hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_06137

Confidence: Medium

Genename	Protein Name	Links
S100A10	Protein S100-A10 (Calpactin I light chain) (Calpactin-1 light chain) (Cellular ligand of annexin II) (S100 calcium-binding protein A10) (p10 protein) (p11)	UniProt NCBI
PRDX1	Peroxiredoxin-1 (EC 1.11.1.15) (Natural killer cell-enhancing factor A) (NKEF-A) (Proliferation-associated gene protein) (PAG) (Thioredoxin peroxidase 2) (Thioredoxin-dependent peroxide reductase 2)	UniProt NCBI
PRDX2	Peroxiredoxin-2 (EC 1.11.1.15) (Natural killer cell-enhancing factor B) (NKEF-B) (PRP) (Thiol-specific antioxidant protein) (TSA) (Thioredoxin peroxidase 1) (Thioredoxin-dependent peroxide reductase 1)	UniProt NCBI
KPNA1	Importin subunit alpha-5 (Karyopherin subunit alpha-1) (Nucleoprotein interactor 1) (NPI-1) (RAG cohort protein 2) (SRP1-beta) [Cleaved into: Importin subunit alpha-5, N-terminally processed]	UniProt NCBI
PRDX3	Thioredoxin-dependent peroxide reductase, mitochondrial (EC 1.11.1.15) (Antioxidant protein 1) (AOP-1) (HBC189) (Peroxiredoxin III) (Prx-III) (Peroxiredoxin-3) (Protein MER5 homolog)	UniProt NCBI
KPNA6	Importin subunit alpha-7 (Karyopherin subunit alpha-6)	UniProt NCBI
RNMT	mRNA cap guanine-N7 methyltransferase (EC 2.1.1.56) (RG7MT1) (mRNA (guanine-N(7)-)-methyltransferase) (mRNA cap methyltransferase) (hCMT1) (hMet) (hcm1p)	UniProt NCBI
KPNA5	Importin subunit alpha-6 (Karyopherin subunit alpha-5)	UniProt NCBI
MTRR	Methionine synthase reductase (MSR) (EC 1.16.1.8)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0008379	7.62415024416e-05	0.333333333333	PRDX3 PRDX1 PRDX2	thioredoxin peroxidase activity
GO:0051920	7.62415024416e-05	0.333333333333	PRDX3 PRDX1 PRDX2	peroxiredoxin activity
REAC:R-HSA-3299685	0.00011018806463	0.333333333333	PRDX3 PRDX1 PRDX2	Detoxification of Reactive Oxygen Species
WP:WP15	0.000448954899509	0.333333333333	PRDX3 PRDX1 PRDX2	Selenium Micronutrient Network
REAC:R-HSA-1643685	0.000933302100755	0.666666666667	MTRR PRDX2 KPNA1 PRDX1 KPNA5 RNMT	Disease
HP:0003658	0.00225199859711	0.222222222222	MTRR PRDX1	Hypomethioninemia
KEGG:05164	0.00395604421584	0.333333333333	KPNA6 KPNA1 KPNA5	Influenza A
HP:0003524	0.00472623345058	0.222222222222	MTRR PRDX1	Decreased methionine synthase activity
HP:0003223	0.00629966976086	0.222222222222	MTRR PRDX1	Decreased methylcobalamin
HP:0010919	0.00809703709436	0.222222222222	MTRR PRDX1	Abnormal circulating homocysteine concentration
HP:0002160	0.00809703709436	0.222222222222	MTRR PRDX1	Hyperhomocystinemia
HP:0002156	0.00809703709436	0.222222222222	MTRR PRDX1	Homocystinuria
GO:0006607	0.00865220447533	0.333333333333	KPNA6 KPNA1 KPNA5	NLS-bearing protein import into nucleus
GO:0008139	0.0116809984418	0.333333333333	KPNA6 KPNA1 KPNA5	nuclear localization sequence binding
GO:0042744	0.0134290861763	0.333333333333	PRDX3 PRDX1 PRDX2	hydrogen peroxide catabolic process
REAC:R-HSA-8863678	0.0134979585429	0.222222222222	PRDX1 PRDX2	Neurodegenerative Diseases
REAC:R-HSA-8862803	0.0134979585429	0.222222222222	PRDX1 PRDX2	Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
HP:0010901	0.0148306157257	0.222222222222	MTRR PRDX1	Abnormal circulating methionine concentration
CORUM:3151	0.0249698419797	0.111111111111	PRDX1	Sulphiredoxin-peroxiredoxin complex
HP:0001889	0.026930967926	0.222222222222	MTRR PRDX1	Megaloblastic anemia
HP:0004339	0.026930967926	0.222222222222	MTRR PRDX1	Abnormal circulating sulfur amino acid concentration
GO:0045454	0.027657204222	0.333333333333	PRDX3 PRDX1 PRDX2	cell redox homeostasis
HP:0010899	0.0305121976344	0.222222222222	MTRR PRDX1	Abnormal circulating aspartate family amino acid concentration
HP:0040126	0.0343154638255	0.222222222222	MTRR PRDX1	Abnormal vitamin B12 level
REAC:R-HSA-168276	0.0425936191784	0.222222222222	KPNA1 KPNA5	NS1 Mediated Effects on Host Pathways
REAC:R-HSA-168253	0.0449458369245	0.222222222222	KPNA1 KPNA5	Host Interactions with Influenza Factors
CORUM:6675	0.0499262710315	0.111111111111	PRDX1	PI4K2A-PRDX1 complex

