hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_06067

Confidence: Medium High

Genename	Protein Name	Links
H2BC1	Histone H2B type 1-A (Histone H2B, testis) (TSH2B.1) (hTSH2B) (Testis-specific histone H2B)	UniProt NCBI
JAZF1	Juxtaposed with another zinc finger protein 1 (TAK1-interacting protein 27) (Zinc finger protein 802)	UniProt NCBI
ZNHIT1	Zinc finger HIT domain-containing protein 1 (Cyclin-G1-binding protein 1) (Zinc finger protein subfamily 4A member 1) (p18 Hamlet)	UniProt NCBI
H2BC13	Histone H2B type 1-L (Histone H2B.c) (H2B/c)	UniProt NCBI
H2AZ1	Histone H2A.Z (H2A/z)	UniProt NCBI
ACTR6	Actin-related protein 6 (hArp6) (hARPX)	UniProt NCBI
SRCAP	Helicase SRCAP (EC 3.6.4.-) (Domino homolog 2) (Snf2-related CBP activator)	UniProt NCBI
YEATS4	YEATS domain-containing protein 4 (Glioma-amplified sequence 41) (Gas41) (NuMA-binding protein 1) (NuBI-1) (NuBI1)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:304	1.06951346208e-13	0.625	ACTR6 ZNHIT1 YEATS4 H2AZ1 SRCAP	SRCAP-associated chromatin remodeling complex
GO:0006325	5.19270313175e-05	0.875	H2BC1 H2AZ1 SRCAP H2BC13 ZNHIT1 YEATS4 ACTR6	chromatin organization
GO:0034728	0.00028313316466	0.625	H2BC1 ACTR6 ZNHIT1 H2BC13 SRCAP	nucleosome organization
REAC:R-HSA-171306	0.000371059637687	0.375	H2BC1 H2AZ1 H2BC13	Packaging Of Telomere Ends
REAC:R-HSA-73927	0.000441623004719	0.375	H2BC1 H2AZ1 H2BC13	Depurination
REAC:R-HSA-110331	0.000441623004719	0.375	H2BC1 H2AZ1 H2BC13	Cleavage of the damaged purine
REAC:R-HSA-110330	0.000441623004719	0.375	H2BC1 H2AZ1 H2BC13	Recognition and association of DNA glycosylase with site containing an affected purine
REAC:R-HSA-110328	0.000548821623509	0.375	H2BC1 H2AZ1 H2BC13	Recognition and association of DNA glycosylase with site containing an affected pyrimidine
REAC:R-HSA-110329	0.000548821623509	0.375	H2BC1 H2AZ1 H2BC13	Cleavage of the damaged pyrimidine
REAC:R-HSA-73928	0.000548821623509	0.375	H2BC1 H2AZ1 H2BC13	Depyrimidination
REAC:R-HSA-73929	0.000578076872206	0.375	H2BC1 H2AZ1 H2BC13	Base-Excision Repair, AP Site Formation
GO:0043486	0.000666904519799	0.5	H2BC1 ACTR6 ZNHIT1 SRCAP	histone exchange
REAC:R-HSA-73728	0.000672008352303	0.375	H2BC1 H2AZ1 H2BC13	RNA Polymerase I Promoter Opening
REAC:R-HSA-5334118	0.000739937203157	0.375	H2BC1 H2AZ1 H2BC13	DNA methylation
REAC:R-HSA-5625886	0.000812270452605	0.375	H2BC1 H2AZ1 H2BC13	Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
REAC:R-HSA-427359	0.000850130989111	0.375	H2BC1 H2AZ1 H2BC13	SIRT1 negatively regulates rRNA expression
