hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06140
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PSMB3 | Proteasome subunit beta type-3 (EC 3.4.25.1) (Proteasome chain 13) (Proteasome component C10-II) (Proteasome theta chain) | UniProt NCBI |
| PSME2 | Proteasome activator complex subunit 2 (11S regulator complex subunit beta) (REG-beta) (Activator of multicatalytic protease subunit 2) (Proteasome activator 28 subunit beta) (PA28b) (PA28beta) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:03050 | 0.000144438568694 | 1.0 | PSMB3 PSME2 | Proteasome |
| CORUM:192 | 0.000201110815485 | 1.0 | PSMB3 PSME2 | PA28-20S proteasome |
| WP:WP183 | 0.000681823837044 | 1.0 | PSMB3 PSME2 | Proteasome Degradation |
| CORUM:193 | 0.0010558317813 | 1.0 | PSMB3 PSME2 | PA700-20S-PA28 complex |
| REAC:R-HSA-1236978 | 0.00189044166556 | 1.0 | PSMB3 PSME2 | Cross-presentation of soluble exogenous antigens (endosomes) |
| REAC:R-HSA-211733 | 0.00205300624141 | 1.0 | PSMB3 PSME2 | Regulation of activated PAK-2p34 by proteasome mediated degradation |
| REAC:R-HSA-350562 | 0.00213680241453 | 1.0 | PSMB3 PSME2 | Regulation of ornithine decarboxylase (ODC) |
| REAC:R-HSA-75815 | 0.00222227451111 | 1.0 | PSMB3 PSME2 | Ubiquitin-dependent degradation of Cyclin D |
| REAC:R-HSA-69601 | 0.00222227451111 | 1.0 | PSMB3 PSME2 | Ubiquitin Mediated Degradation of Phosphorylated Cdc25A |
| REAC:R-HSA-180534 | 0.00222227451111 | 1.0 | PSMB3 PSME2 | Vpu mediated degradation of CD4 |
| REAC:R-HSA-69610 | 0.00222227451111 | 1.0 | PSMB3 PSME2 | p53-Independent DNA Damage Response |
| REAC:R-HSA-349425 | 0.00222227451111 | 1.0 | PSMB3 PSME2 | Autodegradation of the E3 ubiquitin ligase COP1 |
| REAC:R-HSA-69613 | 0.00222227451111 | 1.0 | PSMB3 PSME2 | p53-Independent G1/S DNA damage checkpoint |
| REAC:R-HSA-180585 | 0.00230942253115 | 1.0 | PSMB3 PSME2 | Vif-mediated degradation of APOBEC3G |
| REAC:R-HSA-9604323 | 0.00230942253115 | 1.0 | PSMB3 PSME2 | Negative regulation of NOTCH4 signaling |
| REAC:R-HSA-450408 | 0.00230942253115 | 1.0 | PSMB3 PSME2 | AUF1 (hnRNP D0) binds and destabilizes mRNA |
| REAC:R-HSA-8941858 | 0.00230942253115 | 1.0 | PSMB3 PSME2 | Regulation of RUNX3 expression and activity |
| REAC:R-HSA-169911 | 0.00230942253115 | 1.0 | PSMB3 PSME2 | Regulation of Apoptosis |
| REAC:R-HSA-8854050 | 0.00239824647466 | 1.0 | PSMB3 PSME2 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis |
| REAC:R-HSA-4641257 | 0.00248874634163 | 1.0 | PSMB3 PSME2 | Degradation of AXIN |
| REAC:R-HSA-5362768 | 0.00248874634163 | 1.0 | PSMB3 PSME2 | Hh mutants that don't undergo autocatalytic processing are degraded by ERAD |
| REAC:R-HSA-174113 | 0.00248874634163 | 1.0 | PSMB3 PSME2 | SCF-beta-TrCP mediated degradation of Emi1 |
| REAC:R-HSA-69541 | 0.00267477384595 | 1.0 | PSMB3 PSME2 | Stabilization of p53 |
| REAC:R-HSA-5387390 | 0.00267477384595 | 1.0 | PSMB3 PSME2 | Hh mutants abrogate ligand secretion |
| REAC:R-HSA-351202 | 0.00267477384595 | 1.0 | PSMB3 PSME2 | Metabolism of polyamines |
| REAC:R-HSA-4641258 | 0.00267477384595 | 1.0 | PSMB3 PSME2 | Degradation of DVL |
| REAC:R-HSA-5610780 | 0.00286750504412 | 1.0 | PSMB3 PSME2 | Degradation of GLI1 by the proteasome |
