hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06109
Confidence: Extremely High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| ACTL6A | Actin-like protein 6A (53 kDa BRG1-associated factor A) (Actin-related protein Baf53a) (ArpNbeta) (BRG1-associated factor 53A) (BAF53A) (INO80 complex subunit K) | UniProt NCBI |
| SMARCD2 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 (60 kDa BRG-1/Brm-associated factor subunit B) (BRG1-associated factor 60B) (BAF60B) | UniProt NCBI |
| SMARCC1 | SWI/SNF complex subunit SMARCC1 (BRG1-associated factor 155) (BAF155) (SWI/SNF complex 155 kDa subunit) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1) | UniProt NCBI |
| SMARCD1 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 (60 kDa BRG-1/Brm-associated factor subunit A) (BRG1-associated factor 60A) (BAF60A) (SWI/SNF complex 60 kDa subunit) | UniProt NCBI |
| SMARCE1 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 (BRG1-associated factor 57) (BAF57) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:555 | 1.53598648539e-15 | 1.0 | ACTL6A SMARCC1 SMARCE1 SMARCD1 SMARCD2 | BAF complex |
| CORUM:554 | 3.07197297078e-15 | 1.0 | ACTL6A SMARCC1 SMARCE1 SMARCD1 SMARCD2 | PBAF complex (Polybromo- and BAF containing complex) |
| CORUM:1252 | 3.07197297078e-15 | 1.0 | ACTL6A SMARCC1 SMARCE1 SMARCD1 SMARCD2 | EBAFa complex |
| CORUM:1239 | 3.07197297078e-15 | 1.0 | ACTL6A SMARCC1 SMARCE1 SMARCD1 SMARCD2 | EBAFb complex |
| CORUM:808 | 3.07197297078e-15 | 1.0 | ACTL6A SMARCC1 SMARCE1 SMARCD1 SMARCD2 | BRM-associated complex |
| CORUM:806 | 9.65477219389e-15 | 1.0 | ACTL6A SMARCC1 SMARCE1 SMARCD1 SMARCD2 | BRM-SIN3A-HDAC complex |
| CORUM:713 | 2.44051186012e-14 | 1.0 | ACTL6A SMARCC1 SMARCE1 SMARCD1 SMARCD2 | BRG1-SIN3A complex |
| CORUM:714 | 3.66076779018e-14 | 1.0 | ACTL6A SMARCC1 SMARCE1 SMARCD1 SMARCD2 | BRM-SIN3A complex |
| WP:WP4204 | 8.64739911456e-13 | 1.0 | ACTL6A SMARCC1 SMARCE1 SMARCD1 SMARCD2 | Tumor suppressor activity of SMARCB1 |
| REAC:R-HSA-8939243 | 9.24638111139e-12 | 1.0 | ACTL6A SMARCC1 SMARCE1 SMARCD1 SMARCD2 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known |
| CORUM:1251 | 1.27032908949e-11 | 0.8 | SMARCC1 SMARCE1 SMARCD1 ACTL6A | BAF complex |
| CORUM:564 | 1.27032908949e-11 | 0.8 | SMARCC1 SMARCE1 SMARCD1 ACTL6A | BAF complex |
| CORUM:566 | 2.28646948215e-11 | 0.8 | SMARCC1 SMARCE1 SMARCD1 ACTL6A | BAF complex |
| CORUM:807 | 2.28646948215e-11 | 0.8 | SMARCC1 SMARCE1 SMARCD1 ACTL6A | BRG1-associated complex |
