hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06112
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CWC27 | Spliceosome-associated protein CWC27 homolog (Antigen NY-CO-10) (Probable inactive peptidyl-prolyl cis-trans isomerase CWC27 homolog) (PPIase CWC27) (Serologically defined colon cancer antigen 10) | UniProt NCBI |
| LSM2 | U6 snRNA-associated Sm-like protein LSm2 (Protein G7b) (Small nuclear ribonuclear protein D homolog) (snRNP core Sm-like protein Sm-x5) | UniProt NCBI |
| DDX39B | Spliceosome RNA helicase DDX39B (EC 3.6.4.13) (56 kDa U2AF65-associated protein) (ATP-dependent RNA helicase p47) (DEAD box protein UAP56) (HLA-B-associated transcript 1 protein) | UniProt NCBI |
| LSM3 | U6 snRNA-associated Sm-like protein LSm3 | UniProt NCBI |
| LSM6 | U6 snRNA-associated Sm-like protein LSm6 | UniProt NCBI |
| LSM7 | U6 snRNA-associated Sm-like protein LSm7 | UniProt NCBI |
| LSM8 | U6 snRNA-associated Sm-like protein LSm8 | UniProt NCBI |
| LSM4 | U6 snRNA-associated Sm-like protein LSm4 (Glycine-rich protein) (GRP) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0005688 | 9.93317232561e-20 | 0.875 | LSM2 LSM3 LSM4 LSM6 LSM7 DDX39B LSM8 | U6 snRNP |
| CORUM:562 | 5.99037691178e-19 | 0.75 | LSM3 LSM2 LSM6 LSM7 LSM4 LSM8 | LSm2-8 complex |
| GO:0120115 | 6.46960706472e-16 | 0.75 | LSM3 LSM2 LSM6 LSM7 LSM4 LSM8 | Lsm2-8 complex |
| CORUM:561 | 8.91710393203e-15 | 0.625 | LSM6 LSM3 LSM4 LSM7 LSM2 | LSm1-7 complex |
| REAC:R-HSA-72203 | 6.04901220136e-13 | 1.0 | DDX39B CWC27 LSM3 LSM4 LSM6 LSM7 LSM2 LSM8 | Processing of Capped Intron-Containing Pre-mRNA |
| GO:0071005 | 1.237149436e-12 | 0.875 | CWC27 LSM3 LSM4 LSM6 LSM7 LSM2 LSM8 | U2-type precatalytic spliceosome |
| KEGG:03040 | 1.25215332445e-12 | 0.875 | LSM2 LSM3 LSM4 LSM6 LSM7 DDX39B LSM8 | Spliceosome |
| GO:0071011 | 1.43388416779e-12 | 0.875 | CWC27 LSM3 LSM4 LSM6 LSM7 LSM2 LSM8 | precatalytic spliceosome |
| GO:0097525 | 3.2732826498e-12 | 0.875 | LSM2 LSM3 LSM4 LSM6 LSM7 DDX39B LSM8 | spliceosomal snRNP complex |
| REAC:R-HSA-430039 | 4.87697936989e-12 | 0.625 | LSM6 LSM3 LSM4 LSM7 LSM2 | mRNA decay by 5' to 3' exoribonuclease |
| GO:0030532 | 6.84745736664e-12 | 0.875 | LSM2 LSM3 LSM4 LSM6 LSM7 DDX39B LSM8 | small nuclear ribonucleoprotein complex |
| GO:0005681 | 7.82658917187e-12 | 1.0 | DDX39B CWC27 LSM3 LSM4 LSM6 LSM7 LSM2 LSM8 | spliceosomal complex |
| KEGG:03018 | 1.92742194135e-11 | 0.75 | LSM3 LSM2 LSM6 LSM7 LSM4 LSM8 | RNA degradation |
| GO:0120114 | 2.22577271357e-11 | 0.875 | LSM2 LSM3 LSM4 LSM6 LSM7 DDX39B LSM8 | Sm-like protein family complex |
| REAC:R-HSA-72163 | 4.3453483174e-11 | 0.875 | CWC27 LSM3 LSM4 LSM6 LSM7 LSM2 LSM8 | mRNA Splicing - Major Pathway |
| GO:0046540 | 5.47331906216e-11 | 0.75 | LSM3 LSM2 LSM6 LSM7 LSM4 LSM8 | U4/U6 x U5 tri-snRNP complex |
