:R-HSA-69580 | 8.64091630355e-05 | 0.285714285714 | CDK2 CDKN1B CDKN1A CCNE2 | p53-Dependent G1/S DNA damage checkpoint |
| REAC:R-HSA-69563 | 8.64091630355e-05 | 0.285714285714 | CDK2 CDKN1B CDKN1A CCNE2 | p53-Dependent G1 DNA Damage Response |
| GO:0044819 | 8.71192010683e-05 | 0.357142857143 | CDK2 CDKN1B CCND1 CDKN1A RBL2 | mitotic G1/S transition checkpoint |
| GO:0031571 | 8.71192010683e-05 | 0.357142857143 | CDK2 CDKN1B CCND1 CDKN1A RBL2 | mitotic G1 DNA damage checkpoint |
| GO:0044783 | 9.48497850136e-05 | 0.357142857143 | CDK2 CDKN1B CCND1 CDKN1A RBL2 | G1 DNA damage checkpoint |
| REAC:R-HSA-69615 | 9.75338164565e-05 | 0.285714285714 | CDK2 CDKN1B CDKN1A CCNE2 | G1/S DNA Damage Checkpoints |
| REAC:R-HSA-3700989 | 0.000101410178945 | 0.428571428571 | RBL2 CCNE2 RBL1 CDKN1A CDKN1B CDK2 | Transcriptional Regulation by TP53 |
| REAC:R-HSA-8934593 | 0.000113226716384 | 0.214285714286 | CCND2 CCND3 CCND1 | Regulation of RUNX1 Expression and Activity |
| REAC:R-HSA-9617828 | 0.000113226716384 | 0.214285714286 | CDKN1B CDKN1A RBL2 | FOXO-mediated transcription of cell cycle genes |
| CORUM:1656 | 0.000130860292961 | 0.142857142857 | CDKN1B CDK2 | p27-cyclinE-CDK2 complex |
| CORUM:1634 | 0.000130860292961 | 0.142857142857 | CDKN1A CCND1 | CyclinD1-CDK4-p21 complex |
| GO:0010948 | 0.000136850047303 | 0.5 | RBL2 CCND1 RBL1 CDKN1A CDKN2C CDKN1B CDK2 | negative regulation of cell cycle process |
| REAC:R-HSA-2559583 | 0.000140767645221 | 0.357142857143 | CDK2 CDKN1B CDKN1A CDKN2C CCNE2 | Cellular Senescence |
| HP:0003118 | 0.000146911292241 | 0.214285714286 | CDKN1B CDKN1A CDKN2C | Increased circulating cortisol level |
| HP:0012334 | 0.000146911292241 | 0.214285714286 | CDKN1B CDKN1A CDKN2C | Extrahepatic cholestasis |
| REAC:R-HSA-2559586 | 0.000178882113574 | 0.285714285714 | CDK2 CDKN1B CDKN1A CCNE2 | DNA Damage/Telomere Stress Induced Senescence |
| KEGG:04630 | 0.00020700416654 | 0.285714285714 | CCND2 CCND1 CDKN1A CCND3 | JAK-STAT signaling pathway |
| HP:0100733 | 0.00023346356002 | 0.214285714286 | CDKN1B CDKN1A CDKN2C | Neoplasm of the parathyroid gland |
| HP:0002897 | 0.00023346356002 | 0.214285714286 | CDKN1B CDKN1A CDKN2C | Parathyroid adenoma |
| WP:WP3981 | 0.000256343482254 | 0.214285714286 | CDKN1B CDKN1A CCND1 | miRNA regulation of prostate cancer signaling pathways |
| CORUM:5101 | 0.00026157999168 | 0.142857142857 | CDKN1A CCND3 | CyclinD3-CDK4-CDK6-p21 complex |
| CORUM:312 | 0.00026157999168 | 0.142857142857 | CDKN1A CCND1 | Cell cycle kinase complex CDK4 |
| HP:0003165 | 0.000287180540568 | 0.214285714286 | CDKN1B CDKN1A CDKN2C | Elevated circulating parathyroid hormone level |
| HP:0000854 | 0.000287180540568 | 0.214285714286 | CDKN1B CDKN1A CDKN2C | Thyroid adenoma |
| WP:WP366 | 0.000310338798814 | 0.285714285714 | RBL2 CCND1 CDKN1A RBL1 | TGF-beta Signaling Pathway |
| HP:0010929 | 0.000312325586567 | 0.357142857143 | CDKN1B CCND1 CDKN1A CDKN2C CDKN1C | Abnormal blood cation concentration |