Edges

Protein 1	Protein 2	Score	Precision	Evidence
PRDX2	PRDX3	0.998	0.945	hein_WMM bioplex (PRDX3) bioplex_WMM boldt (PRDX2) youn_WMM Malo gupta_WMM fraction boldt_WMM treiber_WMM
PRDX2	PRDX1	0.993	0.918	hein_WMM bioplex_WMM boldt (PRDX2) hein (PRDX1) Malo fraction boldt_WMM treiber_WMM
PRDX3	PRDX1	0.917	0.84	hein_WMM bioplex (PRDX3) bioplex_WMM boldt Malo fraction boldt_WMM treiber_WMM
PRDX3	RNMT	0.324	0.512	bioplex (RNMT) bioplex_WMM fraction
PRDX3	MTRR	0.109	0.375	fraction
PRDX2	RNMT	0.068	0.347	bioplex (RNMT) bioplex_WMM youn_WMM fraction
KPNA1	RNMT	0.06	0.335	hein_WMM bioplex (RNMT) bioplex_WMM youn_WMM hein (KPNA1)
KPNA6	KPNA1	0.05	0.296	hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only boldt_WMM
KPNA6	RNMT	0.033	0.252	bioplex (RNMT) bioplex_WMM youn_WMM
PRDX1	RNMT	0.029	0.231	bioplex (RNMT) bioplex_WMM fraction
PRDX1	S100A10	0.026	0.224	bioplex_WMM fraction treiber_WMM
KPNA5	RNMT	0.023	0.21	bioplex (RNMT) bioplex_WMM youn_WMM
KPNA6	KPNA5	0.012	0.146	bioplex_WMM youn_WMM gupta_WMM WMM_only
KPNA1	KPNA5	0.012	0.144	bioplex_WMM youn_WMM gupta_WMM WMM_only
KPNA6	PRDX1	0.008	0.007	bioplex_WMM WMM_only
KPNA6	PRDX2	0.007	0.01	bioplex_WMM youn_WMM gupta_WMM WMM_only
PRDX1	KPNA1	0.007	0.014	bioplex_WMM WMM_only
PRDX2	KPNA1	0.007	0.003	bioplex_WMM youn_WMM gupta_WMM WMM_only
PRDX1	KPNA5	0.007	0.009	bioplex_WMM WMM_only
PRDX3	KPNA5	0.007	0.008	bioplex_WMM youn_WMM gupta_WMM WMM_only
PRDX3	KPNA1	0.007	0.008	bioplex_WMM youn_WMM gupta_WMM WMM_only
KPNA6	PRDX3	0.007	0.005	bioplex_WMM youn_WMM gupta_WMM WMM_only
PRDX2	KPNA5	0.007	0.004	bioplex_WMM youn_WMM gupta_WMM WMM_only
PRDX3	S100A10	0.007	0.006	bioplex_WMM youn_WMM WMM_only treiber_WMM
KPNA6	S100A10	0.007	0.004	bioplex_WMM WMM_only
S100A10	RNMT	0.007	0.001	bioplex_WMM WMM_only
PRDX2	S100A10	0.007	0.004	bioplex_WMM youn_WMM WMM_only treiber_WMM
KPNA5	S100A10	0.007	0.006	bioplex_WMM WMM_only
KPNA1	S100A10	0.007	0.002	bioplex_WMM youn_WMM WMM_only
PRDX1	MTRR	0.007	0.006	hein_WMM WMM_only

Images

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Complex HuMAP2_06137 has an average edge precision of 0.196 which is ranked 6231 out of all 6965 complexes.

Related Complexes

Genename	Complexes
S100A10	HuMAP2_03927 HuMAP2_04702 HuMAP2_05147 HuMAP2_05526 HuMAP2_06137
PRDX1	HuMAP2_01228 HuMAP2_03283 HuMAP2_05526 HuMAP2_05584 HuMAP2_06137
PRDX2	HuMAP2_01228 HuMAP2_03714 HuMAP2_03724 HuMAP2_05584 HuMAP2_06137
KPNA1	HuMAP2_01285 HuMAP2_01473 HuMAP2_04098 HuMAP2_04630 HuMAP2_05768 HuMAP2_06117 HuMAP2_06137 HuMAP2_06218
PRDX3	HuMAP2_01228 HuMAP2_05584 HuMAP2_06137 HuMAP2_06810
KPNA6	HuMAP2_00200 HuMAP2_01285 HuMAP2_02561 HuMAP2_04098 HuMAP2_04630 HuMAP2_06137 HuMAP2_06218
RNMT	HuMAP2_04098 HuMAP2_04630 HuMAP2_05584 HuMAP2_05768 HuMAP2_06137 HuMAP2_06218
KPNA5	HuMAP2_03236 HuMAP2_04098 HuMAP2_04630 HuMAP2_06137 HuMAP2_06218
MTRR	HuMAP2_05584 HuMAP2_06137 HuMAP2_06810

hu.MAP 2.0: Complex View

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Complex: HuMAP2_06137