| REAC:R-HSA-68827 | 0.00286750504412 | 1.0 | PSMB3 PSME2 | CDT1 association with the CDC6:ORC:origin complex |
| REAC:R-HSA-5676590 | 0.00286750504412 | 1.0 | PSMB3 PSME2 | NIK-->noncanonical NF-kB signaling |
| REAC:R-HSA-187577 | 0.00286750504412 | 1.0 | PSMB3 PSME2 | SCF(Skp2)-mediated degradation of p27/p21 |
| REAC:R-HSA-5610783 | 0.0029663845284 | 1.0 | PSMB3 PSME2 | Degradation of GLI2 by the proteasome |
| REAC:R-HSA-5610785 | 0.0029663845284 | 1.0 | PSMB3 PSME2 | GLI3 is processed to GLI3R by the proteasome |
| REAC:R-HSA-5607761 | 0.0029663845284 | 1.0 | PSMB3 PSME2 | Dectin-1 mediated noncanonical NF-kB signaling |
| REAC:R-HSA-5678895 | 0.0029663845284 | 1.0 | PSMB3 PSME2 | Defective CFTR causes cystic fibrosis |
| REAC:R-HSA-5358346 | 0.00316917126735 | 1.0 | PSMB3 PSME2 | Hedgehog ligand biogenesis |
| REAC:R-HSA-174084 | 0.00316917126735 | 1.0 | PSMB3 PSME2 | Autodegradation of Cdh1 by Cdh1:APC/C |
| REAC:R-HSA-4608870 | 0.00327307852202 | 1.0 | PSMB3 PSME2 | Asymmetric localization of PCP proteins |
| REAC:R-HSA-1234176 | 0.00348592080174 | 1.0 | PSMB3 PSME2 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha |
| REAC:R-HSA-69580 | 0.00359485582679 | 1.0 | PSMB3 PSME2 | p53-Dependent G1/S DNA damage checkpoint |
| REAC:R-HSA-69563 | 0.00359485582679 | 1.0 | PSMB3 PSME2 | p53-Dependent G1 DNA Damage Response |
| REAC:R-HSA-1169091 | 0.00359485582679 | 1.0 | PSMB3 PSME2 | Activation of NF-kappaB in B cells |
| REAC:R-HSA-8939902 | 0.00359485582679 | 1.0 | PSMB3 PSME2 | Regulation of RUNX2 expression and activity |
| REAC:R-HSA-174154 | 0.00359485582679 | 1.0 | PSMB3 PSME2 | APC/C:Cdc20 mediated degradation of Securin |
| REAC:R-HSA-5658442 | 0.00370546677531 | 1.0 | PSMB3 PSME2 | Regulation of RAS by GAPs |
| REAC:R-HSA-69615 | 0.00381775364729 | 1.0 | PSMB3 PSME2 | G1/S DNA Damage Checkpoints |
| REAC:R-HSA-8948751 | 0.00381775364729 | 1.0 | PSMB3 PSME2 | Regulation of PTEN stability and activity |
| REAC:R-HSA-68867 | 0.00381775364729 | 1.0 | PSMB3 PSME2 | Assembly of the pre-replicative complex |
| REAC:R-HSA-174178 | 0.004164669804 | 1.0 | PSMB3 PSME2 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 |
| REAC:R-HSA-174184 | 0.004164669804 | 1.0 | PSMB3 PSME2 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A |
| REAC:R-HSA-69017 | 0.004164669804 | 1.0 | PSMB3 PSME2 | CDK-mediated phosphorylation and removal of Cdc6 |
| REAC:R-HSA-68949 | 0.004164669804 | 1.0 | PSMB3 PSME2 | Orc1 removal from chromatin |
| REAC:R-HSA-179419 | 0.00428366036983 | 1.0 | PSMB3 PSME2 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint |
| REAC:R-HSA-176409 | 0.00452666927187 | 1.0 | PSMB3 PSME2 | APC/C:Cdc20 mediated degradation of mitotic proteins |
| REAC:R-HSA-1234174 | 0.00452666927187 | 1.0 | PSMB3 PSME2 | Cellular response to hypoxia |
| REAC:R-HSA-176814 | 0.00465068760809 | 1.0 | PSMB3 PSME2 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins |
| REAC:R-HSA-8852276 | 0.00477638186777 | 1.0 | PSMB3 PSME2 | The role of GTSE1 in G2/M progression after G2 checkpoint |
| REAC:R-HSA-2871837 | 0.00477638186777 | 1.0 | PSMB3 PSME2 | FCERI mediated NF-kB activation |
| REAC:R-HSA-5619084 | 0.00477638186777 | 1.0 | PSMB3 PSME2 | ABC transporter disorders |
