hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06127
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CXXC1 | CXXC-type zinc finger protein 1 (CpG-binding protein) (PHD finger and CXXC domain-containing protein 1) | UniProt NCBI |
| SETD1A | Histone-lysine N-methyltransferase SETD1A (EC 2.1.1.43) (Lysine N-methyltransferase 2F) (SET domain-containing protein 1A) (hSET1A) (Set1/Ash2 histone methyltransferase complex subunit SET1) | UniProt NCBI |
| BOD1L1 | Biorientation of chromosomes in cell division protein 1-like 1 | UniProt NCBI |
| SETD1B | Histone-lysine N-methyltransferase SETD1B (EC 2.1.1.43) (Lysine N-methyltransferase 2G) (SET domain-containing protein 1B) (hSET1B) | UniProt NCBI |
| WDR5 | WD repeat-containing protein 5 (BMP2-induced 3-kb gene protein) | UniProt NCBI |
| ASH2L | Set1/Ash2 histone methyltransferase complex subunit ASH2 (ASH2-like protein) | UniProt NCBI |
| RBBP5 | Retinoblastoma-binding protein 5 (RBBP-5) (Retinoblastoma-binding protein RBQ-3) | UniProt NCBI |
| BOD1 | Biorientation of chromosomes in cell division protein 1 (Biorientation defective protein 1) (Protein FAM44B) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6470 | 9.10326711735e-21 | 0.875 | BOD1 WDR5 SETD1B ASH2L CXXC1 BOD1L1 RBBP5 | Set1B complex |
| CORUM:2731 | 2.54817186464e-15 | 0.625 | RBBP5 SETD1A ASH2L CXXC1 WDR5 | Set1A complex |
| CORUM:2730 | 2.54817186464e-15 | 0.625 | RBBP5 SETD1B ASH2L CXXC1 WDR5 | Set1B complex |
| GO:0048188 | 4.267974068e-14 | 0.75 | WDR5 SETD1A ASH2L CXXC1 SETD1B RBBP5 | Set1C/COMPASS complex |
| CORUM:6469 | 1.06951346208e-13 | 0.625 | RBBP5 SETD1A ASH2L CXXC1 WDR5 | Set1A complex |
| GO:0042800 | 4.62150859702e-13 | 0.75 | WDR5 SETD1A ASH2L CXXC1 SETD1B RBBP5 | histone methyltransferase activity (H3-K4 specific) |
| GO:0018024 | 3.00431142893e-10 | 0.75 | WDR5 SETD1A ASH2L CXXC1 SETD1B RBBP5 | histone-lysine N-methyltransferase activity |
| GO:0042054 | 1.12882105879e-09 | 0.75 | WDR5 SETD1A ASH2L CXXC1 SETD1B RBBP5 | histone methyltransferase activity |
| GO:0016279 | 1.87185712979e-09 | 0.75 | WDR5 SETD1A ASH2L CXXC1 SETD1B RBBP5 | protein-lysine N-methyltransferase activity |
| GO:0016278 | 2.11057393149e-09 | 0.75 | WDR5 SETD1A ASH2L CXXC1 SETD1B RBBP5 | lysine N-methyltransferase activity |
| CORUM:6850 | 4.70911134935e-09 | 0.375 | RBBP5 WDR5 ASH2L | WRA complex (WDR5, RBBP5, ASH2L) |
| CORUM:6845 | 1.8831701816e-08 | 0.375 | RBBP5 WDR5 ASH2L | NIF1-ASH2L-RBBP5-WDR5 complex |
| CORUM:6849 | 1.8831701816e-08 | 0.375 | RBBP5 WDR5 ASH2L | WRAD complex (WDR5, RBBP5, ASH2L, DPY30) |
| CORUM:6457 | 1.8831701816e-08 | 0.375 | RBBP5 WDR5 ASH2L | MLL1 core complex |
| CORUM:1399 | 1.8831701816e-08 | 0.375 | RBBP5 WDR5 ASH2L | WDR5-ASH2L-RBBP5-MLL2 complex |
