hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06059
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| VSX2 | Visual system homeobox 2 (Ceh-10 homeodomain-containing homolog) (Homeobox protein CHX10) | UniProt NCBI |
| WDR48 | WD repeat-containing protein 48 (USP1-associated factor 1) (WD repeat endosomal protein) (p80) | UniProt NCBI |
| DMWD | Dystrophia myotonica WD repeat-containing protein (Dystrophia myotonica-containing WD repeat motif protein) (Protein 59) (Protein DMR-N9) | UniProt NCBI |
| RAD51AP1 | RAD51-associated protein 1 (RAD51-interacting protein) | UniProt NCBI |
| USP46 | Ubiquitin carboxyl-terminal hydrolase 46 (EC 3.4.19.12) (Deubiquitinating enzyme 46) (Ubiquitin thioesterase 46) (Ubiquitin-specific-processing protease 46) | UniProt NCBI |
| WDR20 | WD repeat-containing protein 20 (Protein DMR) | UniProt NCBI |
| USP1 | Ubiquitin carboxyl-terminal hydrolase 1 (EC 3.4.19.12) (Deubiquitinating enzyme 1) (hUBP) (Ubiquitin thioesterase 1) (Ubiquitin-specific-processing protease 1) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6635 | 3.38154272427e-09 | 0.428571428571 | USP46 WDR20 WDR48 | WDR20-USP46-UAF1 complex |
| CORUM:3176 | 1.007158685e-05 | 0.285714285714 | USP1 WDR48 | USP1-UAF1 complex |
| CORUM:6637 | 1.007158685e-05 | 0.285714285714 | USP46 WDR48 | USP46-UAF1 complex |
| CORUM:6638 | 1.007158685e-05 | 0.285714285714 | USP1 WDR48 | USP1-UAF1 complex |
| CORUM:6634 | 3.02079974644e-05 | 0.285714285714 | WDR20 WDR48 | WDR20-USP12-UAF1 complex |
| CORUM:6521 | 0.000211266711219 | 0.285714285714 | USP1 WDR48 | Akt-PHLPP1-PHLPP2-FANCI-FANCD2-USP1-UAF1 complex |
| KEGG:03460 | 0.0115481650768 | 0.285714285714 | USP1 WDR48 | Fanconi anemia pathway |
| REAC:R-HSA-110314 | 0.0136873957341 | 0.285714285714 | USP1 WDR48 | Recognition of DNA damage by PCNA-containing replication complex |
| REAC:R-HSA-6783310 | 0.0187008825863 | 0.285714285714 | USP1 WDR48 | Fanconi Anemia Pathway |
| REAC:R-HSA-73893 | 0.0338846637816 | 0.285714285714 | USP1 WDR48 | DNA Damage Bypass |
| CORUM:6636 | 0.0499886427319 | 0.142857142857 | WDR48 | USP12-UAF1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| WDR20 | WDR48 | 0.92 | 0.844 | hein_WMM bioplex (WDR20) bioplex_WMM boldt hein (WDR48) gupta_WMM boldt_WMM |
| USP46 | DMWD | 0.893 | 0.819 | bioplex (USP46) bioplex_WMM |
| USP46 | WDR48 | 0.72 | 0.732 | bioplex (USP46) bioplex_WMM boldt gupta_WMM boldt_WMM |
| USP46 | WDR20 | 0.67 | 0.704 | bioplex (USP46,WDR20) bioplex_WMM boldt gupta_WMM boldt_WMM |
| WDR48 | USP1 | 0.18 | 0.437 | hein_WMM bioplex (USP1) bioplex_WMM hein (WDR48) boldt_WMM |
| WDR48 | RAD51AP1 | 0.073 | 0.354 | bioplex (RAD51AP1) bioplex_WMM |
| VSX2 | WDR20 | 0.061 | 0.339 | bioplex (VSX2) bioplex_WMM |
| USP46 | RAD51AP1 | 0.013 | 0.144 | bioplex (RAD51AP1) bioplex_WMM |
| WDR20 | DMWD | 0.008 | 0.082 | hein_WMM bioplex_WMM WMM_only |
| USP1 | DMWD | 0.007 | 0.0 | hein_WMM bioplex_WMM WMM_only |
| WDR20 | USP1 | 0.007 | 0.001 | hein_WMM bioplex_WMM WMM_only |
| USP46 | USP1 | 0.007 | 0.0 | bioplex_WMM WMM_only |
| WDR48 | DMWD | 0.006 | 0.003 | hein_WMM bioplex_WMM hein (WDR48) |
| VSX2 | WDR48 | 0.0 | 0.014 | bioplex (VSX2) bioplex_WMM |
| USP1 | RAD51AP1 | 0.0 | 0.01 | bioplex (RAD51AP1) bioplex_WMM |
Images
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Complex HuMAP2_06059 has an average edge precision of 0.299 which is ranked 4614 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| VSX2 | HuMAP2_01079 HuMAP2_06059 |
| WDR48 | HuMAP2_01079 HuMAP2_01858 HuMAP2_04664 HuMAP2_05585 HuMAP2_06059 |
| DMWD | HuMAP2_01079 HuMAP2_01772 HuMAP2_01858 HuMAP2_06059 |
| RAD51AP1 | HuMAP2_01079 HuMAP2_04664 HuMAP2_06059 |
| USP46 | HuMAP2_01079 HuMAP2_01772 HuMAP2_01858 HuMAP2_06059 |
| WDR20 | HuMAP2_01079 HuMAP2_01858 HuMAP2_04145 HuMAP2_05585 HuMAP2_06059 |
| USP1 | HuMAP2_01079 HuMAP2_04664 HuMAP2_06059 |