hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_06086

Confidence: Medium High

Genename	Protein Name	Links
PDHA1	Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (EC 1.2.4.1) (PDHE1-A type I)	UniProt NCBI
PDHB	Pyruvate dehydrogenase E1 component subunit beta, mitochondrial (PDHE1-B) (EC 1.2.4.1)	UniProt NCBI
PDHX	Pyruvate dehydrogenase protein X component, mitochondrial (Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex) (E3-binding protein) (E3BP) (Lipoyl-containing pyruvate dehydrogenase complex component X) (proX)	UniProt NCBI
PDK3	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 3)	UniProt NCBI
DLAT	Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial (EC 2.3.1.12) (70 kDa mitochondrial autoantigen of primary biliary cirrhosis) (PBC) (Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex) (M2 antigen complex 70 kDa subunit) (Pyruvate dehydrogenase complex component E2) (PDC-E2) (PDCE2)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-204174	1.07132757975e-13	1.0	PDK3 PDHB DLAT PDHA1 PDHX	Regulation of pyruvate dehydrogenase (PDH) complex
REAC:R-HSA-70268	2.91267185745e-12	1.0	PDK3 PDHB DLAT PDHA1 PDHX	Pyruvate metabolism
REAC:R-HSA-5362517	1.6138784755e-11	1.0	PDK3 PDHB DLAT PDHA1 PDHX	Signaling by Retinoic Acid
REAC:R-HSA-71406	6.37439909952e-11	1.0	PDK3 PDHB DLAT PDHA1 PDHX	Pyruvate metabolism and Citric Acid (TCA) cycle
GO:0004738	1.82947049513e-09	0.8	PDHB DLAT PDHA1 PDHX	pyruvate dehydrogenase activity
GO:0045254	1.82947049513e-09	0.8	PDHB DLAT PDHA1 PDHX	pyruvate dehydrogenase complex
REAC:R-HSA-389661	9.99440778064e-09	0.8	PDHB DLAT PDHA1 PDHX	Glyoxylate metabolism and glycine degradation
REAC:R-HSA-1428517	2.3513360199e-08	1.0	PDK3 PDHB DLAT PDHA1 PDHX	The citric acid (TCA) cycle and respiratory electron transport
GO:0006086	6.03530623185e-08	0.8	PDK3 PDHB PDHA1 PDHX	acetyl-CoA biosynthetic process from pyruvate
REAC:R-HSA-9006931	1.69628241468e-07	1.0	PDK3 PDHB DLAT PDHA1 PDHX	Signaling by Nuclear Receptors
GO:0006085	2.90104413489e-07	0.8	PDK3 PDHB PDHA1 PDHX	acetyl-CoA biosynthetic process
GO:0006084	1.82141275099e-06	0.8	PDK3 PDHB PDHA1 PDHX	acetyl-CoA metabolic process
GO:0006090	1.92126330028e-06	1.0	PDK3 PDHB DLAT PDHA1 PDHX	pyruvate metabolic process
KEGG:00020	3.15221459068e-06	0.6	PDHB PDHA1 DLAT	Citrate cycle (TCA cycle)
GO:0034603	3.6323771075e-06	0.6	PDHB DLAT PDHX	pyruvate dehydrogenase [NAD(P)+] activity
GO:0034604	3.6323771075e-06	0.6	PDHB DLAT PDHX	pyruvate dehydrogenase (NAD+) activity
KEGG:00620	7.87603768796e-06	0.6	PDHB PDHA1 DLAT	Pyruvate metabolism
GO:0016903	1.2328136433e-05	0.8	PDHB DLAT PDHA1 PDHX	oxidoreductase activity, acting on the aldehyde or oxo group of donors
GO:0071616	1.36251014669e-05	0.8	PDK3 PDHB PDHA1 PDHX	acyl-CoA biosynthetic process
GO:0035384	1.36251014669e-05	0.8	PDK3 PDHB PDHA1 PDHX	thioester biosynthetic process
HP:0003128	2.52775106148e-05	0.8	PDHB DLAT PDHA1 PDHX	Lactic acidosis
KEGG:00010	3.41403204501e-05	0.6	PDHB PDHA1 DLAT	Glycolysis / Gluconeogenesis
GO:0033866	4.46760620155e-05	0.8	PDK3 PDHB PDHA1 PDHX	nucleoside bisphosphate biosynthetic process
GO:0034030	4.46760620155e-05	0.8	PDK3 PDHB PDHA1 PDHX	ribonucleoside bisphosphate biosynthetic process
GO:0034033	4.46760620155e-05	0.8	PDK3 PDHB PDHA1 PDHX	purine nucleoside bisphosphate biosynthetic process
HP:0002928	4.63036319887e-05	0.6	PDHX PDHA1 DLAT	Decreased activity of the pyruvate dehydrogenase complex
GO:0035383	0.000192129923302	0.8	PDK3 PDHB PDHA1 PDHX	thioester metabolic process
GO:0006637	0.000192129923302	0.8	PDK3 PDHB PDHA1 PDHX	acyl-CoA metabolic process
KEGG:01200	0.000205667969449	0.6	PDHB PDHA1 DLAT	Carbon metabolism
REAC:R-HSA-71291	0.000217774869126	0.8	PDHB DLAT PDHA1 PDHX	Metabolism of amino acids and derivatives
GO:1990204	0.000283155128059	0.8	PDHB DLAT PDHA1 PDHX	oxidoreductase complex
