hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06111
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| E2F1 | Transcription factor E2F1 (E2F-1) (PBR3) (Retinoblastoma-associated protein 1) (RBAP-1) (Retinoblastoma-binding protein 3) (RBBP-3) (pRB-binding protein E2F-1) | UniProt NCBI |
| TFDP2 | Transcription factor Dp-2 (E2F dimerization partner 2) | UniProt NCBI |
| E2F5 | Transcription factor E2F5 (E2F-5) | UniProt NCBI |
| E2F4 | Transcription factor E2F4 (E2F-4) | UniProt NCBI |
| E2F2 | Transcription factor E2F2 (E2F-2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-69236 | 2.08641046157e-11 | 1.0 | E2F4 E2F2 E2F1 E2F5 TFDP2 | G1 Phase |
| REAC:R-HSA-69231 | 2.08641046157e-11 | 1.0 | E2F4 E2F2 E2F1 E2F5 TFDP2 | Cyclin D associated events in G1 |
| REAC:R-HSA-1362300 | 6.64240954906e-10 | 0.8 | E2F4 E2F1 E2F5 TFDP2 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 |
| WP:WP179 | 9.73258611228e-10 | 1.0 | E2F4 E2F2 E2F1 E2F5 TFDP2 | Cell Cycle |
| REAC:R-HSA-1362277 | 1.41438609596e-09 | 0.8 | E2F4 E2F1 E2F5 TFDP2 | Transcription of E2F targets under negative control by DREAM complex |
| KEGG:04110 | 1.48685851061e-09 | 1.0 | E2F4 E2F2 E2F1 E2F5 TFDP2 | Cell cycle |
| REAC:R-HSA-1538133 | 6.40139272836e-09 | 0.8 | E2F4 E2F1 E2F5 TFDP2 | G0 and Early G1 |
| REAC:R-HSA-69205 | 7.46788976858e-09 | 0.8 | E2F4 E2F1 E2F5 TFDP2 | G1/S-Specific Transcription |
| REAC:R-HSA-453279 | 1.30977028086e-08 | 1.0 | E2F4 E2F2 E2F1 E2F5 TFDP2 | Mitotic G1-G1/S phases |
| REAC:R-HSA-69202 | 6.36085103797e-07 | 0.8 | E2F4 E2F1 E2F5 TFDP2 | Cyclin E associated events during G1/S transition |
| REAC:R-HSA-69656 | 7.01630822759e-07 | 0.8 | E2F4 E2F1 E2F5 TFDP2 | Cyclin A:Cdk2-associated events at S phase entry |
| KEGG:04218 | 2.03672600773e-06 | 0.8 | E2F4 E2F2 E2F1 E2F5 | Cellular senescence |
| REAC:R-HSA-69206 | 4.12021471894e-06 | 0.8 | E2F4 E2F1 E2F5 TFDP2 | G1/S Transition |
| GO:0090575 | 4.22583570616e-06 | 1.0 | E2F4 E2F2 E2F1 E2F5 TFDP2 | RNA polymerase II transcription factor complex |
| REAC:R-HSA-69278 | 7.33273154143e-06 | 1.0 | E2F4 E2F2 E2F1 E2F5 TFDP2 | Cell Cycle, Mitotic |
| REAC:R-HSA-69242 | 9.2847398572e-06 | 0.8 | E2F4 E2F1 E2F5 TFDP2 | S Phase |
| GO:0044798 | 1.05770080233e-05 | 1.0 | E2F4 E2F2 E2F1 E2F5 TFDP2 | nuclear transcription factor complex |
| REAC:R-HSA-2173796 | 1.21879917622e-05 | 0.6 | E2F4 TFDP2 E2F5 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| REAC:R-HSA-2559585 | 1.34474619847e-05 | 0.6 | E2F2 E2F1 TFDP2 | Oncogene Induced Senescence |
| REAC:R-HSA-1640170 | 1.81282652788e-05 | 1.0 | E2F4 E2F2 E2F1 E2F5 TFDP2 | Cell Cycle |
| WP:WP45 | 2.65535825723e-05 | 0.6 | E2F2 E2F1 TFDP2 | G1 to S cell cycle control |
| REAC:R-HSA-2173793 | 3.34215806492e-05 | 0.6 | E2F4 TFDP2 E2F5 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer |
