hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06151
Confidence: Extremely High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| TPM1 | Tropomyosin alpha-1 chain (Alpha-tropomyosin) (Tropomyosin-1) | UniProt NCBI |
| TPM4 | Tropomyosin alpha-4 chain (TM30p1) (Tropomyosin-4) | UniProt NCBI |
| TPM3 | Tropomyosin alpha-3 chain (Gamma-tropomyosin) (Tropomyosin-3) (Tropomyosin-5) (hTM5) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0005862 | 3.63274304092e-07 | 1.0 | TPM4 TPM1 TPM3 | muscle thin filament tropomyosin |
| WP:WP383 | 5.00468323191e-07 | 1.0 | TPM4 TPM1 TPM3 | Striated Muscle Contraction Pathway |
| KEGG:04260 | 2.11408804451e-06 | 1.0 | TPM4 TPM1 TPM3 | Cardiac muscle contraction |
| REAC:R-HSA-445355 | 2.45300074645e-06 | 1.0 | TPM4 TPM1 TPM3 | Smooth Muscle Contraction |
| KEGG:05410 | 2.56577513453e-06 | 1.0 | TPM4 TPM1 TPM3 | Hypertrophic cardiomyopathy (HCM) |
| REAC:R-HSA-390522 | 2.94261178253e-06 | 1.0 | TPM4 TPM1 TPM3 | Striated Muscle Contraction |
| KEGG:05414 | 2.97024859397e-06 | 1.0 | TPM4 TPM1 TPM3 | Dilated cardiomyopathy (DCM) |
| KEGG:04261 | 1.05104157597e-05 | 1.0 | TPM4 TPM1 TPM3 | Adrenergic signaling in cardiomyocytes |
| GO:0005865 | 0.000103533176666 | 1.0 | TPM4 TPM1 TPM3 | striated muscle thin filament |
| GO:0036379 | 0.000139860607076 | 1.0 | TPM4 TPM1 TPM3 | myofilament |
| REAC:R-HSA-397014 | 0.000374667089817 | 1.0 | TPM4 TPM1 TPM3 | Muscle contraction |
| GO:0033275 | 0.000766145507331 | 1.0 | TPM4 TPM1 TPM3 | actin-myosin filament sliding |
| GO:0030049 | 0.000766145507331 | 1.0 | TPM4 TPM1 TPM3 | muscle filament sliding |
| GO:0097517 | 0.00167324144465 | 1.0 | TPM4 TPM1 TPM3 | contractile actin filament bundle |
| GO:0001725 | 0.00167324144465 | 1.0 | TPM4 TPM1 TPM3 | stress fiber |
| GO:0032432 | 0.00225266395968 | 1.0 | TPM4 TPM1 TPM3 | actin filament bundle |
| GO:0042641 | 0.00265735153444 | 1.0 | TPM4 TPM1 TPM3 | actomyosin |
| GO:0070252 | 0.00929437307021 | 1.0 | TPM4 TPM1 TPM3 | actin-mediated cell contraction |
| GO:0005884 | 0.0133902908488 | 1.0 | TPM4 TPM1 TPM3 | actin filament |
| GO:0030048 | 0.0170248502613 | 1.0 | TPM4 TPM1 TPM3 | actin filament-based movement |
| GO:0030017 | 0.0248678516681 | 1.0 | TPM4 TPM1 TPM3 | sarcomere |
| GO:0030016 | 0.0340260876928 | 1.0 | TPM4 TPM1 TPM3 | myofibril |
| GO:0044449 | 0.0356085105614 | 1.0 | TPM4 TPM1 TPM3 | contractile fiber part |
| GO:0043292 | 0.0415322430011 | 1.0 | TPM4 TPM1 TPM3 | contractile fiber |
| GO:0051015 | 0.0424286223465 | 1.0 | TPM4 TPM1 TPM3 | actin filament binding |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| TPM4 | TPM1 | 1.0 | 0.949 | hein_WMM bioplex (TPM1) bioplex_WMM youn_WMM hein (TPM1,TPM4) gupta_WMM |
| TPM1 | TPM3 | 1.0 | 0.949 | hein_WMM bioplex (TPM1) bioplex_WMM boldt youn_WMM hein (TPM1) gupta_WMM fraction boldt_WMM treiber_WMM |
| TPM4 | TPM3 | 0.025 | 0.214 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only treiber_WMM |
Images
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Complex HuMAP2_06151 has an average edge precision of 0.704 which is ranked 1356 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| TPM1 | HuMAP2_01077 HuMAP2_04204 HuMAP2_06151 HuMAP2_06387 |
| TPM4 | HuMAP2_00779 HuMAP2_04204 HuMAP2_06151 HuMAP2_06387 |
| TPM3 | HuMAP2_01077 HuMAP2_01543 HuMAP2_04204 HuMAP2_06151 |