| CORUM:1237 | 2.28646948215e-11 | 0.8 | SMARCC1 SMARCE1 SMARCD1 ACTL6A | BAF complex |
| CORUM:1238 | 2.28646948215e-11 | 0.8 | SMARCC1 SMARCE1 SMARCD1 ACTL6A | PBAF complex (Polybromo- and BAF containing complex) |
| CORUM:711 | 2.28646948215e-11 | 0.8 | SMARCC1 SMARCE1 SMARCD1 ACTL6A | Brm-associated complex |
| CORUM:710 | 2.28646948215e-11 | 0.8 | SMARCC1 SMARCE1 SMARCD1 ACTL6A | Brg1-associated complex I |
| CORUM:565 | 2.28646948215e-11 | 0.8 | SMARCC1 SMARCE1 SMARCD1 ACTL6A | PBAF complex (Polybromo- and BAF containing complex) |
| CORUM:556 | 2.28646948215e-11 | 0.8 | SMARCC1 SMARCE1 SMARCD1 ACTL6A | PBAF complex (Polybromo- and BAF containing complex) |
| CORUM:3065 | 2.28646948215e-11 | 0.8 | SMARCC1 SMARCE1 SMARCD1 ACTL6A | RNA polymerase II complex, chromatin structure modifying |
| CORUM:149 | 3.81057767206e-11 | 0.8 | SMARCC1 SMARCE1 SMARCD1 ACTL6A | PBAF complex (Polybromo- and BAF containing complex) |
| CORUM:238 | 3.81057767206e-11 | 0.8 | SMARCC1 SMARCE1 ACTL6A SMARCD2 | SWI-SNF chromatin remodeling-related-BRCA1 complex |
| CORUM:803 | 5.98772880178e-11 | 0.8 | SMARCC1 SMARCE1 SMARCD1 ACTL6A | BRG1-SIN3A-HDAC containing SWI/SNF remodeling complex I |
| CORUM:7372 | 5.98772880178e-11 | 0.8 | SMARCC1 SMARCE1 SMARCD1 ACTL6A | BRD7-SWI-SNF complex |
| CORUM:189 | 1.29720178257e-10 | 0.8 | SMARCC1 SMARCE1 SMARCD1 ACTL6A | BAF complex |
| GO:0016514 | 1.66697541287e-10 | 1.0 | ACTL6A SMARCC1 SMARCE1 SMARCD1 SMARCD2 | SWI/SNF complex |
| CORUM:1230 | 1.81598487512e-10 | 0.8 | SMARCC1 SMARCE1 SMARCD1 ACTL6A | WINAC complex |
| WP:WP4321 | 4.56851805387e-10 | 1.0 | ACTL6A SMARCC1 SMARCE1 SMARCD1 SMARCD2 | Thermogenesis |
| REAC:R-HSA-3214858 | 5.17786010889e-10 | 1.0 | ACTL6A SMARCC1 SMARCE1 SMARCD1 SMARCD2 | RMTs methylate histone arginines |
| CORUM:778 | 7.02983565551e-10 | 0.8 | SMARCC1 SMARCE1 ACTL6A SMARCD2 | LARC complex (LCR-associated remodeling complex) |
| KEGG:05225 | 6.20048608976e-09 | 1.0 | ACTL6A SMARCC1 SMARCE1 SMARCD1 SMARCD2 | Hepatocellular carcinoma |
| KEGG:04714 | 2.47068071467e-08 | 1.0 | ACTL6A SMARCC1 SMARCE1 SMARCD1 SMARCD2 | Thermogenesis |
| GO:0071564 | 4.0237537548e-08 | 0.8 | SMARCC1 SMARCE1 SMARCD1 ACTL6A | npBAF complex |
| REAC:R-HSA-8878171 | 9.83356432349e-08 | 1.0 | ACTL6A SMARCC1 SMARCE1 SMARCD1 SMARCD2 | Transcriptional regulation by RUNX1 |
| GO:0070603 | 1.61854596378e-07 | 1.0 | ACTL6A SMARCC1 SMARCE1 SMARCD1 SMARCD2 | SWI/SNF superfamily-type complex |
| CORUM:86 | 1.62061692851e-07 | 0.6 | SMARCC1 SMARCD1 SMARCE1 | NUMAC complex (nucleosomal methylation activator complex) |