| CORUM:7367 | 1.8831701816e-08 | 0.375 | RBBP5 WDR5 ASH2L | ASH2L-KDM6B-KDM6B-WDR5 complex |
| GO:0008276 | 2.004518819e-08 | 0.75 | WDR5 SETD1A ASH2L CXXC1 SETD1B RBBP5 | protein methyltransferase activity |
| REAC:R-HSA-3214841 | 2.09464996215e-08 | 0.625 | RBBP5 SETD1A WDR5 SETD1B ASH2L | PKMTs methylate histone lysines |
| GO:0035097 | 2.75401480006e-08 | 0.75 | WDR5 SETD1A ASH2L CXXC1 SETD1B RBBP5 | histone methyltransferase complex |
| GO:0008170 | 3.72358645043e-08 | 0.75 | WDR5 SETD1A ASH2L CXXC1 SETD1B RBBP5 | N-methyltransferase activity |
| CORUM:6851 | 4.70673981352e-08 | 0.375 | RBBP5 WDR5 ASH2L | MWRAD complex (MLL1, WDR5, RBBP5, ASH2L, DPY30) |
| REAC:R-HSA-8936459 | 7.88368047942e-08 | 0.625 | RBBP5 SETD1A WDR5 SETD1B ASH2L | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function |
| CORUM:1254 | 1.64652925394e-07 | 0.375 | RBBP5 WDR5 ASH2L | Menin-associated histone methyltransferase complex |
| CORUM:1256 | 1.64652925394e-07 | 0.375 | RBBP5 WDR5 ASH2L | MLL-HCF complex |
| GO:0034708 | 1.65113188105e-07 | 0.75 | WDR5 SETD1A ASH2L CXXC1 SETD1B RBBP5 | methyltransferase complex |
| GO:0051568 | 2.28991321124e-07 | 0.625 | RBBP5 SETD1B ASH2L CXXC1 WDR5 | histone H3-K4 methylation |
| CORUM:6462 | 2.63378327565e-07 | 0.375 | RBBP5 WDR5 ASH2L | MLL1 complex |
| CORUM:6461 | 3.94967983144e-07 | 0.375 | RBBP5 WDR5 ASH2L | MLL3 complex |
| CORUM:6467 | 3.94967983144e-07 | 0.375 | RBBP5 WDR5 ASH2L | MLL4 complex |
| CORUM:6460 | 5.64097851901e-07 | 0.375 | RBBP5 WDR5 ASH2L | MLL2 complex |
| CORUM:5195 | 5.64097851901e-07 | 0.375 | RBBP5 WDR5 ASH2L | PTIP-HMT complex |
| CORUM:1401 | 5.64097851901e-07 | 0.375 | SETD1A WDR5 RBBP5 | MOF complex |
| GO:0008757 | 8.53858620988e-07 | 0.75 | WDR5 SETD1A ASH2L CXXC1 SETD1B RBBP5 | S-adenosylmethionine-dependent methyltransferase activity |
| CORUM:3075 | 1.03365844178e-06 | 0.375 | RBBP5 WDR5 ASH2L | UTX-MLL2/3 complex |
| GO:0008168 | 1.99864802897e-06 | 0.75 | WDR5 SETD1A ASH2L CXXC1 SETD1B RBBP5 | methyltransferase activity |
| GO:0016741 | 2.68322227653e-06 | 0.75 | WDR5 SETD1A ASH2L CXXC1 SETD1B RBBP5 | transferase activity, transferring one-carbon groups |
| CORUM:2721 | 3.82814132258e-06 | 0.375 | SETD1A WDR5 ASH2L | HCF-1 complex |
| GO:0034968 | 4.73164200967e-06 | 0.625 | RBBP5 SETD1B ASH2L CXXC1 WDR5 | histone lysine methylation |
| REAC:R-HSA-8878171 | 6.29073501087e-06 | 0.625 | RBBP5 SETD1A WDR5 SETD1B ASH2L | Transcriptional regulation by RUNX1 |
| GO:0018022 | 1.16045096055e-05 | 0.625 | RBBP5 SETD1B ASH2L CXXC1 WDR5 | peptidyl-lysine methylation |
| CORUM:5386 | 1.3691106339e-05 | 0.375 | RBBP5 WDR5 ASH2L | MLL1-WDR5 complex |
| GO:0016571 | 1.48464162406e-05 | 0.625 | RBBP5 SETD1B ASH2L CXXC1 WDR5 | histone methylation |
| REAC:R-HSA-3247509 | 1.75906479738e-05 | 0.625 | RBBP5 SETD1A WDR5 SETD1B ASH2L | Chromatin modifying enzymes |