| HP:0011732 | 0.000318524840399 | 0.285714285714 | CDKN1B CDKN1A CDKN2C CDKN1C | Abnormality of adrenal morphology |
| WP:WP3941 | 0.000364255169475 | 0.214285714286 | CDKN1B CDKN1A CDKN1C | Oxidative Damage |
| HP:0002894 | 0.000378445025335 | 0.285714285714 | CDKN1B CDKN1A CDKN2C CCND1 | Neoplasm of the pancreas |
| HP:0000845 | 0.00041799941853 | 0.214285714286 | CDKN1B CDKN1A CDKN2C | Growth hormone excess |
| HP:0011766 | 0.00041799941853 | 0.214285714286 | CDKN1B CDKN1A CDKN2C | Abnormality of the parathyroid morphology |
| HP:0000843 | 0.000496099236372 | 0.214285714286 | CDKN1B CDKN1A CDKN2C | Hyperparathyroidism |
| WP:WP2586 | 0.000536688745275 | 0.214285714286 | CDKN1B CDKN1A CDK2 | Aryl Hydrocarbon Receptor |
| GO:0060255 | 0.000543056129205 | 1.0 | CDKN1C ZNF2 RBL2 CCNE2 CCND3 CDKN2C RBL1 CDKN3 MAPK15 CCND2 CDK2 CDKN1B CDKN1A CCND1 | regulation of macromolecule metabolic process |
| HP:0003111 | 0.00056015086804 | 0.357142857143 | CDKN1B CCND1 CDKN1A CDKN2C CDKN1C | Abnormal blood ion concentration |
| WP:WP1971 | 0.000576620554298 | 0.214285714286 | CDKN1B CDKN1A CDK2 | Integrated Cancer Pathway |
| KEGG:05202 | 0.000582130189757 | 0.285714285714 | CDKN1B CDKN1A CDKN2C CCND2 | Transcriptional misregulation in cancer |
| REAC:R-HSA-2559582 | 0.000582889654502 | 0.285714285714 | CDKN1B CDKN1A CDKN2C CDK2 | Senescence-Associated Secretory Phenotype (SASP) |
| HP:0004398 | 0.000583322718944 | 0.214285714286 | CDKN1B CDKN1A CDKN2C | Peptic ulcer |
| MIRNA:hsa-miR-503-5p | 0.000596823880628 | 0.357142857143 | CCND2 CCND1 CCNE2 CDKN1A CCND3 | hsa-miR-503-5p |
| GO:0044773 | 0.00061613120339 | 0.357142857143 | CDK2 CDKN1B CCND1 CDKN1A RBL2 | mitotic DNA damage checkpoint |
| WP:WP3998 | 0.00061846923653 | 0.214285714286 | CCND2 CCND1 CDKN2C | Prader-Willi and Angelman Syndrome |
| HP:0032367 | 0.000639942765799 | 0.285714285714 | CDKN1B CDKN1A CDKN2C CDKN1C | Abnormal growth hormone level |
| CORUM:6444 | 0.000653247592095 | 0.142857142857 | RBL2 RBL1 | SMAR1-HDAC1-SIN3A-SIN3B-p107-p130 repressor complex |
| CORUM:310 | 0.000653247592095 | 0.142857142857 | CDKN1A CCND1 | Cell cycle kinase complex CDC2 |
| HP:0010615 | 0.000787124202209 | 0.214285714286 | CDKN1B CDKN1A CDKN2C | Angiofibromas |
| HP:0000825 | 0.000787124202209 | 0.214285714286 | CDKN1B CDKN1A CDKN2C | Hyperinsulinemic hypoglycemia |
| HP:0100633 | 0.000787124202209 | 0.214285714286 | CDKN1B CDKN1A CDKN2C | Esophagitis |
| HP:0006476 | 0.000787124202209 | 0.214285714286 | CDKN1B CDKN1A CDKN2C | Abnormality of the pancreatic islet cells |
| GO:0071156 | 0.00086067535723 | 0.357142857143 | CDK2 CDKN1B CCND1 CDKN1A RBL2 | regulation of cell cycle arrest |
| HP:0012093 | 0.00090469117326 | 0.214285714286 | CDKN1B CDKN1A CDKN2C | Abnormality of endocrine pancreas physiology |
| HP:0001732 | 0.000921930386677 | 0.357142857143 | CDKN1B CCND1 CDKN1A CDKN2C CDKN1C | Abnormality of the pancreas |