| REAC:R-HSA-1168372 | 0.00490375205091 | 1.0 | PSMB3 PSME2 | Downstream signaling events of B Cell Receptor (BCR) |
| REAC:R-HSA-9013694 | 0.00516352018758 | 1.0 | PSMB3 PSME2 | Signaling by NOTCH4 |
| REAC:R-HSA-176408 | 0.00516352018758 | 1.0 | PSMB3 PSME2 | Regulation of APC/C activators between G1/S and early anaphase |
| REAC:R-HSA-5632684 | 0.0052959181411 | 1.0 | PSMB3 PSME2 | Hedgehog 'on' state |
| REAC:R-HSA-69202 | 0.00556574181855 | 1.0 | PSMB3 PSME2 | Cyclin E associated events during G1/S transition |
| REAC:R-HSA-195253 | 0.00556574181855 | 1.0 | PSMB3 PSME2 | Degradation of beta-catenin by the destruction complex |
| REAC:R-HSA-1236974 | 0.00556574181855 | 1.0 | PSMB3 PSME2 | ER-Phagosome pathway |
| REAC:R-HSA-69656 | 0.00584226918984 | 1.0 | PSMB3 PSME2 | Cyclin A:Cdk2-associated events at S phase entry |
| REAC:R-HSA-450531 | 0.00584226918984 | 1.0 | PSMB3 PSME2 | Regulation of mRNA stability by proteins that bind AU-rich elements |
| REAC:R-HSA-453276 | 0.00598304676068 | 1.0 | PSMB3 PSME2 | Regulation of mitotic cell cycle |
| REAC:R-HSA-5668541 | 0.00598304676068 | 1.0 | PSMB3 PSME2 | TNFR2 non-canonical NF-kB pathway |
| REAC:R-HSA-69002 | 0.00598304676068 | 1.0 | PSMB3 PSME2 | DNA Replication Pre-Initiation |
| REAC:R-HSA-174143 | 0.00598304676068 | 1.0 | PSMB3 PSME2 | APC/C-mediated degradation of cell cycle proteins |
| REAC:R-HSA-5687128 | 0.00626962967274 | 1.0 | PSMB3 PSME2 | MAPK6/MAPK4 signaling |
| REAC:R-HSA-69052 | 0.00656291627866 | 1.0 | PSMB3 PSME2 | Switching of origins to a post-replicative state |
| REAC:R-HSA-202424 | 0.00656291627866 | 1.0 | PSMB3 PSME2 | Downstream TCR signaling |
| REAC:R-HSA-4086400 | 0.00686290657842 | 1.0 | PSMB3 PSME2 | PCP/CE pathway |
| REAC:R-HSA-8878159 | 0.0070154156135 | 1.0 | PSMB3 PSME2 | Transcriptional regulation by RUNX3 |
| REAC:R-HSA-5607764 | 0.0070154156135 | 1.0 | PSMB3 PSME2 | CLEC7A (Dectin-1) signaling |
| REAC:R-HSA-1236975 | 0.00732546145404 | 1.0 | PSMB3 PSME2 | Antigen processing-Cross presentation |
| REAC:R-HSA-9020702 | 0.00780309964082 | 1.0 | PSMB3 PSME2 | Interleukin-1 signaling |
| REAC:R-HSA-382556 | 0.00812990471598 | 1.0 | PSMB3 PSME2 | ABC-family proteins mediated transport |
| REAC:R-HSA-5689603 | 0.00829582113875 | 1.0 | PSMB3 PSME2 | UCH proteinases |
| REAC:R-HSA-983705 | 0.00846341348499 | 1.0 | PSMB3 PSME2 | Signaling by the B Cell Receptor (BCR) |
| REAC:R-HSA-8878166 | 0.00897624606448 | 1.0 | PSMB3 PSME2 | Transcriptional regulation by RUNX2 |
| REAC:R-HSA-202403 | 0.00950416195513 | 1.0 | PSMB3 PSME2 | TCR signaling |
| REAC:R-HSA-5610787 | 0.0102315127378 | 1.0 | PSMB3 PSME2 | Hedgehog 'off' state |
| REAC:R-HSA-69239 | 0.0115688996608 | 1.0 | PSMB3 PSME2 | Synthesis of DNA |
| REAC:R-HSA-2454202 | 0.0119660935214 | 1.0 | PSMB3 PSME2 | Fc epsilon receptor (FCERI) signaling |
| REAC:R-HSA-162909 | 0.0123699910758 | 1.0 | PSMB3 PSME2 | Host Interactions of HIV factors |
| REAC:R-HSA-8939236 | 0.0131978972662 | 1.0 | PSMB3 PSME2 | RUNX1 regulates transcription of genes involved in differentiation of HSCs |
| REAC:R-HSA-5621481 | 0.0131978972662 | 1.0 | PSMB3 PSME2 | C-type lectin receptors (CLRs) |
| REAC:R-HSA-69306 | 0.0131978972662 | 1.0 | PSMB3 PSME2 | DNA Replication |
