hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06060
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| INO80B | INO80 complex subunit B (High mobility group AT-hook 1-like 4) (IES2 homolog) (hIes2) (PAP-1-associated protein 1) (PAPA-1) (Zinc finger HIT domain-containing protein 4) | UniProt NCBI |
| UCHL5 | Ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCH-L5) (EC 3.4.19.12) (Ubiquitin C-terminal hydrolase UCH37) (Ubiquitin thioesterase L5) | UniProt NCBI |
| INO80 | Chromatin-remodeling ATPase INO80 (hINO80) (EC 3.6.4.-) (DNA helicase-related INO80 complex homolog 1) (DNA helicase-related protein INO80) (INO80 complex subunit A) | UniProt NCBI |
| ACTR8 | Actin-related protein 8 (hArp8) (INO80 complex subunit N) | UniProt NCBI |
| INO80C | INO80 complex subunit C (IES6 homolog) (hIes6) | UniProt NCBI |
| TFPT | TCF3 fusion partner (INO80 complex subunit F) (Protein FB1) | UniProt NCBI |
| NFRKB | Nuclear factor related to kappa-B-binding protein (DNA-binding protein R kappa-B) (INO80 complex subunit G) | UniProt NCBI |
| ACTR5 | Actin-related protein 5 (hARP5) (Sarcoma antigen NY-SAR-16) | UniProt NCBI |
| INO80E | INO80 complex subunit E (Coiled-coil domain-containing protein 95) | UniProt NCBI |
| INO80D | INO80 complex subunit D | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0031011 | 2.52305847247e-23 | 0.9 | INO80E ACTR8 UCHL5 ACTR5 TFPT INO80B INO80 INO80C NFRKB | Ino80 complex |
| GO:0033202 | 2.52305847247e-23 | 0.9 | INO80E ACTR8 UCHL5 ACTR5 TFPT INO80B INO80 INO80C NFRKB | DNA helicase complex |
| CORUM:302 | 7.18420526491e-23 | 0.8 | INO80E ACTR8 ACTR5 INO80D INO80B INO80 INO80C NFRKB | INO80 chromatin remodeling complex |
| REAC:R-HSA-5696394 | 3.43351819306e-21 | 0.9 | INO80E ACTR8 ACTR5 INO80D TFPT INO80B INO80 INO80C NFRKB | DNA Damage Recognition in GG-NER |
| GO:0097346 | 1.02925626981e-20 | 0.9 | INO80E ACTR8 UCHL5 ACTR5 TFPT INO80B INO80 INO80C NFRKB | INO80-type complex |
| REAC:R-HSA-5689603 | 2.45379856477e-20 | 1.0 | INO80E ACTR8 UCHL5 ACTR5 INO80D TFPT INO80B INO80 INO80C NFRKB | UCH proteinases |
| REAC:R-HSA-5696399 | 7.73246970997e-18 | 0.9 | INO80E ACTR8 ACTR5 INO80D TFPT INO80B INO80 INO80C NFRKB | Global Genome Nucleotide Excision Repair (GG-NER) |
| REAC:R-HSA-5696398 | 9.73760625703e-17 | 0.9 | INO80E ACTR8 ACTR5 INO80D TFPT INO80B INO80 INO80C NFRKB | Nucleotide Excision Repair |
| REAC:R-HSA-5688426 | 5.83748757696e-16 | 1.0 | INO80E ACTR8 UCHL5 ACTR5 INO80D TFPT INO80B INO80 INO80C NFRKB | Deubiquitination |
| GO:0070603 | 8.10189532493e-16 | 0.9 | INO80E ACTR8 UCHL5 ACTR5 TFPT INO80B INO80 INO80C NFRKB | SWI/SNF superfamily-type complex |
| GO:1904949 | 1.16443089564e-15 | 0.9 | INO80E ACTR8 UCHL5 ACTR5 TFPT INO80B INO80 INO80C NFRKB | ATPase complex |
| GO:0016579 | 6.03962516361e-14 | 1.0 | INO80E ACTR8 UCHL5 ACTR5 INO80D TFPT INO80B INO80 INO80C NFRKB | protein deubiquitination |