| GO:0044774 | 0.00100896289404 | 0.357142857143 | CDK2 CDKN1B CCND1 CDKN1A RBL2 | mitotic DNA integrity checkpoint |
| CORUM:3015 | 0.00121808583511 | 0.142857142857 | CDKN1B CDK2 | p27-cyclinE-Cdk2 - Ubiquitin E3 ligase (SKP1A, SKP2, CUL1, CKS1B, RBX1) complex |
| REAC:R-HSA-69200 | 0.00124814818365 | 0.142857142857 | CCNE2 CDK2 | Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes |
| HP:0002717 | 0.00132596742744 | 0.214285714286 | CDKN1B CDKN1A CDKN2C | Adrenal overactivity |
| HP:0011792 | 0.00133269112336 | 0.357142857143 | CDKN1B CCND1 CDKN1A CDKN2C CDKN1C | Neoplasm by histology |
| GO:0001932 | 0.00141863882463 | 0.642857142857 | CDKN1C CCND1 CCNE2 CCND3 CDKN2C CDKN3 CCND2 CDKN1B CDKN1A | regulation of protein phosphorylation |
| GO:0061695 | 0.00143093624411 | 0.428571428571 | CCND1 CCNE2 CCND3 CDKN1A CCND2 CDK2 | transferase complex, transferring phosphorus-containing groups |
| HP:0002893 | 0.00149088659116 | 0.214285714286 | CDKN1B CDKN1A CDKN2C | Pituitary adenoma |
| HP:0032148 | 0.00166886750352 | 0.214285714286 | CDKN1B CDKN1A CDKN2C | Episodic pain |
| HP:0002574 | 0.00166886750352 | 0.214285714286 | CDKN1B CDKN1A CDKN2C | Episodic abdominal pain |
| MIRNA:hsa-miR-196a-5p | 0.0017022610551 | 0.357142857143 | CDKN1B CCND1 CCNE2 CDKN1A CCND2 | hsa-miR-196a-5p |
| WP:WP2572 | 0.00183498747391 | 0.214285714286 | CDKN1B CDKN1A CDKN1C | Primary Focal Segmental Glomerulosclerosis FSGS |
| HP:0100530 | 0.00206596252697 | 0.214285714286 | CDKN1B CDKN1A CDKN2C | Abnormal calcium-phosphate regulating hormone level |
| HP:0011731 | 0.00206596252697 | 0.214285714286 | CDKN1B CDKN1A CDKN2C | Abnormality of circulating cortisol level |
| GO:0019222 | 0.00213698385056 | 1.0 | CDKN1C ZNF2 RBL2 CCNE2 CCND3 CDKN2C RBL1 CDKN3 MAPK15 CCND2 CDK2 CDKN1B CDKN1A CCND1 | regulation of metabolic process |
| KEGG:05220 | 0.00218939585455 | 0.214285714286 | CDKN1B CDKN1A CCND1 | Chronic myeloid leukemia |
| HP:0012111 | 0.00228604785297 | 0.214285714286 | CDKN1B CDKN1A CDKN2C | Abnormality of circulating glucocorticoid level |
| REAC:R-HSA-8848021 | 0.00248730409152 | 0.214285714286 | CDKN1B CDK2 CCND1 | Signaling by PTK6 |
| REAC:R-HSA-9006927 | 0.00248730409152 | 0.214285714286 | CDKN1B CDK2 CCND1 | Signaling by Non-Receptor Tyrosine Kinases |
| GO:0004861 | 0.00276765042703 | 0.214285714286 | CDKN1B CDKN1A CDKN2C | cyclin-dependent protein serine/threonine kinase inhibitor activity |
| HP:0011750 | 0.00277171390187 | 0.214285714286 | CDKN1B CDKN1A CDKN2C | Neoplasm of the anterior pituitary |
| HP:0040277 | 0.00277171390187 | 0.214285714286 | CDKN1B CDKN1A CDKN2C | Neoplasm of the pituitary gland |
| HP:0001012 | 0.00277171390187 | 0.214285714286 | CDKN1B CDKN1A CDKN2C | Multiple lipomas |
| GO:0030234 | 0.00279269826596 | 0.571428571429 | CDKN1C CCND1 CCNE2 CCND3 CDKN2C CCND2 CDKN1B CDKN1A | enzyme regulator activity |