REAC:R-HSA-212300	0.00105704723173	0.375	H2BC1 H2AZ1 H2BC13	PRC2 methylates histones and DNA
REAC:R-HSA-774815	0.00105704723173	0.375	H2BC1 H2AZ1 H2BC13	Nucleosome assembly
REAC:R-HSA-606279	0.00105704723173	0.375	H2BC1 H2AZ1 H2BC13	Deposition of new CENPA-containing nucleosomes at the centromere
REAC:R-HSA-2299718	0.00105704723173	0.375	H2BC1 H2AZ1 H2BC13	Condensation of Prophase Chromosomes
KEGG:05322	0.00111363097676	0.375	H2BC1 H2AZ1 H2BC13	Systemic lupus erythematosus
GO:0000812	0.00111635111712	0.375	ACTR6 ZNHIT1 SRCAP	Swr1 complex
REAC:R-HSA-1221632	0.00119589308872	0.375	H2BC1 H2AZ1 H2BC13	Meiotic synapsis
REAC:R-HSA-427389	0.00119589308872	0.375	H2BC1 H2AZ1 H2BC13	ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
REAC:R-HSA-4839726	0.00121993817485	0.5	H2BC1 H2BC13 H2AZ1 YEATS4	Chromatin organization
REAC:R-HSA-3247509	0.00121993817485	0.5	H2BC1 H2BC13 H2AZ1 YEATS4	Chromatin modifying enzymes
GO:0051276	0.00135023127082	0.875	H2BC1 H2AZ1 SRCAP H2BC13 ZNHIT1 YEATS4 ACTR6	chromosome organization
REAC:R-HSA-2559586	0.00139910469834	0.375	H2BC1 H2AZ1 H2BC13	DNA Damage/Telomere Stress Induced Senescence
REAC:R-HSA-157579	0.00150876121129	0.375	H2BC1 H2AZ1 H2BC13	Telomere Maintenance
REAC:R-HSA-9616222	0.00162396243043	0.375	H2BC1 H2AZ1 H2BC13	Transcriptional regulation of granulopoiesis
REAC:R-HSA-912446	0.00174484118312	0.375	H2BC1 H2AZ1 H2BC13	Meiotic recombination
REAC:R-HSA-73884	0.00187153001854	0.375	H2BC1 H2AZ1 H2BC13	Base Excision Repair
REAC:R-HSA-201722	0.002004161208	0.375	H2BC1 H2AZ1 H2BC13	Formation of the beta-catenin:TCF transactivating complex
REAC:R-HSA-5250924	0.002004161208	0.375	H2BC1 H2AZ1 H2BC13	B-WICH complex positively regulates rRNA expression
REAC:R-HSA-73772	0.00207274644436	0.375	H2BC1 H2AZ1 H2BC13	RNA Polymerase I Promoter Escape
REAC:R-HSA-1912408	0.0021428667452	0.375	H2BC1 H2AZ1 H2BC13	Pre-NOTCH Transcription and Translation
REAC:R-HSA-8936459	0.00221453856641	0.375	H2BC1 H2AZ1 H2BC13	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
REAC:R-HSA-5625740	0.00228777834657	0.375	H2BC1 H2AZ1 H2BC13	RHO GTPases activate PKNs
GO:0071824	0.00257918866807	0.625	H2BC1 ACTR6 ZNHIT1 H2BC13 SRCAP	protein-DNA complex subunit organization
REAC:R-HSA-977225	0.00293211003473	0.375	H2BC1 H2AZ1 H2BC13	Amyloid fiber formation
REAC:R-HSA-5578749	0.00302019832997	0.375	H2BC1 H2AZ1 H2BC13	Transcriptional regulation by small RNAs
REAC:R-HSA-5250913	0.00320158535345	0.375	H2BC1 H2AZ1 H2BC13	Positive epigenetic regulation of rRNA expression