| GO:0097526 | 5.47331906216e-11 | 0.75 | LSM3 LSM2 LSM6 LSM7 LSM4 LSM8 | spliceosomal tri-snRNP complex |
| REAC:R-HSA-72172 | 5.93918061983e-11 | 0.875 | CWC27 LSM3 LSM4 LSM6 LSM7 LSM2 LSM8 | mRNA Splicing |
| GO:0005684 | 1.00008445533e-10 | 0.875 | CWC27 LSM3 LSM4 LSM6 LSM7 LSM2 LSM8 | U2-type spliceosomal complex |
| GO:0017070 | 2.11728099041e-10 | 0.625 | DDX39B LSM2 LSM4 LSM7 LSM8 | U6 snRNA binding |
| CORUM:351 | 7.90609834248e-10 | 0.75 | LSM3 LSM4 LSM6 LSM7 DDX39B LSM2 | Spliceosome |
| GO:0000398 | 1.69684163608e-09 | 1.0 | DDX39B CWC27 LSM3 LSM4 LSM6 LSM7 LSM2 LSM8 | mRNA splicing, via spliceosome |
| GO:0000377 | 1.69684163608e-09 | 1.0 | DDX39B CWC27 LSM3 LSM4 LSM6 LSM7 LSM2 LSM8 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile |
| GO:0000375 | 1.83343792345e-09 | 1.0 | DDX39B CWC27 LSM3 LSM4 LSM6 LSM7 LSM2 LSM8 | RNA splicing, via transesterification reactions |
| REAC:R-HSA-8953854 | 2.29458867922e-09 | 1.0 | DDX39B CWC27 LSM3 LSM4 LSM6 LSM7 LSM2 LSM8 | Metabolism of RNA |
| REAC:R-HSA-429914 | 6.16088685852e-09 | 0.625 | LSM6 LSM3 LSM4 LSM7 LSM2 | Deadenylation-dependent mRNA decay |
| GO:0008380 | 6.73317232465e-09 | 1.0 | DDX39B CWC27 LSM3 LSM4 LSM6 LSM7 LSM2 LSM8 | RNA splicing |
| GO:0006397 | 1.21342588457e-08 | 1.0 | DDX39B CWC27 LSM3 LSM4 LSM6 LSM7 LSM2 LSM8 | mRNA processing |
| GO:0043928 | 1.083663195e-07 | 0.625 | LSM6 LSM3 LSM4 LSM7 LSM2 | exonucleolytic catabolism of deadenylated mRNA |
| GO:0000291 | 1.48175348117e-07 | 0.625 | LSM6 LSM3 LSM4 LSM7 LSM2 | nuclear-transcribed mRNA catabolic process, exonucleolytic |
| GO:0017069 | 1.98894336804e-07 | 0.625 | DDX39B LSM2 LSM4 LSM7 LSM8 | snRNA binding |
| GO:0016071 | 1.32830215932e-06 | 1.0 | DDX39B CWC27 LSM3 LSM4 LSM6 LSM7 LSM2 LSM8 | mRNA metabolic process |
| GO:1990904 | 2.05993093672e-06 | 1.0 | DDX39B CWC27 LSM3 LSM4 LSM6 LSM7 LSM2 LSM8 | ribonucleoprotein complex |
| GO:0006396 | 2.51669931039e-06 | 1.0 | DDX39B CWC27 LSM3 LSM4 LSM6 LSM7 LSM2 LSM8 | RNA processing |
| GO:0000288 | 5.49185841861e-06 | 0.625 | LSM6 LSM3 LSM4 LSM7 LSM2 | nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay |
| GO:1990726 | 5.0832789986e-05 | 0.375 | LSM2 LSM7 LSM3 | Lsm1-7-Pat1 complex |
| CORUM:1181 | 0.000351537576296 | 0.375 | CWC27 LSM3 LSM2 | C complex spliceosome |
| CORUM:0000000 | 0.000356401437906 | 1.0 | DDX39B CWC27 LSM3 LSM4 LSM6 LSM7 LSM2 LSM8 | CORUM root |
| GO:0000956 | 0.0010433634795 | 0.625 | LSM6 LSM3 LSM4 LSM7 LSM2 | nuclear-transcribed mRNA catabolic process |
| GO:0000932 | 0.00114109330922 | 0.5 | LSM6 LSM3 LSM4 LSM2 | P-body |
| CORUM:5613 | 0.00139729614548 | 0.25 | LSM2 LSM8 | Emerin complex 25 |
| GO:0071013 | 0.00308515397949 | 0.5 | CWC27 LSM3 LSM7 LSM2 | catalytic step 2 spliceosome |
| GO:0006402 | 0.0152465526992 | 0.625 | LSM6 LSM3 LSM4 LSM7 LSM2 | mRNA catabolic process |
