hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06086
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PDHA1 | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (EC 1.2.4.1) (PDHE1-A type I) | UniProt NCBI |
| PDHB | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial (PDHE1-B) (EC 1.2.4.1) | UniProt NCBI |
| PDHX | Pyruvate dehydrogenase protein X component, mitochondrial (Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex) (E3-binding protein) (E3BP) (Lipoyl-containing pyruvate dehydrogenase complex component X) (proX) | UniProt NCBI |
| PDK3 | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 3) | UniProt NCBI |
| DLAT | Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial (EC 2.3.1.12) (70 kDa mitochondrial autoantigen of primary biliary cirrhosis) (PBC) (Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex) (M2 antigen complex 70 kDa subunit) (Pyruvate dehydrogenase complex component E2) (PDC-E2) (PDCE2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-204174 | 1.07132757975e-13 | 1.0 | PDHX PDK3 PDHA1 DLAT PDHB | Regulation of pyruvate dehydrogenase (PDH) complex |
| REAC:R-HSA-70268 | 2.91267185745e-12 | 1.0 | PDHX PDK3 PDHA1 DLAT PDHB | Pyruvate metabolism |
| REAC:R-HSA-5362517 | 1.6138784755e-11 | 1.0 | PDHX PDK3 PDHA1 DLAT PDHB | Signaling by Retinoic Acid |
| REAC:R-HSA-71406 | 6.37439909952e-11 | 1.0 | PDHX PDK3 PDHA1 DLAT PDHB | Pyruvate metabolism and Citric Acid (TCA) cycle |
| GO:0004738 | 1.82947049513e-09 | 0.8 | PDHX DLAT PDHA1 PDHB | pyruvate dehydrogenase activity |
| GO:0045254 | 1.82947049513e-09 | 0.8 | PDHX DLAT PDHA1 PDHB | pyruvate dehydrogenase complex |
| REAC:R-HSA-389661 | 9.99440778064e-09 | 0.8 | PDHX DLAT PDHA1 PDHB | Glyoxylate metabolism and glycine degradation |
| REAC:R-HSA-1428517 | 2.3513360199e-08 | 1.0 | PDHX PDK3 PDHA1 DLAT PDHB | The citric acid (TCA) cycle and respiratory electron transport |
| GO:0006086 | 6.03530623185e-08 | 0.8 | PDHX PDK3 PDHA1 PDHB | acetyl-CoA biosynthetic process from pyruvate |
| REAC:R-HSA-9006931 | 1.69628241468e-07 | 1.0 | PDHX PDK3 PDHA1 DLAT PDHB | Signaling by Nuclear Receptors |
| GO:0006085 | 2.90104413489e-07 | 0.8 | PDHX PDK3 PDHA1 PDHB | acetyl-CoA biosynthetic process |
| GO:0006084 | 1.82141275099e-06 | 0.8 | PDHX PDK3 PDHA1 PDHB | acetyl-CoA metabolic process |
| GO:0006090 | 1.92126330028e-06 | 1.0 | PDHX PDK3 PDHA1 DLAT PDHB | pyruvate metabolic process |
| KEGG:00020 | 3.15221459068e-06 | 0.6 | DLAT PDHA1 PDHB | Citrate cycle (TCA cycle) |
| GO:0034603 | 3.6323771075e-06 | 0.6 | PDHX PDHB DLAT | pyruvate dehydrogenase [NAD(P)+] activity |
| GO:0034604 | 3.6323771075e-06 | 0.6 | PDHX PDHB DLAT | pyruvate dehydrogenase (NAD+) activity |
| KEGG:00620 | 7.87603768796e-06 | 0.6 | DLAT PDHA1 PDHB | Pyruvate metabolism |
| GO:0016903 | 1.2328136433e-05 | 0.8 | PDHX DLAT PDHA1 PDHB | oxidoreductase activity, acting on the aldehyde or oxo group of donors |
| GO:0071616 | 1.36251014669e-05 | 0.8 | PDHX PDK3 PDHA1 PDHB | acyl-CoA biosynthetic process |
| GO:0035384 | 1.36251014669e-05 | 0.8 | PDHX PDK3 PDHA1 PDHB | thioester biosynthetic process |
| HP:0003128 | 2.52775106148e-05 | 0.8 | PDHX DLAT PDHA1 PDHB | Lactic acidosis |
| KEGG:00010 | 3.41403204501e-05 | 0.6 | DLAT PDHA1 PDHB | Glycolysis / Gluconeogenesis |
