hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_06159
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| GTF2H2C | General transcription factor IIH subunit 2-like protein (General transcription factor IIH polypeptide 2-like protein) | UniProt NCBI |
| GTF2H2C | General transcription factor IIH subunit 2-like protein (General transcription factor IIH polypeptide 2-like protein) | UniProt NCBI |
| ERCC3 | General transcription and DNA repair factor IIH helicase subunit XPB (TFIIH subunit XPB) (EC 3.6.4.12) (Basic transcription factor 2 89 kDa subunit) (BTF2 p89) (DNA excision repair protein ERCC-3) (DNA repair protein complementing XP-B cells) (TFIIH basal transcription factor complex 89 kDa subunit) (TFIIH 89 kDa subunit) (TFIIH p89) (Xeroderma pigmentosum group B-complementing protein) | UniProt NCBI |
| GTF2H5 | General transcription factor IIH subunit 5 (General transcription factor IIH polypeptide 5) (TFB5 ortholog) (TFIIH basal transcription factor complex TTD-A subunit) | UniProt NCBI |
| GTF2H1 | General transcription factor IIH subunit 1 (Basic transcription factor 2 62 kDa subunit) (BTF2 p62) (General transcription factor IIH polypeptide 1) (TFIIH basal transcription factor complex p62 subunit) | UniProt NCBI |
| GTF2H2 | General transcription factor IIH subunit 2 (Basic transcription factor 2 44 kDa subunit) (BTF2 p44) (General transcription factor IIH polypeptide 2) (TFIIH basal transcription factor complex p44 subunit) | UniProt NCBI |
| GTF2H3 | General transcription factor IIH subunit 3 (Basic transcription factor 2 34 kDa subunit) (BTF2 p34) (General transcription factor IIH polypeptide 3) (TFIIH basal transcription factor complex p34 subunit) | UniProt NCBI |
| GTF2H4 | General transcription factor IIH subunit 4 (Basic transcription factor 2 52 kDa subunit) (BTF2 p52) (General transcription factor IIH polypeptide 4) (TFIIH basal transcription factor complex p52 subunit) | UniProt NCBI |
| PTS | 6-pyruvoyl tetrahydrobiopterin synthase (PTP synthase) (PTPS) (EC 4.2.3.12) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0005675 | 9.83152848673e-18 | 0.875 | GTF2H1 ERCC3 GTF2H2C GTF2H2 GTF2H5 GTF2H4 GTF2H3 GTF2H2C | transcription factor TFIIH holo complex |
| CORUM:1029 | 1.79649228675e-17 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | TFIIH transcription factor complex |
| CORUM:1009 | 1.79649228675e-17 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | TFIIH transcription factor complex |
| GO:0000439 | 9.24336013776e-17 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | transcription factor TFIIH core complex |
| CORUM:1037 | 4.24766632997e-16 | 0.625 | GTF2H1 ERCC3 GTF2H4 GTF2H2 GTF2H3 | TFIIH transcription factor core complex |
| GO:0032806 | 6.25236335033e-16 | 0.875 | GTF2H1 ERCC3 GTF2H2C GTF2H2 GTF2H5 GTF2H4 GTF2H3 GTF2H2C | carboxy-terminal domain protein kinase complex |
| CORUM:1036 | 5.34846555655e-14 | 0.625 | GTF2H1 ERCC3 GTF2H4 GTF2H2 GTF2H3 | TFIIH transcription factor complex |
| CORUM:107 | 5.34846555655e-14 | 0.625 | GTF2H1 ERCC3 GTF2H4 GTF2H2 GTF2H3 | TFIIH transcription factor complex |
| REAC:R-HSA-167160 | 9.67913056005e-14 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection |
| REAC:R-HSA-77075 | 9.67913056005e-14 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | RNA Pol II CTD phosphorylation and interaction with CE |
| REAC:R-HSA-72086 | 1.55289366836e-13 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | mRNA Capping |