| GO:0070646 | 1.15019193315e-13 | 1.0 | INO80E ACTR8 UCHL5 ACTR5 INO80D TFPT INO80B INO80 INO80C NFRKB | protein modification by small protein removal |
| REAC:R-HSA-73894 | 1.84353977994e-12 | 0.9 | INO80E ACTR8 ACTR5 INO80D TFPT INO80B INO80 INO80C NFRKB | DNA Repair |
| REAC:R-HSA-597592 | 3.77108495747e-09 | 1.0 | INO80E ACTR8 UCHL5 ACTR5 INO80D TFPT INO80B INO80 INO80C NFRKB | Post-translational protein modification |
| GO:0070647 | 1.10044104337e-08 | 1.0 | INO80E ACTR8 UCHL5 ACTR5 INO80D TFPT INO80B INO80 INO80C NFRKB | protein modification by small protein conjugation or removal |
| REAC:R-HSA-392499 | 1.42999462702e-07 | 1.0 | INO80E ACTR8 UCHL5 ACTR5 INO80D TFPT INO80B INO80 INO80C NFRKB | Metabolism of proteins |
| GO:0006508 | 7.07530051974e-07 | 1.0 | INO80E ACTR8 UCHL5 ACTR5 INO80D TFPT INO80B INO80 INO80C NFRKB | proteolysis |
| GO:0000790 | 1.08279984617e-06 | 0.9 | INO80E ACTR8 UCHL5 ACTR5 TFPT INO80B INO80 INO80C NFRKB | nuclear chromatin |
| GO:0000785 | 4.79671681544e-06 | 0.9 | INO80E ACTR8 UCHL5 ACTR5 TFPT INO80B INO80 INO80C NFRKB | chromatin |
| GO:0044454 | 6.44350061995e-06 | 0.9 | INO80E ACTR8 UCHL5 ACTR5 TFPT INO80B INO80 INO80C NFRKB | nuclear chromosome part |
| GO:0000228 | 8.18041212093e-06 | 0.9 | INO80E ACTR8 UCHL5 ACTR5 TFPT INO80B INO80 INO80C NFRKB | nuclear chromosome |
| GO:1902494 | 6.22011234658e-05 | 0.9 | INO80E ACTR8 UCHL5 ACTR5 TFPT INO80B INO80 INO80C NFRKB | catalytic complex |
| GO:0044427 | 7.653029207e-05 | 0.9 | INO80E ACTR8 UCHL5 ACTR5 TFPT INO80B INO80 INO80C NFRKB | chromosomal part |
| GO:0005694 | 0.000105741912425 | 0.9 | INO80E ACTR8 UCHL5 ACTR5 TFPT INO80B INO80 INO80C NFRKB | chromosome |
| GO:0036211 | 0.00434612167046 | 1.0 | INO80E ACTR8 UCHL5 ACTR5 INO80D TFPT INO80B INO80 INO80C NFRKB | protein modification process |
| GO:0006464 | 0.00434612167046 | 1.0 | INO80E ACTR8 UCHL5 ACTR5 INO80D TFPT INO80B INO80 INO80C NFRKB | cellular protein modification process |
| GO:0043412 | 0.00773899527665 | 1.0 | INO80E ACTR8 UCHL5 ACTR5 INO80D TFPT INO80B INO80 INO80C NFRKB | macromolecule modification |
| GO:0005654 | 0.00998195755149 | 1.0 | INO80E ACTR8 UCHL5 ACTR5 INO80D TFPT INO80B INO80 INO80C NFRKB | nucleoplasm |
| CORUM:0000000 | 0.0163530596685 | 0.8 | INO80E ACTR8 ACTR5 INO80D INO80B INO80 INO80C NFRKB | CORUM root |
| HPA:026020_22 | 0.0167562295634 | 0.7 | UCHL5 INO80E INO80D TFPT ACTR5 INO80C NFRKB | liver; hepatocytes[Approved,Medium] |
| HPA:047010_23 | 0.0173359082954 | 0.3 | ACTR5 TFPT INO80E | soft tissue 1; adipocytes[Approved,High] |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| ACTR5 | INO80E | 1.0 | 0.949 | hein_WMM bioplex_WMM hein (ACTR5) Malo fraction |
| INO80 | ACTR5 | 1.0 | 0.949 | hein_WMM bioplex_WMM hein (ACTR5) Malo fraction |
| NFRKB | ACTR5 | 1.0 | 0.949 | hein_WMM bioplex_WMM hein (ACTR5) Malo fraction |
| INO80 | INO80E | 0.999 | 0.949 | hein_WMM bioplex_WMM Malo fraction |