| GO:1904949 | 1.96934078318e-07 | 1.0 | ACTL6A SMARCC1 SMARCE1 SMARCD1 SMARCD2 | ATPase complex |
| REAC:R-HSA-3247509 | 2.77321956546e-07 | 1.0 | ACTL6A SMARCC1 SMARCE1 SMARCD1 SMARCD2 | Chromatin modifying enzymes |
| REAC:R-HSA-4839726 | 2.77321956546e-07 | 1.0 | ACTL6A SMARCC1 SMARCE1 SMARCD1 SMARCD2 | Chromatin organization |
| GO:0006337 | 2.90104413489e-07 | 0.8 | SMARCC1 SMARCE1 SMARCD1 SMARCD2 | nucleosome disassembly |
| GO:0031498 | 3.72971334932e-07 | 0.8 | SMARCC1 SMARCE1 SMARCD1 SMARCD2 | chromatin disassembly |
| GO:0032986 | 4.7240495605e-07 | 0.8 | SMARCC1 SMARCE1 SMARCD1 SMARCD2 | protein-DNA complex disassembly |
| CORUM:739 | 7.55830716665e-07 | 0.6 | SMARCC1 SMARCD1 ACTL6A | SIN3-ING1b complex II |
| GO:0006338 | 5.01231551695e-06 | 1.0 | ACTL6A SMARCC1 SMARCE1 SMARCD1 SMARCD2 | chromatin remodeling |
| GO:0031492 | 5.64772495392e-06 | 0.8 | SMARCC1 SMARCE1 ACTL6A SMARCD2 | nucleosomal DNA binding |
| CORUM:2852 | 4.0241279111e-05 | 0.4 | SMARCC1 ACTL6A | Brg1-based SWI/SNF complex |
| GO:0031491 | 6.78326696841e-05 | 0.8 | SMARCC1 SMARCE1 ACTL6A SMARCD2 | nucleosome binding |
| GO:0000980 | 9.31770903001e-05 | 0.8 | SMARCC1 SMARCE1 ACTL6A SMARCD2 | RNA polymerase II distal enhancer sequence-specific DNA binding |
| GO:0003713 | 0.000107359290125 | 1.0 | ACTL6A SMARCC1 SMARCE1 SMARCD1 SMARCD2 | transcription coactivator activity |
| CORUM:3063 | 0.000140787732431 | 0.4 | SMARCC1 ACTL6A | Brg1-associated complex II |
| GO:0001158 | 0.000164422098058 | 0.8 | SMARCC1 SMARCE1 ACTL6A SMARCD2 | enhancer sequence-specific DNA binding |
| GO:0031490 | 0.000173300430897 | 0.8 | SMARCC1 SMARCE1 ACTL6A SMARCD2 | chromatin DNA binding |
| REAC:R-HSA-212436 | 0.000239251603487 | 1.0 | ACTL6A SMARCC1 SMARCE1 SMARCD1 SMARCD2 | Generic Transcription Pathway |
| GO:0043044 | 0.000245904002808 | 0.8 | SMARCC1 SMARCE1 ACTL6A SMARCD2 | ATP-dependent chromatin remodeling |
| GO:0071565 | 0.000259479548289 | 0.6 | SMARCC1 SMARCD1 SMARCE1 | nBAF complex |
| GO:0035326 | 0.000270299027917 | 0.8 | SMARCC1 SMARCE1 ACTL6A SMARCD2 | enhancer binding |
| REAC:R-HSA-73857 | 0.000412889072144 | 1.0 | ACTL6A SMARCC1 SMARCE1 SMARCD1 SMARCD2 | RNA Polymerase II Transcription |
| CORUM:3064 | 0.000703182488552 | 0.4 | SMARCC1 SMARCD1 | RNA polymerase II complex, chromatin structure modifying |
| REAC:R-HSA-74160 | 0.000713316403356 | 1.0 | ACTL6A SMARCC1 SMARCE1 SMARCD1 SMARCD2 | Gene expression (Transcription) |
| GO:0003712 | 0.00158233933247 | 1.0 | ACTL6A SMARCC1 SMARCE1 SMARCD1 SMARCD2 | transcription coregulator activity |