| GO:0006401 | 0.0232909099363 | 0.625 | LSM6 LSM3 LSM4 LSM7 LSM2 | RNA catabolic process |
| GO:0003723 | 0.0270720656443 | 0.875 | LSM2 LSM3 LSM4 LSM6 LSM7 DDX39B LSM8 | RNA binding |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| LSM8 | LSM6 | 1.0 | 0.949 | bioplex (LSM6) bioplex_WMM Guru boldt youn_WMM Malo fraction boldt_WMM |
| LSM2 | LSM6 | 1.0 | 0.949 | youn (LSM2) bioplex (LSM6) bioplex_WMM Guru boldt youn_WMM fraction boldt_WMM |
| LSM8 | LSM3 | 1.0 | 0.949 | bioplex_WMM Guru youn_WMM Malo fraction boldt_WMM |
| LSM6 | LSM3 | 1.0 | 0.949 | bioplex (LSM6) bioplex_WMM Guru youn_WMM Malo fraction boldt_WMM |
| LSM8 | LSM2 | 1.0 | 0.949 | youn (LSM2) bioplex_WMM Guru boldt youn_WMM fraction boldt_WMM |
| LSM2 | LSM3 | 1.0 | 0.949 | youn (LSM2) bioplex_WMM Guru youn_WMM gupta_WMM fraction boldt_WMM |
| LSM8 | LSM4 | 1.0 | 0.949 | youn (LSM4) bioplex_WMM Guru boldt youn_WMM Malo fraction boldt_WMM |
| LSM2 | LSM4 | 1.0 | 0.949 | youn (LSM2,LSM4) bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM |
| LSM6 | LSM7 | 1.0 | 0.949 | bioplex (LSM6) bioplex_WMM Guru youn_WMM fraction boldt_WMM |
| LSM6 | LSM4 | 1.0 | 0.949 | youn (LSM4) bioplex (LSM6) bioplex_WMM Guru boldt youn_WMM Malo fraction boldt_WMM |
| LSM3 | LSM7 | 0.999 | 0.949 | bioplex_WMM Guru youn_WMM fraction boldt_WMM |
| LSM3 | CWC27 | 0.988 | 0.901 | bioplex_WMM youn_WMM fraction |
| LSM4 | LSM3 | 0.959 | 0.863 | youn (LSM4) bioplex_WMM Guru youn_WMM Malo gupta_WMM fraction boldt_WMM |
| LSM2 | LSM7 | 0.952 | 0.858 | youn (LSM2) bioplex_WMM Guru youn_WMM fraction boldt_WMM |
| LSM8 | LSM7 | 0.945 | 0.856 | bioplex_WMM Guru youn_WMM fraction boldt_WMM |
| LSM6 | CWC27 | 0.88 | 0.813 | bioplex_WMM youn_WMM fraction |
| LSM2 | CWC27 | 0.849 | 0.79 | bioplex_WMM youn_WMM fraction |
| LSM6 | DDX39B | 0.825 | 0.774 | bioplex (LSM6) bioplex_WMM youn_WMM fraction |
| LSM2 | DDX39B | 0.632 | 0.681 | youn (LSM2) bioplex_WMM youn_WMM gupta_WMM fraction |
| LSM3 | DDX39B | 0.175 | 0.434 | bioplex_WMM youn_WMM gupta_WMM fraction |
| LSM4 | CWC27 | 0.035 | 0.261 | bioplex_WMM youn_WMM fraction |
| LSM8 | DDX39B | 0.01 | 0.13 | bioplex_WMM youn_WMM fraction |
| LSM4 | DDX39B | 0.008 | 0.091 | youn (LSM4) bioplex_WMM youn_WMM gupta_WMM fraction |
| DDX39B | CWC27 | 0.008 | 0.041 | bioplex_WMM youn_WMM fraction |
| LSM8 | CWC27 | 0.008 | 0.031 | bioplex_WMM youn_WMM fraction |
| LSM7 | DDX39B | 0.006 | 0.0 | youn_WMM fraction |
| LSM4 | LSM7 | 0.005 | 0.007 | youn (LSM4) bioplex_WMM Guru youn_WMM fraction boldt_WMM treiber_WMM |
| LSM7 | CWC27 | 0.0 | 0.008 | youn_WMM fraction |
Images
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Complex HuMAP2_06112 has an average edge precision of 0.642 which is ranked 1702 out of all 6965 complexes.
Related Complexes