hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06122
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| BIRC7 | Baculoviral IAP repeat-containing protein 7 (EC 2.3.2.27) (Kidney inhibitor of apoptosis protein) (KIAP) (Livin) (Melanoma inhibitor of apoptosis protein) (ML-IAP) (RING finger protein 50) (RING-type E3 ubiquitin transferase BIRC7) [Cleaved into: Baculoviral IAP repeat-containing protein 7 30kDa subunit (Truncated livin) (p30-Livin) (tLivin)] | UniProt NCBI |
| BIRC2 | Baculoviral IAP repeat-containing protein 2 (EC 2.3.2.27) (Cellular inhibitor of apoptosis 1) (C-IAP1) (IAP homolog B) (Inhibitor of apoptosis protein 2) (hIAP-2) (hIAP2) (RING finger protein 48) (RING-type E3 ubiquitin transferase BIRC2) (TNFR2-TRAF-signaling complex protein 2) | UniProt NCBI |
| XIAP | E3 ubiquitin-protein ligase XIAP (EC 2.3.2.27) (Baculoviral IAP repeat-containing protein 4) (IAP-like protein) (ILP) (hILP) (Inhibitor of apoptosis protein 3) (IAP-3) (hIAP-3) (hIAP3) (RING-type E3 ubiquitin transferase XIAP) (X-linked inhibitor of apoptosis protein) (X-linked IAP) | UniProt NCBI |
| DUSP22 | Dual specificity protein phosphatase 22 (EC 3.1.3.16) (EC 3.1.3.48) (JNK-stimulatory phosphatase-1) (JSP-1) (Low molecular weight dual specificity phosphatase 2) (LMW-DSP2) (Mitogen-activated protein kinase phosphatase x) (MAP kinase phosphatase x) (MKP-x) | UniProt NCBI |
| DIABLO | Diablo homolog, mitochondrial (Direct IAP-binding protein with low pI) (Second mitochondria-derived activator of caspase) (Smac) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04215 | 1.09102814336e-06 | 0.75 | BIRC2 BIRC7 XIAP | Apoptosis - multiple species |
| GO:1990001 | 3.6323771075e-06 | 0.75 | BIRC2 BIRC7 XIAP | inhibition of cysteine-type endopeptidase activity involved in apoptotic process |
| GO:0097340 | 1.27120391093e-05 | 0.75 | BIRC2 BIRC7 XIAP | inhibition of cysteine-type endopeptidase activity |
| GO:0097341 | 1.27120391093e-05 | 0.75 | BIRC2 BIRC7 XIAP | zymogen inhibition |
| WP:WP1772 | 1.9175652181e-05 | 0.75 | BIRC2 BIRC7 XIAP | Apoptosis Modulation and Signaling |
| KEGG:05222 | 3.36411053102e-05 | 0.75 | BIRC2 BIRC7 XIAP | Small cell lung cancer |
| KEGG:05145 | 3.59048577419e-05 | 0.75 | BIRC2 BIRC7 XIAP | Toxoplasmosis |
| KEGG:04120 | 9.56545898299e-05 | 0.75 | BIRC2 BIRC7 XIAP | Ubiquitin mediated proteolysis |
| GO:0010955 | 0.000246852342475 | 0.75 | BIRC2 BIRC7 XIAP | negative regulation of protein processing |
| GO:1903318 | 0.000246852342475 | 0.75 | BIRC2 BIRC7 XIAP | negative regulation of protein maturation |
| GO:0043027 | 0.000351729129078 | 0.75 | BIRC2 BIRC7 XIAP | cysteine-type endopeptidase inhibitor activity involved in apoptotic process |
| REAC:R-HSA-5675482 | 0.00120515287053 | 0.5 | BIRC2 XIAP | Regulation of necroptotic cell death |
| REAC:R-HSA-5213460 | 0.00153629461685 | 0.5 | BIRC2 XIAP | RIPK1-mediated regulated necrosis |
| REAC:R-HSA-5218859 | 0.00153629461685 | 0.5 | BIRC2 XIAP | Regulated Necrosis |
| GO:0043028 | 0.00179920875514 | 0.75 | BIRC2 BIRC7 XIAP | cysteine-type endopeptidase regulator activity involved in apoptotic process |
| GO:0070613 | 0.00237379826551 | 0.75 | BIRC2 BIRC7 XIAP | regulation of protein processing |