HP:0001941	0.000333341880049	0.8	PDHB DLAT PDHA1 PDHX	Acidosis
WP:WP2453	0.000399978956636	0.4	DLAT PDHA1	TCA Cycle and Deficiency of Pyruvate Dehydrogenase complex (PDHc)
HP:0004360	0.000472831071609	0.8	PDHB DLAT PDHA1 PDHX	Abnormality of acid-base homeostasis
WP:WP4206	0.000632959696686	0.4	PDHB PDHA1	Hereditary leiomyomatosis and renal cell carcinoma pathway
GO:0034032	0.000700189954213	0.8	PDK3 PDHB PDHA1 PDHX	purine nucleoside bisphosphate metabolic process
GO:0033875	0.000700189954213	0.8	PDK3 PDHB PDHA1 PDHX	ribonucleoside bisphosphate metabolic process
GO:0033865	0.000700189954213	0.8	PDK3 PDHB PDHA1 PDHX	nucleoside bisphosphate metabolic process
GO:0005759	0.000762366516291	1.0	PDK3 PDHB DLAT PDHA1 PDHX	mitochondrial matrix
GO:0009108	0.000868135384463	0.8	PDK3 PDHB PDHA1 PDHX	coenzyme biosynthetic process
GO:0009152	0.00106458629457	0.8	PDK3 PDHB PDHA1 PDHX	purine ribonucleotide biosynthetic process
GO:0009260	0.00133388073681	0.8	PDK3 PDHB PDHA1 PDHX	ribonucleotide biosynthetic process
GO:0006164	0.0016027516158	0.8	PDK3 PDHB PDHA1 PDHX	purine nucleotide biosynthetic process
GO:0046390	0.0016027516158	0.8	PDK3 PDHB PDHA1 PDHX	ribose phosphate biosynthetic process
GO:0032787	0.00166813062683	1.0	PDK3 PDHB DLAT PDHA1 PDHX	monocarboxylic acid metabolic process
GO:0072522	0.00219868446227	0.8	PDK3 PDHB PDHA1 PDHX	purine-containing compound biosynthetic process
HP:0003287	0.00253383203522	0.6	PDHX PDHA1 DLAT	Abnormality of mitochondrial metabolism
GO:0044272	0.00279846120143	0.8	PDK3 PDHB PDHA1 PDHX	sulfur compound biosynthetic process
WP:WP4290	0.00285983596887	0.4	PDHB PDHA1	Metabolic reprogramming in colon cancer
WP:WP534	0.00314132080553	0.4	DLAT PDHA1	Glycolysis and Gluconeogenesis
GO:0016620	0.00407078924856	0.6	PDHB DLAT PDHX	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
HP:0012103	0.00431306699981	0.6	PDHX PDHA1 DLAT	Abnormality of the mitochondrion
REAC:R-HSA-1430728	0.00473657209702	1.0	PDK3 PDHB DLAT PDHA1 PDHX	Metabolism
GO:0051188	0.0049971900723	0.8	PDK3 PDHB PDHA1 PDHX	cofactor biosynthetic process
GO:0009165	0.00511048538005	0.8	PDK3 PDHB PDHA1 PDHX	nucleotide biosynthetic process
REAC:R-HSA-162582	0.00595743543191	1.0	PDK3 PDHB DLAT PDHA1 PDHX	Signal Transduction
GO:1901293	0.00608750012464	0.8	PDK3 PDHB PDHA1 PDHX	nucleoside phosphate biosynthetic process
GO:0006732	0.00749792730182	0.8	PDK3 PDHB PDHA1 PDHX	coenzyme metabolic process
KEGG:05230	0.00941045001151	0.4	PDHB PDHA1	Central carbon metabolism in cancer
KEGG:01100	0.0121945453342	0.8	PDHB DLAT PDHA1 PDHX	Metabolic pathways
WP:WP3925	0.0126363339816	0.4	PDHX PDHA1	Amino Acid metabolism
GO:0061732	0.0135228859698	0.4	PDHB PDHX	mitochondrial acetyl-CoA biosynthetic process from pyruvate
HP:0010916	0.0175069025895	0.4	PDHX PDHA1	Abnormal circulating alanine concentration
HP:0003348	0.0175069025895	0.4	PDHX PDHA1	Hyperalaninemia
HP:0010915	0.0175069025895	0.4	PDHX PDHA1	Abnormal circulating pyruvate family amino acid concentration
KEGG:04922	0.0193326076279	0.4	PDHB PDHA1	Glucagon signaling pathway
KEGG:04066	0.020974746694	0.4	PDHB PDHA1	HIF-1 signaling pathway
GO:0044429	0.0210056852384	1.0	PDK3 PDHB DLAT PDHA1 PDHX	mitochondrial part
GO:0019752	0.0246974667253	1.0	PDK3 PDHB DLAT PDHA1 PDHX	carboxylic acid metabolic process
HP:0003011	0.0257924002128	1.0	PDK3 PDHB DLAT PDHA1 PDHX	Abnormality of the musculature
GO:0009150	0.0361255742156	0.8	PDK3 PDHB PDHA1 PDHX	purine ribonucleotide metabolic process
GO:0043436	0.0374817807184	1.0	PDK3 PDHB DLAT PDHA1 PDHX	oxoacid metabolic process
GO:0006790	0.0376297096835	0.8	PDK3 PDHB PDHA1 PDHX	sulfur compound metabolic process
GO:0006082	0.0403101804931	1.0	PDK3 PDHB DLAT PDHA1 PDHX	organic acid metabolic process
GO:0009259	0.0407779900821	0.8	PDK3 PDHB PDHA1 PDHX	ribonucleotide metabolic process
GO:0019693	0.0452771886593	0.8	PDK3 PDHB PDHA1 PDHX	ribose phosphate metabolic process