| WP:WP4336 | 0.00348622816412 | 0.214285714286 | CCND2 CCND3 CCND1 | ncRNAs involved in Wnt signaling in hepatocellular carcinoma |
| GO:0000077 | 0.00407754647627 | 0.357142857143 | CDK2 CDKN1B CCND1 CDKN1A RBL2 | DNA damage checkpoint |
| GO:0019901 | 0.00409997802941 | 0.5 | CCND1 CCNE2 CCND3 CDKN2C CCND2 CDKN1B CDKN1A | protein kinase binding |
| HP:0012031 | 0.00427372510078 | 0.214285714286 | CDKN1B CDKN1A CDKN2C | Lipomatous tumor |
| HP:0200013 | 0.00427372510078 | 0.214285714286 | CDKN1B CDKN1A CDKN2C | Neoplasm of fatty tissue |
| WP:WP673 | 0.00450864759866 | 0.214285714286 | CDKN1B CDKN1A CCND1 | ErbB Signaling Pathway |
| WP:WP4258 | 0.00483308697841 | 0.214285714286 | CCND2 CCND3 CCND1 | LncRNA involvement in canonical Wnt signaling and colorectal cancer |
| REAC:R-HSA-9614085 | 0.00502234212288 | 0.214285714286 | CDKN1B CDKN1A RBL2 | FOXO-mediated transcription |
| WP:WP2431 | 0.00517246893741 | 0.214285714286 | CDKN1B CDK2 CCND1 | Spinal Cord Injury |
| HP:0001001 | 0.00539143972189 | 0.214285714286 | CDKN1B CDKN1A CDKN2C | Abnormality of subcutaneous fat tissue |
| KEGG:00000 | 0.00545659360645 | 0.928571428571 | CDKN1C ZNF2 RBL2 CCNE2 CCND3 CDKN2C RBL1 MAPK15 CCND2 CDK2 CDKN1B CDKN1A CCND1 | KEGG root term |
| HP:0004375 | 0.00559173408326 | 0.285714285714 | CDKN1B CDKN1A CDKN2C CCND1 | Neoplasm of the nervous system |
| HP:0000777 | 0.00580294705829 | 0.214285714286 | CDKN1B CDKN1A CDKN2C | Abnormality of the thymus |
| REAC:R-HSA-2262752 | 0.0061621875213 | 0.357142857143 | CDK2 CDKN1B CDKN1A CDKN2C CCNE2 | Cellular responses to stress |
| GO:0004672 | 0.00627119811296 | 0.5 | CCND1 CCNE2 CCND3 CDKN1A MAPK15 CCND2 CDK2 | protein kinase activity |
| GO:0031570 | 0.00638739744156 | 0.357142857143 | CDK2 CDKN1B CCND1 CDKN1A RBL2 | DNA integrity checkpoint |
| GO:0004860 | 0.00644260262255 | 0.285714285714 | CDKN1B CDKN1A CDKN2C CDKN1C | protein kinase inhibitor activity |
| WP:WP399 | 0.00668566008136 | 0.214285714286 | CCND2 CCND3 CCND1 | Wnt Signaling Pathway and Pluripotency |
| MIRNA:hsa-miR-146a-5p | 0.00680951682332 | 0.285714285714 | CCND2 CCND1 CDKN1A CDKN3 | hsa-miR-146a-5p |
| HP:0000834 | 0.00695901401201 | 0.285714285714 | CDKN1B CDKN1A CDKN2C CDKN1C | Abnormality of the adrenal glands |
| GO:0006977 | 0.00751791370526 | 0.285714285714 | CDK2 CDKN1B CDKN1A RBL2 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest |
| GO:1902400 | 0.00810319072712 | 0.285714285714 | CDK2 CDKN1B CDKN1A RBL2 | intracellular signal transduction involved in G1 DNA damage checkpoint |
| GO:0072431 | 0.00810319072712 | 0.285714285714 | CDK2 CDKN1B CDKN1A RBL2 | signal transduction involved in mitotic G1 DNA damage checkpoint |
| CORUM:5614 | 0.00821246655217 | 0.142857142857 | RBL2 RBL1 | Emerin complex 32 |
| GO:0007093 | 0.00843225804822 | 0.357142857143 | CDK2 CDKN1B CCND1 CDKN1A RBL2 | mitotic cell cycle checkpoint |
| GO:0019210 | 0.00872181655801 | 0.285714285714 | CDKN1B CDKN1A CDKN2C CDKN1C | kinase inhibitor activity |
