hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06134
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SEC24C | Protein transport protein Sec24C (SEC24-related protein C) | UniProt NCBI |
| SEC23B | Protein transport protein Sec23B (hSec23B) (SEC23-related protein B) | UniProt NCBI |
| SEC24B | Protein transport protein Sec24B (SEC24-related protein B) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP1982 | 2.94741704881e-06 | 1.0 | SEC24B SEC24C SEC23B | Sterol Regulatory Element-Binding Proteins (SREBP) signalling |
| KEGG:04141 | 1.90270931244e-05 | 1.0 | SEC24B SEC24C SEC23B | Protein processing in endoplasmic reticulum |
| GO:0090110 | 3.30579616724e-05 | 1.0 | SEC24B SEC24C SEC23B | COPII-coated vesicle cargo loading |
| GO:0030127 | 4.13224520905e-05 | 1.0 | SEC24B SEC24C SEC23B | COPII vesicle coat |
| GO:0035459 | 0.000160839698137 | 1.0 | SEC24B SEC24C SEC23B | vesicle cargo loading |
| GO:0012507 | 0.00128871559377 | 1.0 | SEC24B SEC24C SEC23B | ER to Golgi transport vesicle membrane |
| GO:0030120 | 0.00147262321021 | 1.0 | SEC24B SEC24C SEC23B | vesicle coat |
| REAC:R-HSA-983170 | 0.00200655101382 | 0.666666666667 | SEC24B SEC24C | Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| REAC:R-HSA-5694530 | 0.00234745427481 | 0.666666666667 | SEC24B SEC24C | Cargo concentration in the ER |
| GO:0051668 | 0.00295242108794 | 1.0 | SEC24B SEC24C SEC23B | localization within membrane |
| GO:0090114 | 0.00415585803882 | 1.0 | SEC24B SEC24C SEC23B | COPII-coated vesicle budding |
| GO:0048475 | 0.00564855215433 | 1.0 | SEC24B SEC24C SEC23B | coated membrane |
| GO:0048194 | 0.00564855215433 | 1.0 | SEC24B SEC24C SEC23B | Golgi vesicle budding |
| GO:0030117 | 0.00564855215433 | 1.0 | SEC24B SEC24C SEC23B | membrane coat |
| GO:0030134 | 0.00564855215433 | 1.0 | SEC24B SEC24C SEC23B | COPII-coated ER to Golgi transport vesicle |
| KEGG:05130 | 0.00692087445383 | 0.666666666667 | SEC24B SEC24C | Pathogenic Escherichia coli infection |
| REAC:R-HSA-1655829 | 0.00818423736949 | 0.666666666667 | SEC24B SEC24C | Regulation of cholesterol biosynthesis by SREBP (SREBF) |
| GO:0030660 | 0.00929437307021 | 1.0 | SEC24B SEC24C SEC23B | Golgi-associated vesicle membrane |
| HP:0001081 | 0.0112458624499 | 0.666666666667 | SEC24C SEC23B | Cholelithiasis |
| GO:0006900 | 0.011404996777 | 1.0 | SEC24B SEC24C SEC23B | vesicle budding from membrane |
| REAC:R-HSA-204005 | 0.012220214888 | 0.666666666667 | SEC24B SEC24C | COPII-mediated vesicle transport |
| HP:0012437 | 0.0156055992881 | 0.666666666667 | SEC24C SEC23B | Abnormal gallbladder morphology |
| GO:0030658 | 0.0175207196864 | 1.0 | SEC24B SEC24C SEC23B | transport vesicle membrane |
| HP:0005264 | 0.0218987389569 | 0.666666666667 | SEC24C SEC23B | Abnormality of the gallbladder |
| GO:0030662 | 0.033252767518 | 1.0 | SEC24B SEC24C SEC23B | coated vesicle membrane |
| GO:0005798 | 0.0372392489125 | 1.0 | SEC24B SEC24C SEC23B | Golgi-associated vesicle |
| REAC:R-HSA-2132295 | 0.0444303896492 | 0.666666666667 | SEC24B SEC24C | MHC class II antigen presentation |
| HP:0001053 | 0.0480420769795 | 0.666666666667 | SEC24C SEC23B | Hypopigmented skin patches |
| CORUM:7139 | 0.0499776345577 | 0.333333333333 | SEC24B | SEC23-SEC24 adaptor complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| SEC24C | SEC23B | 0.999 | 0.949 | hein_WMM bioplex_WMM youn_WMM hein (SEC24C) Malo gupta_WMM fraction |
| SEC23B | SEC24B | 0.966 | 0.875 | hein_WMM bioplex_WMM youn_WMM gupta_WMM fraction |
| SEC24C | SEC24B | 0.084 | 0.347 | hein_WMM bioplex_WMM youn_WMM hein (SEC24C) gupta_WMM fraction |
Images
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Complex HuMAP2_06134 has an average edge precision of 0.724 which is ranked 1299 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| SEC24C | HuMAP2_00758 HuMAP2_01054 HuMAP2_02478 HuMAP2_02576 HuMAP2_05176 HuMAP2_05341 HuMAP2_06134 |
| SEC23B | HuMAP2_00758 HuMAP2_02617 HuMAP2_05176 HuMAP2_06134 HuMAP2_06365 |
| SEC24B | HuMAP2_00758 HuMAP2_02057 HuMAP2_05176 HuMAP2_06134 HuMAP2_06430 |