hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_06086
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PDHA1 | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (EC 1.2.4.1) (PDHE1-A type I) | UniProt NCBI |
| PDHB | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial (PDHE1-B) (EC 1.2.4.1) | UniProt NCBI |
| PDHX | Pyruvate dehydrogenase protein X component, mitochondrial (Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex) (E3-binding protein) (E3BP) (Lipoyl-containing pyruvate dehydrogenase complex component X) (proX) | UniProt NCBI |
| PDK3 | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 3) | UniProt NCBI |
| DLAT | Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial (EC 2.3.1.12) (70 kDa mitochondrial autoantigen of primary biliary cirrhosis) (PBC) (Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex) (M2 antigen complex 70 kDa subunit) (Pyruvate dehydrogenase complex component E2) (PDC-E2) (PDCE2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-204174 | 1.07132757975e-13 | 1.0 | DLAT PDHX PDHA1 PDK3 PDHB | Regulation of pyruvate dehydrogenase (PDH) complex |
| REAC:R-HSA-70268 | 2.91267185745e-12 | 1.0 | DLAT PDHX PDHA1 PDK3 PDHB | Pyruvate metabolism |
| REAC:R-HSA-5362517 | 1.6138784755e-11 | 1.0 | DLAT PDHX PDHA1 PDK3 PDHB | Signaling by Retinoic Acid |
| REAC:R-HSA-71406 | 6.37439909952e-11 | 1.0 | DLAT PDHX PDHA1 PDK3 PDHB | Pyruvate metabolism and Citric Acid (TCA) cycle |
| GO:0004738 | 1.82947049513e-09 | 0.8 | PDHX PDHA1 DLAT PDHB | pyruvate dehydrogenase activity |
| GO:0045254 | 1.82947049513e-09 | 0.8 | PDHX PDHA1 DLAT PDHB | pyruvate dehydrogenase complex |
| REAC:R-HSA-389661 | 9.99440778064e-09 | 0.8 | PDHX PDHA1 DLAT PDHB | Glyoxylate metabolism and glycine degradation |
| REAC:R-HSA-1428517 | 2.3513360199e-08 | 1.0 | DLAT PDHX PDHA1 PDK3 PDHB | The citric acid (TCA) cycle and respiratory electron transport |
| GO:0006086 | 6.03530623185e-08 | 0.8 | PDHX PDHA1 PDK3 PDHB | acetyl-CoA biosynthetic process from pyruvate |
| REAC:R-HSA-9006931 | 1.69628241468e-07 | 1.0 | DLAT PDHX PDHA1 PDK3 PDHB | Signaling by Nuclear Receptors |
| GO:0006085 | 2.90104413489e-07 | 0.8 | PDHX PDHA1 PDK3 PDHB | acetyl-CoA biosynthetic process |
| GO:0006084 | 1.82141275099e-06 | 0.8 | PDHX PDHA1 PDK3 PDHB | acetyl-CoA metabolic process |
| GO:0006090 | 1.92126330028e-06 | 1.0 | DLAT PDHX PDHA1 PDK3 PDHB | pyruvate metabolic process |
| KEGG:00020 | 3.15221459068e-06 | 0.6 | PDHA1 DLAT PDHB | Citrate cycle (TCA cycle) |
| GO:0034603 | 3.6323771075e-06 | 0.6 | PDHB DLAT PDHX | pyruvate dehydrogenase [NAD(P)+] activity |
| GO:0034604 | 3.6323771075e-06 | 0.6 | PDHB DLAT PDHX | pyruvate dehydrogenase (NAD+) activity |
| KEGG:00620 | 7.87603768796e-06 | 0.6 | PDHA1 DLAT PDHB | Pyruvate metabolism |
| GO:0016903 | 1.2328136433e-05 | 0.8 | PDHX PDHA1 DLAT PDHB | oxidoreductase activity, acting on the aldehyde or oxo group of donors |
| GO:0071616 | 1.36251014669e-05 | 0.8 | PDHX PDHA1 PDK3 PDHB | acyl-CoA biosynthetic process |
| GO:0035384 | 1.36251014669e-05 | 0.8 | PDHX PDHA1 PDK3 PDHB | thioester biosynthetic process |
| HP:0003128 | 2.52775106148e-05 | 0.8 | PDHX PDHA1 DLAT PDHB | Lactic acidosis |
| KEGG:00010 | 3.41403204501e-05 | 0.6 | PDHA1 DLAT PDHB | Glycolysis / Gluconeogenesis |