| GO:0072413 | 0.00872181655801 | 0.285714285714 | CDK2 CDKN1B CDKN1A RBL2 | signal transduction involved in mitotic cell cycle checkpoint |
| GO:1902403 | 0.00872181655801 | 0.285714285714 | CDK2 CDKN1B CDKN1A RBL2 | signal transduction involved in mitotic DNA integrity checkpoint |
| GO:1902402 | 0.00872181655801 | 0.285714285714 | CDK2 CDKN1B CDKN1A RBL2 | signal transduction involved in mitotic DNA damage checkpoint |
| WP:WP428 | 0.00895047358668 | 0.214285714286 | CCND2 CCND3 CCND1 | Wnt Signaling |
| WP:WP236 | 0.00971598293615 | 0.214285714286 | RBL2 CDKN1A RBL1 | Adipogenesis |
| GO:0019900 | 0.00971615061592 | 0.5 | CCND1 CCNE2 CCND3 CDKN2C CCND2 CDKN1B CDKN1A | kinase binding |
| HP:0010614 | 0.0104742778885 | 0.214285714286 | CDKN1B CDKN1A CDKN2C | Fibroma |
| GO:0031399 | 0.0117061074789 | 0.642857142857 | CDKN1C CCND1 CCNE2 CCND3 CDKN2C CDKN3 CCND2 CDKN1B CDKN1A | regulation of protein modification process |
| HP:0012316 | 0.0117694313437 | 0.214285714286 | CDKN1B CDKN1A CDKN2C | Fibrous tissue neoplasm |
| HP:0011767 | 0.0124548409874 | 0.214285714286 | CDKN1B CDKN1A CDKN2C | Abnormality of the parathyroid physiology |
| WP:000000 | 0.0127289265067 | 0.857142857143 | CDKN1C CCND1 RBL2 CCNE2 CCND3 CDKN2C RBL1 MAPK15 CCND2 CDK2 CDKN1B CDKN1A | WIKIPATHWAYS |
| GO:0080090 | 0.0128864273657 | 0.928571428571 | CDKN1C ZNF2 RBL2 CCNE2 CCND3 CDKN2C RBL1 CDKN3 MAPK15 CCND2 CDKN1B CDKN1A CCND1 | regulation of primary metabolic process |
| MIRNA:hsa-miR-892b | 0.0129527960215 | 0.214285714286 | CCND1 RBL1 CDK2 | hsa-miR-892b |
| KEGG:05160 | 0.0133803659922 | 0.214285714286 | CCND1 CDKN1A CDK2 | Hepatitis C |
| WP:WP205 | 0.0135483736716 | 0.142857142857 | CDKN1B CCND1 | IL-7 Signaling Pathway |
| MIRNA:hsa-miR-203a-5p | 0.0141508449145 | 0.214285714286 | CDKN1B CDKN1A CCND2 | hsa-miR-203a-5p |
| HP:0100031 | 0.0146679065289 | 0.214285714286 | CDKN1B CDKN1A CDKN2C | Neoplasm of the thyroid gland |
| REAC:R-HSA-8953897 | 0.0147089275439 | 0.357142857143 | CDK2 CDKN1B CDKN1A CDKN2C CCNE2 | Cellular responses to external stimuli |
| KEGG:04390 | 0.0151942329623 | 0.214285714286 | CCND2 CCND3 CCND1 | Hippo signaling pathway |
| GO:0042127 | 0.0165523962607 | 0.571428571429 | CDKN1C CDKN2C CDKN1A CDKN3 MAPK15 CCND2 CDKN1B CDK2 | regulation of cell population proliferation |
| KEGG:04310 | 0.0168219118682 | 0.214285714286 | CCND2 CCND3 CCND1 | Wnt signaling pathway |
| HP:0007378 | 0.0174165196422 | 0.285714285714 | CDKN1B CDKN1A CDKN2C CDKN1C | Neoplasm of the gastrointestinal tract |
| WP:WP34 | 0.0175669592019 | 0.142857142857 | CDKN1B CCND2 | Ovarian Infertility Genes |
| HP:0011747 | 0.0177834746851 | 0.285714285714 | CDKN1B CDKN1A CDKN2C CDKN1C | Abnormality of the anterior pituitary |
| GO:0045737 | 0.0183795545963 | 0.214285714286 | CCND2 CCND3 CCND1 | positive regulation of cyclin-dependent protein serine/threonine kinase activity |
