hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06086
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PDHA1 | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (EC 1.2.4.1) (PDHE1-A type I) | UniProt NCBI |
| PDHB | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial (PDHE1-B) (EC 1.2.4.1) | UniProt NCBI |
| PDHX | Pyruvate dehydrogenase protein X component, mitochondrial (Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex) (E3-binding protein) (E3BP) (Lipoyl-containing pyruvate dehydrogenase complex component X) (proX) | UniProt NCBI |
| PDK3 | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 3) | UniProt NCBI |
| DLAT | Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial (EC 2.3.1.12) (70 kDa mitochondrial autoantigen of primary biliary cirrhosis) (PBC) (Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex) (M2 antigen complex 70 kDa subunit) (Pyruvate dehydrogenase complex component E2) (PDC-E2) (PDCE2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-204174 | 1.07132757975e-13 | 1.0 | PDK3 PDHA1 DLAT PDHB PDHX | Regulation of pyruvate dehydrogenase (PDH) complex |
| REAC:R-HSA-70268 | 2.91267185745e-12 | 1.0 | PDK3 PDHA1 DLAT PDHB PDHX | Pyruvate metabolism |
| REAC:R-HSA-5362517 | 1.6138784755e-11 | 1.0 | PDK3 PDHA1 DLAT PDHB PDHX | Signaling by Retinoic Acid |
| REAC:R-HSA-71406 | 6.37439909952e-11 | 1.0 | PDK3 PDHA1 DLAT PDHB PDHX | Pyruvate metabolism and Citric Acid (TCA) cycle |
| GO:0004738 | 1.82947049513e-09 | 0.8 | PDHA1 DLAT PDHB PDHX | pyruvate dehydrogenase activity |
| GO:0045254 | 1.82947049513e-09 | 0.8 | PDHA1 DLAT PDHB PDHX | pyruvate dehydrogenase complex |
| REAC:R-HSA-389661 | 9.99440778064e-09 | 0.8 | PDHA1 DLAT PDHB PDHX | Glyoxylate metabolism and glycine degradation |
| REAC:R-HSA-1428517 | 2.3513360199e-08 | 1.0 | PDK3 PDHA1 DLAT PDHB PDHX | The citric acid (TCA) cycle and respiratory electron transport |
| GO:0006086 | 6.03530623185e-08 | 0.8 | PDK3 PDHA1 PDHB PDHX | acetyl-CoA biosynthetic process from pyruvate |
| REAC:R-HSA-9006931 | 1.69628241468e-07 | 1.0 | PDK3 PDHA1 DLAT PDHB PDHX | Signaling by Nuclear Receptors |
| GO:0006085 | 2.90104413489e-07 | 0.8 | PDK3 PDHA1 PDHB PDHX | acetyl-CoA biosynthetic process |
| GO:0006084 | 1.82141275099e-06 | 0.8 | PDK3 PDHA1 PDHB PDHX | acetyl-CoA metabolic process |
| GO:0006090 | 1.92126330028e-06 | 1.0 | PDK3 PDHA1 DLAT PDHB PDHX | pyruvate metabolic process |
| KEGG:00020 | 3.15221459068e-06 | 0.6 | PDHA1 PDHB DLAT | Citrate cycle (TCA cycle) |
| GO:0034603 | 3.6323771075e-06 | 0.6 | PDHX PDHB DLAT | pyruvate dehydrogenase [NAD(P)+] activity |
| GO:0034604 | 3.6323771075e-06 | 0.6 | PDHX PDHB DLAT | pyruvate dehydrogenase (NAD+) activity |
| KEGG:00620 | 7.87603768796e-06 | 0.6 | PDHA1 PDHB DLAT | Pyruvate metabolism |
| GO:0016903 | 1.2328136433e-05 | 0.8 | PDHA1 DLAT PDHB PDHX | oxidoreductase activity, acting on the aldehyde or oxo group of donors |
| GO:0071616 | 1.36251014669e-05 | 0.8 | PDK3 PDHA1 PDHB PDHX | acyl-CoA biosynthetic process |
| GO:0035384 | 1.36251014669e-05 | 0.8 | PDK3 PDHA1 PDHB PDHX | thioester biosynthetic process |
| HP:0003128 | 2.52775106148e-05 | 0.8 | PDHA1 DLAT PDHB PDHX | Lactic acidosis |
| KEGG:00010 | 3.41403204501e-05 | 0.6 | PDHA1 PDHB DLAT | Glycolysis / Gluconeogenesis |
