hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06099
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PRMT5 | Protein arginine N-methyltransferase 5 (EC 2.1.1.320) (72 kDa ICln-binding protein) (Histone-arginine N-methyltransferase PRMT5) (Jak-binding protein 1) (Shk1 kinase-binding protein 1 homolog) (SKB1 homolog) (SKB1Hs) [Cleaved into: Protein arginine N-methyltransferase 5, N-terminally processed] | UniProt NCBI |
| RBMS1 | RNA-binding motif, single-stranded-interacting protein 1 (Single-stranded DNA-binding protein MSSP-1) (Suppressor of CDC2 with RNA-binding motif 2) | UniProt NCBI |
| RBFOX2 | RNA binding protein fox-1 homolog 2 (Fox-1 homolog B) (Hexaribonucleotide-binding protein 2) (RNA-binding motif protein 9) (RNA-binding protein 9) (Repressor of tamoxifen transcriptional activity) | UniProt NCBI |
| COPRS | Coordinator of PRMT5 and differentiation stimulator (Cooperator of PRMT5) (Protein TTP1) | UniProt NCBI |
| FAM168B | Myelin-associated neurite-outgrowth inhibitor (Mani) (p20) | UniProt NCBI |
| RBMS2 | RNA-binding motif, single-stranded-interacting protein 2 (Suppressor of CDC2 with RNA-binding motif 3) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6853 | 8.39001385941e-06 | 0.333333333333 | COPRS PRMT5 | COPRS-PRMT5 complex |
| CORUM:6852 | 5.0322056017e-05 | 0.333333333333 | COPRS PRMT5 | COPRS-PRMT5-RUNX1-CBFB complex |
| GO:0043985 | 0.020283420769 | 0.333333333333 | COPRS PRMT5 | histone H4-R3 methylation |
| CORUM:1748 | 0.0249904952816 | 0.166666666667 | PRMT5 | PRMT5 complex |
| CORUM:2764 | 0.0249904952816 | 0.166666666667 | PRMT5 | PRMT5 complex |
| CORUM:836 | 0.0499726005494 | 0.166666666667 | PRMT5 | 20S methyltransferase core complex |
| CORUM:7410 | 0.0499726005494 | 0.166666666667 | PRMT5 | CAPG-PRMT5 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| FAM168B | RBFOX2 | 0.772 | 0.751 | bioplex (RBFOX2) bioplex_WMM |
| PRMT5 | COPRS | 0.492 | 0.62 | hein_WMM bioplex_WMM youn_WMM hein (PRMT5) gupta_WMM boldt_WMM |
| RBFOX2 | PRMT5 | 0.31 | 0.503 | bioplex (RBFOX2) bioplex_WMM boldt youn_WMM boldt_WMM |
| RBFOX2 | COPRS | 0.118 | 0.391 | bioplex (RBFOX2) bioplex_WMM |
| RBFOX2 | RBMS1 | 0.089 | 0.355 | youn (RBMS1) bioplex (RBFOX2) bioplex_WMM boldt youn_WMM boldt_WMM |
| RBFOX2 | RBMS2 | 0.08 | 0.351 | bioplex (RBFOX2) bioplex_WMM youn_WMM |
| RBMS2 | RBMS1 | 0.012 | 0.146 | youn (RBMS1) bioplex_WMM youn_WMM treiber_WMM |
| FAM168B | RBMS2 | 0.008 | 0.091 | bioplex_WMM WMM_only |
| FAM168B | RBMS1 | 0.008 | 0.046 | bioplex_WMM WMM_only |
| RBMS2 | COPRS | 0.008 | 0.035 | bioplex_WMM WMM_only |
| RBMS2 | PRMT5 | 0.008 | 0.033 | bioplex_WMM youn_WMM WMM_only |
| FAM168B | COPRS | 0.008 | 0.025 | bioplex_WMM WMM_only |
| FAM168B | PRMT5 | 0.008 | 0.015 | bioplex_WMM WMM_only |
| RBMS1 | COPRS | 0.007 | 0.003 | bioplex_WMM youn_WMM WMM_only |
| RBMS1 | PRMT5 | 0.007 | 0.004 | youn (RBMS1) bioplex_WMM youn_WMM |
Images
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Complex HuMAP2_06099 has an average edge precision of 0.225 which is ranked 5783 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| PRMT5 | HuMAP2_02069 HuMAP2_04365 HuMAP2_04507 HuMAP2_05928 HuMAP2_06099 HuMAP2_06950 |
| RBMS1 | HuMAP2_01052 HuMAP2_02586 HuMAP2_06099 |
| RBFOX2 | HuMAP2_00002 HuMAP2_02508 HuMAP2_03447 HuMAP2_04289 HuMAP2_06099 |
| COPRS | HuMAP2_04365 HuMAP2_06099 HuMAP2_06950 |
| FAM168B | HuMAP2_00002 HuMAP2_02508 HuMAP2_03447 HuMAP2_04289 HuMAP2_06099 |
| RBMS2 | HuMAP2_00002 HuMAP2_00999 HuMAP2_02016 HuMAP2_04289 HuMAP2_06099 HuMAP2_06650 |