| NFRKB | INO80E | 0.998 | 0.944 | hein_WMM bioplex_WMM Malo fraction |
| NFRKB | ACTR8 | 0.998 | 0.944 | hein_WMM bioplex_WMM youn_WMM Malo fraction |
| INO80 | NFRKB | 0.997 | 0.93 | hein_WMM bioplex_WMM Malo fraction |
| UCHL5 | INO80E | 0.919 | 0.841 | bioplex (UCHL5) bioplex_WMM |
| UCHL5 | INO80 | 0.85 | 0.79 | bioplex (UCHL5) bioplex_WMM |
| UCHL5 | NFRKB | 0.848 | 0.79 | bioplex (UCHL5) bioplex_WMM |
| UCHL5 | TFPT | 0.343 | 0.533 | bioplex (UCHL5) bioplex_WMM |
| INO80C | ACTR5 | 0.337 | 0.527 | hein_WMM bioplex_WMM hein (ACTR5) |
| UCHL5 | ACTR5 | 0.317 | 0.509 | bioplex (UCHL5) bioplex_WMM |
| INO80B | UCHL5 | 0.316 | 0.51 | bioplex (UCHL5) bioplex_WMM |
| UCHL5 | ACTR8 | 0.299 | 0.497 | bioplex (UCHL5) bioplex_WMM |
| UCHL5 | INO80C | 0.261 | 0.482 | bioplex (UCHL5) bioplex_WMM |
| TFPT | ACTR5 | 0.229 | 0.468 | hein_WMM bioplex_WMM hein (ACTR5) |
| ACTR5 | ACTR8 | 0.076 | 0.358 | hein_WMM bioplex_WMM hein (ACTR5) |
| INO80D | ACTR5 | 0.074 | 0.356 | hein_WMM bioplex_WMM hein (ACTR5) |
| TFPT | INO80E | 0.033 | 0.252 | hein_WMM bioplex_WMM WMM_only |
| INO80C | INO80E | 0.024 | 0.214 | hein_WMM bioplex_WMM WMM_only |
| INO80 | INO80C | 0.023 | 0.206 | hein_WMM bioplex_WMM WMM_only |
| INO80B | ACTR5 | 0.023 | 0.211 | hein_WMM bioplex_WMM hein (ACTR5) |
| INO80C | ACTR8 | 0.022 | 0.205 | hein_WMM bioplex_WMM WMM_only |
| INO80B | INO80C | 0.022 | 0.196 | hein_WMM bioplex_WMM WMM_only |
| INO80D | UCHL5 | 0.021 | 0.188 | bioplex (UCHL5) bioplex_WMM |
| ACTR8 | INO80E | 0.021 | 0.184 | hein_WMM bioplex_WMM WMM_only |
| INO80B | INO80E | 0.02 | 0.185 | hein_WMM bioplex_WMM WMM_only |
| INO80 | ACTR8 | 0.02 | 0.187 | hein_WMM bioplex_WMM WMM_only |
| INO80B | TFPT | 0.02 | 0.188 | hein_WMM bioplex_WMM WMM_only |
| INO80B | INO80 | 0.019 | 0.183 | hein_WMM bioplex_WMM WMM_only |
| INO80C | TFPT | 0.018 | 0.18 | hein_WMM bioplex_WMM WMM_only |
| INO80B | ACTR8 | 0.018 | 0.182 | hein_WMM bioplex_WMM WMM_only |
| INO80B | INO80D | 0.018 | 0.177 | hein_WMM bioplex_WMM WMM_only |
| INO80D | INO80C | 0.018 | 0.177 | hein_WMM bioplex_WMM WMM_only |
| TFPT | NFRKB | 0.018 | 0.176 | hein_WMM bioplex_WMM WMM_only |
| INO80D | INO80E | 0.017 | 0.173 | hein_WMM bioplex_WMM WMM_only |
| INO80B | NFRKB | 0.017 | 0.173 | hein_WMM bioplex_WMM WMM_only |
| INO80D | TFPT | 0.017 | 0.17 | hein_WMM bioplex_WMM WMM_only |
| INO80 | TFPT | 0.016 | 0.159 | hein_WMM bioplex_WMM WMM_only |
| INO80C | NFRKB | 0.016 | 0.161 | hein_WMM bioplex_WMM WMM_only |
| TFPT | ACTR8 | 0.016 | 0.155 | hein_WMM bioplex_WMM WMM_only |
| INO80D | NFRKB | 0.015 | 0.151 | hein_WMM bioplex_WMM WMM_only |
| INO80D | INO80 | 0.015 | 0.146 | hein_WMM bioplex_WMM WMM_only |
| INO80D | ACTR8 | 0.015 | 0.143 | hein_WMM bioplex_WMM WMM_only |
Images
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Complex HuMAP2_06060 has an average edge precision of 0.4 which is ranked 3325 out of all 6965 complexes.
Related Complexes