hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06069
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| MSANTD4 | Myb/SANT-like DNA-binding domain-containing protein 4 (Myb/SANT-like DNA-binding domain containing 4 with coiled-coils) | UniProt NCBI |
| RALBP1 | RalA-binding protein 1 (RalBP1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase) (Ral-interacting protein 1) | UniProt NCBI |
| AAK1 | AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1) | UniProt NCBI |
| REPS2 | RalBP1-associated Eps domain-containing protein 2 (Partner of RalBP1) (RalBP1-interacting protein 2) | UniProt NCBI |
| REPS1 | RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1) | UniProt NCBI |
| SKI | Ski oncogene (Proto-oncogene c-Ski) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8856825 | 0.000667561375412 | 0.5 | REPS1 AAK1 REPS2 | Cargo recognition for clathrin-mediated endocytosis |
| REAC:R-HSA-8856828 | 0.00204204589337 | 0.5 | REPS1 AAK1 REPS2 | Clathrin-mediated endocytosis |
| HPA:006010_22 | 0.0463413854558 | 0.666666666667 | REPS1 RALBP1 SKI MSANTD4 | caudate; glial cells[Approved,Medium] |
| CORUM:3198 | 0.0499726005494 | 0.166666666667 | SKI | SKI-SMAD2 complex |
| CORUM:3199 | 0.0499726005494 | 0.166666666667 | SKI | SKI-SMAD3 complex |
| CORUM:3200 | 0.0499726005494 | 0.166666666667 | SKI | SMAD4-SKI complex |
| CORUM:3729 | 0.0499726005494 | 0.166666666667 | SKI | SKI-SMAD2 complex |
| CORUM:3733 | 0.0499726005494 | 0.166666666667 | SKI | SKI-SMAD3 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| REPS1 | RALBP1 | 1.0 | 0.949 | hein_WMM bioplex (RALBP1,REPS1) bioplex_WMM Guru youn_WMM Malo fraction |
| REPS2 | RALBP1 | 0.944 | 0.856 | bioplex (RALBP1) bioplex_WMM |
| MSANTD4 | RALBP1 | 0.76 | 0.75 | bioplex (RALBP1) bioplex_WMM |
| REPS1 | AAK1 | 0.601 | 0.671 | hein_WMM bioplex (REPS1) bioplex_WMM youn_WMM gupta_WMM |
| SKI | RALBP1 | 0.358 | 0.54 | bioplex (RALBP1) bioplex_WMM |
| REPS1 | REPS2 | 0.119 | 0.392 | bioplex (REPS1) bioplex_WMM youn_WMM |
| RALBP1 | AAK1 | 0.055 | 0.311 | hein_WMM bioplex (RALBP1) bioplex_WMM youn_WMM |
| REPS2 | AAK1 | 0.01 | 0.142 | bioplex_WMM youn_WMM WMM_only |
| MSANTD4 | REPS2 | 0.008 | 0.093 | bioplex_WMM WMM_only |
| MSANTD4 | SKI | 0.008 | 0.091 | bioplex_WMM WMM_only |
| SKI | REPS2 | 0.008 | 0.086 | bioplex_WMM WMM_only |
| MSANTD4 | AAK1 | 0.008 | 0.082 | bioplex_WMM WMM_only |
| SKI | AAK1 | 0.008 | 0.046 | bioplex_WMM WMM_only |
| REPS1 | MSANTD4 | 0.008 | 0.041 | bioplex_WMM WMM_only |
| REPS1 | SKI | 0.008 | 0.022 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_06069 has an average edge precision of 0.338 which is ranked 4146 out of all 6965 complexes.
Related Complexes