hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_06061

Confidence: Medium

Genename	Protein Name	Links
NPAS1	Neuronal PAS domain-containing protein 1 (Neuronal PAS1) (Basic-helix-loop-helix-PAS protein MOP5) (Class E basic helix-loop-helix protein 11) (bHLHe11) (Member of PAS protein 5) (PAS domain-containing protein 5)	UniProt NCBI
HIF1A	Hypoxia-inducible factor 1-alpha (HIF-1-alpha) (HIF1-alpha) (ARNT-interacting protein) (Basic-helix-loop-helix-PAS protein MOP1) (Class E basic helix-loop-helix protein 78) (bHLHe78) (Member of PAS protein 1) (PAS domain-containing protein 8)	UniProt NCBI
TPM2	Tropomyosin beta chain (Beta-tropomyosin) (Tropomyosin-2)	UniProt NCBI
ARNT	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Class E basic helix-loop-helix protein 2) (bHLHe2) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1-beta) (HIF-1-beta) (HIF1-beta)	UniProt NCBI
MYH6	Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha)	UniProt NCBI
MYH3	Myosin-3 (Muscle embryonic myosin heavy chain) (Myosin heavy chain 3) (Myosin heavy chain, fast skeletal muscle, embryonic) (SMHCE)	UniProt NCBI
MYL1	Myosin light chain 1/3, skeletal muscle isoform (MLC1/MLC3) (MLC1F/MLC3F) (Myosin light chain alkali 1/2) (Myosin light chain A1/A2)	UniProt NCBI
TNNC2	Troponin C, skeletal muscle	UniProt NCBI
TNNI1	Troponin I, slow skeletal muscle (Troponin I, slow-twitch isoform)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
WP:WP383	7.67926768304e-13	0.666666666667	TPM2 TNNC2 MYH3 MYL1 MYH6 TNNI1	Striated Muscle Contraction Pathway
REAC:R-HSA-390522	1.78427406466e-12	0.666666666667	TPM2 TNNC2 MYH3 MYL1 MYH6 TNNI1	Striated Muscle Contraction
GO:0030049	7.61315645071e-10	0.666666666667	TPM2 TNNC2 MYH3 MYL1 MYH6 TNNI1	muscle filament sliding
GO:0033275	7.61315645071e-10	0.666666666667	TPM2 TNNC2 MYH3 MYL1 MYH6 TNNI1	actin-myosin filament sliding
REAC:R-HSA-397014	3.53444316376e-08	0.666666666667	TPM2 TNNC2 MYH3 MYL1 MYH6 TNNI1	Muscle contraction
GO:0070252	1.28581290314e-07	0.666666666667	TPM2 TNNC2 MYH3 MYL1 MYH6 TNNI1	actin-mediated cell contraction
GO:0030048	4.38685424933e-07	0.666666666667	TPM2 TNNC2 MYH3 MYL1 MYH6 TNNI1	actin filament-based movement
GO:0030017	9.43606495994e-07	0.666666666667	TPM2 TNNC2 MYH3 MYL1 MYH6 TNNI1	sarcomere
GO:0030016	1.77633848738e-06	0.666666666667	TPM2 TNNC2 MYH3 MYL1 MYH6 TNNI1	myofibril
GO:0044449	1.9467822868e-06	0.666666666667	TPM2 TNNC2 MYH3 MYL1 MYH6 TNNI1	contractile fiber part
GO:0043292	2.654325789e-06	0.666666666667	TPM2 TNNC2 MYH3 MYL1 MYH6 TNNI1	contractile fiber
CORUM:5382	1.34129279418e-05	0.222222222222	HIF1A ARNT	ARNT-HIF1A complex
GO:0006936	3.61558716505e-05	0.666666666667	TPM2 TNNC2 MYH3 MYL1 MYH6 TNNI1	muscle contraction
GO:0003012	9.55694655192e-05	0.666666666667	TPM2 TNNC2 MYH3 MYL1 MYH6 TNNI1	muscle system process
GO:0015629	0.00116435611083	0.666666666667	TPM2 TNNC2 MYH3 MYL1 MYH6 TNNI1	actin cytoskeleton
REAC:R-HSA-1234158	0.00290241019689	0.222222222222	HIF1A ARNT	Regulation of gene expression by Hypoxia-inducible Factor
HP:0100830	0.00337693930593	0.222222222222	TPM2 MYH3	Round ear
WP:WP1539	0.00488522165191	0.222222222222	HIF1A ARNT	Angiogenesis
GO:0005859	0.00619690362803	0.333333333333	MYH3 MYH6 MYL1	muscle myosin complex
GO:0099512	0.00683762712252	0.666666666667	TPM2 TNNC2 MYH3 MYL1 MYH6 TNNI1	supramolecular fiber
GO:0099081	0.00731851242279	0.666666666667	TPM2 TNNC2 MYH3 MYL1 MYH6 TNNI1	supramolecular polymer
GO:0099080	0.00740131690528	0.666666666667	TPM2 TNNC2 MYH3 MYL1 MYH6 TNNI1	supramolecular complex
WP:WP4241	0.00838107930075	0.222222222222	HIF1A ARNT	Type 2 papillary renal cell carcinoma
GO:0005865	0.00865220447533	0.333333333333	TPM2 TNNC2 TNNI1	striated muscle thin filament
WP:WP3614	0.0101633326185	0.222222222222	HIF1A ARNT	Photodynamic therapy-induced HIF-1 survival signaling
GO:0036379	0.0116809984418	0.333333333333	TPM2 TNNC2 TNNI1	myofilament
GO:0016460	0.0116809984418	0.333333333333	MYH3 MYH6 MYL1	myosin II complex
GO:0030029	0.0120206677953	0.666666666667	TPM2 TNNC2 MYH3 MYL1 MYH6 TNNI1	actin filament-based process
HP:0003049	0.0123627209	0.222222222222	TPM2 MYH3	Ulnar deviation of the wrist
GO:0006941	0.0178863307425	0.444444444444	MYH3 MYH6 TNNI1 TNNC2	striated muscle contraction
GO:0003009	0.03072093226	0.333333333333	MYH3 TNNC2 TNNI1	skeletal muscle contraction
KEGG:05211	0.031828111578	0.222222222222	HIF1A ARNT	Renal cell carcinoma
HP:0001623	0.0343154638255	0.222222222222	TPM2 MYH3	Breech presentation
GO:0016459	0.0412466387549	0.333333333333	MYH3 MYH6 MYL1	myosin complex
KEGG:04260	0.0462575571181	0.222222222222	TPM2 MYH6	Cardiac muscle contraction
GO:0050881	0.0494494038063	0.333333333333	MYH3 TNNC2 TNNI1	musculoskeletal movement
GO:0050879	0.0494494038063	0.333333333333	MYH3 TNNC2 TNNI1	multicellular organismal movement
CORUM:4043	0.0499262710315	0.111111111111	ARNT	NEMO-HIF2(alpha)-ARNT complex
CORUM:7273	0.0499262710315	0.111111111111	HIF1A	ARNTL-HIF1A complex
CORUM:2152	0.0499262710315	0.111111111111	ARNT	ARNT-HLF complex