REAC:R-HSA-427413	0.00329491656206	0.375	H2BC1 H2AZ1 H2BC13	NoRC negatively regulates rRNA expression
REAC:R-HSA-2559582	0.00339002786017	0.375	H2BC1 H2AZ1 H2BC13	Senescence-Associated Secretory Phenotype (SASP)
GO:0043044	0.0033979161892	0.5	H2BC1 ACTR6 ZNHIT1 SRCAP	ATP-dependent chromatin remodeling
REAC:R-HSA-1912422	0.00348693544502	0.375	H2BC1 H2AZ1 H2BC13	Pre-NOTCH Expression and Processing
KEGG:05034	0.00351343024853	0.375	H2BC1 H2AZ1 H2BC13	Alcoholism
REAC:R-HSA-5250941	0.00358565549664	0.375	H2BC1 H2AZ1 H2BC13	Negative epigenetic regulation of rRNA expression
REAC:R-HSA-73886	0.00358565549664	0.375	H2BC1 H2AZ1 H2BC13	Chromosome Maintenance
REAC:R-HSA-73854	0.00368620417793	0.375	H2BC1 H2AZ1 H2BC13	RNA Polymerase I Promoter Clearance
REAC:R-HSA-73864	0.00378859763463	0.375	H2BC1 H2AZ1 H2BC13	RNA Polymerase I Transcription
REAC:R-HSA-1500620	0.00421694153061	0.375	H2BC1 H2AZ1 H2BC13	Meiosis
REAC:R-HSA-5619507	0.00432880045086	0.375	H2BC1 H2AZ1 H2BC13	Activation of HOX genes during differentiation
REAC:R-HSA-5617472	0.00432880045086	0.375	H2BC1 H2AZ1 H2BC13	Activation of anterior HOX genes in hindbrain development during early embryogenesis
REAC:R-HSA-2559580	0.0051670652774	0.375	H2BC1 H2AZ1 H2BC13	Oxidative Stress Induced Senescence
REAC:R-HSA-8939236	0.00569089099284	0.375	H2BC1 H2AZ1 H2BC13	RUNX1 regulates transcription of genes involved in differentiation of HSCs
REAC:R-HSA-1474165	0.00582709935665	0.375	H2BC1 H2AZ1 H2BC13	Reproduction
REAC:R-HSA-211000	0.00654044450585	0.375	H2BC1 H2AZ1 H2BC13	Gene Silencing by RNA
REAC:R-HSA-68875	0.00654044450585	0.375	H2BC1 H2AZ1 H2BC13	Mitotic Prophase
REAC:R-HSA-9018519	0.00796510224121	0.375	H2BC1 H2AZ1 H2BC13	Estrogen-dependent gene expression
REAC:R-HSA-3214847	0.00813495132609	0.375	H2BC1 H2BC13 YEATS4	HATs acetylate histones
REAC:R-HSA-212165	0.00883818351303	0.375	H2BC1 H2AZ1 H2BC13	Epigenetic regulation of gene expression
GO:0097346	0.0116327718591	0.375	ACTR6 ZNHIT1 SRCAP	INO80-type complex
REAC:R-HSA-2559583	0.0187572963581	0.375	H2BC1 H2AZ1 H2BC13	Cellular Senescence
REAC:R-HSA-8939211	0.0238986209347	0.375	H2BC1 H2AZ1 H2BC13	ESR-mediated signaling
REAC:R-HSA-8878171	0.0294850761153	0.375	H2BC1 H2AZ1 H2BC13	Transcriptional regulation by RUNX1
REAC:R-HSA-157118	0.0298851158783	0.375	H2BC1 H2AZ1 H2BC13	Signaling by NOTCH
REAC:R-HSA-201681	0.0306958072782	0.375	H2BC1 H2AZ1 H2BC13	TCF dependent signaling in response to WNT
GO:0006338	0.0344306307973	0.5	H2BC1 ACTR6 ZNHIT1 SRCAP	chromatin remodeling
REAC:R-HSA-9006931	0.040578478522	0.375	H2BC1 H2AZ1 H2BC13	Signaling by Nuclear Receptors