| REAC:R-HSA-73863 | 2.40643017581e-13 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | RNA Polymerase I Transcription Termination |
| REAC:R-HSA-113418 | 3.61909436458e-13 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | Formation of the Early Elongation Complex |
| REAC:R-HSA-167158 | 3.61909436458e-13 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | Formation of the HIV-1 Early Elongation Complex |
| KEGG:03022 | 4.64306719673e-13 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | Basal transcription factors |
| KEGG:03420 | 6.24655480034e-13 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | Nucleotide excision repair |
| REAC:R-HSA-5696400 | 1.46788664477e-12 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | Dual Incision in GG-NER |
| REAC:R-HSA-5696395 | 1.98978347566e-12 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | Formation of Incision Complex in GG-NER |
| REAC:R-HSA-167246 | 2.30369396892e-12 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | Tat-mediated elongation of the HIV-1 transcript |
| REAC:R-HSA-167200 | 2.30369396892e-12 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | Formation of HIV-1 elongation complex containing HIV-1 Tat |
| REAC:R-HSA-167169 | 2.30369396892e-12 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | HIV Transcription Elongation |
| REAC:R-HSA-167152 | 3.05611924013e-12 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | Formation of HIV elongation complex in the absence of HIV Tat |
| REAC:R-HSA-167162 | 3.50295189489e-12 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | RNA Polymerase II HIV Promoter Escape |
| REAC:R-HSA-73779 | 3.50295189489e-12 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| REAC:R-HSA-76042 | 3.50295189489e-12 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | RNA Polymerase II Transcription Initiation And Promoter Clearance |
| REAC:R-HSA-167161 | 3.50295189489e-12 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | HIV Transcription Initiation |
| REAC:R-HSA-75953 | 3.50295189489e-12 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | RNA Polymerase II Transcription Initiation |
| REAC:R-HSA-73776 | 3.50295189489e-12 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | RNA Polymerase II Promoter Escape |
| REAC:R-HSA-73762 | 3.50295189489e-12 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | RNA Polymerase I Transcription Initiation |
| GO:0006293 | 5.00715728072e-12 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | nucleotide-excision repair, preincision complex stabilization |
| GO:0006295 | 5.00715728072e-12 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | nucleotide-excision repair, DNA incision, 3'-to lesion |
| GO:0000717 | 6.88404783182e-12 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | nucleotide-excision repair, DNA duplex unwinding |
| REAC:R-HSA-6781823 | 7.4843047216e-12 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | Formation of TC-NER Pre-Incision Complex |
| REAC:R-HSA-112382 | 1.46788890653e-11 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | Formation of RNA Pol II elongation complex |
| REAC:R-HSA-75955 | 1.46788890653e-11 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | RNA Polymerase II Transcription Elongation |
| CORUM:103 | 1.79967425227e-11 | 0.625 | GTF2H1 ERCC3 GTF2H4 GTF2H2 GTF2H3 | RNA polymerase II holoenzyme complex |
| GO:0016591 | 1.82220076006e-11 | 0.875 | GTF2H1 ERCC3 GTF2H2C GTF2H2 GTF2H5 GTF2H4 GTF2H3 GTF2H2C | RNA polymerase II, holoenzyme |