| REAC:R-HSA-446652 | 0.0131978972662 | 1.0 | PSMB3 PSME2 | Interleukin-1 family signaling |
| REAC:R-HSA-69206 | 0.014052618232 | 1.0 | PSMB3 PSME2 | G1/S Transition |
| REAC:R-HSA-6807070 | 0.0151587277172 | 1.0 | PSMB3 PSME2 | PTEN Regulation |
| REAC:R-HSA-3858494 | 0.0156129029755 | 1.0 | PSMB3 PSME2 | Beta-catenin independent WNT signaling |
| REAC:R-HSA-5358351 | 0.0167776697818 | 1.0 | PSMB3 PSME2 | Signaling by Hedgehog |
| REAC:R-HSA-453279 | 0.0179843346747 | 1.0 | PSMB3 PSME2 | Mitotic G1-G1/S phases |
| REAC:R-HSA-5619115 | 0.0202619146601 | 1.0 | PSMB3 PSME2 | Disorders of transmembrane transporters |
| REAC:R-HSA-69242 | 0.0210512746109 | 1.0 | PSMB3 PSME2 | S Phase |
| REAC:R-HSA-69481 | 0.023229975112 | 1.0 | PSMB3 PSME2 | G2/M Checkpoints |
| REAC:R-HSA-9010553 | 0.0235098543302 | 1.0 | PSMB3 PSME2 | Regulation of expression of SLITs and ROBOs |
| REAC:R-HSA-109581 | 0.0237914094719 | 1.0 | PSMB3 PSME2 | Apoptosis |
| REAC:R-HSA-5357801 | 0.0246461304377 | 1.0 | PSMB3 PSME2 | Programmed Cell Death |
| REAC:R-HSA-2467813 | 0.0279091534189 | 1.0 | PSMB3 PSME2 | Separation of Sister Chromatids |
| REAC:R-HSA-69275 | 0.0300912057669 | 1.0 | PSMB3 PSME2 | G2/M Transition |
| REAC:R-HSA-68882 | 0.0304096312248 | 1.0 | PSMB3 PSME2 | Mitotic Anaphase |
| REAC:R-HSA-5689880 | 0.0307297326061 | 1.0 | PSMB3 PSME2 | Ub-specific processing proteases |
| REAC:R-HSA-453274 | 0.0307297326061 | 1.0 | PSMB3 PSME2 | Mitotic G2-G2/M phases |
| REAC:R-HSA-2555396 | 0.0307297326061 | 1.0 | PSMB3 PSME2 | Mitotic Metaphase and Anaphase |
| REAC:R-HSA-5673001 | 0.0313749631391 | 1.0 | PSMB3 PSME2 | RAF/MAP kinase cascade |
| REAC:R-HSA-5684996 | 0.0330173681322 | 1.0 | PSMB3 PSME2 | MAPK1/MAPK3 signaling |
| REAC:R-HSA-9607240 | 0.0371300843089 | 1.0 | PSMB3 PSME2 | FLT3 Signaling |
| REAC:R-HSA-376176 | 0.0378389999335 | 1.0 | PSMB3 PSME2 | Signaling by ROBO receptors |
| REAC:R-HSA-8878171 | 0.0400059689703 | 1.0 | PSMB3 PSME2 | Transcriptional regulation by RUNX1 |
| REAC:R-HSA-157118 | 0.0403729962086 | 1.0 | PSMB3 PSME2 | Signaling by NOTCH |
| REAC:R-HSA-201681 | 0.0411120784555 | 1.0 | PSMB3 PSME2 | TCF dependent signaling in response to WNT |
| REAC:R-HSA-8951664 | 0.0411120784555 | 1.0 | PSMB3 PSME2 | Neddylation |
| REAC:R-HSA-162906 | 0.0414841334642 | 1.0 | PSMB3 PSME2 | HIV Infection |
| REAC:R-HSA-1257604 | 0.0422332712518 | 1.0 | PSMB3 PSME2 | PIP3 activates AKT signaling |
| REAC:R-HSA-449836 | 0.0429891127334 | 1.0 | PSMB3 PSME2 | Other interleukin signaling |
| REAC:R-HSA-5683057 | 0.0464733576116 | 1.0 | PSMB3 PSME2 | MAPK family signaling cascades |
| CORUM:30 | 0.0499173803268 | 0.5 | PSME2 | PA28 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PSMB3 | PSME2 | 0.807 | 0.767 | hein_WMM bioplex (PSMB3) bioplex_WMM treiber_WMM |
Images
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Complex HuMAP2_06140 has an average edge precision of 0.767 which is ranked 1057 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| PSMB3 | HuMAP2_00311 HuMAP2_00642 HuMAP2_01585 HuMAP2_04248 HuMAP2_04270 HuMAP2_06140 HuMAP2_06975 |
| PSME2 | HuMAP2_00642 HuMAP2_01585 HuMAP2_01996 HuMAP2_04248 HuMAP2_04270 HuMAP2_06140 HuMAP2_06852 HuMAP2_06975 |