Edges

Protein 1	Protein 2	Score	Precision	Evidence
PDHA1	PDHB	1.0	0.949	hein_WMM bioplex (PDHB) bioplex_WMM Guru Malo gupta_WMM fraction boldt_WMM treiber_WMM
DLAT	PDHB	1.0	0.949	hein_WMM bioplex (PDHB) bioplex_WMM Guru youn_WMM fraction
PDK3	PDHB	0.736	0.738	bioplex (PDHB,PDK3) bioplex_WMM treiber_WMM
PDHX	PDHB	0.531	0.636	hein_WMM bioplex (PDHB,PDHX) bioplex_WMM boldt_WMM
PDK3	PDHA1	0.165	0.42	bioplex (PDK3) bioplex_WMM youn_WMM treiber_WMM
PDHA1	DLAT	0.149	0.41	hein_WMM bioplex_WMM Guru youn_WMM fraction
PDK3	PDHX	0.145	0.408	bioplex (PDK3) bioplex_WMM
PDK3	DLAT	0.09	0.356	bioplex (PDK3) bioplex_WMM youn_WMM
PDHX	DLAT	0.062	0.341	hein_WMM bioplex (PDHX) bioplex_WMM
PDHA1	PDHX	0.054	0.304	hein_WMM bioplex (PDHX) bioplex_WMM

Images

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Complex HuMAP2_06086 has an average edge precision of 0.551 which is ranked 2189 out of all 6965 complexes.

Related Complexes

Genename	Complexes
PDHA1	HuMAP2_03652 HuMAP2_04771 HuMAP2_06086
PDHB	HuMAP2_04771 HuMAP2_06086
PDHX	HuMAP2_03652 HuMAP2_04548 HuMAP2_04760 HuMAP2_06086
PDK3	HuMAP2_00749 HuMAP2_01188 HuMAP2_02405 HuMAP2_02908 HuMAP2_06086
DLAT	HuMAP2_04548 HuMAP2_06086 HuMAP2_06633

hu.MAP 2.0: Complex View

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Complex: HuMAP2_06086