| GO:0033866 | 4.46760620155e-05 | 0.8 | PDHX PDK3 PDHA1 PDHB | nucleoside bisphosphate biosynthetic process |
| GO:0034030 | 4.46760620155e-05 | 0.8 | PDHX PDK3 PDHA1 PDHB | ribonucleoside bisphosphate biosynthetic process |
| GO:0034033 | 4.46760620155e-05 | 0.8 | PDHX PDK3 PDHA1 PDHB | purine nucleoside bisphosphate biosynthetic process |
| HP:0002928 | 4.63036319887e-05 | 0.6 | PDHX PDHA1 DLAT | Decreased activity of the pyruvate dehydrogenase complex |
| GO:0035383 | 0.000192129923302 | 0.8 | PDHX PDK3 PDHA1 PDHB | thioester metabolic process |
| GO:0006637 | 0.000192129923302 | 0.8 | PDHX PDK3 PDHA1 PDHB | acyl-CoA metabolic process |
| KEGG:01200 | 0.000205667969449 | 0.6 | DLAT PDHA1 PDHB | Carbon metabolism |
| REAC:R-HSA-71291 | 0.000217774869126 | 0.8 | PDHX DLAT PDHA1 PDHB | Metabolism of amino acids and derivatives |
| GO:1990204 | 0.000283155128059 | 0.8 | PDHX DLAT PDHA1 PDHB | oxidoreductase complex |
| HP:0001941 | 0.000333341880049 | 0.8 | PDHX DLAT PDHA1 PDHB | Acidosis |
| WP:WP2453 | 0.000399978956636 | 0.4 | PDHA1 DLAT | TCA Cycle and Deficiency of Pyruvate Dehydrogenase complex (PDHc) |
| HP:0004360 | 0.000472831071609 | 0.8 | PDHX DLAT PDHA1 PDHB | Abnormality of acid-base homeostasis |
| WP:WP4206 | 0.000632959696686 | 0.4 | PDHA1 PDHB | Hereditary leiomyomatosis and renal cell carcinoma pathway |
| GO:0034032 | 0.000700189954213 | 0.8 | PDHX PDK3 PDHA1 PDHB | purine nucleoside bisphosphate metabolic process |
| GO:0033875 | 0.000700189954213 | 0.8 | PDHX PDK3 PDHA1 PDHB | ribonucleoside bisphosphate metabolic process |
| GO:0033865 | 0.000700189954213 | 0.8 | PDHX PDK3 PDHA1 PDHB | nucleoside bisphosphate metabolic process |
| GO:0005759 | 0.000762366516291 | 1.0 | PDHX PDK3 PDHA1 DLAT PDHB | mitochondrial matrix |
| GO:0009108 | 0.000868135384463 | 0.8 | PDHX PDK3 PDHA1 PDHB | coenzyme biosynthetic process |
| GO:0009152 | 0.00106458629457 | 0.8 | PDHX PDK3 PDHA1 PDHB | purine ribonucleotide biosynthetic process |
| GO:0009260 | 0.00133388073681 | 0.8 | PDHX PDK3 PDHA1 PDHB | ribonucleotide biosynthetic process |
| GO:0006164 | 0.0016027516158 | 0.8 | PDHX PDK3 PDHA1 PDHB | purine nucleotide biosynthetic process |
| GO:0046390 | 0.0016027516158 | 0.8 | PDHX PDK3 PDHA1 PDHB | ribose phosphate biosynthetic process |
| GO:0032787 | 0.00166813062683 | 1.0 | PDHX PDK3 PDHA1 DLAT PDHB | monocarboxylic acid metabolic process |
| GO:0072522 | 0.00219868446227 | 0.8 | PDHX PDK3 PDHA1 PDHB | purine-containing compound biosynthetic process |
| HP:0003287 | 0.00253383203522 | 0.6 | PDHX PDHA1 DLAT | Abnormality of mitochondrial metabolism |
| GO:0044272 | 0.00279846120143 | 0.8 | PDHX PDK3 PDHA1 PDHB | sulfur compound biosynthetic process |
| WP:WP4290 | 0.00285983596887 | 0.4 | PDHA1 PDHB | Metabolic reprogramming in colon cancer |
| WP:WP534 | 0.00314132080553 | 0.4 | PDHA1 DLAT | Glycolysis and Gluconeogenesis |
| GO:0016620 | 0.00407078924856 | 0.6 | PDHX PDHB DLAT | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| HP:0012103 | 0.00431306699981 | 0.6 | PDHX PDHA1 DLAT | Abnormality of the mitochondrion |
| REAC:R-HSA-1430728 | 0.00473657209702 | 1.0 | PDHX PDK3 PDHA1 DLAT PDHB | Metabolism |
| GO:0051188 | 0.0049971900723 | 0.8 | PDHX PDK3 PDHA1 PDHB | cofactor biosynthetic process |
| GO:0009165 | 0.00511048538005 | 0.8 | PDHX PDK3 PDHA1 PDHB | nucleotide biosynthetic process |