| GO:0033866 | 4.46760620155e-05 | 0.8 | PDHX PDHA1 PDK3 PDHB | nucleoside bisphosphate biosynthetic process |
| GO:0034030 | 4.46760620155e-05 | 0.8 | PDHX PDHA1 PDK3 PDHB | ribonucleoside bisphosphate biosynthetic process |
| GO:0034033 | 4.46760620155e-05 | 0.8 | PDHX PDHA1 PDK3 PDHB | purine nucleoside bisphosphate biosynthetic process |
| HP:0002928 | 4.63036319887e-05 | 0.6 | PDHA1 DLAT PDHX | Decreased activity of the pyruvate dehydrogenase complex |
| GO:0035383 | 0.000192129923302 | 0.8 | PDHX PDHA1 PDK3 PDHB | thioester metabolic process |
| GO:0006637 | 0.000192129923302 | 0.8 | PDHX PDHA1 PDK3 PDHB | acyl-CoA metabolic process |
| KEGG:01200 | 0.000205667969449 | 0.6 | PDHA1 DLAT PDHB | Carbon metabolism |
| REAC:R-HSA-71291 | 0.000217774869126 | 0.8 | PDHX PDHA1 DLAT PDHB | Metabolism of amino acids and derivatives |
| GO:1990204 | 0.000283155128059 | 0.8 | PDHX PDHA1 DLAT PDHB | oxidoreductase complex |
| HP:0001941 | 0.000333341880049 | 0.8 | PDHX PDHA1 DLAT PDHB | Acidosis |
| WP:WP2453 | 0.000399978956636 | 0.4 | PDHA1 DLAT | TCA Cycle and Deficiency of Pyruvate Dehydrogenase complex (PDHc) |
| HP:0004360 | 0.000472831071609 | 0.8 | PDHX PDHA1 DLAT PDHB | Abnormality of acid-base homeostasis |
| WP:WP4206 | 0.000632959696686 | 0.4 | PDHA1 PDHB | Hereditary leiomyomatosis and renal cell carcinoma pathway |
| GO:0034032 | 0.000700189954213 | 0.8 | PDHX PDHA1 PDK3 PDHB | purine nucleoside bisphosphate metabolic process |
| GO:0033875 | 0.000700189954213 | 0.8 | PDHX PDHA1 PDK3 PDHB | ribonucleoside bisphosphate metabolic process |
| GO:0033865 | 0.000700189954213 | 0.8 | PDHX PDHA1 PDK3 PDHB | nucleoside bisphosphate metabolic process |
| GO:0005759 | 0.000762366516291 | 1.0 | DLAT PDHX PDHA1 PDK3 PDHB | mitochondrial matrix |
| GO:0009108 | 0.000868135384463 | 0.8 | PDHX PDHA1 PDK3 PDHB | coenzyme biosynthetic process |
| GO:0009152 | 0.00106458629457 | 0.8 | PDHX PDHA1 PDK3 PDHB | purine ribonucleotide biosynthetic process |
| GO:0009260 | 0.00133388073681 | 0.8 | PDHX PDHA1 PDK3 PDHB | ribonucleotide biosynthetic process |
| GO:0006164 | 0.0016027516158 | 0.8 | PDHX PDHA1 PDK3 PDHB | purine nucleotide biosynthetic process |
| GO:0046390 | 0.0016027516158 | 0.8 | PDHX PDHA1 PDK3 PDHB | ribose phosphate biosynthetic process |
| GO:0032787 | 0.00166813062683 | 1.0 | DLAT PDHX PDHA1 PDK3 PDHB | monocarboxylic acid metabolic process |
| GO:0072522 | 0.00219868446227 | 0.8 | PDHX PDHA1 PDK3 PDHB | purine-containing compound biosynthetic process |
| HP:0003287 | 0.00253383203522 | 0.6 | PDHA1 DLAT PDHX | Abnormality of mitochondrial metabolism |
| GO:0044272 | 0.00279846120143 | 0.8 | PDHX PDHA1 PDK3 PDHB | sulfur compound biosynthetic process |
| WP:WP4290 | 0.00285983596887 | 0.4 | PDHA1 PDHB | Metabolic reprogramming in colon cancer |
| WP:WP534 | 0.00314132080553 | 0.4 | PDHA1 DLAT | Glycolysis and Gluconeogenesis |
| GO:0016620 | 0.00407078924856 | 0.6 | PDHB DLAT PDHX | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| HP:0012103 | 0.00431306699981 | 0.6 | PDHA1 DLAT PDHX | Abnormality of the mitochondrion |
| REAC:R-HSA-1430728 | 0.00473657209702 | 1.0 | DLAT PDHX PDHA1 PDK3 PDHB | Metabolism |
| GO:0051188 | 0.0049971900723 | 0.8 | PDHX PDHA1 PDK3 PDHB | cofactor biosynthetic process |
| GO:0009165 | 0.00511048538005 | 0.8 | PDHX PDHA1 PDK3 PDHB | nucleotide biosynthetic process |