| REAC:R-HSA-6796648 | 2.00203192713e-11 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | TP53 Regulates Transcription of DNA Repair Genes |
| GO:0070911 | 2.12320072238e-11 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | global genome nucleotide-excision repair |
| GO:1902554 | 2.22577271357e-11 | 0.875 | GTF2H1 ERCC3 GTF2H2C GTF2H2 GTF2H5 GTF2H4 GTF2H3 GTF2H2C | serine/threonine protein kinase complex |
| REAC:R-HSA-6782210 | 2.44111553107e-11 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | Gap-filling DNA repair synthesis and ligation in TC-NER |
| REAC:R-HSA-6782135 | 2.68905388425e-11 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | Dual incision in TC-NER |
| CORUM:2825 | 2.78427394284e-11 | 0.625 | GTF2H1 ERCC3 GTF2H4 GTF2H2 GTF2H3 | BRCA1-RNA polymerase II complex |
| GO:0006294 | 4.37916014478e-11 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | nucleotide-excision repair, preincision complex assembly |
| GO:0006362 | 4.37916014478e-11 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | transcription elongation from RNA polymerase I promoter |
| REAC:R-HSA-167172 | 4.65934508627e-11 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | Transcription of the HIV genome |
| GO:0006363 | 6.7861330958e-11 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | termination of RNA polymerase I transcription |
| GO:1902911 | 7.84532520885e-11 | 0.875 | GTF2H1 ERCC3 GTF2H2C GTF2H2 GTF2H5 GTF2H4 GTF2H3 GTF2H2C | protein kinase complex |
| REAC:R-HSA-6781827 | 8.34939665073e-11 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) |
| GO:0009452 | 8.35120073918e-11 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | 7-methylguanosine RNA capping |
| GO:0006370 | 8.35120073918e-11 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | 7-methylguanosine mRNA capping |
| GO:0006361 | 8.35120073918e-11 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | transcription initiation from RNA polymerase I promoter |
| GO:0036260 | 1.02058461081e-10 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | RNA capping |
| REAC:R-HSA-674695 | 1.13773399664e-10 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | RNA Polymerase II Pre-transcription Events |
| REAC:R-HSA-5696399 | 1.3204207271e-10 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | Global Genome Nucleotide Excision Repair (GG-NER) |
| GO:0055029 | 1.47228725799e-10 | 0.875 | GTF2H1 ERCC3 GTF2H2C GTF2H2 GTF2H5 GTF2H4 GTF2H3 GTF2H2C | nuclear DNA-directed RNA polymerase complex |
| GO:0000428 | 1.58670473288e-10 | 0.875 | GTF2H1 ERCC3 GTF2H2C GTF2H2 GTF2H5 GTF2H4 GTF2H3 GTF2H2C | DNA-directed RNA polymerase complex |
| GO:0030880 | 1.97682500908e-10 | 0.875 | GTF2H1 ERCC3 GTF2H2C GTF2H2 GTF2H5 GTF2H4 GTF2H3 GTF2H2C | RNA polymerase complex |
| REAC:R-HSA-73772 | 2.02110741528e-10 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | RNA Polymerase I Promoter Escape |
| GO:0006296 | 2.14121788489e-10 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | nucleotide-excision repair, DNA incision, 5'-to lesion |
| GO:0006289 | 2.80996417058e-10 | 0.875 | GTF2H1 ERCC3 GTF2H2C GTF2H2 GTF2H5 GTF2H4 GTF2H3 GTF2H2C | nucleotide-excision repair |
| GO:0033683 | 3.00431142893e-10 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | nucleotide-excision repair, DNA incision |
| WP:WP405 | 3.45861239295e-10 | 0.625 | GTF2H1 ERCC3 GTF2H4 GTF2H2 GTF2H3 | Eukaryotic Transcription Initiation |
