hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06133
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| BBC3 | Bcl-2-binding component 3 (JFY-1) (p53 up-regulated modulator of apoptosis) | UniProt NCBI |
| MCL1 | Induced myeloid leukemia cell differentiation protein Mcl-1 (Bcl-2-like protein 3) (Bcl2-L-3) (Bcl-2-related protein EAT/mcl1) (mcl1/EAT) | UniProt NCBI |
| BAX | Apoptosis regulator BAX (Bcl-2-like protein 4) (Bcl2-L-4) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP254 | 4.00606535768e-06 | 1.0 | BBC3 MCL1 BAX | Apoptosis |
| WP:WP1772 | 5.49549000446e-06 | 1.0 | BBC3 MCL1 BAX | Apoptosis Modulation and Signaling |
| KEGG:04210 | 9.55549752694e-06 | 1.0 | BBC3 MCL1 BAX | Apoptosis |
| GO:0043525 | 0.000103533176666 | 1.0 | BBC3 MCL1 BAX | positive regulation of neuron apoptotic process |
| WP:WP1742 | 0.000130363431616 | 0.666666666667 | BBC3 BAX | TP53 Network |
| WP:WP3872 | 0.000182100906477 | 0.666666666667 | BAX MCL1 | Regulation of Apoptosis by Parathyroid Hormone-related Protein |
| KEGG:04215 | 0.00019456526656 | 0.666666666667 | BBC3 BAX | Apoptosis - multiple species |
| WP:WP3982 | 0.000221376526859 | 0.666666666667 | BBC3 BAX | miRNA regulation of p53 pathway in prostate cancer |
| WP:WP3614 | 0.000505754093136 | 0.666666666667 | BAX MCL1 | Photodynamic therapy-induced HIF-1 survival signaling |
| GO:2001244 | 0.000829990966275 | 1.0 | BBC3 MCL1 BAX | positive regulation of intrinsic apoptotic signaling pathway |
| WP:WP1971 | 0.000864566693143 | 0.666666666667 | BBC3 BAX | Integrated Cancer Pathway |
| KEGG:04115 | 0.000900335185999 | 0.666666666667 | BBC3 BAX | p53 signaling pathway |
| WP:WP3611 | 0.00103480501892 | 0.666666666667 | BAX MCL1 | Photodynamic therapy-induced AP-1 survival signaling. |
| KEGG:01524 | 0.0011410864499 | 0.666666666667 | BBC3 BAX | Platinum drug resistance |
| GO:1901216 | 0.00120280122085 | 1.0 | BBC3 MCL1 BAX | positive regulation of neuron death |
| REAC:R-HSA-6803204 | 0.00127110038679 | 0.666666666667 | BBC3 BAX | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release |
| KEGG:05210 | 0.00148194300046 | 0.666666666667 | BBC3 BAX | Colorectal cancer |
| WP:WP707 | 0.00211461727653 | 0.666666666667 | BBC3 BAX | DNA Damage Response |
| WP:WP1530 | 0.00230941333173 | 0.666666666667 | BBC3 BAX | miRNA Regulation of DNA Damage Response |
| WP:WP4216 | 0.00237624614213 | 0.666666666667 | BBC3 BAX | Chromosomal and microsatellite instability in colorectal cancer |
| KEGG:05162 | 0.00361949387372 | 0.666666666667 | BBC3 BAX | Measles |
| WP:WP710 | 0.00511400973198 | 0.666666666667 | BBC3 BAX | DNA Damage Response (only ATM dependent) |
| REAC:R-HSA-5633008 | 0.00521352578002 | 0.666666666667 | BBC3 BAX | TP53 Regulates Transcription of Cell Death Genes |
| KEGG:05016 | 0.00684298122566 | 0.666666666667 | BBC3 BAX | Huntington disease |
| GO:0043523 | 0.00804289309261 | 1.0 | BBC3 MCL1 BAX | regulation of neuron apoptotic process |
| GO:0051400 | 0.00811409485621 | 0.666666666667 | BAX MCL1 | BH domain binding |
| GO:0051434 | 0.00811409485621 | 0.666666666667 | BAX MCL1 | BH3 domain binding |
| REAC:R-HSA-109606 | 0.00818423736949 | 0.666666666667 | BBC3 BAX | Intrinsic Pathway for Apoptosis |
| WP:WP4396 | 0.00888189132931 | 0.666666666667 | BBC3 BAX | Nonalcoholic fatty liver disease |
| GO:0051402 | 0.0117851633362 | 1.0 | BBC3 MCL1 BAX | neuron apoptotic process |
| MIRNA:hsa-miR-876-3p | 0.0178183335155 | 0.666666666667 | BBC3 MCL1 | hsa-miR-876-3p |
| GO:2001235 | 0.0185411572066 | 1.0 | BBC3 MCL1 BAX | positive regulation of apoptotic signaling pathway |
| GO:2001242 | 0.0196004650773 | 1.0 | BBC3 MCL1 BAX | regulation of intrinsic apoptotic signaling pathway |
| GO:0070513 | 0.020283420769 | 0.666666666667 | BAX MCL1 | death domain binding |
| GO:0097136 | 0.020283420769 | 0.666666666667 | BAX MCL1 | Bcl-2 family protein complex |
| CORUM:2000 | 0.0249904952816 | 0.333333333333 | BAX | BAX homo-oligomer complex |
| CORUM:3492 | 0.0249904952816 | 0.333333333333 | BAX | BAX homo-oligomer complex |
| GO:0005741 | 0.0268132763851 | 1.0 | BBC3 MCL1 BAX | mitochondrial outer membrane |
| WP:WP4399 | 0.0285649389616 | 0.333333333333 | MCL1 | MicroRNA network associated with chronic lymphocytic leukemia |
| GO:0031968 | 0.0340260876928 | 1.0 | BBC3 MCL1 BAX | organelle outer membrane |
| GO:0019867 | 0.0348113051011 | 1.0 | BBC3 MCL1 BAX | outer membrane |
| HPA:005010_23 | 0.0375593404485 | 1.0 | BBC3 MCL1 BAX | bronchus; respiratory epithelial cells[Approved,High] |
| GO:1903896 | 0.0378589948753 | 0.666666666667 | BBC3 BAX | positive regulation of IRE1-mediated unfolded protein response |
| GO:1901214 | 0.0424286223465 | 1.0 | BBC3 MCL1 BAX | regulation of neuron death |
| MIRNA:hsa-miR-504-5p | 0.0439350747985 | 0.666666666667 | BBC3 BAX | hsa-miR-504-5p |
| KEGG:05200 | 0.0473113658041 | 0.666666666667 | BBC3 BAX | Pathways in cancer |
| CORUM:5823 | 0.0499776345577 | 0.333333333333 | MCL1 | MCL1-BAK1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| MCL1 | BBC3 | 0.628 | 0.68 | bioplex (MCL1) |
| MCL1 | BAX | 0.273 | 0.487 | bioplex (MCL1) bioplex_WMM |
| BAX | BBC3 | 0.01 | 0.098 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_06133 has an average edge precision of 0.422 which is ranked 3096 out of all 6965 complexes.
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