| GO:0033866 | 4.46760620155e-05 | 0.8 | PDK3 PDHA1 PDHB PDHX | nucleoside bisphosphate biosynthetic process |
| GO:0034030 | 4.46760620155e-05 | 0.8 | PDK3 PDHA1 PDHB PDHX | ribonucleoside bisphosphate biosynthetic process |
| GO:0034033 | 4.46760620155e-05 | 0.8 | PDK3 PDHA1 PDHB PDHX | purine nucleoside bisphosphate biosynthetic process |
| HP:0002928 | 4.63036319887e-05 | 0.6 | PDHA1 DLAT PDHX | Decreased activity of the pyruvate dehydrogenase complex |
| GO:0035383 | 0.000192129923302 | 0.8 | PDK3 PDHA1 PDHB PDHX | thioester metabolic process |
| GO:0006637 | 0.000192129923302 | 0.8 | PDK3 PDHA1 PDHB PDHX | acyl-CoA metabolic process |
| KEGG:01200 | 0.000205667969449 | 0.6 | PDHA1 PDHB DLAT | Carbon metabolism |
| REAC:R-HSA-71291 | 0.000217774869126 | 0.8 | PDHA1 DLAT PDHB PDHX | Metabolism of amino acids and derivatives |
| GO:1990204 | 0.000283155128059 | 0.8 | PDHA1 DLAT PDHB PDHX | oxidoreductase complex |
| HP:0001941 | 0.000333341880049 | 0.8 | PDHA1 DLAT PDHB PDHX | Acidosis |
| WP:WP2453 | 0.000399978956636 | 0.4 | PDHA1 DLAT | TCA Cycle and Deficiency of Pyruvate Dehydrogenase complex (PDHc) |
| HP:0004360 | 0.000472831071609 | 0.8 | PDHA1 DLAT PDHB PDHX | Abnormality of acid-base homeostasis |
| WP:WP4206 | 0.000632959696686 | 0.4 | PDHA1 PDHB | Hereditary leiomyomatosis and renal cell carcinoma pathway |
| GO:0034032 | 0.000700189954213 | 0.8 | PDK3 PDHA1 PDHB PDHX | purine nucleoside bisphosphate metabolic process |
| GO:0033875 | 0.000700189954213 | 0.8 | PDK3 PDHA1 PDHB PDHX | ribonucleoside bisphosphate metabolic process |
| GO:0033865 | 0.000700189954213 | 0.8 | PDK3 PDHA1 PDHB PDHX | nucleoside bisphosphate metabolic process |
| GO:0005759 | 0.000762366516291 | 1.0 | PDK3 PDHA1 DLAT PDHB PDHX | mitochondrial matrix |
| GO:0009108 | 0.000868135384463 | 0.8 | PDK3 PDHA1 PDHB PDHX | coenzyme biosynthetic process |
| GO:0009152 | 0.00106458629457 | 0.8 | PDK3 PDHA1 PDHB PDHX | purine ribonucleotide biosynthetic process |
| GO:0009260 | 0.00133388073681 | 0.8 | PDK3 PDHA1 PDHB PDHX | ribonucleotide biosynthetic process |
| GO:0006164 | 0.0016027516158 | 0.8 | PDK3 PDHA1 PDHB PDHX | purine nucleotide biosynthetic process |
| GO:0046390 | 0.0016027516158 | 0.8 | PDK3 PDHA1 PDHB PDHX | ribose phosphate biosynthetic process |
| GO:0032787 | 0.00166813062683 | 1.0 | PDK3 PDHA1 DLAT PDHB PDHX | monocarboxylic acid metabolic process |
| GO:0072522 | 0.00219868446227 | 0.8 | PDK3 PDHA1 PDHB PDHX | purine-containing compound biosynthetic process |
| HP:0003287 | 0.00253383203522 | 0.6 | PDHA1 DLAT PDHX | Abnormality of mitochondrial metabolism |
| GO:0044272 | 0.00279846120143 | 0.8 | PDK3 PDHA1 PDHB PDHX | sulfur compound biosynthetic process |
| WP:WP4290 | 0.00285983596887 | 0.4 | PDHA1 PDHB | Metabolic reprogramming in colon cancer |
| WP:WP534 | 0.00314132080553 | 0.4 | PDHA1 DLAT | Glycolysis and Gluconeogenesis |
| GO:0016620 | 0.00407078924856 | 0.6 | PDHX PDHB DLAT | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| HP:0012103 | 0.00431306699981 | 0.6 | PDHA1 DLAT PDHX | Abnormality of the mitochondrion |
| REAC:R-HSA-1430728 | 0.00473657209702 | 1.0 | PDK3 PDHA1 DLAT PDHB PDHX | Metabolism |
| GO:0051188 | 0.0049971900723 | 0.8 | PDK3 PDHA1 PDHB PDHX | cofactor biosynthetic process |
| GO:0009165 | 0.00511048538005 | 0.8 | PDK3 PDHA1 PDHB PDHX | nucleotide biosynthetic process |