| REAC:R-HSA-6791312 | 4.68169513367e-05 | 0.6 | E2F4 E2F1 TFDP2 | TP53 Regulates Transcription of Cell Cycle Genes |
| CORUM:2975 | 6.7059790554e-05 | 0.4 | E2F4 E2F5 | SMAD3-E2F4/5-p107-DP1 complex |
| GO:0005667 | 6.80047135479e-05 | 1.0 | E2F4 E2F2 E2F1 E2F5 TFDP2 | transcription factor complex |
| WP:WP2446 | 7.07040269841e-05 | 0.6 | E2F2 E2F1 TFDP2 | Retinoblastoma Gene in Cancer |
| CORUM:5118 | 0.000100576175246 | 0.4 | E2F4 E2F5 | RBL2 complex (E2F4, E2F5, HDAC1, SUV39H1, P300, RBL2) |
| CORUM:1474 | 0.000100576175246 | 0.4 | E2F4 E2F5 | SMAD3/4-E2F4/5-p107-DP1 complex |
| CORUM:5117 | 0.000100576175246 | 0.4 | E2F4 E2F5 | RBL2 complex (DNMT1, E2F4, E2F5, HDAC1, SUV39H1, RBL2) |
| REAC:R-HSA-111448 | 0.000134922692372 | 0.4 | E2F1 TFDP2 | Activation of NOXA and translocation to mitochondria |
| REAC:R-HSA-170834 | 0.000135380656388 | 0.6 | E2F4 TFDP2 E2F5 | Signaling by TGF-beta Receptor Complex |
| REAC:R-HSA-9006936 | 0.000306125075711 | 0.6 | E2F4 TFDP2 E2F5 | Signaling by TGF-beta family members |
| REAC:R-HSA-139915 | 0.000485460775426 | 0.4 | E2F1 TFDP2 | Activation of PUMA and translocation to mitochondria |
| REAC:R-HSA-68689 | 0.000741476933235 | 0.4 | E2F1 E2F2 | CDC6 association with the ORC:origin complex |
| REAC:R-HSA-2559580 | 0.000793200049211 | 0.6 | E2F2 E2F1 TFDP2 | Oxidative Stress Induced Senescence |
| REAC:R-HSA-113501 | 0.00105126658749 | 0.4 | E2F1 TFDP2 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 |
| REAC:R-HSA-6804114 | 0.00206071490935 | 0.4 | E2F4 TFDP2 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest |
| GO:0008134 | 0.00262050801915 | 1.0 | E2F4 E2F2 E2F1 E2F5 TFDP2 | transcription factor binding |
| KEGG:05219 | 0.00284609034939 | 0.4 | E2F1 E2F2 | Bladder cancer |
| REAC:R-HSA-2559583 | 0.00290844270817 | 0.6 | E2F2 E2F1 TFDP2 | Cellular Senescence |
| REAC:R-HSA-113510 | 0.0031096034254 | 0.4 | E2F1 TFDP2 | E2F mediated regulation of DNA replication |
| REAC:R-HSA-114452 | 0.00584945327803 | 0.4 | E2F1 TFDP2 | Activation of BH3-only proteins |
| MIRNA:hsa-miR-98-5p | 0.00726374078252 | 0.8 | E2F4 E2F2 E2F1 E2F5 | hsa-miR-98-5p |
| REAC:R-HSA-8953750 | 0.0075397219523 | 0.4 | E2F1 TFDP2 | Transcriptional Regulation by E2F6 |
| WP:WP4255 | 0.00799132765459 | 0.4 | E2F1 E2F2 | Non-small cell lung cancer |
| KEGG:05218 | 0.00805388520034 | 0.4 | E2F1 E2F2 | Melanoma |
| KEGG:05223 | 0.00858395707223 | 0.4 | E2F1 E2F2 | Non-small cell lung cancer |
| KEGG:05214 | 0.00969431019543 | 0.4 | E2F1 E2F2 | Glioma |
| KEGG:05212 | 0.0105709544625 | 0.4 | E2F1 E2F2 | Pancreatic cancer |
| WP:WP4263 | 0.0112409645576 | 0.4 | E2F1 E2F2 | Pancreatic adenocarcinoma pathway |
| KEGG:05220 | 0.0114851584748 | 0.4 | E2F1 E2F2 | Chronic myeloid leukemia |
| KEGG:04350 | 0.0127624438559 | 0.4 | E2F4 E2F5 | TGF-beta signaling pathway |
| WP:WP2431 | 0.0129250833235 | 0.4 | E2F1 E2F5 | Spinal Cord Injury |