| GO:0034728 | 0.00258642853082 | 0.8 | SMARCC1 SMARCE1 SMARCD1 SMARCD2 | nucleosome organization |
| GO:0006333 | 0.00287194934458 | 0.8 | SMARCC1 SMARCE1 SMARCD1 SMARCD2 | chromatin assembly or disassembly |
| GO:0006325 | 0.00448062284804 | 1.0 | ACTL6A SMARCC1 SMARCE1 SMARCD1 SMARCD2 | chromatin organization |
| GO:0071824 | 0.0151765771023 | 0.8 | SMARCC1 SMARCE1 SMARCD1 SMARCD2 | protein-DNA complex subunit organization |
| GO:0000790 | 0.0171953090779 | 1.0 | ACTL6A SMARCC1 SMARCE1 SMARCD1 SMARCD2 | nuclear chromatin |
| GO:0032984 | 0.0305542041182 | 0.8 | SMARCC1 SMARCE1 SMARCD1 SMARCD2 | protein-containing complex disassembly |
| GO:0000785 | 0.0394223237212 | 1.0 | ACTL6A SMARCC1 SMARCE1 SMARCD1 SMARCD2 | chromatin |
| GO:0051276 | 0.046479053704 | 1.0 | ACTL6A SMARCC1 SMARCE1 SMARCD1 SMARCD2 | chromosome organization |
| GO:0044454 | 0.046479053704 | 1.0 | ACTL6A SMARCC1 SMARCE1 SMARCD1 SMARCD2 | nuclear chromosome part |
| CORUM:0000000 | 0.0474603483533 | 1.0 | ACTL6A SMARCC1 SMARCE1 SMARCD1 SMARCD2 | CORUM root |
| CORUM:1175 | 0.0499494897235 | 0.2 | ACTL6A | TRRAP-BAF53-HAT complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| SMARCC1 | SMARCD2 | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru youn_WMM hein (SMARCC1) Malo fraction |
| SMARCC1 | SMARCE1 | 1.0 | 0.949 | hein_WMM bioplex (SMARCE1) bioplex_WMM youn_WMM hein (SMARCC1) Malo gupta_WMM fraction |
| SMARCC1 | SMARCD1 | 1.0 | 0.949 | hein_WMM bioplex (SMARCD1) bioplex_WMM Guru youn_WMM hein (SMARCC1) Malo gupta_WMM fraction |
| SMARCC1 | ACTL6A | 1.0 | 0.949 | hein_WMM bioplex (ACTL6A) bioplex_WMM Guru youn_WMM hein (SMARCC1) fraction |
| SMARCD1 | ACTL6A | 1.0 | 0.949 | hein_WMM bioplex (ACTL6A,SMARCD1) bioplex_WMM Guru youn_WMM fraction |
| ACTL6A | SMARCE1 | 1.0 | 0.949 | hein_WMM bioplex (ACTL6A,SMARCE1) bioplex_WMM youn_WMM fraction |
| SMARCD1 | SMARCE1 | 1.0 | 0.949 | hein_WMM bioplex (SMARCD1,SMARCE1) bioplex_WMM youn_WMM Malo gupta_WMM fraction |
| SMARCD2 | SMARCE1 | 0.999 | 0.949 | hein_WMM bioplex (SMARCE1) bioplex_WMM youn_WMM Malo gupta_WMM fraction |
| SMARCD2 | ACTL6A | 0.999 | 0.946 | hein_WMM bioplex (ACTL6A) bioplex_WMM Guru youn_WMM fraction |
| SMARCD1 | SMARCD2 | 0.997 | 0.935 | hein_WMM bioplex (SMARCD1) bioplex_WMM youn_WMM Malo fraction |
Images
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Complex HuMAP2_06109 has an average edge precision of 0.947 which is ranked 358 out of all 6965 complexes.
Related Complexes