| REAC:R-HSA-427413 | 5.21512796871e-10 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | NoRC negatively regulates rRNA expression |
| REAC:R-HSA-5250941 | 6.1987759906e-10 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | Negative epigenetic regulation of rRNA expression |
| REAC:R-HSA-73854 | 6.55911003059e-10 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | RNA Polymerase I Promoter Clearance |
| REAC:R-HSA-5696398 | 6.93671673589e-10 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | Nucleotide Excision Repair |
| REAC:R-HSA-73864 | 6.93671673589e-10 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | RNA Polymerase I Transcription |
| GO:0032508 | 1.87185712979e-09 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | DNA duplex unwinding |
| REAC:R-HSA-162599 | 2.21469663925e-09 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | Late Phase of HIV Life Cycle |
| GO:0090575 | 2.98596798236e-09 | 0.875 | GTF2H1 ERCC3 GTF2H2C GTF2H2 GTF2H5 GTF2H4 GTF2H3 GTF2H2C | RNA polymerase II transcription factor complex |
| REAC:R-HSA-162587 | 3.90972446151e-09 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | HIV Life Cycle |
| REAC:R-HSA-212165 | 3.90972446151e-09 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | Epigenetic regulation of gene expression |
| GO:0008353 | 3.92197879176e-09 | 0.625 | GTF2H1 ERCC3 GTF2H4 GTF2H2 GTF2H3 | RNA polymerase II CTD heptapeptide repeat kinase activity |
| GO:0006360 | 4.13944671642e-09 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | transcription by RNA polymerase I |
| GO:0032392 | 5.64573003451e-09 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | DNA geometric change |
| GO:0044798 | 1.0858675425e-08 | 0.875 | GTF2H1 ERCC3 GTF2H2C GTF2H2 GTF2H5 GTF2H4 GTF2H3 GTF2H2C | nuclear transcription factor complex |
| GO:0006353 | 1.56138575562e-08 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | DNA-templated transcription, termination |
| GO:0006283 | 1.56138575562e-08 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | transcription-coupled nucleotide-excision repair |
| GO:0006368 | 2.547758265e-08 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | transcription elongation from RNA polymerase II promoter |
| REAC:R-HSA-162906 | 5.10155898542e-08 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | HIV Infection |
| GO:0061695 | 6.06564742e-08 | 0.875 | GTF2H1 ERCC3 GTF2H2C GTF2H2 GTF2H5 GTF2H4 GTF2H3 GTF2H2C | transferase complex, transferring phosphorus-containing groups |
| GO:0005669 | 1.27028803235e-07 | 0.625 | GTF2H3 ERCC3 GTF2H5 GTF2H2 GTF2H4 | transcription factor TFIID complex |
| GO:0006354 | 1.47066608718e-07 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | DNA-templated transcription, elongation |
| GO:0005667 | 1.4816665503e-07 | 0.875 | GTF2H1 ERCC3 GTF2H2C GTF2H2 GTF2H5 GTF2H4 GTF2H3 GTF2H2C | transcription factor complex |
| REAC:R-HSA-73894 | 4.58113657776e-07 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | DNA Repair |
| GO:0090305 | 4.94306486873e-07 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | nucleic acid phosphodiester bond hydrolysis |
| GO:0070816 | 5.62690127955e-07 | 0.5 | GTF2H1 GTF2H5 GTF2H4 GTF2H3 | phosphorylation of RNA polymerase II C-terminal domain |
| REAC:R-HSA-3700989 | 7.44106092364e-07 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | Transcriptional Regulation by TP53 |
| REAC:R-HSA-5663205 | 8.82014831142e-07 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | Infectious disease |
