hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_06086

Confidence: Medium High

Genename	Protein Name	Links
PDHA1	Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (EC 1.2.4.1) (PDHE1-A type I)	UniProt NCBI
PDHB	Pyruvate dehydrogenase E1 component subunit beta, mitochondrial (PDHE1-B) (EC 1.2.4.1)	UniProt NCBI
PDHX	Pyruvate dehydrogenase protein X component, mitochondrial (Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex) (E3-binding protein) (E3BP) (Lipoyl-containing pyruvate dehydrogenase complex component X) (proX)	UniProt NCBI
PDK3	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 3)	UniProt NCBI
DLAT	Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial (EC 2.3.1.12) (70 kDa mitochondrial autoantigen of primary biliary cirrhosis) (PBC) (Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex) (M2 antigen complex 70 kDa subunit) (Pyruvate dehydrogenase complex component E2) (PDC-E2) (PDCE2)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-204174	1.07132757975e-13	1.0	PDK3 DLAT PDHX PDHA1 PDHB	Regulation of pyruvate dehydrogenase (PDH) complex
REAC:R-HSA-70268	2.91267185745e-12	1.0	PDK3 DLAT PDHX PDHA1 PDHB	Pyruvate metabolism
REAC:R-HSA-5362517	1.6138784755e-11	1.0	PDK3 DLAT PDHX PDHA1 PDHB	Signaling by Retinoic Acid
REAC:R-HSA-71406	6.37439909952e-11	1.0	PDK3 DLAT PDHX PDHA1 PDHB	Pyruvate metabolism and Citric Acid (TCA) cycle
GO:0004738	1.82947049513e-09	0.8	DLAT PDHX PDHA1 PDHB	pyruvate dehydrogenase activity
GO:0045254	1.82947049513e-09	0.8	DLAT PDHX PDHA1 PDHB	pyruvate dehydrogenase complex
REAC:R-HSA-389661	9.99440778064e-09	0.8	DLAT PDHX PDHA1 PDHB	Glyoxylate metabolism and glycine degradation
REAC:R-HSA-1428517	2.3513360199e-08	1.0	PDK3 DLAT PDHX PDHA1 PDHB	The citric acid (TCA) cycle and respiratory electron transport
GO:0006086	6.03530623185e-08	0.8	PDK3 PDHX PDHA1 PDHB	acetyl-CoA biosynthetic process from pyruvate
REAC:R-HSA-9006931	1.69628241468e-07	1.0	PDK3 DLAT PDHX PDHA1 PDHB	Signaling by Nuclear Receptors
GO:0006085	2.90104413489e-07	0.8	PDK3 PDHX PDHA1 PDHB	acetyl-CoA biosynthetic process
GO:0006084	1.82141275099e-06	0.8	PDK3 PDHX PDHA1 PDHB	acetyl-CoA metabolic process
GO:0006090	1.92126330028e-06	1.0	PDK3 DLAT PDHX PDHA1 PDHB	pyruvate metabolic process
KEGG:00020	3.15221459068e-06	0.6	DLAT PDHA1 PDHB	Citrate cycle (TCA cycle)
GO:0034603	3.6323771075e-06	0.6	DLAT PDHB PDHX	pyruvate dehydrogenase [NAD(P)+] activity
GO:0034604	3.6323771075e-06	0.6	DLAT PDHB PDHX	pyruvate dehydrogenase (NAD+) activity
KEGG:00620	7.87603768796e-06	0.6	DLAT PDHA1 PDHB	Pyruvate metabolism
GO:0016903	1.2328136433e-05	0.8	DLAT PDHX PDHA1 PDHB	oxidoreductase activity, acting on the aldehyde or oxo group of donors
GO:0071616	1.36251014669e-05	0.8	PDK3 PDHX PDHA1 PDHB	acyl-CoA biosynthetic process
GO:0035384	1.36251014669e-05	0.8	PDK3 PDHX PDHA1 PDHB	thioester biosynthetic process
HP:0003128	2.52775106148e-05	0.8	DLAT PDHX PDHA1 PDHB	Lactic acidosis
KEGG:00010	3.41403204501e-05	0.6	DLAT PDHA1 PDHB	Glycolysis / Gluconeogenesis
GO:0033866	4.46760620155e-05	0.8	PDK3 PDHX PDHA1 PDHB	nucleoside bisphosphate biosynthetic process
GO:0034030	4.46760620155e-05	0.8	PDK3 PDHX PDHA1 PDHB	ribonucleoside bisphosphate biosynthetic process
GO:0034033	4.46760620155e-05	0.8	PDK3 PDHX PDHA1 PDHB	purine nucleoside bisphosphate biosynthetic process
HP:0002928	4.63036319887e-05	0.6	DLAT PDHA1 PDHX	Decreased activity of the pyruvate dehydrogenase complex
GO:0035383	0.000192129923302	0.8	PDK3 PDHX PDHA1 PDHB	thioester metabolic process
GO:0006637	0.000192129923302	0.8	PDK3 PDHX PDHA1 PDHB	acyl-CoA metabolic process
KEGG:01200	0.000205667969449	0.6	DLAT PDHA1 PDHB	Carbon metabolism
REAC:R-HSA-71291	0.000217774869126	0.8	DLAT PDHX PDHA1 PDHB	Metabolism of amino acids and derivatives
GO:1990204	0.000283155128059	0.8	DLAT PDHX PDHA1 PDHB	oxidoreductase complex
