hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06117
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| NUP50 | Nuclear pore complex protein Nup50 (50 kDa nucleoporin) (Nuclear pore-associated protein 60 kDa-like) (Nucleoporin Nup50) | UniProt NCBI |
| KIFC1 | Kinesin-like protein KIFC1 (Kinesin-like protein 2) (Kinesin-related protein HSET) | UniProt NCBI |
| KPNA1 | Importin subunit alpha-5 (Karyopherin subunit alpha-1) (Nucleoprotein interactor 1) (NPI-1) (RAG cohort protein 2) (SRP1-beta) [Cleaved into: Importin subunit alpha-5, N-terminally processed] | UniProt NCBI |
| RNGTT | mRNA-capping enzyme (HCAP1) (HCE) [Includes: Polynucleotide 5'-triphosphatase (EC 3.1.3.33) (mRNA 5'-triphosphatase) (TPase); mRNA guanylyltransferase (EC 2.7.7.50) (GTP--RNA guanylyltransferase) (GTase)] | UniProt NCBI |
| WDHD1 | WD repeat and HMG-box DNA-binding protein 1 (Acidic nucleoplasmic DNA-binding protein 1) (And-1) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-162587 | 0.00136170542712 | 0.6 | KPNA1 NUP50 RNGTT | HIV Life Cycle |
| REAC:R-HSA-162906 | 0.00484900153486 | 0.6 | KPNA1 NUP50 RNGTT | HIV Infection |
| REAC:R-HSA-168271 | 0.00508433997358 | 0.4 | KPNA1 NUP50 | Transport of Ribonucleoproteins into the Host Nucleus |
| REAC:R-HSA-180910 | 0.00584945327803 | 0.4 | KPNA1 NUP50 | Vpr-mediated nuclear import of PICs |
| REAC:R-HSA-176033 | 0.00709716303977 | 0.4 | KPNA1 NUP50 | Interactions of Vpr with host cellular proteins |
| REAC:R-HSA-168276 | 0.00894729002053 | 0.4 | KPNA1 NUP50 | NS1 Mediated Effects on Host Pathways |
| REAC:R-HSA-168253 | 0.00944309181669 | 0.4 | KPNA1 NUP50 | Host Interactions with Influenza Factors |
| REAC:R-HSA-5663205 | 0.0198891654246 | 0.6 | KPNA1 NUP50 RNGTT | Infectious disease |
| REAC:R-HSA-1169408 | 0.0295837500362 | 0.4 | KPNA1 NUP50 | ISG15 antiviral mechanism |
| REAC:R-HSA-1169410 | 0.0361060371214 | 0.4 | KPNA1 NUP50 | Antiviral mechanism by IFN-stimulated genes |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| NUP50 | KIFC1 | 1.0 | 0.949 | hein_WMM bioplex (NUP50) bioplex_WMM youn_WMM hein (KIFC1) gupta_WMM |
| WDHD1 | NUP50 | 0.999 | 0.949 | bioplex (NUP50) bioplex_WMM youn_WMM gupta_WMM fraction |
| NUP50 | RNGTT | 0.986 | 0.901 | youn (RNGTT) bioplex (NUP50,RNGTT) bioplex_WMM boldt youn_WMM boldt_WMM |
| KPNA1 | NUP50 | 0.894 | 0.82 | hein_WMM bioplex (NUP50) bioplex_WMM youn_WMM hein (KPNA1) gupta_WMM treiber_WMM |
| WDHD1 | KPNA1 | 0.008 | 0.067 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| KPNA1 | KIFC1 | 0.008 | 0.065 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| KPNA1 | RNGTT | 0.007 | 0.007 | bioplex_WMM youn_WMM WMM_only |
| WDHD1 | RNGTT | 0.007 | 0.002 | youn (RNGTT) bioplex_WMM youn_WMM |
| RNGTT | KIFC1 | 0.003 | 0.007 | youn (RNGTT) bioplex_WMM youn_WMM fraction |
| WDHD1 | KIFC1 | 0.0 | 0.013 | bioplex_WMM youn_WMM gupta_WMM fraction |
Images
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Complex HuMAP2_06117 has an average edge precision of 0.378 which is ranked 3542 out of all 6965 complexes.
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