| GO:0006367 | 2.78106571135e-06 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | transcription initiation from RNA polymerase II promoter |
| GO:0031334 | 4.64476236147e-06 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | positive regulation of protein complex assembly |
| GO:0000438 | 5.08584025729e-06 | 0.375 | GTF2H3 GTF2H2 GTF2H4 | core TFIIH complex portion of holo TFIIH complex |
| GO:0065004 | 5.28764207876e-06 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | protein-DNA complex assembly |
| GO:0006281 | 9.24577430132e-06 | 0.875 | GTF2H1 ERCC3 GTF2H2C GTF2H2 GTF2H5 GTF2H4 GTF2H3 GTF2H2C | DNA repair |
| GO:0006352 | 9.72116557692e-06 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | DNA-templated transcription, initiation |
| GO:0071103 | 1.92422832206e-05 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | DNA conformation change |
| GO:0071824 | 2.02568459214e-05 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | protein-DNA complex subunit organization |
| GO:0008094 | 2.2231978952e-05 | 0.625 | GTF2H1 ERCC3 GTF2H4 GTF2H2 GTF2H3 | DNA-dependent ATPase activity |
| REAC:R-HSA-8953854 | 3.16815271587e-05 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | Metabolism of RNA |
| KEGG:05203 | 7.95424377416e-05 | 0.5 | GTF2H1 GTF2H4 GTF2H2 GTF2H3 | Viral carcinogenesis |
| GO:0043254 | 0.00011100450493 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | regulation of protein complex assembly |
| GO:1990234 | 0.000186987138222 | 0.875 | GTF2H1 ERCC3 GTF2H2C GTF2H2 GTF2H5 GTF2H4 GTF2H3 GTF2H2C | transferase complex |
| GO:0006259 | 0.000210601211554 | 0.875 | GTF2H1 ERCC3 GTF2H2C GTF2H2 GTF2H5 GTF2H4 GTF2H3 GTF2H2C | DNA metabolic process |
| GO:0006974 | 0.000212679246578 | 0.875 | GTF2H1 ERCC3 GTF2H2C GTF2H2 GTF2H5 GTF2H4 GTF2H3 GTF2H2C | cellular response to DNA damage stimulus |
| GO:0044089 | 0.00027480965678 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | positive regulation of cellular component biogenesis |
| REAC:R-HSA-1643685 | 0.000292759547505 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | Disease |
| GO:0006397 | 0.000469384667037 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | mRNA processing |
| REAC:R-HSA-212436 | 0.000485403591864 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | Generic Transcription Pathway |
| CORUM:3066 | 0.000908974898571 | 0.25 | GTF2H3 ERCC3 | RNA polymerase II complex, chromatin structure modifying |
| REAC:R-HSA-73857 | 0.000921019711578 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | RNA Polymerase II Transcription |
| CORUM:1141 | 0.00122296268731 | 0.25 | GTF2H4 ERCC3 | CF IIAm complex (Cleavage factor IIAm complex) |
| GO:0044451 | 0.00126161552133 | 0.875 | GTF2H1 ERCC3 GTF2H2C GTF2H2 GTF2H5 GTF2H4 GTF2H3 GTF2H2C | nucleoplasm part |
| GO:0016251 | 0.00145089086092 | 0.375 | GTF2H3 GTF2H2 GTF2H4 | RNA polymerase II general transcription initiation factor activity |
| GO:0042623 | 0.00147220946451 | 0.625 | GTF2H1 ERCC3 GTF2H4 GTF2H2 GTF2H3 | ATPase activity, coupled |
| REAC:R-HSA-74160 | 0.00174657105004 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | Gene expression (Transcription) |
| HP:0012760 | 0.00248871678952 | 0.25 | GTF2H5 ERCC3 | Impaired social reciprocity |
| HP:0045055 | 0.00248871678952 | 0.25 | GTF2H5 ERCC3 | Tiger tail banding |
| HP:0007381 | 0.00248871678952 | 0.25 | GTF2H5 ERCC3 | Congenital exfoliative erythroderma |