HP:0001941	0.000333341880049	0.8	DLAT PDHX PDHA1 PDHB	Acidosis
WP:WP2453	0.000399978956636	0.4	PDHA1 DLAT	TCA Cycle and Deficiency of Pyruvate Dehydrogenase complex (PDHc)
HP:0004360	0.000472831071609	0.8	DLAT PDHX PDHA1 PDHB	Abnormality of acid-base homeostasis
WP:WP4206	0.000632959696686	0.4	PDHA1 PDHB	Hereditary leiomyomatosis and renal cell carcinoma pathway
GO:0034032	0.000700189954213	0.8	PDK3 PDHX PDHA1 PDHB	purine nucleoside bisphosphate metabolic process
GO:0033875	0.000700189954213	0.8	PDK3 PDHX PDHA1 PDHB	ribonucleoside bisphosphate metabolic process
GO:0033865	0.000700189954213	0.8	PDK3 PDHX PDHA1 PDHB	nucleoside bisphosphate metabolic process
GO:0005759	0.000762366516291	1.0	PDK3 DLAT PDHX PDHA1 PDHB	mitochondrial matrix
GO:0009108	0.000868135384463	0.8	PDK3 PDHX PDHA1 PDHB	coenzyme biosynthetic process
GO:0009152	0.00106458629457	0.8	PDK3 PDHX PDHA1 PDHB	purine ribonucleotide biosynthetic process
GO:0009260	0.00133388073681	0.8	PDK3 PDHX PDHA1 PDHB	ribonucleotide biosynthetic process
GO:0006164	0.0016027516158	0.8	PDK3 PDHX PDHA1 PDHB	purine nucleotide biosynthetic process
GO:0046390	0.0016027516158	0.8	PDK3 PDHX PDHA1 PDHB	ribose phosphate biosynthetic process
GO:0032787	0.00166813062683	1.0	PDK3 DLAT PDHX PDHA1 PDHB	monocarboxylic acid metabolic process
GO:0072522	0.00219868446227	0.8	PDK3 PDHX PDHA1 PDHB	purine-containing compound biosynthetic process
HP:0003287	0.00253383203522	0.6	DLAT PDHA1 PDHX	Abnormality of mitochondrial metabolism
GO:0044272	0.00279846120143	0.8	PDK3 PDHX PDHA1 PDHB	sulfur compound biosynthetic process
WP:WP4290	0.00285983596887	0.4	PDHA1 PDHB	Metabolic reprogramming in colon cancer
WP:WP534	0.00314132080553	0.4	PDHA1 DLAT	Glycolysis and Gluconeogenesis
GO:0016620	0.00407078924856	0.6	DLAT PDHB PDHX	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
HP:0012103	0.00431306699981	0.6	DLAT PDHA1 PDHX	Abnormality of the mitochondrion
REAC:R-HSA-1430728	0.00473657209702	1.0	PDK3 DLAT PDHX PDHA1 PDHB	Metabolism
GO:0051188	0.0049971900723	0.8	PDK3 PDHX PDHA1 PDHB	cofactor biosynthetic process
GO:0009165	0.00511048538005	0.8	PDK3 PDHX PDHA1 PDHB	nucleotide biosynthetic process
REAC:R-HSA-162582	0.00595743543191	1.0	PDK3 DLAT PDHX PDHA1 PDHB	Signal Transduction
GO:1901293	0.00608750012464	0.8	PDK3 PDHX PDHA1 PDHB	nucleoside phosphate biosynthetic process
GO:0006732	0.00749792730182	0.8	PDK3 PDHX PDHA1 PDHB	coenzyme metabolic process
KEGG:05230	0.00941045001151	0.4	PDHA1 PDHB	Central carbon metabolism in cancer
KEGG:01100	0.0121945453342	0.8	DLAT PDHX PDHA1 PDHB	Metabolic pathways
WP:WP3925	0.0126363339816	0.4	PDHA1 PDHX	Amino Acid metabolism
GO:0061732	0.0135228859698	0.4	PDHB PDHX	mitochondrial acetyl-CoA biosynthetic process from pyruvate
HP:0010916	0.0175069025895	0.4	PDHA1 PDHX	Abnormal circulating alanine concentration
HP:0003348	0.0175069025895	0.4	PDHA1 PDHX	Hyperalaninemia
HP:0010915	0.0175069025895	0.4	PDHA1 PDHX	Abnormal circulating pyruvate family amino acid concentration
KEGG:04922	0.0193326076279	0.4	PDHA1 PDHB	Glucagon signaling pathway
KEGG:04066	0.020974746694	0.4	PDHA1 PDHB	HIF-1 signaling pathway
GO:0044429	0.0210056852384	1.0	PDK3 DLAT PDHX PDHA1 PDHB	mitochondrial part
GO:0019752	0.0246974667253	1.0	PDK3 DLAT PDHX PDHA1 PDHB	carboxylic acid metabolic process
HP:0003011	0.0257924002128	1.0	PDK3 DLAT PDHX PDHA1 PDHB	Abnormality of the musculature
GO:0009150	0.0361255742156	0.8	PDK3 PDHX PDHA1 PDHB	purine ribonucleotide metabolic process
GO:0043436	0.0374817807184	1.0	PDK3 DLAT PDHX PDHA1 PDHB	oxoacid metabolic process
GO:0006790	0.0376297096835	0.8	PDK3 PDHX PDHA1 PDHB	sulfur compound metabolic process
GO:0006082	0.0403101804931	1.0	PDK3 DLAT PDHX PDHA1 PDHB	organic acid metabolic process
GO:0009259	0.0407779900821	0.8	PDK3 PDHX PDHA1 PDHB	ribonucleotide metabolic process
GO:0019693	0.0452771886593	0.8	PDK3 PDHX PDHA1 PDHB	ribose phosphate metabolic process