| REAC:R-HSA-162582 | 0.00595743543191 | 1.0 | PDK3 PDHA1 DLAT PDHB PDHX | Signal Transduction |
| GO:1901293 | 0.00608750012464 | 0.8 | PDK3 PDHA1 PDHB PDHX | nucleoside phosphate biosynthetic process |
| GO:0006732 | 0.00749792730182 | 0.8 | PDK3 PDHA1 PDHB PDHX | coenzyme metabolic process |
| KEGG:05230 | 0.00941045001151 | 0.4 | PDHA1 PDHB | Central carbon metabolism in cancer |
| KEGG:01100 | 0.0121945453342 | 0.8 | PDHA1 DLAT PDHB PDHX | Metabolic pathways |
| WP:WP3925 | 0.0126363339816 | 0.4 | PDHA1 PDHX | Amino Acid metabolism |
| GO:0061732 | 0.0135228859698 | 0.4 | PDHX PDHB | mitochondrial acetyl-CoA biosynthetic process from pyruvate |
| HP:0010916 | 0.0175069025895 | 0.4 | PDHA1 PDHX | Abnormal circulating alanine concentration |
| HP:0003348 | 0.0175069025895 | 0.4 | PDHA1 PDHX | Hyperalaninemia |
| HP:0010915 | 0.0175069025895 | 0.4 | PDHA1 PDHX | Abnormal circulating pyruvate family amino acid concentration |
| KEGG:04922 | 0.0193326076279 | 0.4 | PDHA1 PDHB | Glucagon signaling pathway |
| KEGG:04066 | 0.020974746694 | 0.4 | PDHA1 PDHB | HIF-1 signaling pathway |
| GO:0044429 | 0.0210056852384 | 1.0 | PDK3 PDHA1 DLAT PDHB PDHX | mitochondrial part |
| GO:0019752 | 0.0246974667253 | 1.0 | PDK3 PDHA1 DLAT PDHB PDHX | carboxylic acid metabolic process |
| HP:0003011 | 0.0257924002128 | 1.0 | PDK3 PDHA1 DLAT PDHB PDHX | Abnormality of the musculature |
| GO:0009150 | 0.0361255742156 | 0.8 | PDK3 PDHA1 PDHB PDHX | purine ribonucleotide metabolic process |
| GO:0043436 | 0.0374817807184 | 1.0 | PDK3 PDHA1 DLAT PDHB PDHX | oxoacid metabolic process |
| GO:0006790 | 0.0376297096835 | 0.8 | PDK3 PDHA1 PDHB PDHX | sulfur compound metabolic process |
| GO:0006082 | 0.0403101804931 | 1.0 | PDK3 PDHA1 DLAT PDHB PDHX | organic acid metabolic process |
| GO:0009259 | 0.0407779900821 | 0.8 | PDK3 PDHA1 PDHB PDHX | ribonucleotide metabolic process |
| GO:0019693 | 0.0452771886593 | 0.8 | PDK3 PDHA1 PDHB PDHX | ribose phosphate metabolic process |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PDHA1 | PDHB | 1.0 | 0.949 | hein_WMM bioplex (PDHB) bioplex_WMM Guru Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| DLAT | PDHB | 1.0 | 0.949 | hein_WMM bioplex (PDHB) bioplex_WMM Guru youn_WMM fraction |
| PDK3 | PDHB | 0.736 | 0.738 | bioplex (PDHB,PDK3) bioplex_WMM treiber_WMM |
| PDHX | PDHB | 0.531 | 0.636 | hein_WMM bioplex (PDHB,PDHX) bioplex_WMM boldt_WMM |
| PDK3 | PDHA1 | 0.165 | 0.42 | bioplex (PDK3) bioplex_WMM youn_WMM treiber_WMM |
| PDHA1 | DLAT | 0.149 | 0.41 | hein_WMM bioplex_WMM Guru youn_WMM fraction |
| PDK3 | PDHX | 0.145 | 0.408 | bioplex (PDK3) bioplex_WMM |
| PDK3 | DLAT | 0.09 | 0.356 | bioplex (PDK3) bioplex_WMM youn_WMM |
| PDHX | DLAT | 0.062 | 0.341 | hein_WMM bioplex (PDHX) bioplex_WMM |
| PDHA1 | PDHX | 0.054 | 0.304 | hein_WMM bioplex (PDHX) bioplex_WMM |
Images
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Complex HuMAP2_06086 has an average edge precision of 0.551 which is ranked 2189 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| PDHA1 | HuMAP2_03652 HuMAP2_04771 HuMAP2_06086 |
| PDHB | HuMAP2_04771 HuMAP2_06086 |
| PDHX | HuMAP2_03652 HuMAP2_04548 HuMAP2_04760 HuMAP2_06086 |
| PDK3 | HuMAP2_00749 HuMAP2_01188 HuMAP2_02405 HuMAP2_02908 HuMAP2_06086 |
| DLAT | HuMAP2_04548 HuMAP2_06086 HuMAP2_06633 |