Edges

Protein 1	Protein 2	Score	Precision	Evidence
YEATS4	ACTR6	0.999	0.949	hein_WMM bioplex (YEATS4) bioplex_WMM hein (YEATS4)
YEATS4	ZNHIT1	0.986	0.901	hein_WMM bioplex (YEATS4) bioplex_WMM hein (YEATS4)
YEATS4	SRCAP	0.963	0.871	hein_WMM bioplex (YEATS4) bioplex_WMM hein (YEATS4)
YEATS4	JAZF1	0.949	0.856	hein_WMM bioplex (YEATS4) bioplex_WMM hein (YEATS4)
H2BC1	H2BC13	0.94	0.852	bioplex (H2BC1) bioplex_WMM
H2BC1	ZNHIT1	0.844	0.788	bioplex (H2BC1) bioplex_WMM
ZNHIT1	ACTR6	0.77	0.749	hein_WMM bioplex (ACTR6) bioplex_WMM
H2BC1	ACTR6	0.714	0.727	bioplex (H2BC1) bioplex_WMM
H2BC1	SRCAP	0.514	0.632	bioplex (H2BC1) bioplex_WMM
H2BC1	JAZF1	0.311	0.504	bioplex (H2BC1) bioplex_WMM
H2BC1	H2AZ1	0.071	0.351	bioplex (H2BC1) bioplex_WMM youn_WMM gupta_WMM treiber_WMM
H2BC1	YEATS4	0.061	0.337	bioplex (H2BC1) bioplex_WMM
SRCAP	ACTR6	0.04	0.267	hein_WMM bioplex (ACTR6) bioplex_WMM
ZNHIT1	SRCAP	0.032	0.245	hein_WMM bioplex_WMM WMM_only
ZNHIT1	JAZF1	0.013	0.155	hein_WMM bioplex_WMM WMM_only
ACTR6	JAZF1	0.012	0.147	hein_WMM bioplex_WMM WMM_only
SRCAP	JAZF1	0.01	0.115	hein_WMM bioplex_WMM WMM_only
H2AZ1	JAZF1	0.008	0.081	bioplex_WMM WMM_only
H2BC13	ZNHIT1	0.008	0.014	bioplex_WMM WMM_only
H2BC13	JAZF1	0.008	0.01	bioplex_WMM WMM_only
H2BC13	ACTR6	0.007	0.009	bioplex_WMM WMM_only
H2AZ1	ZNHIT1	0.007	0.009	bioplex_WMM WMM_only
H2BC13	SRCAP	0.007	0.009	bioplex_WMM WMM_only
H2AZ1	SRCAP	0.007	0.001	bioplex_WMM youn_WMM WMM_only
H2BC13	YEATS4	0.007	0.005	bioplex_WMM WMM_only
H2AZ1	H2BC13	0.007	0.007	bioplex_WMM WMM_only
H2AZ1	ACTR6	0.006	0.007	bioplex (ACTR6) bioplex_WMM youn_WMM
H2AZ1	YEATS4	0.0	0.018	bioplex (YEATS4) bioplex_WMM youn_WMM

Images

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Complex HuMAP2_06067 has an average edge precision of 0.343 which is ranked 4081 out of all 6965 complexes.

Related Complexes

Genename	Complexes
H2BC1	HuMAP2_00219 HuMAP2_01712 HuMAP2_02888 HuMAP2_05240 HuMAP2_06067 HuMAP2_06636 HuMAP2_06674
JAZF1	HuMAP2_01817 HuMAP2_03860 HuMAP2_04912 HuMAP2_06035 HuMAP2_06067
ZNHIT1	HuMAP2_01310 HuMAP2_01377 HuMAP2_01559 HuMAP2_01712 HuMAP2_01982 HuMAP2_04912 HuMAP2_06035 HuMAP2_06067
H2BC13	HuMAP2_00219 HuMAP2_01712 HuMAP2_02888 HuMAP2_05240 HuMAP2_05645 HuMAP2_06067 HuMAP2_06674
H2AZ1	HuMAP2_00219 HuMAP2_02888 HuMAP2_06067 HuMAP2_06636
ACTR6	HuMAP2_01559 HuMAP2_01712 HuMAP2_01982 HuMAP2_06035 HuMAP2_06067
SRCAP	HuMAP2_01377 HuMAP2_01559 HuMAP2_01982 HuMAP2_04912 HuMAP2_05240 HuMAP2_06067
YEATS4	HuMAP2_01310 HuMAP2_01559 HuMAP2_01817 HuMAP2_02678 HuMAP2_03860 HuMAP2_04349 HuMAP2_04912 HuMAP2_06035 HuMAP2_06067

hu.MAP 2.0: Complex View

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Complex: HuMAP2_06067