| REAC:R-HSA-4839726 | 1.75906479738e-05 | 0.625 | RBBP5 SETD1A WDR5 SETD1B ASH2L | Chromatin organization |
| GO:0008213 | 6.911459806e-05 | 0.625 | RBBP5 SETD1B ASH2L CXXC1 WDR5 | protein alkylation |
| GO:0006479 | 6.911459806e-05 | 0.625 | RBBP5 SETD1B ASH2L CXXC1 WDR5 | protein methylation |
| CORUM:6340 | 0.00011678598518 | 0.25 | RBBP5 ASH2L | PITX2-MLL4-ASH2L-RBBP5-PTIP complex |
| CORUM:1400 | 0.000245118829946 | 0.25 | RBBP5 ASH2L | ASCOM complex |
| CORUM:0000000 | 0.000356401437906 | 1.0 | RBBP5 WDR5 BOD1 SETD1A ASH2L CXXC1 SETD1B BOD1L1 | CORUM root |
| MIRNA:hsa-miR-4758-3p | 0.000832983978188 | 0.375 | SETD1A WDR5 BOD1 | hsa-miR-4758-3p |
| GO:0044666 | 0.000837474301274 | 0.375 | RBBP5 WDR5 ASH2L | MLL3/4 complex |
| GO:0043414 | 0.00133752034868 | 0.625 | RBBP5 SETD1B ASH2L CXXC1 WDR5 | macromolecule methylation |
| GO:0051276 | 0.00135023127082 | 0.875 | BOD1 WDR5 SETD1A ASH2L CXXC1 SETD1B RBBP5 | chromosome organization |
| GO:0045652 | 0.00163549131335 | 0.5 | RBBP5 SETD1A WDR5 ASH2L | regulation of megakaryocyte differentiation |
| GO:0030219 | 0.00193552303911 | 0.5 | RBBP5 SETD1A WDR5 ASH2L | megakaryocyte differentiation |
| GO:0032259 | 0.00194231555299 | 0.625 | RBBP5 SETD1B ASH2L CXXC1 WDR5 | methylation |
| KEGG:04934 | 0.00215976810771 | 0.375 | RBBP5 WDR5 ASH2L | Cushing syndrome |
| REAC:R-HSA-5619507 | 0.00432880045086 | 0.375 | RBBP5 WDR5 ASH2L | Activation of HOX genes during differentiation |
| REAC:R-HSA-5617472 | 0.00432880045086 | 0.375 | RBBP5 WDR5 ASH2L | Activation of anterior HOX genes in hindbrain development during early embryogenesis |
| CORUM:1257 | 0.00438731229196 | 0.25 | RBBP5 WDR5 | ALL-1 supercomplex |
| GO:0006325 | 0.00454489646996 | 0.75 | WDR5 SETD1A ASH2L CXXC1 SETD1B RBBP5 | chromatin organization |
| GO:0018205 | 0.00673460397389 | 0.625 | RBBP5 SETD1B ASH2L CXXC1 WDR5 | peptidyl-lysine modification |
| GO:0016570 | 0.0127306091497 | 0.625 | RBBP5 SETD1B ASH2L CXXC1 WDR5 | histone modification |
| REAC:R-HSA-212436 | 0.0132859010078 | 0.625 | RBBP5 SETD1A WDR5 SETD1B ASH2L | Generic Transcription Pathway |
| GO:1990234 | 0.0135103212283 | 0.75 | WDR5 SETD1A ASH2L CXXC1 SETD1B RBBP5 | transferase complex |
| GO:0016569 | 0.0159334115767 | 0.625 | RBBP5 SETD1B ASH2L CXXC1 WDR5 | covalent chromatin modification |
| KEGG:00310 | 0.0218622840624 | 0.25 | SETD1A SETD1B | Lysine degradation |
| REAC:R-HSA-73857 | 0.0224473446481 | 0.625 | RBBP5 SETD1A WDR5 SETD1B ASH2L | RNA Polymerase II Transcription |
| WP:WP2369 | 0.0269379290762 | 0.25 | SETD1A SETD1B | Histone Modifications |
| REAC:R-HSA-3769402 | 0.0328409413955 | 0.25 | RBBP5 ASH2L | Deactivation of the beta-catenin transactivating complex |
