hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06130
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SRSF12 | Serine/arginine-rich splicing factor 12 (35 kDa SR repressor protein) (SRrp35) (Splicing factor, arginine/serine-rich 13B) (Splicing factor, arginine/serine-rich 19) | UniProt NCBI |
| SRSF8 | Serine/arginine-rich splicing factor 8 (Pre-mRNA-splicing factor SRP46) (Splicing factor SRp46) (Splicing factor, arginine/serine-rich 2B) | UniProt NCBI |
| CLK1 | Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1) | UniProt NCBI |
| USP9Y | Probable ubiquitin carboxyl-terminal hydrolase FAF-Y (EC 3.4.19.12) (Deubiquitinating enzyme FAF-Y) (Fat facets protein-related, Y-linked) (Ubiquitin thioesterase FAF-Y) (Ubiquitin-specific protease 9, Y chromosome) (Ubiquitin-specific-processing protease FAF-Y) | UniProt NCBI |
| CLK3 | Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3) | UniProt NCBI |
| CLK2 | Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0043484 | 9.30691639939e-06 | 0.833333333333 | CLK3 SRSF8 SRSF12 CLK2 CLK1 | regulation of RNA splicing |
| WP:WP411 | 0.000468249477071 | 0.5 | CLK3 CLK1 CLK2 | mRNA Processing |
| GO:0008380 | 0.00270779091032 | 0.833333333333 | CLK3 SRSF8 SRSF12 CLK2 CLK1 | RNA splicing |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CLK3 | USP9Y | 0.124 | 0.395 | bioplex (CLK3) bioplex_WMM youn_WMM |
| CLK3 | CLK2 | 0.122 | 0.393 | bioplex (CLK2,CLK3) bioplex_WMM |
| CLK3 | SRSF8 | 0.119 | 0.392 | hein_WMM bioplex (CLK3) bioplex_WMM youn_WMM |
| SRSF8 | CLK2 | 0.113 | 0.38 | bioplex (CLK2) bioplex_WMM |
| CLK3 | SRSF12 | 0.106 | 0.373 | bioplex (CLK3) bioplex_WMM |
| CLK1 | CLK2 | 0.081 | 0.351 | bioplex (CLK2) bioplex_WMM |
| SRSF12 | CLK2 | 0.042 | 0.27 | bioplex (CLK2) bioplex_WMM boldt_WMM |
| SRSF12 | SRSF8 | 0.013 | 0.148 | bioplex_WMM WMM_only |
| SRSF12 | CLK1 | 0.011 | 0.145 | bioplex_WMM WMM_only |
| CLK3 | CLK1 | 0.01 | 0.136 | bioplex_WMM WMM_only |
| SRSF8 | CLK1 | 0.01 | 0.126 | bioplex_WMM WMM_only |
| SRSF12 | USP9Y | 0.007 | 0.008 | bioplex_WMM WMM_only |
| USP9Y | SRSF8 | 0.007 | 0.001 | bioplex_WMM WMM_only |
| USP9Y | CLK2 | 0.007 | 0.005 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_06130 has an average edge precision of 0.223 which is ranked 5807 out of all 6965 complexes.
Related Complexes