| HP:0410219 | 0.00248871678952 | 0.25 | GTF2H5 ERCC3 | Hypoplasia of mandible relative to maxilla |
| HP:0002562 | 0.00348326758344 | 0.25 | GTF2H5 ERCC3 | Low-set nipples |
| GO:0140223 | 0.00413439262839 | 0.375 | GTF2H3 GTF2H2 GTF2H4 | general transcription initiation factor activity |
| HP:0001809 | 0.00464310919637 | 0.25 | GTF2H5 ERCC3 | Split nail |
| HP:0007587 | 0.00464310919637 | 0.25 | GTF2H5 ERCC3 | Numerous pigmented freckles |
| HP:0007034 | 0.0059681081945 | 0.25 | GTF2H5 ERCC3 | Generalized hyperreflexia |
| HP:0006538 | 0.0059681081945 | 0.25 | GTF2H5 ERCC3 | Recurrent bronchopulmonary infections |
| HP:0025428 | 0.0059681081945 | 0.25 | GTF2H5 ERCC3 | Bronchospasm |
| HP:0025356 | 0.0062473531373 | 0.375 | GTF2H5 ERCC3 PTS | Psychomotor retardation |
| HP:0025427 | 0.00745813121128 | 0.25 | GTF2H5 ERCC3 | Abnormal bronchus physiology |
| GO:1902494 | 0.00783585998931 | 0.875 | GTF2H1 ERCC3 GTF2H2C GTF2H2 GTF2H5 GTF2H4 GTF2H3 GTF2H2C | catalytic complex |
| HP:0001598 | 0.00911304494741 | 0.25 | GTF2H5 ERCC3 | Concave nail |
| HP:0007485 | 0.00911304494741 | 0.25 | GTF2H5 ERCC3 | Absence of subcutaneous fat |
| GO:0044087 | 0.00969277227106 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | regulation of cellular component biogenesis |
| GO:0016887 | 0.0107256534277 | 0.625 | GTF2H1 ERCC3 GTF2H4 GTF2H2 GTF2H3 | ATPase activity |
| HP:0000320 | 0.0109327161708 | 0.25 | GTF2H5 ERCC3 | Bird-like facies |
| HP:0003079 | 0.0109327161708 | 0.25 | GTF2H5 ERCC3 | Defective DNA repair after ultraviolet radiation damage |
| HP:0100275 | 0.0109327161708 | 0.25 | GTF2H5 ERCC3 | Diffuse cerebellar atrophy |
| HP:0007266 | 0.0109327161708 | 0.25 | GTF2H5 ERCC3 | Cerebral dysmyelination |
| HP:0025548 | 0.0129170117165 | 0.25 | GTF2H5 ERCC3 | Increased mean corpuscular hemoglobin concentration |
| HP:0007479 | 0.0129170117165 | 0.25 | GTF2H5 ERCC3 | Congenital nonbullous ichthyosiform erythroderma |
| GO:0016071 | 0.0151982958681 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | mRNA metabolic process |
| HP:0003254 | 0.0173789434513 | 0.25 | GTF2H5 ERCC3 | Abnormality of DNA repair |
| HP:0025546 | 0.0198563136463 | 0.25 | GTF2H5 ERCC3 | Abnormal mean corpuscular hemoglobin concentration |
| HP:0007633 | 0.0198563136463 | 0.25 | GTF2H5 ERCC3 | Bilateral microphthalmos |
| HP:0003139 | 0.0224977761754 | 0.25 | GTF2H5 ERCC3 | Panhypogammaglobulinemia |
| GO:0006357 | 0.0225750987374 | 0.875 | GTF2H1 ERCC3 GTF2H2C GTF2H2 GTF2H5 GTF2H4 GTF2H3 GTF2H2C | regulation of transcription by RNA polymerase II |
| GO:0004674 | 0.0232909099363 | 0.625 | GTF2H1 ERCC3 GTF2H4 GTF2H2 GTF2H3 | protein serine/threonine kinase activity |
| GO:0006396 | 0.0243548281027 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | RNA processing |
| HP:0006970 | 0.0253031982095 | 0.25 | GTF2H5 ERCC3 | Periventricular leukomalacia |
| HP:0001807 | 0.0347018940535 | 0.25 | GTF2H5 ERCC3 | Ridged nail |
| GO:0051130 | 0.037137043425 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | positive regulation of cellular component organization |
| HP:0001808 | 0.0381618271547 | 0.25 | GTF2H5 ERCC3 | Fragile nails |
| GO:0034622 | 0.0424653981371 | 0.75 | GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H5 GTF2H4 | cellular protein-containing complex assembly |
| HP:0007431 | 0.0455714500205 | 0.25 | GTF2H5 ERCC3 | Congenital ichthyosiform erythroderma |
| HP:0002293 | 0.0455714500205 | 0.25 | GTF2H5 ERCC3 | Alopecia of scalp |