| REAC:R-HSA-162582 | 0.00595743543191 | 1.0 | DLAT PDHX PDHA1 PDK3 PDHB | Signal Transduction |
| GO:1901293 | 0.00608750012464 | 0.8 | PDHX PDHA1 PDK3 PDHB | nucleoside phosphate biosynthetic process |
| GO:0006732 | 0.00749792730182 | 0.8 | PDHX PDHA1 PDK3 PDHB | coenzyme metabolic process |
| KEGG:05230 | 0.00941045001151 | 0.4 | PDHA1 PDHB | Central carbon metabolism in cancer |
| KEGG:01100 | 0.0121945453342 | 0.8 | PDHX PDHA1 DLAT PDHB | Metabolic pathways |
| WP:WP3925 | 0.0126363339816 | 0.4 | PDHA1 PDHX | Amino Acid metabolism |
| GO:0061732 | 0.0135228859698 | 0.4 | PDHB PDHX | mitochondrial acetyl-CoA biosynthetic process from pyruvate |
| HP:0010916 | 0.0175069025895 | 0.4 | PDHA1 PDHX | Abnormal circulating alanine concentration |
| HP:0003348 | 0.0175069025895 | 0.4 | PDHA1 PDHX | Hyperalaninemia |
| HP:0010915 | 0.0175069025895 | 0.4 | PDHA1 PDHX | Abnormal circulating pyruvate family amino acid concentration |
| KEGG:04922 | 0.0193326076279 | 0.4 | PDHA1 PDHB | Glucagon signaling pathway |
| KEGG:04066 | 0.020974746694 | 0.4 | PDHA1 PDHB | HIF-1 signaling pathway |
| GO:0044429 | 0.0210056852384 | 1.0 | DLAT PDHX PDHA1 PDK3 PDHB | mitochondrial part |
| GO:0019752 | 0.0246974667253 | 1.0 | DLAT PDHX PDHA1 PDK3 PDHB | carboxylic acid metabolic process |
| HP:0003011 | 0.0257924002128 | 1.0 | DLAT PDHX PDHA1 PDK3 PDHB | Abnormality of the musculature |
| GO:0009150 | 0.0361255742156 | 0.8 | PDHX PDHA1 PDK3 PDHB | purine ribonucleotide metabolic process |
| GO:0043436 | 0.0374817807184 | 1.0 | DLAT PDHX PDHA1 PDK3 PDHB | oxoacid metabolic process |
| GO:0006790 | 0.0376297096835 | 0.8 | PDHX PDHA1 PDK3 PDHB | sulfur compound metabolic process |
| GO:0006082 | 0.0403101804931 | 1.0 | DLAT PDHX PDHA1 PDK3 PDHB | organic acid metabolic process |
| GO:0009259 | 0.0407779900821 | 0.8 | PDHX PDHA1 PDK3 PDHB | ribonucleotide metabolic process |
| GO:0019693 | 0.0452771886593 | 0.8 | PDHX PDHA1 PDK3 PDHB | ribose phosphate metabolic process |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PDHA1 | PDHB | 1.0 | 0.949 | hein_WMM bioplex (PDHB) bioplex_WMM Guru Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| DLAT | PDHB | 1.0 | 0.949 | hein_WMM bioplex (PDHB) bioplex_WMM Guru youn_WMM fraction |
| PDK3 | PDHB | 0.736 | 0.738 | bioplex (PDHB,PDK3) bioplex_WMM treiber_WMM |
| PDHX | PDHB | 0.531 | 0.636 | hein_WMM bioplex (PDHB,PDHX) bioplex_WMM boldt_WMM |
| PDK3 | PDHA1 | 0.165 | 0.42 | bioplex (PDK3) bioplex_WMM youn_WMM treiber_WMM |
| PDHA1 | DLAT | 0.149 | 0.41 | hein_WMM bioplex_WMM Guru youn_WMM fraction |
| PDK3 | PDHX | 0.145 | 0.408 | bioplex (PDK3) bioplex_WMM |
| PDK3 | DLAT | 0.09 | 0.356 | bioplex (PDK3) bioplex_WMM youn_WMM |
| PDHX | DLAT | 0.062 | 0.341 | hein_WMM bioplex (PDHX) bioplex_WMM |
| PDHA1 | PDHX | 0.054 | 0.304 | hein_WMM bioplex (PDHX) bioplex_WMM |
Images
Click to enlarge
Complex HuMAP2_06086 has an average edge precision of 0.551 which is ranked 2189 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| PDHA1 | HuMAP2_03652 HuMAP2_04771 HuMAP2_06086 |
| PDHB | HuMAP2_04771 HuMAP2_06086 |
| PDHX | HuMAP2_03652 HuMAP2_04548 HuMAP2_04760 HuMAP2_06086 |
| PDK3 | HuMAP2_00749 HuMAP2_01188 HuMAP2_02405 HuMAP2_02908 HuMAP2_06086 |
| DLAT | HuMAP2_04548 HuMAP2_06086 HuMAP2_06633 |