| REAC:R-HSA-198323 | 0.0188288105354 | 0.142857142857 | CDKN1B CDKN1A | AKT phosphorylates targets in the cytosol |
| HP:0000828 | 0.0189064868532 | 0.214285714286 | CDKN1B CDKN1A CDKN2C | Abnormality of the parathyroid gland |
| MIRNA:hsa-miR-646 | 0.01943077596 | 0.285714285714 | CCND2 CCND1 RBL1 CCNE2 | hsa-miR-646 |
| KEGG:05161 | 0.0196540027372 | 0.214285714286 | CCNE2 CDKN1A CDK2 | Hepatitis B |
| GO:0016773 | 0.0198914049163 | 0.5 | CCND1 CCNE2 CCND3 CDKN1A MAPK15 CCND2 CDK2 | phosphotransferase activity, alcohol group as acceptor |
| GO:0072401 | 0.0203855897856 | 0.285714285714 | CDK2 CDKN1B CDKN1A RBL2 | signal transduction involved in DNA integrity checkpoint |
| GO:0072422 | 0.0203855897856 | 0.285714285714 | CDK2 CDKN1B CDKN1A RBL2 | signal transduction involved in DNA damage checkpoint |
| GO:0072395 | 0.0216094383664 | 0.285714285714 | CDK2 CDKN1B CDKN1A RBL2 | signal transduction involved in cell cycle checkpoint |
| GO:0031323 | 0.0222385693586 | 0.928571428571 | CDKN1C ZNF2 RBL2 CCNE2 CCND3 CDKN2C RBL1 CDKN3 MAPK15 CCND2 CDKN1B CDKN1A CCND1 | regulation of cellular metabolic process |
| MIRNA:hsa-miR-95-3p | 0.022823187435 | 0.142857142857 | CDKN1A CCND1 | hsa-miR-95-3p |
| REAC:R-HSA-1362300 | 0.0248025369645 | 0.142857142857 | RBL2 RBL1 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 |
| GO:0071158 | 0.0256107687765 | 0.285714285714 | CDK2 CDKN1B CDKN1A RBL2 | positive regulation of cell cycle arrest |
| HP:0010514 | 0.026090620311 | 0.214285714286 | CDKN1B CDKN1A CDKN2C | Hyperpituitarism |
| HP:0004386 | 0.026090620311 | 0.214285714286 | CDKN1B CDKN1A CDKN2C | Gastrointestinal inflammation |
| HP:0012503 | 0.0263870847301 | 0.285714285714 | CDKN1B CDKN1A CDKN2C CDKN1C | Abnormality of the pituitary gland |
| GO:0000075 | 0.0284703298969 | 0.357142857143 | CDK2 CDKN1B CCND1 CDKN1A RBL2 | cell cycle checkpoint |
| KEGG:05219 | 0.0284948915127 | 0.142857142857 | CDKN1A CCND1 | Bladder cancer |
| KEGG:05216 | 0.0284948915127 | 0.142857142857 | CDKN1A CCND1 | Thyroid cancer |
| REAC:R-HSA-69620 | 0.0294521342177 | 0.285714285714 | CDK2 CDKN1B CDKN1A CCNE2 | Cell Cycle Checkpoints |
| REAC:R-HSA-6804114 | 0.0315892760266 | 0.142857142857 | RBL2 RBL1 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest |
| GO:1904030 | 0.0317503511278 | 0.214285714286 | CDKN1B CDKN1A CDKN1C | negative regulation of cyclin-dependent protein kinase activity |
| GO:1904031 | 0.0317503511278 | 0.214285714286 | CCND2 CCND3 CCND1 | positive regulation of cyclin-dependent protein kinase activity |
| MIRNA:hsa-miR-708-5p | 0.0334871906601 | 0.214285714286 | CCND1 CDKN1A CCND3 | hsa-miR-708-5p |
| MIRNA:hsa-miR-3616-3p | 0.0345842311958 | 0.214285714286 | CDKN1B CDKN1A CCND2 | hsa-miR-3616-3p |
| KEGG:04510 | 0.0350883777295 | 0.214285714286 | CCND2 CCND3 CCND1 | Focal adhesion |
| GO:0016301 | 0.0352456236842 | 0.5 | CCND1 CCNE2 CCND3 CDKN1A MAPK15 CCND2 CDK2 | kinase activity |