| GO:0006366 | 0.0475044023837 | 0.875 | GTF2H1 ERCC3 GTF2H2C GTF2H2 GTF2H5 GTF2H4 GTF2H3 GTF2H2C | transcription by RNA polymerase II |
| HP:0008887 | 0.0495208749973 | 0.25 | GTF2H5 ERCC3 | Adipose tissue loss |
| HP:0008391 | 0.0495208749973 | 0.25 | GTF2H5 ERCC3 | Dystrophic fingernails |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| GTF2H2C | GTF2H2C | 1.0 | 0.949 | bioplex (GTF2H2C;) bioplex_WMM |
| GTF2H2C | GTF2H1 | 1.0 | 0.949 | bioplex (GTF2H2C;) bioplex_WMM Malo fraction |
| GTF2H1 | ERCC3 | 1.0 | 0.949 | hein_WMM bioplex (ERCC3) bioplex_WMM Malo fraction |
| GTF2H1 | GTF2H3 | 1.0 | 0.949 | hein_WMM bioplex (GTF2H3) bioplex_WMM Malo fraction |
| GTF2H2C | ERCC3 | 1.0 | 0.949 | bioplex (GTF2H2C;) bioplex_WMM Malo fraction |
| GTF2H4 | ERCC3 | 1.0 | 0.949 | hein_WMM bioplex (ERCC3) bioplex_WMM Malo fraction |
| GTF2H2C | GTF2H3 | 0.998 | 0.939 | bioplex (GTF2H2C;) bioplex_WMM Malo fraction |
| GTF2H1 | GTF2H4 | 0.998 | 0.936 | hein_WMM bioplex_WMM Malo fraction |
| GTF2H2 | ERCC3 | 0.989 | 0.905 | hein_WMM bioplex (ERCC3) bioplex_WMM Malo fraction |
| GTF2H5 | GTF2H3 | 0.986 | 0.901 | hein_WMM bioplex (GTF2H3,GTF2H5) bioplex_WMM hein (GTF2H5) |
| GTF2H5 | GTF2H4 | 0.983 | 0.898 | hein_WMM bioplex (GTF2H5) bioplex_WMM hein (GTF2H5) |
| GTF2H5 | GTF2H1 | 0.98 | 0.896 | hein_WMM bioplex (GTF2H5) bioplex_WMM hein (GTF2H5) |
| GTF2H1 | GTF2H2 | 0.964 | 0.872 | hein_WMM bioplex_WMM Malo fraction |
| GTF2H3 | GTF2H2 | 0.962 | 0.87 | hein_WMM bioplex (GTF2H3) bioplex_WMM Malo fraction |
| GTF2H5 | ERCC3 | 0.951 | 0.858 | hein_WMM bioplex (ERCC3,GTF2H5) bioplex_WMM hein (GTF2H5) |
| GTF2H3 | ERCC3 | 0.945 | 0.856 | hein_WMM bioplex (ERCC3,GTF2H3) bioplex_WMM Malo fraction |
| GTF2H3 | GTF2H4 | 0.93 | 0.846 | hein_WMM bioplex (GTF2H3) bioplex_WMM Malo fraction |
| GTF2H2 | GTF2H4 | 0.823 | 0.774 | hein_WMM bioplex_WMM Malo fraction |
| GTF2H5 | GTF2H2 | 0.747 | 0.741 | hein_WMM bioplex (GTF2H5) bioplex_WMM hein (GTF2H5) |
| GTF2H2C | GTF2H5 | 0.529 | 0.634 | bioplex (GTF2H2C;) bioplex_WMM |
| GTF2H2C | PTS | 0.221 | 0.466 | bioplex (GTF2H2C;) bioplex_WMM |
| GTF2H2C | GTF2H4 | 0.213 | 0.464 | bioplex (GTF2H2C;) bioplex_WMM Malo fraction |
| GTF2H2C | GTF2H4 | 0.009 | 0.108 | bioplex_WMM WMM_only |
| GTF2H2C | GTF2H5 | 0.009 | 0.108 | bioplex_WMM WMM_only |
| GTF2H2C | PTS | 0.009 | 0.101 | bioplex_WMM WMM_only |
| GTF2H2C | GTF2H3 | 0.009 | 0.09 | bioplex_WMM youn_WMM WMM_only |
| GTF2H2C | GTF2H1 | 0.009 | 0.089 | bioplex_WMM WMM_only |
| GTF2H2C | ERCC3 | 0.009 | 0.095 | bioplex_WMM WMM_only |
| PTS | GTF2H5 | 0.008 | 0.088 | bioplex_WMM WMM_only |
| PTS | GTF2H4 | 0.008 | 0.088 | bioplex_WMM WMM_only |
| PTS | GTF2H3 | 0.008 | 0.083 | bioplex_WMM WMM_only |
| PTS | GTF2H1 | 0.008 | 0.083 | bioplex_WMM WMM_only |
| PTS | ERCC3 | 0.008 | 0.067 | bioplex_WMM WMM_only |
Images
Click to enlarge
Complex HuMAP2_06159 has an average edge precision of 0.592 which is ranked 1979 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| GTF2H2C | HuMAP2_01329 HuMAP2_01999 HuMAP2_04213 HuMAP2_05362 HuMAP2_06159 |
| GTF2H2C | HuMAP2_01329 HuMAP2_04213 HuMAP2_05362 HuMAP2_06159 |
| ERCC3 | HuMAP2_01999 HuMAP2_04213 HuMAP2_06159 HuMAP2_06407 |
| GTF2H5 | HuMAP2_01967 HuMAP2_01999 HuMAP2_04213 HuMAP2_06159 |
| GTF2H1 | HuMAP2_01999 HuMAP2_04213 HuMAP2_06159 |
| GTF2H2 | HuMAP2_01999 HuMAP2_04213 HuMAP2_06159 |
| GTF2H3 | HuMAP2_01999 HuMAP2_04213 HuMAP2_06159 |
| GTF2H4 | HuMAP2_01999 HuMAP2_04213 HuMAP2_06159 |
| PTS | HuMAP2_01329 HuMAP2_04213 HuMAP2_06159 |