| REAC:R-HSA-162582 | 0.00595743543191 | 1.0 | PDHX PDK3 PDHA1 DLAT PDHB | Signal Transduction |
| GO:1901293 | 0.00608750012464 | 0.8 | PDHX PDK3 PDHA1 PDHB | nucleoside phosphate biosynthetic process |
| GO:0006732 | 0.00749792730182 | 0.8 | PDHX PDK3 PDHA1 PDHB | coenzyme metabolic process |
| KEGG:05230 | 0.00941045001151 | 0.4 | PDHA1 PDHB | Central carbon metabolism in cancer |
| KEGG:01100 | 0.0121945453342 | 0.8 | PDHX DLAT PDHA1 PDHB | Metabolic pathways |
| WP:WP3925 | 0.0126363339816 | 0.4 | PDHX PDHA1 | Amino Acid metabolism |
| GO:0061732 | 0.0135228859698 | 0.4 | PDHX PDHB | mitochondrial acetyl-CoA biosynthetic process from pyruvate |
| HP:0010916 | 0.0175069025895 | 0.4 | PDHX PDHA1 | Abnormal circulating alanine concentration |
| HP:0003348 | 0.0175069025895 | 0.4 | PDHX PDHA1 | Hyperalaninemia |
| HP:0010915 | 0.0175069025895 | 0.4 | PDHX PDHA1 | Abnormal circulating pyruvate family amino acid concentration |
| KEGG:04922 | 0.0193326076279 | 0.4 | PDHA1 PDHB | Glucagon signaling pathway |
| KEGG:04066 | 0.020974746694 | 0.4 | PDHA1 PDHB | HIF-1 signaling pathway |
| GO:0044429 | 0.0210056852384 | 1.0 | PDHX PDK3 PDHA1 DLAT PDHB | mitochondrial part |
| GO:0019752 | 0.0246974667253 | 1.0 | PDHX PDK3 PDHA1 DLAT PDHB | carboxylic acid metabolic process |
| HP:0003011 | 0.0257924002128 | 1.0 | PDHX PDK3 PDHA1 DLAT PDHB | Abnormality of the musculature |
| GO:0009150 | 0.0361255742156 | 0.8 | PDHX PDK3 PDHA1 PDHB | purine ribonucleotide metabolic process |
| GO:0043436 | 0.0374817807184 | 1.0 | PDHX PDK3 PDHA1 DLAT PDHB | oxoacid metabolic process |
| GO:0006790 | 0.0376297096835 | 0.8 | PDHX PDK3 PDHA1 PDHB | sulfur compound metabolic process |
| GO:0006082 | 0.0403101804931 | 1.0 | PDHX PDK3 PDHA1 DLAT PDHB | organic acid metabolic process |
| GO:0009259 | 0.0407779900821 | 0.8 | PDHX PDK3 PDHA1 PDHB | ribonucleotide metabolic process |
| GO:0019693 | 0.0452771886593 | 0.8 | PDHX PDK3 PDHA1 PDHB | ribose phosphate metabolic process |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PDHA1 | PDHB | 1.0 | 0.949 | hein_WMM bioplex (PDHB) bioplex_WMM Guru Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| DLAT | PDHB | 1.0 | 0.949 | hein_WMM bioplex (PDHB) bioplex_WMM Guru youn_WMM fraction |
| PDK3 | PDHB | 0.736 | 0.738 | bioplex (PDHB,PDK3) bioplex_WMM treiber_WMM |
| PDHX | PDHB | 0.531 | 0.636 | hein_WMM bioplex (PDHB,PDHX) bioplex_WMM boldt_WMM |
| PDK3 | PDHA1 | 0.165 | 0.42 | bioplex (PDK3) bioplex_WMM youn_WMM treiber_WMM |
| PDHA1 | DLAT | 0.149 | 0.41 | hein_WMM bioplex_WMM Guru youn_WMM fraction |
| PDK3 | PDHX | 0.145 | 0.408 | bioplex (PDK3) bioplex_WMM |
| PDK3 | DLAT | 0.09 | 0.356 | bioplex (PDK3) bioplex_WMM youn_WMM |
| PDHX | DLAT | 0.062 | 0.341 | hein_WMM bioplex (PDHX) bioplex_WMM |
| PDHA1 | PDHX | 0.054 | 0.304 | hein_WMM bioplex (PDHX) bioplex_WMM |
Images
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Complex HuMAP2_06086 has an average edge precision of 0.551 which is ranked 2189 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| PDHA1 | HuMAP2_03652 HuMAP2_04771 HuMAP2_06086 |
| PDHB | HuMAP2_04771 HuMAP2_06086 |
| PDHX | HuMAP2_03652 HuMAP2_04548 HuMAP2_04760 HuMAP2_06086 |
| PDK3 | HuMAP2_00749 HuMAP2_01188 HuMAP2_02405 HuMAP2_02908 HuMAP2_06086 |
| DLAT | HuMAP2_04548 HuMAP2_06086 HuMAP2_06633 |