hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_06084
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SPTBN4 | Spectrin beta chain, non-erythrocytic 4 (Beta-IV spectrin) (Spectrin, non-erythroid beta chain 3) | UniProt NCBI |
| FRYL | Protein furry homolog-like (ALL1-fused gene from chromosome 4p12 protein) | UniProt NCBI |
| HOMER1 | Homer protein homolog 1 (Homer-1) | UniProt NCBI |
| TRAF5 | TNF receptor-associated factor 5 (RING finger protein 84) | UniProt NCBI |
| HOMER3 | Homer protein homolog 3 (Homer-3) | UniProt NCBI |
| HOMER2 | Homer protein homolog 2 (Homer-2) (Cupidin) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0035256 | 1.81582264982e-05 | 0.5 | HOMER2 HOMER3 HOMER1 | G protein-coupled glutamate receptor binding |
| GO:2001256 | 0.000101639975642 | 0.5 | HOMER2 HOMER3 HOMER1 | regulation of store-operated calcium entry |
| REAC:R-HSA-6794361 | 0.00013845803743 | 0.5 | HOMER2 HOMER3 HOMER1 | Neurexins and neuroligins |
| KEGG:04724 | 0.000267985848775 | 0.5 | HOMER2 HOMER3 HOMER1 | Glutamatergic synapse |
| KEGG:04068 | 0.000397675631396 | 0.5 | HOMER2 HOMER3 HOMER1 | FoxO signaling pathway |
| REAC:R-HSA-6794362 | 0.000502143964773 | 0.5 | HOMER2 HOMER3 HOMER1 | Protein-protein interactions at synapses |
| GO:0007216 | 0.000518697707158 | 0.5 | HOMER2 HOMER3 HOMER1 | G protein-coupled glutamate receptor signaling pathway |
| GO:0002115 | 0.000660060925697 | 0.5 | HOMER2 HOMER3 HOMER1 | store-operated calcium entry |
| GO:0035254 | 0.000824951429902 | 0.5 | HOMER2 HOMER3 HOMER1 | glutamate receptor binding |
| GO:0010959 | 0.0309640430511 | 0.666666666667 | HOMER2 SPTBN4 HOMER3 HOMER1 | regulation of metal ion transport |
| REAC:R-HSA-112316 | 0.0370544697669 | 0.5 | HOMER2 HOMER3 HOMER1 | Neuronal System |
| CORUM:74 | 0.0499726005494 | 0.166666666667 | HOMER3 | HOMER3-IP3R-TRPC1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| HOMER3 | HOMER1 | 1.0 | 0.949 | hein_WMM bioplex (HOMER1,HOMER3) bioplex_WMM hein (HOMER1) |
| HOMER2 | HOMER1 | 1.0 | 0.949 | bioplex (HOMER1) bioplex_WMM |
| HOMER3 | HOMER2 | 0.929 | 0.845 | bioplex (HOMER3) bioplex_WMM |
| HOMER1 | SPTBN4 | 0.867 | 0.801 | bioplex (HOMER1) bioplex_WMM |
| HOMER1 | TRAF5 | 0.141 | 0.405 | bioplex (HOMER1) bioplex_WMM |
| HOMER1 | FRYL | 0.112 | 0.381 | hein_WMM bioplex (FRYL) bioplex_WMM hein (HOMER1) |
| HOMER3 | FRYL | 0.024 | 0.216 | hein_WMM bioplex (FRYL,HOMER3) bioplex_WMM |
| SPTBN4 | TRAF5 | 0.008 | 0.089 | bioplex_WMM WMM_only |
| HOMER2 | SPTBN4 | 0.008 | 0.084 | bioplex_WMM WMM_only |
| HOMER2 | TRAF5 | 0.008 | 0.083 | bioplex_WMM WMM_only |
| HOMER3 | SPTBN4 | 0.008 | 0.082 | bioplex_WMM WMM_only |
| HOMER3 | TRAF5 | 0.008 | 0.075 | bioplex_WMM WMM_only |
| HOMER2 | FRYL | 0.008 | 0.042 | bioplex_WMM WMM_only |
| SPTBN4 | FRYL | 0.007 | 0.005 | WMM_only boldt_WMM |
Images
Click to enlarge
Complex HuMAP2_06084 has an average edge precision of 0.358 which is ranked 3797 out of all 6965 complexes.
Related Complexes