hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06091
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| UPF3A | Regulator of nonsense transcripts 3A (Nonsense mRNA reducing factor 3A) (Up-frameshift suppressor 3 homolog A) (hUpf3) | UniProt NCBI |
| HBA1 | Hemoglobin subunit alpha (Alpha-globin) (Hemoglobin alpha chain) | UniProt NCBI |
| CA1 | Carbonic anhydrase 1 (EC 4.2.1.1) (Carbonate dehydratase I) (Carbonic anhydrase B) (CAB) (Carbonic anhydrase I) (CA-I) | UniProt NCBI |
| HBD | Hemoglobin subunit delta (Delta-globin) (Hemoglobin delta chain) | UniProt NCBI |
| HBB | Hemoglobin subunit beta (Beta-globin) (Hemoglobin beta chain) [Cleaved into: LVV-hemorphin-7; Spinorphin] | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-1247673 | 0.000281403908969 | 0.5 | CA1 HBB | Erythrocytes take up oxygen and release carbon dioxide |
| REAC:R-HSA-1237044 | 0.000452175281072 | 0.5 | CA1 HBB | Erythrocytes take up carbon dioxide and release oxygen |
| REAC:R-HSA-1480926 | 0.000452175281072 | 0.5 | CA1 HBB | O2/CO2 exchange in erythrocytes |
| HP:0001935 | 0.00737157747856 | 0.5 | HBD HBB | Microcytic anemia |
| HP:0011902 | 0.00796059020261 | 0.5 | HBD HBB | Abnormal hemoglobin |
| GO:0031721 | 0.0162267366884 | 0.5 | HBD HBB | hemoglobin alpha binding |
| GO:0030492 | 0.0405595771497 | 0.5 | HBD HBB | hemoglobin binding |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| HBB | UPF3A | 0.165 | 0.42 | bioplex (UPF3A) bioplex_WMM |
| UPF3A | HBD | 0.091 | 0.354 | bioplex (UPF3A) bioplex_WMM |
| UPF3A | CA1 | 0.066 | 0.349 | bioplex (UPF3A) bioplex_WMM |
| HBA1 | UPF3A | 0.053 | 0.301 | bioplex (UPF3A) bioplex_WMM |
| HBA1 | HBB | 0.019 | 0.184 | bioplex_WMM WMM_only |
| HBB | CA1 | 0.007 | 0.005 | bioplex_WMM WMM_only |
| HBD | CA1 | 0.007 | 0.003 | bioplex_WMM WMM_only |
| HBA1 | CA1 | 0.007 | 0.005 | bioplex_WMM WMM_only |
| HBB | HBD | 0.006 | 0.007 | bioplex_WMM WMM_only boldt_WMM |
| HBA1 | HBD | 0.006 | 0.005 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_06091 has an average edge precision of 0.163 which is ranked 6593 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| UPF3A | HuMAP2_04634 HuMAP2_06091 HuMAP2_06651 |
| HBA1 | HuMAP2_03680 HuMAP2_04634 HuMAP2_06091 |
| CA1 | HuMAP2_04634 HuMAP2_06091 HuMAP2_06651 |
| HBD | HuMAP2_04634 HuMAP2_06091 HuMAP2_06651 |
| HBB | HuMAP2_04634 HuMAP2_06091 HuMAP2_06651 |