| WP:WP4658 | 0.0147251965341 | 0.4 | E2F1 E2F2 | Small cell lung cancer |
| REAC:R-HSA-212436 | 0.0163364711391 | 0.8 | E2F4 E2F1 E2F5 TFDP2 | Generic Transcription Pathway |
| REAC:R-HSA-109606 | 0.0164283536306 | 0.4 | E2F1 TFDP2 | Intrinsic Pathway for Apoptosis |
| KEGG:05215 | 0.0169933560846 | 0.4 | E2F1 E2F2 | Prostate cancer |
| KEGG:01522 | 0.0169933560846 | 0.4 | E2F1 E2F2 | Endocrine resistance |
| GO:0000790 | 0.0171953090779 | 1.0 | E2F4 E2F2 E2F1 E2F5 TFDP2 | nuclear chromatin |
| KEGG:05222 | 0.0177565608839 | 0.4 | E2F1 E2F2 | Small cell lung cancer |
| GO:0043565 | 0.0182392633913 | 1.0 | E2F4 E2F2 E2F1 E2F5 TFDP2 | sequence-specific DNA binding |
| REAC:R-HSA-3700989 | 0.0182828935298 | 0.6 | E2F4 E2F1 TFDP2 | Transcriptional Regulation by TP53 |
| GO:0000981 | 0.0187192194024 | 1.0 | E2F4 E2F2 E2F1 E2F5 TFDP2 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO:0045944 | 0.0197094416222 | 1.0 | E2F4 E2F2 E2F1 E2F5 TFDP2 | positive regulation of transcription by RNA polymerase II |
| WP:WP236 | 0.0197310835566 | 0.4 | E2F4 E2F1 | Adipogenesis |
| GO:0006977 | 0.022411068229 | 0.6 | E2F4 E2F1 TFDP2 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest |
| GO:1902400 | 0.0237016209836 | 0.6 | E2F4 E2F1 TFDP2 | intracellular signal transduction involved in G1 DNA damage checkpoint |
| GO:0072431 | 0.0237016209836 | 0.6 | E2F4 E2F1 TFDP2 | signal transduction involved in mitotic G1 DNA damage checkpoint |
| GO:1902402 | 0.0250406933376 | 0.6 | E2F4 E2F1 TFDP2 | signal transduction involved in mitotic DNA damage checkpoint |
| GO:1902403 | 0.0250406933376 | 0.6 | E2F4 E2F1 TFDP2 | signal transduction involved in mitotic DNA integrity checkpoint |
| GO:0072413 | 0.0250406933376 | 0.6 | E2F4 E2F1 TFDP2 | signal transduction involved in mitotic cell cycle checkpoint |
| WP:WP366 | 0.0250517914711 | 0.4 | E2F4 E2F5 | TGF-beta Signaling Pathway |
| REAC:R-HSA-73857 | 0.0251017869848 | 0.8 | E2F4 E2F1 E2F5 TFDP2 | RNA Polymerase II Transcription |
| REAC:R-HSA-2262752 | 0.0291077226575 | 0.6 | E2F2 E2F1 TFDP2 | Cellular responses to stress |
| REAC:R-HSA-68867 | 0.0304761248659 | 0.4 | E2F1 E2F2 | Assembly of the pre-replicative complex |
| GO:0031571 | 0.0308999432136 | 0.6 | E2F4 E2F1 TFDP2 | mitotic G1 DNA damage checkpoint |
| GO:0044819 | 0.0308999432136 | 0.6 | E2F4 E2F1 TFDP2 | mitotic G1/S transition checkpoint |
| WP:WP4262 | 0.0314432287467 | 0.4 | E2F1 E2F2 | Breast cancer pathway |
| GO:0044783 | 0.0324949337356 | 0.6 | E2F4 E2F1 TFDP2 | G1 DNA damage checkpoint |
| GO:0045892 | 0.0328678033498 | 1.0 | E2F4 E2F2 E2F1 E2F5 TFDP2 | negative regulation of transcription, DNA-templated |
| GO:1903507 | 0.0332499840271 | 1.0 | E2F4 E2F2 E2F1 E2F5 TFDP2 | negative regulation of nucleic acid-templated transcription |
| GO:1902679 | 0.0334424029162 | 1.0 | E2F4 E2F2 E2F1 E2F5 TFDP2 | negative regulation of RNA biosynthetic process |