| GO:0045637 | 0.0362947680097 | 0.5 | RBBP5 SETD1A WDR5 ASH2L | regulation of myeloid cell differentiation |
| REAC:R-HSA-74160 | 0.037866398773 | 0.625 | RBBP5 SETD1A WDR5 SETD1B ASH2L | Gene expression (Transcription) |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CXXC1 | SETD1B | 0.997 | 0.931 | hein_WMM bioplex (CXXC1) bioplex_WMM youn_WMM hein (CXXC1,SETD1B) |
| CXXC1 | SETD1A | 0.994 | 0.919 | hein_WMM bioplex (CXXC1) bioplex_WMM youn_WMM hein (CXXC1) fraction |
| SETD1B | WDR5 | 0.981 | 0.896 | hein_WMM bioplex (WDR5) bioplex_WMM hein (SETD1B) |
| CXXC1 | BOD1L1 | 0.98 | 0.896 | hein_WMM bioplex (CXXC1) bioplex_WMM youn_WMM hein (BOD1L1,CXXC1) |
| CXXC1 | WDR5 | 0.964 | 0.872 | hein_WMM bioplex (CXXC1,WDR5) bioplex_WMM hein (CXXC1,WDR5) |
| ASH2L | WDR5 | 0.931 | 0.846 | hein_WMM bioplex (WDR5) bioplex_WMM youn_WMM |
| BOD1 | CXXC1 | 0.883 | 0.818 | hein_WMM bioplex (CXXC1) bioplex_WMM hein (BOD1,CXXC1) |
| WDR5 | SETD1A | 0.878 | 0.812 | hein_WMM bioplex (WDR5) bioplex_WMM youn_WMM |
| RBBP5 | WDR5 | 0.866 | 0.801 | hein_WMM bioplex (WDR5) bioplex_WMM youn_WMM |
| CXXC1 | ASH2L | 0.677 | 0.706 | hein_WMM bioplex (CXXC1) bioplex_WMM youn_WMM hein (CXXC1) fraction |
| WDR5 | BOD1L1 | 0.635 | 0.685 | hein_WMM bioplex (WDR5) bioplex_WMM youn_WMM |
| CXXC1 | RBBP5 | 0.617 | 0.675 | hein_WMM bioplex (CXXC1) bioplex_WMM youn_WMM hein (CXXC1) |
| SETD1A | BOD1L1 | 0.157 | 0.416 | hein_WMM bioplex_WMM youn_WMM hein (BOD1L1) |
| BOD1 | WDR5 | 0.045 | 0.279 | hein_WMM bioplex (BOD1,WDR5) bioplex_WMM hein (BOD1) |
| RBBP5 | SETD1B | 0.043 | 0.269 | hein_WMM bioplex_WMM youn_WMM hein (SETD1B) |
| BOD1 | SETD1B | 0.039 | 0.263 | hein_WMM bioplex_WMM hein (BOD1) |
| RBBP5 | ASH2L | 0.034 | 0.26 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| ASH2L | SETD1B | 0.016 | 0.155 | hein_WMM bioplex_WMM youn_WMM hein (SETD1B) |
| ASH2L | BOD1L1 | 0.012 | 0.147 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| RBBP5 | SETD1A | 0.011 | 0.142 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| SETD1B | SETD1A | 0.01 | 0.129 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| SETD1B | BOD1L1 | 0.01 | 0.105 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| BOD1 | BOD1L1 | 0.01 | 0.099 | hein_WMM bioplex_WMM WMM_only |
| BOD1 | SETD1A | 0.009 | 0.11 | hein_WMM bioplex_WMM WMM_only |
| BOD1 | RBBP5 | 0.007 | 0.003 | hein_WMM bioplex_WMM hein (BOD1) |
| BOD1 | ASH2L | 0.005 | 0.014 | hein_WMM bioplex_WMM hein (BOD1) |
| RBBP5 | BOD1L1 | 0.005 | 0.007 | hein_WMM bioplex_WMM youn_WMM hein (BOD1L1) |
| ASH2L | SETD1A | 0.0 | 0.014 | hein_WMM bioplex_WMM youn_WMM gupta_WMM fraction |
Images
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Complex HuMAP2_06127 has an average edge precision of 0.438 which is ranked 2948 out of all 6965 complexes.
Related Complexes