Edges

Protein 1	Protein 2	Score	Precision	Evidence
HIF1A	MYH6	0.996	0.928	bioplex (HIF1A) bioplex_WMM
MYH6	TPM2	0.985	0.899	Guru fraction
TPM2	MYH3	0.959	0.863	Guru fraction
HIF1A	ARNT	0.896	0.821	hein_WMM bioplex (HIF1A) bioplex_WMM youn_WMM hein (HIF1A)
ARNT	NPAS1	0.712	0.728	bioplex (NPAS1) bioplex_WMM
HIF1A	MYH3	0.23	0.468	bioplex (HIF1A) bioplex_WMM
TPM2	TNNI1	0.078	0.352	Guru fraction
HIF1A	MYL1	0.063	0.347	bioplex (HIF1A) bioplex_WMM
HIF1A	TNNC2	0.046	0.292	bioplex (HIF1A) bioplex_WMM
MYH6	TNNC2	0.008	0.085	bioplex_WMM WMM_only
MYH6	ARNT	0.008	0.065	bioplex_WMM WMM_only
MYH6	MYH3	0.008	0.067	bioplex_WMM WMM_only
TNNC2	MYL1	0.008	0.04	bioplex_WMM WMM_only
ARNT	MYL1	0.008	0.022	bioplex_WMM WMM_only
ARNT	TNNC2	0.008	0.013	bioplex_WMM WMM_only
TNNC2	MYH3	0.008	0.011	bioplex_WMM WMM_only
ARNT	MYH3	0.007	0.008	bioplex_WMM WMM_only
MYH3	MYL1	0.003	0.019	bioplex_WMM fraction
TNNI1	MYL1	0.0	0.007	fraction
TNNI1	MYH3	0.0	0.001	Guru fraction
MYH6	TNNI1	0.0	0.001	Guru fraction
MYH6	MYL1	0.0	0.001	bioplex_WMM fraction
TPM2	MYL1	0.0	0.002	fraction

Images

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Complex HuMAP2_06061 has an average edge precision of 0.263 which is ranked 5187 out of all 6965 complexes.

Related Complexes

Genename	Complexes
NPAS1	HuMAP2_02257 HuMAP2_03565 HuMAP2_04482 HuMAP2_04978 HuMAP2_05466 HuMAP2_06061 HuMAP2_06260
HIF1A	HuMAP2_00710 HuMAP2_03104 HuMAP2_04482 HuMAP2_04733 HuMAP2_06061
TPM2	HuMAP2_02652 HuMAP2_04204 HuMAP2_06061 HuMAP2_06387 HuMAP2_06391
ARNT	HuMAP2_02257 HuMAP2_03104 HuMAP2_03565 HuMAP2_04482 HuMAP2_04978 HuMAP2_05466 HuMAP2_06061 HuMAP2_06260
MYH6	HuMAP2_00710 HuMAP2_01870 HuMAP2_02652 HuMAP2_03104 HuMAP2_04204 HuMAP2_06061 HuMAP2_06387
MYH3	HuMAP2_04733 HuMAP2_06061 HuMAP2_06391
MYL1	HuMAP2_06061
TNNC2	HuMAP2_03899 HuMAP2_04612 HuMAP2_05977 HuMAP2_06061
TNNI1	HuMAP2_02652 HuMAP2_06061 HuMAP2_06387

hu.MAP 2.0: Complex View

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Complex: HuMAP2_06061