| KEGG:05224 | 0.0353865382697 | 0.4 | E2F1 E2F2 | Breast cancer |
| KEGG:05226 | 0.0359303198923 | 0.4 | E2F1 E2F2 | Gastric cancer |
| REAC:R-HSA-74160 | 0.038571388232 | 0.8 | E2F4 E2F1 E2F5 TFDP2 | Gene expression (Transcription) |
| KEGG:05160 | 0.038710268063 | 0.4 | E2F1 E2F2 | Hepatitis C |
| GO:0000785 | 0.0394223237212 | 1.0 | E2F4 E2F2 E2F1 E2F5 TFDP2 | chromatin |
| GO:0051726 | 0.0398642747089 | 1.0 | E2F4 E2F2 E2F1 E2F5 TFDP2 | regulation of cell cycle |
| KEGG:04934 | 0.0415917953149 | 0.4 | E2F1 E2F2 | Cushing syndrome |
| REAC:R-HSA-9616222 | 0.0454350363854 | 0.4 | E2F1 TFDP2 | Transcriptional regulation of granulopoiesis |
| GO:0003700 | 0.0459792824187 | 1.0 | E2F4 E2F2 E2F1 E2F5 TFDP2 | DNA-binding transcription factor activity |
| GO:0044454 | 0.046479053704 | 1.0 | E2F4 E2F2 E2F1 E2F5 TFDP2 | nuclear chromosome part |
| GO:0072401 | 0.0472676873043 | 0.6 | E2F4 E2F1 TFDP2 | signal transduction involved in DNA integrity checkpoint |
| GO:0072422 | 0.0472676873043 | 0.6 | E2F4 E2F1 TFDP2 | signal transduction involved in DNA damage checkpoint |
| REAC:R-HSA-69002 | 0.0476518941102 | 0.4 | E2F1 E2F2 | DNA Replication Pre-Initiation |
| GO:0072395 | 0.0493791608738 | 0.6 | E2F4 E2F1 TFDP2 | signal transduction involved in cell cycle checkpoint |
| REAC:R-HSA-8953897 | 0.0498194225693 | 0.6 | E2F2 E2F1 TFDP2 | Cellular responses to external stimuli |
| CORUM:5160 | 0.0499494897235 | 0.2 | E2F4 | E2F4-p130 complex |
| CORUM:5143 | 0.0499494897235 | 0.2 | E2F1 | RB-E2F1 complex |
| CORUM:5099 | 0.0499494897235 | 0.2 | E2F4 | RB1(hypophosphorylated)-E2F4 complex |
| CORUM:1250 | 0.0499494897235 | 0.2 | E2F1 | RB-E2F1 complex |
| CORUM:6588 | 0.0499494897235 | 0.2 | E2F1 | E2F-1-DP-1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| TFDP2 | E2F2 | 0.999 | 0.946 | bioplex (TFDP2) bioplex_WMM |
| E2F1 | TFDP2 | 0.996 | 0.926 | bioplex (TFDP2) bioplex_WMM |
| TFDP2 | E2F5 | 0.967 | 0.879 | bioplex (TFDP2) bioplex_WMM boldt_WMM |
| TFDP2 | E2F4 | 0.753 | 0.747 | bioplex (TFDP2) bioplex_WMM boldt_WMM |
| E2F5 | E2F4 | 0.012 | 0.145 | bioplex_WMM boldt (E2F4) boldt_WMM |
| E2F1 | E2F2 | 0.01 | 0.105 | bioplex_WMM WMM_only |
| E2F1 | E2F5 | 0.009 | 0.102 | bioplex_WMM WMM_only |
| E2F2 | E2F5 | 0.009 | 0.102 | bioplex_WMM WMM_only |
| E2F2 | E2F4 | 0.009 | 0.096 | bioplex_WMM WMM_only |
| E2F1 | E2F4 | 0.009 | 0.096 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_06111 has an average edge precision of 0.414 which is ranked 3158 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| E2F1 | HuMAP2_00571 HuMAP2_01975 HuMAP2_02343 HuMAP2_06111 |
| TFDP2 | HuMAP2_00571 HuMAP2_01975 HuMAP2_02343 HuMAP2_06111 |
| E2F5 | HuMAP2_00593 HuMAP2_02343 HuMAP2_04040 HuMAP2_06111 |
| E2F4 | HuMAP2_01975 HuMAP2_02343 HuMAP2_04984 HuMAP2_06111 |
| E2F2 | HuMAP2_00571 HuMAP2_01975 HuMAP2_02343 HuMAP2_06111 |