| REAC:R-HSA-9634638 | 0.0352867003479 | 0.142857142857 | CDKN1B CCND1 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling |
| REAC:R-HSA-1362277 | 0.0352867003479 | 0.142857142857 | RBL2 RBL1 | Transcription of E2F targets under negative control by DREAM complex |
| WP:WP2828 | 0.0366733081208 | 0.142857142857 | CDKN1A CCND1 | Bladder Cancer |
| KEGG:04340 | 0.0403228683416 | 0.142857142857 | CCND2 CCND1 | Hedgehog signaling pathway |
| WP:WP4249 | 0.0408788252207 | 0.142857142857 | CCND2 CCND1 | Hedgehog Signaling Pathway |
| GO:1905178 | 0.0410249304355 | 0.142857142857 | CDKN1B CDKN1A | regulation of cardiac muscle tissue regeneration |
| GO:0097135 | 0.0410249304355 | 0.142857142857 | CCNE2 CDK2 | cyclin E2-CDK2 complex |
| GO:1905179 | 0.0410249304355 | 0.142857142857 | CDKN1B CDKN1A | negative regulation of cardiac muscle tissue regeneration |
| WP:WP2516 | 0.0430653585518 | 0.142857142857 | CDKN1A CDK2 | ATM Signaling Pathway |
| HP:0010785 | 0.0453999173521 | 0.214285714286 | CDKN1B CCND1 CDKN1C | Gonadal neoplasm |
| HP:0030448 | 0.0453999173521 | 0.214285714286 | CDKN1B CDKN1A CDKN2C | Soft tissue sarcoma |
| WP:WP306 | 0.0469828487906 | 0.214285714286 | CCND2 CCND3 CCND1 | Focal Adhesion |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CDKN1B | CDK2 | 0.999 | 0.949 | hein_WMM bioplex (CDK2) bioplex_WMM hein (CDK2) gupta_WMM |
| CDKN1A | CCND3 | 0.999 | 0.949 | hein_WMM bioplex (CCND3) bioplex_WMM hein (CDKN1A) |
| CDK2 | CDKN1C | 0.998 | 0.941 | hein_WMM bioplex (CDK2) bioplex_WMM hein (CDK2) |
| CDKN1A | CCNE2 | 0.996 | 0.927 | hein_WMM bioplex (CCNE2) bioplex_WMM hein (CDKN1A) |
| CDK2 | CCNE2 | 0.992 | 0.915 | hein_WMM bioplex (CCNE2,CDK2) bioplex_WMM hein (CDK2) |
| RBL1 | CDK2 | 0.988 | 0.902 | bioplex (CDK2) bioplex_WMM boldt boldt_WMM |
| CDK2 | CDKN1A | 0.971 | 0.882 | hein_WMM bioplex (CDK2) bioplex_WMM hein (CDK2,CDKN1A) |
| CDKN1B | CCND3 | 0.93 | 0.846 | hein_WMM bioplex (CCND3) bioplex_WMM |
| CCND3 | CDKN1C | 0.747 | 0.741 | hein_WMM bioplex (CCND3) bioplex_WMM |
| RBL2 | CDK2 | 0.667 | 0.701 | bioplex (CDK2) bioplex_WMM boldt_WMM |
| CDKN1A | CCND2 | 0.463 | 0.6 | bioplex (CCND2) bioplex_WMM |
| CDK2 | CDKN3 | 0.458 | 0.597 | bioplex (CDK2) bioplex_WMM |
| CCND3 | ZNF2 | 0.445 | 0.589 | bioplex (CCND3) bioplex_WMM |
| CDK2 | CCND3 | 0.356 | 0.539 | hein_WMM bioplex (CCND3) bioplex_WMM hein (CDK2) |
| CDK2 | MAPK15 | 0.331 | 0.521 | bioplex (CDK2) bioplex_WMM |
| CDKN2C | CCND3 | 0.145 | 0.409 | bioplex (CCND3) bioplex_WMM |
| CDKN1B | CCND1 | 0.133 | 0.406 | hein_WMM bioplex (CCND1) bioplex_WMM hein (CCND1) |
| CDKN1B | CCND2 | 0.119 | 0.393 | bioplex (CCND2) bioplex_WMM |
| CCND2 | CDKN1C | 0.111 | 0.381 | bioplex (CCND2) bioplex_WMM |
| CCND1 | CDKN1C | 0.099 | 0.359 | hein_WMM bioplex (CCND1) bioplex_WMM |
| CCND1 | CDKN1A | 0.065 | 0.347 | hein_WMM bioplex (CCND1) bioplex_WMM |
| CDKN1B | CDKN1C | 0.036 | 0.267 | hein_WMM bioplex_WMM WMM_only |