| GO:1903317 | 0.00281780772825 | 0.75 | BIRC2 BIRC7 XIAP | regulation of protein maturation |
| GO:0004869 | 0.00358246159338 | 0.75 | BIRC2 BIRC7 XIAP | cysteine-type endopeptidase inhibitor activity |
| REAC:R-HSA-5357956 | 0.00407268683926 | 0.5 | BIRC2 XIAP | TNFR1-induced NFkappaB signaling pathway |
| REAC:R-HSA-5357905 | 0.00436320194063 | 0.5 | BIRC2 XIAP | Regulation of TNFR1 signaling |
| KEGG:05200 | 0.00437599198048 | 0.75 | BIRC2 BIRC7 XIAP | Pathways in cancer |
| WP:WP254 | 0.00438725142358 | 0.5 | BIRC2 XIAP | Apoptosis |
| KEGG:01524 | 0.00508931242344 | 0.5 | BIRC2 XIAP | Platinum drug resistance |
| KEGG:04064 | 0.00613079763587 | 0.5 | BIRC2 XIAP | NF-kappa B signaling pathway |
| GO:0043154 | 0.00667745927673 | 0.75 | BIRC2 BIRC7 XIAP | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| WP:WP4658 | 0.00743927140269 | 0.5 | BIRC2 BIRC7 | Small cell lung cancer |
| REAC:R-HSA-75893 | 0.0078166615373 | 0.5 | BIRC2 XIAP | TNF signaling |
| GO:2000117 | 0.00950554068334 | 0.75 | BIRC2 BIRC7 XIAP | negative regulation of cysteine-type endopeptidase activity |
| KEGG:04210 | 0.0153578793248 | 0.5 | BIRC2 XIAP | Apoptosis |
| KEGG:04217 | 0.0226863463099 | 0.5 | BIRC2 XIAP | Necroptosis |
| KEGG:04621 | 0.0245056398731 | 0.5 | BIRC2 XIAP | NOD-like receptor signaling pathway |
| GO:0070424 | 0.0270421395626 | 0.5 | BIRC2 XIAP | regulation of nucleotide-binding oligomerization domain containing signaling pathway |
| WP:WP306 | 0.0290430519819 | 0.5 | BIRC2 XIAP | Focal Adhesion |
| KEGG:04510 | 0.0350038155474 | 0.5 | BIRC2 XIAP | Focal adhesion |
| GO:0043086 | 0.0379253389459 | 1.0 | BIRC2 DUSP22 BIRC7 XIAP | negative regulation of catalytic activity |
| GO:1902916 | 0.0405595771497 | 0.5 | BIRC2 XIAP | positive regulation of protein polyubiquitination |
| GO:0031398 | 0.0469269676219 | 0.75 | BIRC2 BIRC7 XIAP | positive regulation of protein ubiquitination |
| CORUM:5529 | 0.0499140284799 | 0.25 | BIRC2 | TRAF2-cIAP1/BIRC2 complex |
| CORUM:6292 | 0.0499140284799 | 0.25 | XIAP | HAX-1-XIAP complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| XIAP | DIABLO | 0.528 | 0.633 | bioplex (DIABLO) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| BIRC7 | DIABLO | 0.181 | 0.436 | bioplex (BIRC7) bioplex_WMM |
| DUSP22 | DIABLO | 0.151 | 0.411 | bioplex (DIABLO) bioplex_WMM |
| DIABLO | BIRC2 | 0.05 | 0.294 | bioplex (BIRC2,DIABLO) bioplex_WMM |
| DUSP22 | XIAP | 0.008 | 0.014 | bioplex_WMM WMM_only |
| DUSP22 | BIRC2 | 0.007 | 0.005 | bioplex_WMM WMM_only |
| XIAP | BIRC2 | 0.006 | 0.006 | bioplex (BIRC2) bioplex_WMM |
| XIAP | BIRC7 | 0.0 | 0.003 | bioplex (BIRC7) bioplex_WMM |
| BIRC7 | BIRC2 | 0.0 | 0.0 | bioplex (BIRC7) bioplex_WMM |
Images
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Complex HuMAP2_06122 has an average edge precision of 0.2 which is ranked 6171 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| BIRC7 | HuMAP2_00392 HuMAP2_01437 HuMAP2_01596 HuMAP2_03984 HuMAP2_05879 HuMAP2_06122 |
| BIRC2 | HuMAP2_01596 HuMAP2_06122 |
| XIAP | HuMAP2_00392 HuMAP2_00911 HuMAP2_01596 HuMAP2_03984 HuMAP2_05376 HuMAP2_06122 |
| DUSP22 | HuMAP2_00392 HuMAP2_01596 HuMAP2_03984 HuMAP2_06122 HuMAP2_06125 |
| DIABLO | HuMAP2_00392 HuMAP2_00911 HuMAP2_01596 HuMAP2_03984 HuMAP2_06122 |