Edges

Protein 1	Protein 2	Score	Precision	Evidence
PDHA1	PDHB	1.0	0.949	hein_WMM bioplex (PDHB) bioplex_WMM Guru Malo gupta_WMM fraction boldt_WMM treiber_WMM
DLAT	PDHB	1.0	0.949	hein_WMM bioplex (PDHB) bioplex_WMM Guru youn_WMM fraction
PDK3	PDHB	0.736	0.738	bioplex (PDHB,PDK3) bioplex_WMM treiber_WMM
PDHX	PDHB	0.531	0.636	hein_WMM bioplex (PDHB,PDHX) bioplex_WMM boldt_WMM
PDK3	PDHA1	0.165	0.42	bioplex (PDK3) bioplex_WMM youn_WMM treiber_WMM
PDHA1	DLAT	0.149	0.41	hein_WMM bioplex_WMM Guru youn_WMM fraction
PDK3	PDHX	0.145	0.408	bioplex (PDK3) bioplex_WMM
PDK3	DLAT	0.09	0.356	bioplex (PDK3) bioplex_WMM youn_WMM
PDHX	DLAT	0.062	0.341	hein_WMM bioplex (PDHX) bioplex_WMM
PDHA1	PDHX	0.054	0.304	hein_WMM bioplex (PDHX) bioplex_WMM

Images

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Complex HuMAP2_06086 has an average edge precision of 0.551 which is ranked 2189 out of all 6965 complexes.

Related Complexes

Genename	Complexes
PDHA1	HuMAP2_03652 HuMAP2_04771 HuMAP2_06086
PDHB	HuMAP2_04771 HuMAP2_06086
PDHX	HuMAP2_03652 HuMAP2_04548 HuMAP2_04760 HuMAP2_06086
PDK3	HuMAP2_00749 HuMAP2_01188 HuMAP2_02405 HuMAP2_02908 HuMAP2_06086
DLAT	HuMAP2_04548 HuMAP2_06086 HuMAP2_06633

hu.MAP 2.0: Complex View

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Complex: HuMAP2_06086