| CDKN2C | CCND1 | 0.035 | 0.261 | bioplex (CCND1) bioplex_WMM |
| CDKN1B | CDKN1A | 0.029 | 0.232 | hein_WMM bioplex_WMM WMM_only |
| CDKN1A | CDKN1C | 0.029 | 0.233 | hein_WMM bioplex_WMM WMM_only |
| RBL2 | CCND3 | 0.029 | 0.23 | bioplex (CCND3) bioplex_WMM |
| RBL2 | CDKN1C | 0.013 | 0.149 | bioplex_WMM WMM_only |
| RBL2 | RBL1 | 0.011 | 0.149 | bioplex_WMM WMM_only boldt_WMM |
| CDKN1B | RBL2 | 0.011 | 0.138 | bioplex_WMM WMM_only |
| RBL2 | CDKN1A | 0.011 | 0.14 | bioplex_WMM WMM_only |
| CDKN1C | CDKN3 | 0.01 | 0.131 | bioplex_WMM WMM_only |
| CDKN1B | CCNE2 | 0.01 | 0.126 | hein_WMM bioplex_WMM WMM_only |
| CDKN1C | CCNE2 | 0.01 | 0.12 | hein_WMM bioplex_WMM WMM_only |
| CDKN1B | CDKN3 | 0.01 | 0.104 | bioplex_WMM WMM_only |
| CDKN1A | CDKN3 | 0.009 | 0.104 | bioplex_WMM WMM_only |
| CDKN1B | CDKN2C | 0.009 | 0.101 | bioplex_WMM WMM_only |
| MAPK15 | CDKN3 | 0.009 | 0.101 | bioplex_WMM WMM_only |
| CDKN2C | CDKN1A | 0.009 | 0.09 | bioplex_WMM WMM_only |
| CDKN2C | CDKN1C | 0.009 | 0.099 | bioplex_WMM WMM_only |
| CCND3 | CCNE2 | 0.009 | 0.099 | hein_WMM WMM_only |
| CCND2 | CCND3 | 0.008 | 0.096 | bioplex_WMM WMM_only |
| RBL1 | CDKN1C | 0.008 | 0.089 | bioplex_WMM WMM_only |
| CCNE2 | MAPK15 | 0.008 | 0.089 | bioplex_WMM WMM_only |
| RBL1 | MAPK15 | 0.008 | 0.089 | bioplex_WMM WMM_only |
| RBL2 | MAPK15 | 0.008 | 0.085 | bioplex_WMM WMM_only |
| RBL2 | ZNF2 | 0.008 | 0.085 | bioplex_WMM WMM_only |
| RBL1 | CDKN3 | 0.008 | 0.085 | bioplex_WMM WMM_only |
| CCNE2 | CDKN3 | 0.008 | 0.085 | bioplex_WMM WMM_only |
| RBL2 | CDKN3 | 0.008 | 0.08 | bioplex_WMM WMM_only |
| CDKN1C | ZNF2 | 0.008 | 0.083 | bioplex_WMM WMM_only |
| CDKN1C | MAPK15 | 0.008 | 0.083 | bioplex_WMM WMM_only |
| CDKN1B | RBL1 | 0.008 | 0.06 | bioplex_WMM WMM_only |
| CDKN2C | ZNF2 | 0.008 | 0.059 | bioplex_WMM WMM_only |
| RBL1 | CDKN1A | 0.008 | 0.06 | bioplex_WMM WMM_only |
| CDKN1B | MAPK15 | 0.008 | 0.044 | bioplex_WMM WMM_only |
| CDKN1B | ZNF2 | 0.008 | 0.044 | bioplex_WMM WMM_only |
| CDKN1A | ZNF2 | 0.008 | 0.043 | bioplex_WMM WMM_only |
| CDKN1A | MAPK15 | 0.008 | 0.043 | bioplex_WMM WMM_only |
| CDKN2C | CCND2 | 0.008 | 0.045 | bioplex_WMM WMM_only |
| RBL1 | CCNE2 | 0.008 | 0.031 | bioplex_WMM WMM_only |
| RBL2 | CCNE2 | 0.008 | 0.033 | bioplex_WMM WMM_only |
| CDK2 | ZNF2 | 0.008 | 0.023 | bioplex_WMM WMM_only |
| CCND1 | CCNE2 | 0.008 | 0.023 | hein_WMM WMM_only |
| CCND1 | CCND3 | 0.007 | 0.002 | hein_WMM WMM_only |
| RBL2 | CDKN2C | 0.007 | 0.009 | bioplex_WMM WMM_only |
| CDK2 | CDKN2C | 0.007 | 0.006 | bioplex_WMM WMM_only |
| CDK2 | CCND1 | 0.003 | 0.011 | hein_WMM bioplex (CCND1) bioplex_WMM hein (CDK2) |
| CDK2 | CCND2 | 0.0 | 0.01 | bioplex (CCND2) bioplex_WMM |
| RBL2 | CCND2 | 0.0 | 0.001 | bioplex (CCND2) bioplex_WMM |
Images
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Complex HuMAP2_06056 has an average edge precision of 0.265 which is ranked 5135 out of all 6965 complexes.
Related Complexes