hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06172
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| RDH13 | Retinol dehydrogenase 13 (EC 1.1.1.300) (Short chain dehydrogenase/reductase family 7C member 3) | UniProt NCBI |
| STK24 | Serine/threonine-protein kinase 24 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 3) (MST-3) (STE20-like kinase MST3) [Cleaved into: Serine/threonine-protein kinase 24 36 kDa subunit (Mammalian STE20-like protein kinase 3 N-terminal) (MST3/N); Serine/threonine-protein kinase 24 12 kDa subunit (Mammalian STE20-like protein kinase 3 C-terminal) (MST3/C)] | UniProt NCBI |
| STK26 | Serine/threonine-protein kinase 26 (EC 2.7.11.1) (MST3 and SOK1-related kinase) (Mammalian STE20-like protein kinase 4) (MST-4) (STE20-like kinase MST4) (Serine/threonine-protein kinase MASK) | UniProt NCBI |
| STK25 | Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Ste20-like kinase) (Sterile 20/oxidant stress-response kinase 1) (SOK-1) (Ste20/oxidant stress response kinase 1) | UniProt NCBI |
| PDCD10 | Programmed cell death protein 10 (Cerebral cavernous malformations 3 protein) (TF-1 cell apoptosis-related protein 15) | UniProt NCBI |
| PROSER2 | Proline and serine-rich protein 2 | UniProt NCBI |
| C9orf78 | Telomere length and silencing protein 1 homolog (Hepatocellular carcinoma-associated antigen 59) | UniProt NCBI |
| C4orf19 | Uncharacterized protein C4orf19 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0036473 | 0.000534279096056 | 0.5 | STK25 STK24 PDCD10 STK26 | cell death in response to oxidative stress |
| GO:0042542 | 0.00076806868397 | 0.5 | STK25 STK24 PDCD10 STK26 | response to hydrogen peroxide |
| GO:0036474 | 0.00344619549436 | 0.375 | STK25 STK26 PDCD10 | cell death in response to hydrogen peroxide |
| GO:0046677 | 0.00928778966369 | 0.5 | STK25 STK24 PDCD10 STK26 | response to antibiotic |
| GO:0000302 | 0.0115267991945 | 0.5 | STK25 STK24 PDCD10 STK26 | response to reactive oxygen species |
| GO:0008631 | 0.0275393607475 | 0.375 | STK25 STK24 PDCD10 | intrinsic apoptotic signaling pathway in response to oxidative stress |
| REAC:R-HSA-111465 | 0.0295328318157 | 0.25 | STK24 STK26 | Apoptotic cleavage of cellular proteins |
| GO:0009636 | 0.0434166732227 | 0.5 | STK25 STK24 PDCD10 STK26 | response to toxic substance |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| STK24 | STK25 | 1.0 | 0.949 | bioplex (STK25) bioplex_WMM |
| STK24 | PDCD10 | 1.0 | 0.949 | hein_WMM bioplex (PDCD10) bioplex_WMM Malo fraction |
| STK25 | STK26 | 1.0 | 0.949 | bioplex (STK25) bioplex_WMM |
| STK26 | PDCD10 | 1.0 | 0.949 | hein_WMM bioplex (PDCD10) bioplex_WMM Malo fraction |
| STK25 | PDCD10 | 0.999 | 0.949 | bioplex (PDCD10,STK25) bioplex_WMM Malo fraction |
| STK24 | C4orf19 | 0.929 | 0.845 | bioplex (C4orf19) bioplex_WMM |
| PDCD10 | C4orf19 | 0.561 | 0.65 | bioplex (C4orf19) bioplex_WMM |
| PDCD10 | PROSER2 | 0.36 | 0.543 | bioplex (PROSER2) bioplex_WMM |
| STK24 | PROSER2 | 0.17 | 0.426 | bioplex (PROSER2) bioplex_WMM |
| STK25 | C4orf19 | 0.083 | 0.35 | bioplex (C4orf19) bioplex_WMM |
| STK26 | C4orf19 | 0.081 | 0.351 | bioplex (C4orf19) bioplex_WMM |
| C9orf78 | STK24 | 0.064 | 0.348 | fraction |
| PROSER2 | RDH13 | 0.052 | 0.3 | bioplex (PROSER2) bioplex_WMM |
| STK24 | STK26 | 0.022 | 0.2 | hein_WMM bioplex_WMM WMM_only |
| STK25 | PROSER2 | 0.02 | 0.185 | bioplex (PROSER2) bioplex_WMM |
| STK26 | PROSER2 | 0.02 | 0.187 | bioplex (PROSER2) bioplex_WMM |
| STK26 | RDH13 | 0.007 | 0.003 | bioplex_WMM WMM_only |
| STK24 | RDH13 | 0.007 | 0.005 | bioplex_WMM WMM_only |
| STK25 | RDH13 | 0.007 | 0.003 | bioplex_WMM WMM_only |
| PDCD10 | RDH13 | 0.007 | 0.001 | bioplex_WMM WMM_only |
| C9orf78 | STK25 | 0.0 | 0.01 | fraction |
| C9orf78 | PDCD10 | 0.0 | 0.001 | fraction |
| C9orf78 | STK26 | 0.0 | 0.003 | fraction |
Images
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Complex HuMAP2_06172 has an average edge precision of 0.398 which is ranked 3349 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| RDH13 | HuMAP2_03885 HuMAP2_06150 HuMAP2_06172 HuMAP2_06914 |
| STK24 | HuMAP2_00578 HuMAP2_00795 HuMAP2_00857 HuMAP2_03192 HuMAP2_06172 HuMAP2_06914 |
| STK26 | HuMAP2_00857 HuMAP2_01720 HuMAP2_06172 HuMAP2_06914 |
| STK25 | HuMAP2_00795 HuMAP2_00857 HuMAP2_01720 HuMAP2_04545 HuMAP2_06172 HuMAP2_06914 |
| PDCD10 | HuMAP2_00857 HuMAP2_01720 HuMAP2_06172 HuMAP2_06914 |
| PROSER2 | HuMAP2_03885 HuMAP2_06150 HuMAP2_06172 HuMAP2_06914 |
| C9orf78 | HuMAP2_00578 HuMAP2_06172 HuMAP2_06914 |
| C4orf19 | HuMAP2_00857 HuMAP2_03192 HuMAP2_06172 HuMAP2_06914 |